La dimensión narrativa en el discurso político argentino. La campaña del "Frente de Todos" en redes sociales

En este trabajo propongo repasar algunos spots y tuits durante la campaña presidencial del Frente de Todos en Argentina (2019) con el fin de estudiar la dimensión narrativa de los relatos políticos.Fil: Montero, Ana Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de San Martín; Argentin

Ausencia de un efecto estructural molecular sobre las propiedades termodinámicas de varios materiales tipo biodiesel

In the search to develop the production of vegetable oils for non-food purposes biodiesel stands out for its great versatility as technical material and a cleaner energy technology. Physic nut (Jatropha curcas), castor-oil (Ricinus communis), oil palm (Elaeis guineensis), wine palm (Attalea butyracea) and macaw palm (Acrocomia aculeata) were chosen for study in our laboratory, because they are oleaginous plants with convenient oil yields to produce biodiesel. No significant effect from the nature of fatty-acid chains in biodiesel is observed on thermodynamic properties such as heat of combustion, cubic-expansion thermal coefficient, isothermal compressibility, enthalpy of vaporisation and Hildebrand solubility parameter. Activation energies for viscous flow of biodiesels correlates with the same property of their vegetable oil feedstocks.En la búsqueda de desarrollar la producción de aceites vegetales para fines no alimenticios, el biodiesel se destaca por su gran versatilidad como material técnico y como una tecnología de energía más limpia. Tempate (Jatropha curcas), higuerilla (Ricinus communis), palma aceitera (Elaeis guineensis),  palma real (Attalea butyracea) y coyol (Acrocomia aculeata) fueron elegidos para su estudio en nuestro laboratorio, porque son plantas oleaginosas con rendimientos convenientes para producir biodiesel. No se observa ningún efecto significativo de la naturaleza de las cadenas de ácidos grasos en el biodiesel sobre las propiedades termodinámicas como el calor de combustión, el coeficiente térmico de expansión cúbica, la compresibilidad isotérmica, la entalpía de vaporización y el parámetro de solubilidad de Hildebrand. Las energías de activación para el flujo viscoso de biodiesel se correlacionan con la misma propiedad de sus materias primas de aceite vegetal

Biometrical Analysis of the Anterior Communicating Artery and the Anterior Cerebral Artery in the Precommunicating Segment of the Cerebral Arterial Circle

Indexación: ScieloLa conformación del círculo arterial cerebral tiene relevancia en la clínica neuroquirúrgica por la relación compleja que presentan las arterias que lo originan y su gran variabilidad. Debido a la alta frecuencia con que se observan aneurismas en las arteria comunicante anterior y en el segmento precomunicante (A1) de la arteria cerebral anterior se efectuó un análisis biométrico de ellas. El trabajo se realizó en 36 cerebros frescos procedentes de especímenes cuyos datos bioantropológicos estaban registrados. El calibre de la arteria comunicante anterior fue de 1.68 mm y la longitud, en promedio, de 2.50 mm. En el lado derecho el segmento A1 de la arteria cerebral anterior tenía una longitud de 12.91mm y un calibre de 2.39 mm. En el lado izquierdo, la longitud de este segmento fue de 12.77 mm y presentó un calibre de 2.46mm. En un 29% de las muestras analizadas, se presentaron arterias comunicantes dobles, con una longitud de 2.92 mm y un calibre de 0.95 mm. Se observó variabilidad en los componentes que constituyen el círculo arterial cerebral, cuando se consideran variables como lado, sexo e índice cefálico. PALABRAS CLAVE: Arteria comunicante anterior; Arteria cerebral anterior; Círculo arterial del cerebro; Índice cefálico.SUMMARY: The conformation of the cerebral arterial circle has relevance in the clinical neurosurgery for the complex relate that present the arteries that originate it and its great variability. Due to the high frequency with that aneurysms are observed in the anterior communicant artery and the anterior cerebral artery in the precommunicating segment (A1), we have decided to make an analysis biometrical in them. The work had done in 36 available fresh brains in the laboratories and they come from specimens whose data bioanthropological were registered. The caliber of the anterior communicating artery corresponds to 1.68 mm and the longitude to 2.50 mm. The segment A1 of the anterior cerebral artery it corresponds to a longitude of 12.91mm and it presents a caliber of 2.39 mm in the right side. In the left side the longitude of this segment is of 12.77 mm and it presents a caliber of 2.46. In 29% of the analyzed samples, they register double communicating arteries, with a longitude of 2.92 mm and a caliber of 0.95 mm. Variability of the components is observed that they constitute the cerebral arterial circle when is considered: side, sex and cephalic index KEY WORDS: Anterior communicating artery; Anterior cerebral artery; Cerebral arterial circle; Cephalix index

Biometrical Characteristics of Anterior Choroidal Artery in its Cisternal Segment

Indexación: Web of Science; ScieloLas implicancias clínicas que tienen los procesos oclusivos de la Arteria Coroidea Anterior (AChA), son de considerable importancia y nos han motivado para efectuar su análisis biométrico incorporando algunos otros parámetros. Para su ejecución, se utilizaron cerebros inyectados con látex coloreado de rojo fijados en solución de formol, provenientes del Servicio Médico Legal, Santiago.Para su observación, se usó lupa luminiscente 4 X y las mediciones efectuadas con Caliper Mitutoyo Digital. Esta arteria se originó de la Carótida Interna (ACI) en un 83,3 % y en un 16,7 % de la Arteria Comunicante Posterior (ACoP ). El calibre medio observado en su origen fue de 0,68 ± 0,31 mm; en el tercio medio de 0,60 ± 0,21 mm; en el punto de entrada en el plexo coroideo de 0,48 ± 0,23 mm. La longitud media desde el origen de la AChA al plexo coroideo fue de 28,67 ±6,33 mm; la distancia media desde su origen al de la ACoP fue de 6,97 ± 4,89 mm. El número promedio de ramas perforantes registradas fue de 6. Nuestros resultados pueden ser una contribución a considerar en la clínica.SUMMARY:The clinical implications of occlusive processes in the anterior choroidal artery (AChA) are of considerable importance and have motivated us to perform a biometrical analysis of the afore mentioned artery including new biometric parameters (measurements). This study was perfomed on vascularized brains that were both fixed with for formalin solution and injected whith red tinted latex and brains that were not fixed with formalin solution, which were obtained from the Medical Legal Service, Santiago. They were observed using a luminescent 4 X magnifying glass and the measurements perfomed using a Mitutoyo Digital Caliper. This artery originated from the internal carotid artery (ICA) in 83.3 % of the cases observed, and in 16.7 % it originated from the posterior communicating artery ( PCoA). The mean caliber (diameter) of the artery was 0.68 ± 0.31 mm at the point of origin; the middle third was 0.60 mm ± 0.21 mm; at the point of entry into the choroidal plexus it was 0.48 mm ± 0.23 mm. The mean length from its origin at the AChA to the choroidal plexus was 28.67 mm ± 6.33 mm; the mean distance from its origin at the PCoAwas 6.97mm± 4.89 mm. The number of perforating branches of the AChA was 6. Our results can be considered a clinical contribution. KEY WORDS : Anterior choroidal artery ; Biometry; Cephalix index; Internal carotid artery.http://ref.scielo.org/26fk9

Sleep and Anabolic/Catabolic Hormonal Profile in Sedentary Middle-Aged Adults: The FIT-AGEING Study

Sleep quality plays an important role in the modulation of several aging markers. This influence could be explained by aging-induced hormonal changes. Indeed, poor sleep quality has been associated with the development of several endocrine-related health complications. This study examined the relationship of both subjective and objective sleep quantity and quality, with basal levels of selected plasma anabolic and catabolic hormones in sedentary middle-aged adults. A total of 74 volunteers (52.7% women; aged 53.7 5.1) were recruited for this study. Subjective sleep quality was assessed by the Pittsburgh Sleep Quality Index (PSQI; higher scores indicate worse sleep quality), and objective sleep quality parameters (total sleep time [TST], wake after sleep onset [WASO], and sleep efficiency [SE]) were measured using a wrist-worn accelerometer. Basal levels of plasma dehydroepiandrosterone sulphate (DHEAS), total testosterone, sex hormone binding globulin (SHBG), somatotropin, and cortisol levels, were determined. Free testosterone was calculated from the total testosterone and SHBG levels. No associations of global PSQI score, TST, WASO, and SE with DHEAS, free testosterone, and somatotropin plasma levels were found, neither in men nor in women (all p 0.05). Global PSQI score was inversely related to cortisol plasma levels in women (p = 0.043). WASO was positively associated with cortisol plasma levels, while SE was negatively associated with cortisol plasma levels in women (all p 0.027). Sleep quality is not related to levels of plasma anabolic hormones, but to levels of catabolic hormones, in sedentary middle-aged adults. Therefore, these results suggest that potential changes in aging biomarkers associated with sleep disturbances, could be mediated by age-related changes in the catabolic endocrine system

Hemogram-derived ratios as prognostic markers of ICU admission in COVID-19.

Background The vast impact of COVID-19 call for the identification of clinical parameter that can help predict a torpid evolution. Among these, endothelial injury has been proposed as one of the main pathophysiological mechanisms underlying the disease, promoting a hyperinflammatory and prothrombotic state leading to worse clinical outcomes. Leukocytes and platelets play a key role in inflammation and thrombogenesis, hence the objective of the current study was to study whether neutrophil-to-lymphocyte ratio (NLR), platelets-to-lymphocyte ratio (PLR), the systemic immune-inflammation index (SII) as well as the new parameter neutrophil-to-platelet ratio (NPR), could help identify patients who at risk of admission at Intensive Care Units. Methods A retrospective observational study was performed at HM Hospitales including electronic health records from 2245 patients admitted due to COVID-19 from March 1 to June 10, 2020. Patients were divided into two groups, admitted at ICU or not. Results Patients who were admitted at the ICU had significantly higher values in all hemogram-derived ratios at the moment of hospital admission compared to those who did not need ICU admission. Specifically, we found significant differences in NLR (6.9 [4–11.7] vs 4.1 [2.6–7.6], p <  0.0001), PLR (2 [1.4–3.3] vs 1.9 [1.3–2.9], p = 0.023), NPR (3 [2.1–4.2] vs 2.3 [1.6–3.2], p <  0.0001) and SII (13 [6.5–25.7] vs 9 [4.9–17.5], p <  0.0001) compared to those who did not require ICU admission. After multivariable logistic regression models, NPR was the hemogram-derived ratio with the highest predictive value of ICU admission, (OR 1.11 (95% CI: 0.98–1.22, p = 0.055). Conclusions Simple, hemogram-derived ratios obtained from early hemogram at hospital admission, especially the novelty NPR, have shown to be useful predictors of risk of ICU admission in patients hospitalized due to COVID-19.post-print997 K

Improved Expression of SARS-CoV-2 Spike RBD Using the Insect Cell-Baculovirus System

Insect cell-baculovirus expression vector system is one of the most established platforms to produce biological products, and it plays a fundamental role in the context of COVID-19 emergency, providing recombinant proteins for treatment, diagnosis, and prevention. SARS-CoV-2 infection is mediated by the interaction of the spike glycoprotein trimer via its receptor-binding domain (RBD) with the host’s cellular receptor. As RBD is required for many applications, in the context of pandemic it is important to meet the challenge of producing a high amount of recombinant RBD (rRBD). For this reason, in the present study, we developed a process based on Sf9 insect cells to improve rRBD yield. rRBD was recovered from the supernatant of infected cells and easily purified by metal ion affinity chromatography, with a yield of 82% and purity higher than 95%. Expressed under a novel chimeric promoter (polh-pSeL), the yield of rRBD after purification was 21.1 ± 3.7 mg/L, which is the highest performance described in Sf9 cell lines. Finally, rRBD was successfully used in an assay to detect specific antibodies in COVID-19 serum samples. The efficient strategy herein described has the potential to produce high-quality rRBD in Sf9 cell line for diagnostic purpose.Fil: Poodts, Joaquín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Nanobiotecnología. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Nanobiotecnología; ArgentinaFil: Smith, Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Nanobiotecnología. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Nanobiotecnología; ArgentinaFil: Birenbaum, Joaquín Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Nanobiotecnología. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Nanobiotecnología; ArgentinaFil: Rodriguez, María Sol. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Nanobiotecnología. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Nanobiotecnología; ArgentinaFil: Montero, Luciano. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Nanobiotecnología. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Nanobiotecnología; ArgentinaFil: Wolman, Federico Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Nanobiotecnología. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Nanobiotecnología; ArgentinaFil: Marfía, Juan Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; ArgentinaFil: Valdez, Silvina Noemi. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; ArgentinaFil: Alonso, Leonardo Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Nanobiotecnología. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Nanobiotecnología; ArgentinaFil: Targovnik, Alexandra Marisa. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Nanobiotecnología. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Nanobiotecnología; ArgentinaFil: Miranda, Maria Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Nanobiotecnología. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Nanobiotecnología; Argentin

La imagen y la narrativa como herramientas para el abordaje psicosocial en escenarios de violencia Municipios de Bucaramanga, Barrancabermeja y Yondó.

En este trabajo encontrara un análisis detallado a cerca del caso de Camilo, un muchacho afrocolombiano que ha sido desplazado por la violencia debido a amenazas de las FARC, con el desarrollo de variados interrogantes que permitieron ahondar en las derivaciones que deja el conflicto en las personas que lo padecen. Considerando, el gran sufrimiento psicológico, físico y emocional que dejan estos atroces hechos como el de Camilo o el de Peñas coloradas, es importante que como psicólogos contemos con la formación para poner en práctica estrategias adecuadas, con fundamento científico que contribuyan con los procesos de reivindicación cultural, personal social y comunitario para salvaguardar la historia y la riqueza de las tradiciones respetando lo que los ha configurado, contando relatos transparentes sin anular el dolor de quieres padecieron todos los flagelos de la guerra. Favorecer la interpretación de diferentes realidades en diversos contextos promueve la aceptación, el cambio y el empoderamiento de las comunidades para ser mucho más resilientes. Por esto, la arterapia, la narrativa la escucha, entre otras son maniobras significativas en la recuperación de la identidad en un país en el que claramente las injusticias y la violencia han sido el pan diario para las comunidades más vulnerables, por esto, la narrativa de las víctimas y sobrevivientes son descriptivos, metafóricos, acordes a su interpretación de lo experimentado de esta forma, quien los escucha también puede hacer una catarsis de su propia realidad y darle el significado que considere para expresarse, sanar o contar su propia percepción de la historia.In this work you will find a detailed analysis of the case of Camilo, a young Afro-Colombian displaced by violence due to threats from the farc, with the development of various questions that allowed delving into the consequences that the armed conflict leaves on the people who suffered it suffer. Considering the great psychological, physical and emotional suffering caused by these atrocious events such as that of Camilo or Peñas Coloradas, it is important that as psychologists we have the training to put into practice adequate strategies, with a scientific basis that contribute to the processes of cultural, personal, social and community claim to safeguard history and the richness of traditions, respecting what has shaped them, telling transparent stories without canceling out the pain that all the scourges of war suffered. Favoring the interpretation of different realities in various contexts promotes acceptance, change and the empowerment of communities to be much more resilient. For this reason, therapy, listening to the narrative, among others, are significant maneuvers in the recovery of identity in a country where injustices and violence have clearly been the daily bread for the most vulnerable communities, for this reason, the narrative of the victims and survivors are descriptive, metaphorical, according to their interpretation of what they experienced in this way, whoever listens to them can also make a catharsis of their own reality and give it the meaning they consider to express themselves, heal or tell their own perception of the history

Debates contemporáneos sobre el poder político de ideas y discursos en América Latina

This edition of Foro de Debate presents different articles on contemporary debates on the political power of ideas and discourses in Latin America from a theoretical and practical analysis. Several approaches to the topic are presented. They begin with an academic review of concepts, government regimes and electoral rules, proposing a pending agenda for study followed by a methodological reflection on discourse and politics as a proposal to address the topic of study. Along the same lines, an analysis of the importance of speech in social research is presented. This is followed by a look at discursive attribution as a possibility for political action. And finally, an empirical application of discourse, problem and policy analysis applied to poverty and inequality is presented.Esta edición del Foro de Debate presenta diferentes artículos en torno a los debates contemporáneos sobre el poder político de ideas y discursos en América Latina desde un análisis teórico y también práctico. Se presentan diversas aristas para abordar el tema. Comienza con una revisión teórica de las ideas, regímenes de gobierno y reglas electorales. Sigue con una reflexión metodológica sobre discurso y política. Luego se presenta un análisis sobre la importancia del discurso en la investigación social. A continuación, se echa una mirada a la atribución discursiva como posibilidad para la acción política. Finalmente, se presenta una aplicación empírica de análisis de discurso, problemas y política a temas de pobreza y desigualdad

Atrasentan and renal events in patients with type 2 diabetes and chronic kidney disease (SONAR): a double-blind, randomised, placebo-controlled trial

Background: Short-term treatment for people with type 2 diabetes using a low dose of the selective endothelin A receptor antagonist atrasentan reduces albuminuria without causing significant sodium retention. We report the long-term effects of treatment with atrasentan on major renal outcomes. Methods: We did this double-blind, randomised, placebo-controlled trial at 689 sites in 41 countries. We enrolled adults aged 18–85 years with type 2 diabetes, estimated glomerular filtration rate (eGFR)25–75 mL/min per 1·73 m 2 of body surface area, and a urine albumin-to-creatinine ratio (UACR)of 300–5000 mg/g who had received maximum labelled or tolerated renin–angiotensin system inhibition for at least 4 weeks. Participants were given atrasentan 0·75 mg orally daily during an enrichment period before random group assignment. Those with a UACR decrease of at least 30% with no substantial fluid retention during the enrichment period (responders)were included in the double-blind treatment period. Responders were randomly assigned to receive either atrasentan 0·75 mg orally daily or placebo. All patients and investigators were masked to treatment assignment. The primary endpoint was a composite of doubling of serum creatinine (sustained for ≥30 days)or end-stage kidney disease (eGFR <15 mL/min per 1·73 m 2 sustained for ≥90 days, chronic dialysis for ≥90 days, kidney transplantation, or death from kidney failure)in the intention-to-treat population of all responders. Safety was assessed in all patients who received at least one dose of their assigned study treatment. The study is registered with ClinicalTrials.gov, number NCT01858532. Findings: Between May 17, 2013, and July 13, 2017, 11 087 patients were screened; 5117 entered the enrichment period, and 4711 completed the enrichment period. Of these, 2648 patients were responders and were randomly assigned to the atrasentan group (n=1325)or placebo group (n=1323). Median follow-up was 2·2 years (IQR 1·4–2·9). 79 (6·0%)of 1325 patients in the atrasentan group and 105 (7·9%)of 1323 in the placebo group had a primary composite renal endpoint event (hazard ratio [HR]0·65 [95% CI 0·49–0·88]; p=0·0047). Fluid retention and anaemia adverse events, which have been previously attributed to endothelin receptor antagonists, were more frequent in the atrasentan group than in the placebo group. Hospital admission for heart failure occurred in 47 (3·5%)of 1325 patients in the atrasentan group and 34 (2·6%)of 1323 patients in the placebo group (HR 1·33 [95% CI 0·85–2·07]; p=0·208). 58 (4·4%)patients in the atrasentan group and 52 (3·9%)in the placebo group died (HR 1·09 [95% CI 0·75–1·59]; p=0·65). Interpretation: Atrasentan reduced the risk of renal events in patients with diabetes and chronic kidney disease who were selected to optimise efficacy and safety. These data support a potential role for selective endothelin receptor antagonists in protecting renal function in patients with type 2 diabetes at high risk of developing end-stage kidney disease. Funding: AbbVie