9 research outputs found
Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries
- Author
- Abad-Motos A.
- Abbas A.M.
- Abbas M.
- Abbasi M.
- Abbott T.
- Abdalaal I.
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- Ć antak G.
- Ć imko K.
- ĆœateckĂœ J.
- Publication venue
- Oxford University Press (OUP)
- Publication date
- 01/07/2023
- Field of study
Background
Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres.
Methods
This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and lowâmiddle-income countries.
Results
In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of âsingle-useâ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for lowâmiddle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia.
Conclusion
This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both highâ and lowâmiddleâincome countries
Abstracts from the Food Allergy and Anaphylaxis Meeting 2016
- Author
- A. Wesley Burks
- Abdulhadi Al-Qahtani
- Abdullah Alfhaid
- Abir Haddi
- Adam T. Fox
- Adam WawrzeĆczyk
- Adnan Custovic
- Adriana Machinena
- Adriana Muntean
- Adriano Mari
- Aeilko Zwinderman
- Afke M. M. Schins
- Agata Michalska
- Agata Szymkiewicz
- Agha Rehan Khaliq
- Agnieszka Lipiec
- Agurtzane Bilbao
- Agustin Madroñero
- Aida del Campo GarcĂa
- Aida Semic-Jusufagic
- Aideen Byrne
- Aimee Lou Nano
- Aimée Dorkenoo
- Aine Adams
- Akanksha Sharma
- Akila Rekima
- Alba Pablos-Tanarro
- Alejandro Joral
- Aleksandar Bulog
- Alena Berger
- Alessandro Fiocchi
- Alessandro Travaglini
- Alexander Rohrbach
- Alexandra Rodrigues
- Alf Weimann
- Ali Almontasheri
- Alice Coimbra
- Alina ZbrĂłg
- Aline Sprikkelman
- Alkerta Ibranji
- Amaranta Traversa
- Amena Warner
- Amyra Ali Azamar JĂĄcome
- Ana CĂ©lia Costa
- Ana Fiandor
- Ana MarĂa Plaza
- Ana Miranda
- Ana Molina
- Ana Paula Moschione Castro
- Ana Pereira
- Ana Prieto
- Ana Prieto del Prado
- Ana Reis Ferreira
- Ana Rodolfo
- Ana Rodriguez-Fernandez
- Anastasia Cirisano
- Anastasia Papadopoulou
- Anders Blom Jensen
- Andre Knulst
- Andrea Costanzi
- Andrea Di Rienzo Businco
- Andrea Keiko Gushken
- Andrea Mikkelsen
- Andrea Vereda
- Andrea Wangorsch
- Andreas Frey
- Andreia Forno
- André C. Knulst
- André Moreira
- André Wolterbeek
- Aneta Tomaszewska
- Angela Simpson
- Angelica Ehrenberg
- Ania Carsin
- Anja Jeverica
- Anja Koren Jeverica
- Anna G. Vidarsdottir
- Anna Iliopoulou
- Anna Kaarina Kukkonen
- Anna Kuklinska-Pijanka
- Anna Pelkonen
- Anna Selby
- Anna Sokolova
- Anna Szyc
- Anna WawrzeĆczyk
- Anna-Lena BramstÄng Björk
- Anna-Maija Hanni
- Annabelle Capt
- Annamaria Bianchi
- Anne Miles
- Anne Moneret-Vautrin
- Anne-Fleur Schoemaker
- Anne-Marie Kochuyt
- Anne-Marie Oomkes-Pilon
- Anne-Sofie Ballegaard
- Annette Jamin
- Annick Bastiaensen
- Annick Mercenier
- Anouska D. Michelsen-Huisman
- Anthony Dubois
- Anthony E. J. Dubois
- Antima Banerjee
- Antoine Deschildre
- Antoine Magnan
- Anton A. Shekhetov
- Anton Hartmann
- Antonia Rojas
- Antonino Romano
- Antonio Amoroso
- Antonio Carlos Pastorino
- Antonio Fernandez
- Antonio Pastorino
- AntĂłnio Jorge Cabral
- Arianna Dondi
- Arnaldo Porto
- Arne Homann
- Artur Walkiewicz
- Assad M. Butt
- Astrid G. Kruizinga
- Astrid Kruizinga
- Astrid Versluis
- Athina van Gasse
- Attilio Francesco Speciani
- Audrey Dunn Galvin
- Ayelet Rimon
- Barbara Ballmer
- Barbara Ballmer-Weber
- Barbara Majkowska-Wojciechowska
- Barbara Pfitzner
- Barbara WrĂłblewska
- Beatriz Secades Barbado
- Ben Remington
- BenoĂźt Sterling
- Berber Vlieg-Boerstra
- Bernard Mahon
- Bert Popping
- Bertine M. J. Flokstra-de Blok
- Bertrand Evrard
- Bettina Brix
- Bianca Balbino
- Birgit Kalb
- Birgit Quinting
- Bjorn R. Ludviksson
- Bo Pontoppidan
- Bodo Niggemann
- Boleslaw Samolinski
- Borja Bartalomé
- Borja Bartolomé
- Boudewjin J. Kollen
- Bruna Aquilante
- Bruno Pereira
- Bryan M. Harvey
- Bushra Javed
- Carina Kelleher
- Carl Hamsten
- Carla Camerotto
- Carla Jones
- Carla Mastrorilli
- Carlo Caffarelli
- Carlotta Povesi Dascola
- Carmen Di Scala
- Carmen DâAmelio
- Carmen Ponce
- Carmen Riggioni
- Carmen Saviana Ganea
- Carolina Aranda
- Carolina S. Aranda
- Caroline Klingebiel
- Caroline Thumerelle
- Caroline Zimmermann
- Carsten Bindslev-Jensen
- Catherine Bertholet
- Catherine Nock
- Chantal Agabriel
- Chantal Brossard
- Charlotte Eisenmann
- Charlotte Hands Plovdiv
- Charlotte Madsen
- Charlotte Mortz
- Chia-Chi Wang
- Chiara Fiamingo
- Chiara Pistoletti
- Chiara Rafaiani
- Chris H. Bridts
- Christian Harwanegg
- Christian Radauer
- Christian Schwager
- Christine Breynaert
- Christopher Munro
- Chrystyna Kalicinsky
- Chun-Wei Tung
- Chung-Hsiung Huang
- Claire Claverie
- Claire Mills
- Clara Ippolito
- Claudia Alessandri
- Claudia Pföhler
- Cleonir Lui de Moraes Beck
- Clémence Mordacq
- Colette Larré
- Colin Barber
- Cono Casale
- Constantinos Pitsios
- Corinne Herouet-Guicheney
- Cornelia Bergmayr
- Cornelia Jansen
- Cornelis K. van der Ent
- Cristiane Nunes dos Santos
- Cristiano Caruso
- Cristina ArĂȘde
- Cristina Bueno
- Cristina Deaconu
- Cristina Ornelas
- Cristobalina Mayorga
- Daniel Corbacho
- Daniel Lozano-Ojalvo
- Daniel Sampaio
- Daniela Adriano
- Daniela Manila Bianchi
- Danijela Apostolovic
- Danila Zennaro
- Danilo Villalta
- Dasha Roa-MedellĂn
- David Alejandro Mendoza HernĂĄndez
- David C. A. Candy
- David Endesfelder
- David Gillick
- David Luyt
- Deirdre Galloway
- Denise Borges
- Diana Deleanu
- Diana PĂ©rez Alzate
- Diana Silva
- Dianne Campbell
- Didier Ebo
- Diego Faggian
- Diego G. Peroni
- Diego Peroni
- Dikla Pivko Levy
- Dimitris Mitsias
- Dirceu Solé
- Dirk Verhoeven
- Djamel Saidi
- Djordje Filipovic
- Domingo Barber
- Donatella Bignardi
- Dorien Van Ginkle
- Duncan Brown
- E. N. Clare Mills
- Edward F. Knol
- Edyta Krzych
- Ekaterina Khaleva
- Ekaterini Goudouris
- Ekaterini Papadopoulou
- Elena D. Kuvshinova
- Elena Molina
- Elena Varin
- Eleonora Savi
- Elida Nikolla
- Elin Lustig
- Elisa Gritti
- Elisa Haroun
- Elizabeth Griffiths
- Elodie Drumez
- Elodie Michaud
- Eman Madbouly
- Emanuel Sarinho
- Emiliano De Dominicis
- Emmanouil Manousakis
- Erik Wambre
- Erika Jensen-Jarolim
- Erna Van Hoeyveld
- Esben Eller
- Esozia Arroabarren
- Esther Barrionuevo
- Esther van Twuijver
- Etienne Beaudouin
- Etienne Cavalier
- Eugénia Matos
- Eun Ha Jang
- Eunice Dias de Castro
- Eva Batanero
- Eva Corbet
- Eva Lasa
- Eva Untersmayr
- Evangelia Kompoti
- Evelyne Mangodt
- Evgen Benedik
- Ewa Gawronska-Ukleja
- Ewa Ternesten Hasseus
- Ewout W. Steyerberg
- Fabricia Carolino
- FabrĂcia Carolino
- Faisal R. Bakhsh
- Farrukh Sheikh
- Fernando Bandrés Sånchez-Cruz
- Filip Raciborski
- Filipe Benito-Garcia
- Fiona Kenna
- Fiona Ward
- Flavio Sano
- Florence Pineau
- Florin-Adrian Secureanu
- Florin-Dan Popescu
- Frances Smith
- Francesca Cipriani
- Francesco MacrĂŹ
- Francesco Zinno
- Francine C. van Erp
- Francisca Gomez
- Francisca Palomares
- Francisco Cabrera-Chavez
- Francisco Javier Monteseirin
- Francisco Javier Ruano
- Frans Timmermans
- Franziska Ruëff
- Frauke Schocker
- Frieke Kuper
- Frits Koning
- Frédéric de Blay
- FĂĄtima Duarte
- Gabriel Gastaminza
- Gabriela Canto
- Gabriele Piuri
- Gabriele Schulz
- Gador Bogas
- Gador Gomez
- Gary Stiefel
- Geert F. Houben
- Geert Houben
- Georg Mitterer
- George Du Toit
- Georgios Rentzos
- Gerard H. Koppelman
- Gert van Duijn
- Geunwoong Noh
- Giampaolo Ricci
- Gian Lodovico Rapaccini
- Giorgio Bedogni
- Giovanni Pajno
- Giuseppe Crisafulli
- Giuseppe Pingitore
- Gjustina Loloci
- Glauce Yonamine
- Graham King
- Graham Roberts
- Grzegorz Sergiejko
- Grégory Bouchaud
- Guillaume Pouessel
- Gustavo Soldateli
- H. Kim A. Brand
- H. Mary-Lene de Zeeuw-Brouwer
- Hajime Karasuyama
- Hanan Sharif
- Hanane Kaddouri
- Hannah M. Kansen
- Hanneke van der Kleij
- Hans de Groot
- Hans-JĂžrgen Malling
- Harmieke van Os-Medendorp
- Harry J. Wichers
- Harry Wichers
- Hassan Al-Dhekri
- Heinz Fehrenbach
- Helen Brown
- Helen Lindqvist
- Helena Larramona
- Helga Magnusdottir
- Henk van Loveren
- Henny Otten
- Henrik Fomsgaard Kjaer
- Hervé Bernard
- Hilde Cnossen
- Huan Rao
- Hub P. J. M. Noteborn
- Hulya Ercan Sarıcoban
- Huub F. J. Savelkoul
- Ifigenia Sfika
- Ignacio GarcĂa NĂșñez
- Ileana-Maria Ghiordanescu
- Ilya Vorozhko
- Indre Butiene
- Ine Decuyper
- Ines Mrakovcic-Sutic
- Ines Padua
- Ingo Marenholz
- Ingrid Sutic
- Inmaculada Doña
- Inmaculada SĂĄnchez-MachĂn
- Inna A. Larkova
- Ioana Maris
- Ioanna Manolaraki
- Irena Nedelea
- Irene Berends
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- Maria Teresa Costantino
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- Marianna Murdjeva
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- Marina A. Kiseleva
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- Mario Plebani
- Mariola Dietrich
- Mariona Pascal
- Marit Reitsma
- Mariya Ivanovska
- Marjeta Sedmak
- Mark Blankestijn
- Marleen T. J. Van Ampting
- Marta Anda
- Marta Goñi Esarte
- Marta Lomikovska
- Marta Neto
- Marta Vazquez-Ortiz
- Martin D. Chapman
- Martin Karjalainen
- Martinus Lovik
- Marysia Recto
- MarĂa JosĂ© Barasona Villarejo
- MarĂa Luisa Baeza
- MarĂa Teresa Villalba
- MarĂa Ăngeles Algaba MĂĄrmol
- Mashary Altamimi
- Mathilde Claude
- Mathilde Turfkruyer
- Matt Sperrin
- Matteo Moretti
- Maurits van Maaren
- Maurizio Mennini
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- Mauro Calvani
- Mayra Coutinho Andrade
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- Melina Makatsori
- Meltem Ugras
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- Merima Bublin
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- MichaĆ Przybyszewski
- Michel Neunlist
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- Michelle Epstein
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- Miguel Vieira
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- Mika MÀkelÀ
- Mikael Kuitunen
- Mindy Tsai
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- Montserrat LĂłpez Onieva
- Montserrat Ălvaro
- Morten Christensen
- Moshe Ben-Shoshan
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- MĂĄrio Morais-Almeida
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- The Anaphylaxis Working Group of the French Allergology SocietyThe Anaphylaxis Working Group of the French Allergology Society
- Thomas Eiwegger
- Thomas Keil
- Thomas Marichal
- Tiina Kauppila
- Timothy Watts
- Tina Vesel
- TomaĆŸ PoredoĆĄ
- Tong-Rong Jan
- Tullio Frediani
- Tushar Banerjee
- Ulf Bengtsson
- Ulrike Lehnigk
- Umberto Pelosi
- Urszula Samolinska-Zawisza
- Uta Jappe
- Valentino Pavisic
- Valery Muhortnich
- Valérie Liabeuf
- Valérie Trendelenburg
- Valérie Verhasselt
- Vasti Iancu
- Vera A. Revyakina
- Vera Elisabeth Assmann
- Vicente Albendiz
- Victor Matheu-Delgado
- Vito Sabato
- Viviana Moschese
- Vladimir Micovic
- Vladyslava Barzylovych
- VĂ©ronique NĂšve
- W. Marty Blom
- Waltraud Suer
- Wentong Xue
- Winfried Leeman
- Wolf-Meinhard Becker
- Xavier Domingo MirĂł
- Yanne Boloh
- Yin-Hua Cheng
- Yolanda Meijer
- Yolanda Puente
- Youcef Bouferkas
- Younes Belabbas
- Young-Ae Lee
- Yvonne Vergouwe
- Zbigniew Bartuzi
- Zdenka Baricev-Novakovic
- Zerrin Yalvac
- Zizi Cojocariu
- Zorica Zivkovic
- Zsolt Szepfalusi
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/03/2017
- Field of study
Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries
- Author
- Abad-Motos Ane
- Abbas Ahmed M.
- Abbas Mostafa
- Abbasi Mujeeb
- Abbott Tom
- Abd Karim Muhammad Fairuz Shah
- Abdalaal Ibrahim
- Abdel-Galil Khalid
- Abdelemam Rania
- Abdelgawad Abdalrahman
- Abdelkarim Maryam
- Abdelkhalek Mohamed
- Abdelmageed Abdelfatah
- Abdelmawgoud Sherif
- Abdelmohsen Sarah
- Abdelrahman Ahmed Saber
- Abdelrahman Mostafa
- Abdelwahab Khaled
- Abdou Hossam
- Abdulai Darling Ramatu
- Abdulkhaleq Marwa
- Abdullah Bahiyah
- Abdulsalam Khalifa
- Abdulsalam Shuaib
- Abdur-Rahman Lukman
- Abdus-Salam Rukiyat
- Abdussalam Hameedat Opeyemi
- Abebrese John Tabiri
- Abeldaño Ariel
- Abou-Khalil Jad
- Abou-Taleb Hisham
- Abozid Anwaar
- Abozied Hesham
- Abrate Alberto
- Abu-Zaid Ahmed
- Abubakar Mohammed Kabir
- Abud Burçin
- Abuzaid Mohammed
- Adam Albushra Altayeb
- Adamina Michel
- Adamou Harissou
- Adamu Auwal
- Adamu Kabir Musa
- Adanu Kekeli
- Adebara Idowu
- Adebola Oluwaseyi
- Ademuyiwa Adesoji
- Adeniran Abiodun
- Adepiti Akinfolarin
- Aderogba Adeleke Akeem
- Adesunkanmi Abdulhafiz
- Adeyeye Ademola
- Adisa Adewale
- Adjeso Theophilus Justus Kofi
- Ads Adel Mohamed
- Ads Alaa Mohamed
- Adu-Aryee Nii Armah
- Adumah Collins
- Afzal Irrum
- Agapov Mikhail
- Agarwal Gaurav
- Agarwal Ravi
- Agbeko Anita Eseenam
- Agbeno Evans Kofi
- Agbonrofo Peter
- Agboola Oluseyi
- Aggarwal Gaurav
- Aghadi Ifeanyi
- Aghtarafi Natasha
- Agrawal Amit
- Agresta Ferdinando
- Aguado HĂ©ctor J.
- Aguilera-Arevalo Maria-Lorena
- Aherne Thomas
- Ahmad Aline
- Ahmad Maleeha
- Ahmad Misbahu
- Ahmad Sarwat
- Ahmad Shahzaib
- Ahmad Shoaib
- Ahmed Hayat Tarig Abdelhafiz
- Ahmed Khalid
- Ahmed Sharwany
- Ahmed Shima
- Ahmed Usama
- Aisuodionoe-Shadrach Oseremen
- Aitken Sarah
- Ajenifuja Kayode
- Ajiya Abdulrazak
- Akeel Nouf
- Akin Emrah
- Akinajo Opeyemi
- Akinyemi Tosin
- Akrida Ioanna
- Aktokmakyan Talar Vartanoglu
- Akwaisah Ayoub
- Al Bettar Osama
- Al-Badawi Ismail A.
- Al-Juaifari Maytham
- Al-Khyatt Waleed
- Al-Mallah Abdullah
- Al-Nusairi Ahmed
- Al-Saadi Nina
- Al-Sayaghi Khaled
- Al-Shaiji Tariq
- Al-Shehari Mohammed
- Al-Touny Aiman
- Al-Touny Shimaa A.
- Aladawi Omar
- Aladna Abdallah
- Alali Mahmoud
- Alam Mahmood
- Alam Mohammed Shadrul
- Alarabi Rehab
- Alawneh Yazan
- Alayande Barnabas
- Albanese Erminia
- Albayadi Eslam
- Albdour Maram
- Alconchel Felipe
- Alderazi Amer
- Alegbeleye Bamidele
- Alekberli Tural
- Alemu Misganaw Alemu Adimass
- Alexander Philip
- Alfieri Alex
- Algahtany Khaled
- Algarni Kamal
- Alhamad Ameen
- Alhamid Mohammad
- Alharmi Rawan A. Rahman
- Alharthi Mohammed
- Alhazmi Barrag
- Ali Mohamed Shafi Mahboob
- Ali Stephen
- Alibrahim Hidar
- Aljaaly Hattan
- Aljaiuossi Anas
- Aljanadi Firas
- Aljiffry Murad
- Aljirdabi Noof
- Alkahlan Mohammed
- Alkhalifa Elmustafa
- Alkhatib Sondos
- Alkhatieb Maram
- Allan Anna
- Almarshad Felwa
- Almgla Naser
- Almhimid Ali
- Almiqlash Bushray
- Almoshantaf Mohammad Badr
- Almutairi Abdulmjeed
- Alnsour Abed Alfattah Mahmoud
- Alobied Majd
- Alomar Osama
- Alonso JesĂșs AarĂłn MartĂnez
- Alonso Manuel Diez
- Alonso Nestor Fabian Pedraza
- Alonso Veronica
- Alqallaf Abdullah
- Alqaseer Asma
- Alrayes Bourhan
- Alsefri Maryam
- Alser Osaid
- Alsharif Mohammed
- Alsori Mohamed
- Altaf Abdulmalik
- Altinel Yuksel
- Altiner Saygin
- Altouny Ahmad
- Altun Demet
- Alvarez Natalia
- Alvarez-Lozada Luis Adrian
- Alvi Abdul
- Alwael Athari
- Alwash Mohammed
- Alyami Ziyad
- Alyousef Mohammed
- Alzahrani Saud
- Alzerwi Nasser
- Amin Shivang
- Amir Mohammed
- Ammar Ahmed Siddique
- Ammendola Michele
- Amores Remedios Revilla
- Amrayev Sultan
- Anastasiadou Sofia
- Ancans Guntis
- Anderson Caroline
- Andreani Lorenzo
- Andreotti Dario
- Andreuccetti Jacopo
- Andrianakis Alexandros
- Andro Christophe
- Anesi Alexandre
- Angamuthu Stephen
- Angeles Martina Aida
- Angelico Roberta
- Angelis Fragkiskos
- Angelou Dimitrios
- Angelou Kyveli
- Angulo Victor Pinto
- Anjum Arfa
- Anjum Muhammad Ayyub
- Annicchiarico Alfredo
- Anoldo Pietro
- Ansaloni Luca
- Anthoulakis Christos
- Antonelli Amedeo
- Anwar Mohamed
- Anwar Sumadi Lukman
- Anwer Mariyah
- Anyanwu Lofty-John
- Apostolou Christos
- Apostolou Konstantinos
- Appiah-Kubi Adu
- Aprea Giovanni
- Arbab Hana
- Archer James
- Ardura Francisco
- Aremu Muyiwa
- Arif Tahera
- Arkani Samara
- Armatura Giulia
- Armijos Daniel
- Arnaout Ali
- Arnaoutoglou Eleni
- Arnaud Alexis P.
- Arneja Jugpal
- Arrangoiz Rodrigo
- Arshad Muhammad
- Arthur Joshua
- Ashcroft James
- Ashford Bruce
- Ashraf Fariha
- Asiimwe Daniel
- Asirifi Samuel Amoako
- Asla Amir
- Aslam Ramisha
- Aspide Raffaele
- Ataya Karim
- Ateca Ibabe Villalabeitia
- Atici Semra Demirli
- Atis Gokhan
- Atkins William
- Atkinson Kate
- Attwood Joseph
- Auerkari Aino
- Augestad Knut Magne
- Augustin Goran
- Aujayeb Avinash
- Avella Pasquale
- Awad Ahmed K.
- Awad Hadeel
- Awad Rabih
- Awad Selmy
- Ayad Kusay
- Ayana Birhanu
- Aydin Yener
- Ayeni Funbi
- Aytac Erman
- Azab Ahmed
- Azami Rizwan
- Azize Diallo Abdoul
- Azzam Ahmed Y.
- Azzis Olivier
- Baba Yabasin Iddrisu
- Babis George
- Bacalbasa Nicolae
- Badiani Sarit
- Badran Saif
- Baduell Albert
- Baeesa Saleh
- Baertschiger Reto
- Bafaquh Mohammed
- Bahassan Omar Mohammed
- Bahrami-Hessari Michael
- Baia Marco
- Baidoo Ebikela Ivie
- Bailey Karen
- Baili Efstratia
- Bains Lovenish
- Baiocchi Gian Luca
- Baiocchi Glauco
- Baiyewu Lateef Ayodele
- Bajaj Ankur
- Bajunaid Khalid
- Balagobi Balasingam
- Balasubramanian Ishwarya
- Balduzzi Alberto
- Baldwin Alexander
- Balla Andrea
- Balogh Zsolt J.
- Balogun James A.
- Balogun Simon
- Baloyiannis Ioannis
- Ban Vin Shen
- Bandyopadhyay Samik Kumar
- Bandyopadhyay Soham
- Banerjee Sumit
- Banipal Gurpreet Singh
- Banky Balazs
- Bannone Elisa
- Bansal Sujesh
- Barberis Andrea
- Barbosa-Breda Joao
- Bareka Metaxia
- BariĆĄiÄ Tatjana
- Barlas Aziz Mutlu
- Barlow Ciaran
- Barmayehvar Behrad
- Baroffio Paolo
- Barone Mirko
- Barra Fabio
- Barranquero Alberto G.
- Barugola Giuliano
- Basendowah Mohammed
- Bashir Mahmod
- Basnayake Oshan
- Bass Gary Alan
- Basu Somprakas
- Bateman Antony
- Bateman Kellie
- Batista Sylvia
- Batstone Martin
- Bauer Marlies
- Bauset Juan Carlos CatalĂĄ
- Bawa Ashvind
- Bawa Sayesha
- Bayhan HĂŒseyin
- Bayo Heura Llaquet
- Bazzi Nagham
- Beamish Andrew
- Beasley Nigel
- Beatty Jasmine Winter
- Becerra Angel
- Bedada Alemayehu Ginbo
- Bedzhanyan Arkady
- Begum Farzana
- Beisenov Bekzat
- Bellio Gabriele
- Bello Usman Mohammed
- Bellés Ana Ciscar
- Belzile Etienne
- Benamar Safia
- Bence Matthew
- Benshetrit Guy
- Bensoltane Khadidja
- Bergkvist David JuliĂ
- Beristain-Hernandez Jose-Luis
- Bernante Paolo
- Bernardi Daniele
- Beron Reinaldo Isaacs
- Berselli Bruno
- Berselli Mattia
- Bertelli Giacomo
- Bertoglio Pietro
- Bertolaccini Luca
- Beswick Daniel
- Bette Birgit
- Bezirci Rifat
- Bhangu Aneel
- Bharathan Rasiah
- Bhat Vivek
- Bhatti Khalid
- Bianchi Valentina
- Bianco Francesco
- Bianco Giuseppe
- Bijou Walid
- Bilfaqirah Majed
- Biloslavo Alan
- Bin Alhassan Baba Alhaji
- Binnawara Muhannud
- Bissacco Daniele
- BÄ°ĆGÄ°N TAYFUN
- Blair James
- Blanco Jose
- Blencowe Natalie
- Bloemers Frank
- Board Timothy
- Bobak Peter
- Boccalatte Luis
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- Kauppila Joonas H
- Kaur Amanjot
- Kausar Nabila
- Kavalakat Alfie
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- Kebede Ephrem
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- Kennerton A.S.
- Kent Alistair J
- Keramati Mohammad Reza
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- Kroon Hidde M.
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- Lohmann Tibor Karl
- Lohse Helmut Alfredo Segovia
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- Loubani Mahmoud
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- Mabood Waleed
- MacChiavello Roberto
- MacHain V Gustavo Miguel
- MacHairas Nikolaos
- MacĂas Rosa Montero
- Madhuri Thumuluru Kavitha
- Madhvani Kiran
- Maestri Marco
- Maffioli Anna
- Maffuz-Aziz Antonio
- MagalhĂŁes Carlos
- Maggiore Giandomenico
- Magnone Stefano
- Magouliotis Dimitrios
- Maguire Patrick J.
- MaheÄiÄ Tina TomiÄ
- Mahmood Fahad
- Mahmoud Abdelrahman
- Mahmud Ayesha
- Mains Edward
- Maiola Vincenza
- Majbar Anass Mohammed
- Majd Hooman Soleymani
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- Mako Aleksandro
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- Malek Bouhani
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- Malik Sobia
- Mallick Rebecca
- Mallmann Christoph
- Mallmann Michael R.
- Mambrilla Sara
- Manangi Mallikarjuna
- Manesh Hassan Fatemi
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- Mangi Ali
- Maniaci Antonino
- Manickavasagam Jaiganesh
- Manigrasso Michele
- Manjula S.
- Mannan Syed
- Mantziari Styliani
- MaquilĂłn Alejandra Jara
- Marafante Chiara
- Marano Luigi
- Marei Mahmoud
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- Martinez-Leo Bruno
- Martinez-Mier Gustavo
- Martinez-Perez Carolina
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- Martins Ana
- Martins Claudia Pinto
- Martins Paulo N.
- MartĂnez Daniel FernĂĄndez
- MartĂnez Eunate Ganuza
- MartĂnez VerĂłnica MartĂn
- MartĂnez-SĂĄnchez Marta Isabel
- Masciello Fabrizio
- Masri Ruqaya
- Massaguer Clara
- Massoud John
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- Matthews Emily
- Mauriello Claudio
- Maurus Christine
- Mayer Horacio F.
- Mayo-Yåñez Miguel
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- Mbodi Langanani
- Mbwele Bernard
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- McGrath John
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- McLeish Bethan
- McPherson Duncan
- Meara John G.
- Meead Adullah
- Mehraj Asif
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- Meleiro Hugo
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- Meneghini Simona
- Mengesha Mengistu G.
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- Nacion Aeris Jane D.
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- Nassar Mahmoud A.
- Nasser Sara
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- Newman Samuel
- Ngaserin Sabrina
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- Phillips Jonathan
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- Pinkney Thomas
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- Piozzi Guglielmo NiccolĂČ
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- Prada Carlos
- Pradhan Akhilesh
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- Prodromidou Anastasia
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- Prusty Lydia
- Pu Jingya Jane
- Pucher Philip
- Punjabi Prakash P
- Puri Ajay
- Purich Kieran
- PĂ©rez Beatriz GĂłmez
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- Rickard Jennifer
- RincĂłn Natalia Andrea Rivera
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- Rodriguez-Lopez Mario
- RodrĂguez Lorena Varela
- Rokohl Alexander Christopher
- Roland Christina L
- Rolinger Jens
- Romano Angela
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- Romero Patricia
- Ronellenfitsch Ulrich
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- Russo Iris Shari
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- Ryan James
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- Saad Rema
- Saaid Rahmah
- Sabbagh Abdulrahman J.
- Sabella Danielle
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- Sacdalan Marie Dione
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- Sayyed Raza
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- Shah Hemina
- Shah Jaffer
- Shah Karishma
- Shah Pritik A
- Shah Vinay
- Shaikh Shafaque
- Shalaby Mostafa
- Shalhoub Joseph
- Shamim Shahzad
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- Shiwani Haaris
- Shmukler Daniel
- Shokor Muntaser Abu
- Sholadoye Tunde T.
- Shoukrie Shoukrie I. M.
- Shrestha Rashmit
- Siboe Mark
- Sica Giuseppe
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- Skipworth Richard Je
- Slavchev Mihail
- Sleem Adham
- Smati Ismail
- Smelt Jeremy
- Smith A.
- Smolle-Juettner Freyja-Maria
- Sodhai Vivek
- Sofi Khalid
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- Sole-Sedeno Josep M.
- Soljic Martina
- Solli Piergiorgio
- Soon Wai Cheong
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- Spartalis Michael
- Spellar Kayleigh
- Spiers Harry V. M.
- Spina Alfio
- Spriano Giuseppe
- Squiers John
- Stabler Robert
- Stamatakis Emmanouil
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- Stather Philip
- Stevens Sean
- Stevenson Andrew
- Stewart Grant D.
- Stijns Jasper
- Stogowski Piotr Tomasz
- Stoleriu Mircea Gabriel
- Stoyanov Vladislav
- Street John
- Strotmann Johanna Josefine
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- Su Yu-Xiong
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- Subramani Yamini
- Subramaniam Sentilnathan
- Sue-Chue-Lam Colin
- Suer Muhammed Salih
- Sulaiman Bilal
- Sultania Mahesh
- Sundarraju Shalini
- Sungurtekin Hulya
- Suresh Sreelakshmi
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- Symeonidis Dimitrios
- SzabĂłmihĂĄlyovĂĄ KatarĂna
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- Szatmary Peter
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- SĂĄ-Marta Eduarda
- Sånchez Alberto Cabañero
- SĂĄnchez Rosa
- Sånchez-Guillén Luis
- SĂŒleyman Marlen
- Tadic Boris
- Taha Anas
- Taha-Mehlitz Stephanie
- Tailor Bhavesh
- Taj Eldeen Samaher Taj Eldeen Hassan
- Takeda Flavio Roberto
- Takkenberg Marijn
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- Tallon-Aguilar Luis
- Talwar Rishi
- Tamayo Beatriz Villota
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- Tammo Ămer
- Tamoos Khalil
- Tampaki Ekaterini Christina
- Tampakis Athanasios
- Tan Chih Ying
- Tan Shawn Jia Hwang
- Tanal Mert
- Tanas Yousef
- Tang Alethea
- Tang Yita
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- Tantraworasin Apichat
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- Tapia-Herrero Ana-MarĂa
- Tarek Ahmed
- Tariq Aiman
- Tarle Marko
- Tarsitano Achille
- Tartaglia Dario
- Tartaglia Nicola
- Tashkandi Wail
- Taskiran Cagatay
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- Tatsis Dimitris
- Tawalbeh Ra'Fat
- Tawiah Augustine
- Tebha Sameer
- Techapongsatorn Suphakarn
- Teixeira Pedro
- Tejero-Pintor Francisco J.
- Tellez Karla Susana Martin
- Tellez Luis Garcia-Sancho
- Thaha Mohamed Adhnan
- Thakar Sumit
- Thaw May Htoo
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- Theodoropoulos George
- Theophilidou Elena
- Thereska Dariel
- Thiruchandran Gajendiran
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- Thomas Bradley
- Thomas Jerin Jose
- Thuduvage Vasanthika
- Thumbadoo Ruben
- Tian Sarah
- Tidjane Anisse
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- Toma Elena Adelina
- Tomasicchio Giovanni
- Tomlinson James
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- Torun Bahar Canbay
- Tottman R.
- Tousidonis Manuel
- Trabulsi Nora
- Tranca Sebastian
- Trebol Jacobo
- Trejo-Avila Mario
- Triantafyllou Alexandra
- Triantafyllou Tania
- Trifunovski Aleksandar
- Tripathi Manjul
- Tripathi Prashant
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- Trivik-Barrientos Felipe
- Trostchansky Ivan
- Trulson Alexander
- Trungu Sokol
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- Tsakiridis Ioannis
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- Tsolakidis Alexandros
- Tsoulfas Georgios
- Tucker Olga
- Tuech Jean Jacques
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- Turrado-Rodriguez Victor
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- Ul Huda Maria Noor
- Ulas Ali Bilal
- Uldry Emilie
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- Ulkucu Attila
- Ulman Elif Akbas
- Ulman Hilmican
- UlutaĆ Mehmet EĆref
- Underwood Kirk
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- Uprak Tevfik Kivilcim
- Urriza Pablo Vallés
- Usman Muhammad
- Usman Mustapha Ibrahim
- Vaassen Lauretta
- Vaccara Vincenzo La
- Vagena Xanthoula
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- Vailas Michail
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- Valadez Tania Abigail Cueto
- Valanci Sofia
- Valdespino Cristina Puentes
- Valeanu Liana
- Valioulis Ioannis
- Valladares Sergio ChĂĄvez
- Vallve-Bernal Marc
- Van Acker Jill
- Van Den Eynde Jef
- Van Goor Harry
- Van Vliet Helen
- Van Wyk Naomi Natasha
- Vanni Camilla
- Vas Aurelia
- Vasarhelyi Edward
- Vaschetti Roberto
- Vassiliu Panteleimon
- Vatansever Dogan
- Vatish Jamie
- Vaughan-Shaw Peter G.
- Vaysburg Dennis
- Veglia Antonella
- Velten Markus
- VelĂĄzquez Maria Jose Martinez
- Venkatappa Sunil Kumar
- Venketeswaran Meenakshi
- Venskutonis Donatas
- Verbic Milena Senica
- Verdi Daunia
- Vergara-Fernandez Omar
- Verhoeff Kevin
- Veroux Massimiliano
- Verras Georgios-Ioannis
- Verre Luigi
- Vida Lucian
- Vidya Raghavan
- Viglietta Edoardo
- Vijay Vardhini
- Vijgen Guy
- VilarĂł Blanca Capdevila
- Villanueva Julio
- Vilz Tim O.
- Vincent Elizabeth
- Vinci Danilo
- Viola Simona
- Violante Tommaso
- Vishnoi Jeewan Ram
- Vissapragada Ravi
- Vivancos Laura Guillamon
- Vives Josep Maria Muñoz
- Vizzielli Giuseppe
- Vohra Lubna
- Vokshi Ismail
- Vosinakis Christos
- Våsquez Javier Alberto Gutiérrez
- VĂĄzquez Gil
- VĂĄzquez Irene Ortega
- VÇcÇraĆu Andrei Bogdan
- Wade Ryckie
- Wafi Omar
- Wagner Gabriela
- Wallis Christopher
- Wanjara Samuel
- Waqar Shahzad Hussain
- Warden Claire
- Warner Christian
- Wasim D.
- Wason Shaun
- Wasserman Isaac
- Watcyn-Jones Tom
- Waterson Ben
- Watson David
- Watson Matthew
- Weber Clemens
- Wheatstone P.
- Wheeler James
- Wheldon Luke
- White Michelle
- White Stuart
- White William
- Wickramasinghe Dakshitha
- Widmer Lukas Werner
- Wiedemann Dominik
- Wiesinger Clemens Georg
- Wijekoon Naveen
- Wijenayake Wasantha
- Wijeyaratne Manuk
- Wijeysundera Duminda
- Wiles Matthew
- Wilkin Richard
- Wilkins Alex
- Wilkins James
- William Tinka George
- Williams Omolara Modupe
- Williams Shekinah
- Windsor John
- Winnand Philipp
- Wittmann Maria
- Wolde Amanuel
- Wolfenden John W. D.
- Wong Benjamin Ngie Xiong
- Wong Enoch
- Wong Evan G.
- Wong George Kwok Chu
- Wong Ho Ying Flora
- Wong Kai Yuen
- Wormald Justin
- Wright Deborah
- Wright Joshua
- Wu Fiona
- Wurm Markus
- Xenaki Sofia
- Yadev Ip
- Yahaya Ahmad Shuib
- Yakubu Mustapha
- Yang Wah
- Yanik Ăzge
- Yanowsky-Reyes Guillermo
- Yassin Abubaker
- Yates Elizabeth
- Yebes Alvaro
- Yenli Edwin Mwintiereh Ta-Ang
- Yeoh Tien
- Yeung Justin
- Yiallourou Anneza
- Yigit Banu
- Yildirim Asif
- Yim Guang
- Yiu Andrew
- Yonekura Hiroshi
- Yotsov Tsanko
- Younis Muhammad Umar
- Yunus Alif
- Yusefi Hossein
- Zabaleta Jon
- Zabkiewicz Catheriner
- Zaccaria Giulia
- Zacharia Bincy
- Zafar Syed Nabeel
- Zago Mauro
- Zaheen Zakia
- Zahid Zahra
- Zaimis Tilemachos
- Zakaria Andee Dzulkarnaen
- Zambon Martina
- Zamora Lindsey
- Zampogna Biagio
- Zancana Giuseppa
- Zani Augusto
- Zanin Luca
- Zanini Nicola
- Zapardiel Ignacio
- Zapata Carlos Shiraishi
- Zarif Pierre
- ZarĂĄnd Attila
- Zehnder Philipp
- Zenger Serkan
- Zenha HorĂĄcio
- Zhu Michael Z. L.
- Ziemann Sebastian
- Zimak Danijela Mrazovac
- Zimak Zoran
- Zivkovic Dragana
- Zizzo Maurizio
- Zucker Benjamin
- Zwain Yasir
- Zyskowski Michael
- Ăvila Clara Castro
- ĂlgĂ„ Andreas
- Ăakici Mehmet Ăaǧlar
- Ăelik Enes
- Ăelik Meryem Nur
- Ăzçay Necdet
- Ćevik HĂŒsnĂŒ
- Ć antak Goran
- Ć imko KristiĂĄn
- ĆœateckĂœ Jan
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2023
- Field of study
Abstract
Background
Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres.
Methods
This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and lowâmiddle-income countries.
Results
In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of âsingle-useâ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for lowâmiddle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia.
Conclusion
This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both highâ and lowâmiddleâincome countries
Association between PD1 mRNA and response to anti-PD1 monotherapy across multiple cancers.
- Author
- Adela Rodriguez
- Aleix Prat
- Ana M. Arance
- Begona Mellado
- Blanca GonzĂĄlez-Farre
- Cristina TeixidĂł
- Elia SeguĂ
- Elisabeth Perez Ruiz
- Estela Pineda
- Guillermo Crespo
- Javier Garcia Corbacho
- Josep M. Llovet
- Juan Maurel
- Laia Pare
- MarĂa GonzĂĄlez-Cao
- Miguel Angel Molina-Vila
- Miriam Cuatrecasas
- Noemi Reguart
- Salvador Martin-Algarra
- TomĂÂĄs Pascual
- Publication venue
- 'American Society of Clinical Oncology (ASCO)'
- Publication date
- Field of study
Association between PD1 mRNA and response to anti-PD1 monotherapy across multiple cancer types
- Author
- Adamo B. (B.)
- Arance A. (Ana)
- Crespo G. (Guillermo)
- Cuatrecasas M. (M.)
- Font C. (C.)
- Gaba L. (L.)
- GalvĂĄn P. (P.)
- Garcia-Corbacho J. (J.)
- Gonzalez-Cao M. (MarĂa)
- GonzĂĄlez B. (B.)
- Juan M. (M.)
- Llovet J.M. (J. M.)
- Martin-Algarra S. (Salvador)
- Maurel J. (J.)
- Mellado B. (B.)
- Molina-Vila M.A. (Miguel Angel)
- Muñoz M. (M.)
- Paré L. (L.)
- Pascual T. (T.)
- Perez-Ruiz E. (Elisabeth)
- Pineda E. (E.)
- Prat A. (A.)
- Reguart N. (Noemi)
- Reig Ă. (Ă.)
- RodrĂguez A. (A.)
- Ruiz G. (G.)
- SeguĂ E. (E.)
- TeixidĂł C. (Cristina)
- Torné A. (A.)
- Victoria I. (I.)
- Vidal M. (M.)
- Viladot M. (M.)
- Viñolas N. (N.)
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2018
- Field of study
Background: We hypothesized that the abundance of PD1 mRNA in tumor samples might explain the differences in overall
response rates (ORR) observed following anti-PD1 monotherapy across cancer types.
Patients and methods: RNASeqv2 data from 10 078 tumor samples representing 34 different cancer types was analyzed from
TCGA. Eighteen immune-related gene signatures and 547 immune-related genes, including PD1, were explored. Correlations
between each gene/signature and ORRs reported in the literature following anti-PD1 monotherapy were calculated. To
translate the in silico findings to the clinical setting, we analyzed the expression of PD1 mRNA using the nCounter platform in
773 formalin-fixed paraffin embedded (FFPE) tumor samples across 17 cancer types. To test the direct relationship between
PD1 mRNA, PDL1 immunohistochemistry (IHC), stromal tumor-infiltrating lymphocytes (sTILs) and ORR, we evaluated an
independent FFPE-based dataset of 117 patients with advanced disease treated with anti-PD1 monotherapy.
Results: In pan-cancer TCGA, PD1 mRNA expression was found strongly correlated (r > 0.80) with CD8 T-cell genes and
signatures and the proportion of PD1 mRNA-high tumors (80th percentile) within a given cancer type was variable (0%â84%).
Strikingly, the PD1-high proportions across cancer types were found strongly correlated (r Œ 0.91) with the ORR following antiPD1 monotherapy reported in the literature. Lower correlations were found with other immune-related genes/signatures,
including PDL1. Using the same population-based cutoff (80th percentile), similar proportions of PD1-high disease in a given
cancer type were identified in our in-house 773 tumor dataset as compared with TCGA. Finally, the pre-established PD1 mRNA
FFPE-based cutoff was found significantly associated with anti-PD1 response in 117 patients with advanced disease (PD1-high
51.5%, PD1-intermediate 26.6% and PD1-low 15.0%; odds ratio between PD1-high and PD1-intermediate/low Œ 8.31; P < 0.001).
In this same dataset, PDL1 tumor expression by IHC or percentage of sTILs was not found associated with response.
Conclusions: Our study provides a clinically applicable assay that links PD1 mRNA abundance, activated CD8 T-cells and
anti-PD1 efficacy
The burden of mild asthma: Clinical burden and healthcare resource utilisation in the NOVELTY study
- Author
- Adams F.
- Al-Asadi L. A.
- Andujar R.
- Anees S.
- Anholm J.
- Anoro L.
- Arboleda A. C.
- Aries S. P.
- Averill F.
- Baines S.
- Bals R.
- Bansal S.
- Baptist A.
- Barbetta C.
- Beasley R.
- Beck E.
- Bell A.
- Bendstrup E.
- Benhabib G.
- Bertley J.
- Boersma W.
- Bolivar Grimaldos F.
- Bonniaud P.
- Bowler S.
- Bradman D.
- Braido F.
- Bremner P.
- Broughton E.
- Brun O.
- Brunstad O. P.
- Bueno C. M.
- Bull S.
- Burgel P. -R.
- Campbell C.
- Campo Matias F. D.
- Campos M. A.
- Campos S.
- Cancado J. E. D.
- Cardaci V.
- Cardoso A. P.
- Carroll P.
- Castilla Martinez M.
- Chaalan M.
- Chang Y. -S.
- Cheema A.
- Chen M.
- Chen Y.
- Chipps B.
- Cho Y. J.
- Chouaid C.
- Chouinard G.
- Clini E. M.
- Comeche Casanova L.
- Corbacho D.
- Corral G. F.
- Corzo M. F.
- Cosgrove J.
- Costantino M. T.
- Couturaud F.
- Crook G.
- Csanadi M.
- Cunha T.
- Curiac D.
- Cuttitta G.
- de Blic J.
- de Llano L. P.
- Debieuvre D.
- Deimling A.
- DeLeon S.
- Delsart D.
- Demaegdt A.
- Demoly P.
- Deschildre A.
- Devouassoux G.
- Dhar A.
- Dhillon R.
- di Gioacchino M.
- Djamin R. S.
- Dominguez Peregrina A.
- Echave-Sustaeta J.
- Egron C.
- Eid A.
- Eijsvogel M.
- Einvik G.
- Endo T.
- Epstein E.
- Falchero L.
- Farah C.
- Feimer J.
- Fernandez M. N.
- FitzGerald J. M.
- FitzGerald J. M.
- Flood-Page P.
- Fois A.
- Foschino-Barbaro M. P.
- Franssen F.
- Fritz S.
- Fujita M.
- Fuller E.
- Gamboa Setien P.
- Gammeri E.
- Garcia Clemente M.
- Garcia M. B.
- Garcia Salmones M.
- Garcia-Navarro A. A.
- Golam S. M.
- Goosens M.
- Goupil F.
- Graat-Verboom L.
- Grimm-Sachs V.
- Groth G.
- Gu W.
- Hammerschlag G.
- Hancock K.
- Hara Y.
- Harrington Z.
- Harris H.
- Harrison T.
- Harrison T.
- Hartley D.
- Hattotuwa K.
- Herth F.
- Hewitt M.
- Hilberg O.
- Hoheisel G.
- Hoines K. J.
- Holguin F.
- Horiguchi T.
- Hosoi K.
- Hudes G.
- Hughes R.
- Hui K. M. C.
- Hwang Y. I.
- Ide Y.
- Inchingolo R.
- Inomata M.
- Inoue H.
- Inoue K.
- Inoue S.
- Jackson R.
- Janson C.
- Janssen R.
- Javier R. C.
- Jones G.
- Kanawaty D.
- Kanniess F.
- Kato M.
- Katsoulotos G.
- Kaufman A.
- Kaufman D.
- Kawasaki M.
- Kawayama T.
- Kelly A.
- Kessler R.
- Khusrawi A.
- Killorn W.
- Kim J.
- Kim W. J.
- Kita T.
- Kjellerup C.
- Klapholz A.
- Kobayashi K.
- Koh Y. -I.
- Koto H.
- Krishna H.
- Kuppens K.
- Landry D.
- Langton D.
- Lavorini F.
- Le Roux P.
- Lee B. -J.
- Lee D.
- Lee D.
- Lee K. -H.
- Lee S. -P.
- Lee Y. C.
- Lewis K.
- Li M.
- Li S.
- Lienert T.
- Lif-Tiberg C.
- Lim S. Y.
- Lima M.
- Lin R.
- Lisanti R. E.
- Luton R.
- Luts A.
- Ma L.
- Mabire P.
- Mahay G.
- Maldonado F. C.
- Mandhane P.
- Marin Trigo J. M.
- Marino G.
- Martinez S.
- Maselli-Caceres D.
- Mattarucco W.
- McGarvey L.
- McIvor A.
- Mehta V.
- Melloni B.
- Min K. H.
- Molina de Salazar D.
- Molino A.
- Montano Gonzalez E.
- Moreau L.
- Morice A.
- Moy J. N.
- Mozo P. C.
- Mronga S.
- Mullerova H.
- Nishi K.
- Nogueira J.
- Nucera E.
- Nunez I. G.
- Nwokoro U.
- Oh Y. -M.
- Oien T.
- Olaguibel J. M.
- Olaguibel Rivera J.
- Olmo R. D.
- Palomo S. N.
- Pandya P.
- Papi A.
- Parikh P.
- Parikh S.
- Park C. -S.
- Park H. -S.
- Park H. -W.
- Parody M.
- Pascale P.
- Patel M.
- Patella V.
- Pek B.
- Perrino F.
- Pesci A.
- Peters M.
- Petrella R.
- Prassad L.
- Pueyo Bastida A.
- Qin G.
- Rabahi M.
- Raherison C.
- Rahlen L.
- Ramirez-Venegas A.
- Rano A.
- Rapsomaniki E.
- Reddel H.
- Reddel H. K.
- Reig A. R.
- Reinhardt J.
- Rendon A.
- Rhee C. K.
- Ricciardolo F.
- Riviere E.
- Robaina J. G.
- Rodriguez Gonzalez-Moro J.
- Rodriguez P.
- Rogliani P.
- Rolon R. W.
- Roux-Claude P.
- Roy K.
- Ruhlmann J.
- Ruiz X. B.
- Rustscheff S.
- Sadatsafavi M.
- Saito J.
- Sajkov D.
- Santiago F.
- Sarzani R.
- Sassoon C.
- Sathyamurthy R.
- Schlenska C.
- Serrano C. C.
- Settipane R. A.
- Shimizu Y.
- Shirai T.
- Silva D.
- Simpson F. G.
- Song W.
- Soulier M.
- Sousa D.
- Sriram P.
- Stollery D.
- Stolpe C.
- Sugihara N.
- Svetliza G.
- Tai S.
- Takahashi K. -I.
- Tan W.
- Tang Y.
- Tashimo H.
- Teber I.
- Thiagarajan S.
- Thomas P.
- Timmermann H.
- Tomii K.
- Turner A.
- Ulrich T.
- van de Ven M.
- van den Berge M.
- Vancheri C.
- Veen J. I.
- Velasco Garrido J.
- Velling P.
- Vestbo J.
- Victorio C. F.
- Vignal G.
- Vincenti R.
- Wachs R.
- Wang C.
- Wang T.
- Wark P.
- Wedzicha W.
- Wehgartner-Winkler S.
- Weinreich U.
- Welling J.
- Wen F.
- Wilkinson T.
- Wilson P.
- Winkelmann E. -J.
- Wu F.
- Xiang P.
- Xiao Z.
- Xiong S.
- Yaici A.
- Yamada T.
- Yanai M.
- Yanez A.
- Yang J.
- Yang J.
- Yoon H. -K.
- Yoon H. J.
- Zhang C.
- Zhang M.
- Zhang P.
- Zhang W.
- Zheng X.
- Zhu D.
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2022
- Field of study
Background: Patients with mild asthma represent a substantial proportion of the population with asthma, yet there are limited data on their true burden of disease. We aimed to describe the clinical and healthcare resource utilisation (HCRU) burden of physician-assessed mild asthma. Methods: Patients with mild asthma were included from the NOVEL observational longiTudinal studY (NOVELTY; NCT02760329), a global, 3-year, real-world prospective study of patients with asthma and/or chronic obstructive pulmonary disease from community practice (specialised and primary care). Diagnosis and severity were based on physician discretion. Clinical burden included physician-reported exacerbations and patient-reported measures. HCRU included inpatient and outpatient visits. Results: Overall, 2004 patients with mild asthma were included; 22.8% experienced â„1 exacerbation in the previous 12 months, of whom 72.3% experienced â„1 severe exacerbation. Of 625 exacerbations reported, 48.0% lasted >1 week, 27.7% were preceded by symptomatic worsening lasting >3 days, and 50.1% required oral corticosteroid treatment. Health status was moderately impacted (St George's Respiratory Questionnaire score: 23.5 [standard deviation ± 17.9]). At baseline, 29.7% of patients had asthma symptoms that were not well controlled or very poorly controlled (Asthma Control Test score <20), increasing to 55.6% for those with â„2 exacerbations in the previous year. In terms of HCRU, at least one unscheduled ambulatory visit for exacerbations was required by 9.5% of patients, including 9.2% requiring â„1 emergency department visit and 1.1% requiring â„1 hospital admission. Conclusions: In this global sample representing community practice, a significant proportion of patients with physician-assessed mild asthma had considerable clinical burden and HCRU
Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries
- Author
- Abad-Motos A.
- Abbas A. M.
- Abbas M.
- Abbasi M.
- Abbott T.
- Abd Karim M. F. S.
- Abdalaal I.
- Abdel-Galil K.
- Abdelemam R.
- Abdelgawad A.
- Abdelkarim M.
- Abdelkhalek M.
- Abdelmageed A.
- Abdelmawgoud S.
- Abdelmohsen S.
- Abdelrahman A. S.
- Abdelrahman M.
- Abdelwahab K.
- Abdou H.
- Abdulai D. R.
- Abdulkhaleq M.
- Abdullah B.
- Abdulsalam K.
- Abdulsalam S.
- Abdur-Rahman L.
- Abdus-Salam R.
- Abdussalam H. O.
- Abebrese J. T.
- Abeldano A.
- Abou-Khalil J.
- Abou-Taleb H.
- Abozid A.
- Abozied H.
- Abrate A.
- Abu-Zaid A.
- Abubakar M. K.
- Abud B.
- Abuzaid M.
- Adam A. A.
- Adamina M.
- Adamou H.
- Adamu A.
- Adamu K. M.
- Adanu K.
- Adebara I.
- Adebola O.
- Ademuyiwa A.
- Adeniran A.
- Adepiti A.
- Aderogba A. A.
- Adesunkanmi A.
- Adeyeye A.
- Adisa A.
- Adjeso T. J. K.
- Ads A. M.
- Ads A. M.
- Adu-Aryee N. A.
- Adumah C.
- Afzal I.
- Agapov M.
- Agarwal G.
- Agarwal R.
- Agbeko A. E.
- Agbeno E. K.
- Agbonrofo P.
- Agboola O.
- Aggarwal G.
- Aghadi I.
- Aghtarafi N.
- Agrawal A.
- Agresta F.
- Aguado H. J.
- Aguilera-Arevalo M. -L.
- Aherne T.
- Ahmad A.
- Ahmad M.
- Ahmad M.
- Ahmad S.
- Ahmad S.
- Ahmad S.
- Ahmed H. T. A.
- Ahmed K.
- Ahmed S.
- Ahmed S.
- Ahmed U.
- Aisuodionoe-Shadrach O.
- Aitken S.
- Ajenifuja K.
- Ajiya A.
- Akeel N.
- Akin E.
- Akinajo O.
- Akinyemi T.
- Akrida I.
- Aktokmakyan T. V.
- Akwaisah A.
- Al Bettar O.
- Al-Badawi I. A.
- Al-Juaifari M.
- Al-Khyatt W.
- Al-Mallah A.
- Al-Nusairi A.
- Al-Saadi N.
- Al-Sayaghi K.
- Al-Shaiji T.
- Al-Shehari M.
- Al-Touny A.
- Al-Touny S. A.
- Aladawi O.
- Aladna A.
- Alali M.
- Alam M.
- Alam M. S.
- Alarabi R.
- Alawneh Y.
- Alayande B.
- Albanese E.
- Albayadi E.
- Albdour M.
- Alconchel F.
- Alderazi A.
- Alegbeleye B.
- Alekberli T.
- Alemu M. A. A.
- Alexander P.
- Alfieri A.
- Alga A.
- Algahtany K.
- Algarni K.
- Alhamad A.
- Alhamid M.
- Alharmi R. A. R.
- Alharthi M.
- Alhazmi B.
- Ali M. S. M.
- Ali S.
- Alibrahim H.
- Aljaaly H.
- Aljaiuossi A.
- Aljanadi F.
- Aljiffry M.
- Aljirdabi N.
- Alkahlan M.
- Alkhalifa E.
- Alkhatib S.
- Alkhatieb M.
- Allan A.
- Almarshad F.
- Almgla N.
- Almhimid A.
- Almiqlash B.
- Almoshantaf M. B.
- Almutairi A.
- Alnsour A. A. M.
- Alobied M.
- Alomar O.
- Alonso J. A. M.
- Alonso M. D.
- Alonso N. F. P.
- Alonso V.
- Alqallaf A.
- Alqaseer A.
- Alrayes B.
- Alsefri M.
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- Alsharif M.
- Alsori M.
- Altaf A.
- Altinel Y.
- Altiner S.
- Altouny A.
- Altun D.
- Alvarez N.
- Alvarez-Lozada L. A.
- Alvi A.
- Alwael A.
- Alwash M.
- Alyami Z.
- Alyousef M.
- Alzahrani S.
- Alzerwi N.
- Amin S.
- Amir M.
- Ammar A. S.
- Ammendola M.
- Amores R. R.
- Amrayev S.
- Anastasiadou S.
- Ancans G.
- Anderson C.
- Andreani L.
- Andreotti D.
- Andreuccetti J.
- Andrianakis A.
- Andro C.
- Anesi A.
- Angamuthu S.
- Angeles M. A.
- Angelico R.
- Angelis F.
- Angelou D.
- Angelou K.
- Angulo V. P.
- Anjum A.
- Anjum M. A.
- Annicchiarico A.
- Anoldo P.
- Ansaloni L.
- Anthoulakis C.
- Antonelli A.
- Anwar M.
- Anwar S. L.
- Anwer M.
- Anyanwu L. -J.
- Apostolou C.
- Apostolou K.
- Appiah-Kubi A.
- Aprea G.
- Arbab H.
- Archer J.
- Ardura F.
- Aremu M.
- Arif T.
- Arkani S.
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- Publication venue
- country:GB
- Publication date
- 01/07/2023
- Field of study
Background: Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods: This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was coprioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low-middle-income countries. Results: In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of 'single-use' consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low-middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion: This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high- and low-middle-income countries
Outcomes after perioperative SARS-CoV-2 infection in patients with proximal femoral fractures: an international cohort study
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- Thiruvasagam VG
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- van Ramshorst G
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- Velopulos CG
- Venkatesan Sethuraman A
- Venn ML
- Ventura D
- Verberne C
- Vidya R
- Vidya R
- Vijay V
- Villalabeitia Ateca I
- Villamor Garcia I
- Vimalachandran D
- Vimalachandran D
- Viswanath Y
- Vitone L
- Vivas Lopez A
- Vives-Barquiel M
- Volpe A
- Von Oppell U
- Vovola F
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- Wadham B
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- Weerasinghe C
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- Whelton C
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- Wickramarachchi L
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- Williams MA
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- Winter SC
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- Witek A
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- Woodward Z
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- Xicola Martinez M
- Xyda S
- Yalamanchili S
- Yanez C
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- Yassin N
- Yener A
- Yershov D
- Young A
- Young R
- Yousef Y
- Youssef M
- Zadegan F
- Zafar N
- Zahid H
- Zakai D
- Zamvar V
- Zeiton M
- Zerbib P
- Zhang Y
- Zier L
- Zowgar A
- Publication venue
- 'BMJ'
- Publication date
- 01/01/2021
- Field of study
Objectives Studies have demonstrated high rates of mortality in people with proximal femoral fracture and SARS-CoV-2, but there is limited published data on the factors that influence mortality for clinicians to make informed treatment decisions. This study aims to report the 30-day mortality associated with perioperative infection of patients undergoing surgery for proximal femoral fractures and to examine the factors that influence mortality in a multivariate analysis. Setting Prospective, international, multicentre, observational cohort study. Participants Patients undergoing any operation for a proximal femoral fracture from 1 February to 30 April 2020 and with perioperative SARS-CoV-2 infection (either 7âdays prior or 30-day postoperative). Primary outcome 30-day mortality. Multivariate modelling was performed to identify factors associated with 30-day mortality. Results This study reports included 1063 patients from 174 hospitals in 19 countries. Overall 30-day mortality was 29.4% (313/1063). In an adjusted model, 30-day mortality was associated with male gender (OR 2.29, 95%âCI 1.68 to 3.13, p80 years (OR 1.60, 95%âCI 1.1 to 2.31, p=0.013), preoperative diagnosis of dementia (OR 1.57, 95%âCI 1.15 to 2.16, p=0.005), kidney disease (OR 1.73, 95%âCI 1.18 to 2.55, p=0.005) and congestive heart failure (OR 1.62, 95%âCI 1.06 to 2.48, p=0.025). Mortality at 30 days was lower in patients with a preoperative diagnosis of SARS-CoV-2 (OR 0.6, 95%âCI 0.6 (0.42 to 0.85), p=0.004). There was no difference in mortality in patients with an increase to delay in surgery (p=0.220) or type of anaesthetic given (p=0.787). Conclusions Patients undergoing surgery for a proximal femoral fracture with a perioperative infection of SARS-CoV-2 have a high rate of mortality. This study would support the need for providing these patients with individualised medical and anaesthetic care, including medical optimisation before theatre. Careful preoperative counselling is needed for those with a proximal femoral fracture and SARS-CoV-2, especially those in the highest risk groups. Trial registration number NCT0432364
Association between administration of IL-6 antagonists and mortality among patients hospitalized for COVID-19 : a meta-analysis
- Author
- Abad-Santos Francisco
- Adegunsoye Ayodeji
- Al-Beidh Farah
- Aleman Soo
- ALMEIDA THIAGO M.L.
- Almuedo Alex
- Alonso PĂ©rez Tamara
- Altice Frederick
- ANDRADE LUIS E.C.
- Angus Derek
- Annane Djillali
- Arabi Yaseen
- Arip Masita
- Asensi Victor
- Asgeirsson Hilmir
- Avendaño Solå Cristina
- AVEZUM ALVARO
- Axelrod Matthew
- AZEVEDO LUCIANO C.P.
- Azoulay Elie
- Baillie J Kenneth
- Baillie Kenneth J
- Baron Gabriel
- Barrios Ana
- Basri Sazali
- Bautista-HernĂĄndez Azucena
- Beane Abigail
- Beasley Richard
- Benbenishty Julie S.
- Bensaci Ana Maria
- Berry Lindsay
- Berry Lindsay R.
- Berry Scott
- BERWANGER OTĂVIO
- Bhimani Zahra
- Bidin Farah Nadiah
- Blennow Ola
- Bonten Marc
- Bosteels Cedric
- Bradbury Charlotte
- Broman Niklas
- Brunkhorst Frank
- Buch Maya H
- Bureau Serge
- Buxton Meredith
- Cadranel Jacques
- Campos Esteban José
- Carbonell Cristina
- CARCEL SHEILA
- CARVALHO JULIO CESAR
- CASTRO CLAUDIO G.
- Castro Pedro
- CastĂĄn Clara
- CAVALCANTI ALEXANDRE B.
- Cavalcanti Alexandre Biasi
- Chappell Lucy C
- Chatzidionysiou Katerina
- Cheng Allen
- Chidambaram Suresh
- Chong Meng Li
- Chun Geok Ying
- COELHO JULIANA C.
- Colman Roos
- CONCEIĂĂO FABIO G.
- Cooper Nichola
- Corbacho NoemĂ
- COSTA ANDRĂ N.
- Cove Matt
- Dalmau David
- DAMIANI LUCAS P.
- Day Jeremy N
- de Benito Natividad
- De Buyser Stefanie
- De Jong Menno
- De Leeuw Elisabeth
- DE SOUZA DENISE
- Declercq Jozefien
- Derde Lennie
- Derde Lennie P. G.
- Diaz Janet V.
- Domingo Pere
- Domingo Pere
- Dougados Maxime
- DOURADO LETICIA K.
- Emmerich Joseph
- Espinosa Gerard
- Estcourt Lise
- Estrada Vicente
- FARIAS DANIELLE L.C.
- Fartoukh Muriel
- Faust Saul N
- Fernandes Ana
- Fernandez-Cruz Ana
- Feuth Thijs
- Fisher David
- Fleisher Jorge
- Fortun JesĂșs
- Foulkes Andrea S
- Fowler Robert
- FREITAS FLAVIO G.R.
- Frigault Matthew J
- Galea James
- Galun Eitan
- Garcia Felipe
- Garcia-Vicuna Rosario
- GarcĂa-Fraile Lucio
- GARRIDO JOSE CARLOS
- GEBARA OTAVIO C.E.
- Godolphin Peter J.
- Gonzalez-Alvaro Isidoro
- Goossens Herman
- Gordon Anthony
- Gordon Anthony C.
- Green Cameron
- Guidet Bertrand
- Gutierrez Felix
- Gutierrez Maria del Mar
- GutiĂ©rrez Liarte Ăngela
- Halid Luqman Alhakim
- Haniffa Rashan
- Harvey Liam
- Hasan Mohd Shahnaz
- Haynes Richard
- Haynes Richard
- Healy Brian C
- Henter Jan-Inge
- Hermine Olivier
- Hermine Olivier
- Herrera Silvia
- Higgins Alisa
- Higgins Julian P. T.
- Hills Thomas
- Hohenthal Ulla
- Horby Peter W
- Horby Peter W.
- Horcajada Juan Pablo
- Horick Nora K.
- Horne Anna Carin
- Huckins David S.
- Humbert Marc
- Ibrahim Nur Munirah
- Ichihara Nao
- ISHIHARA LUCIANA M.
- Jaki Thomas
- Janols Helena
- Jeffery Katie
- Juszczak Edmund
- Kamarulzaman Adeeba
- Karrison Theodore
- King Andrew
- Koh Hui Moon
- Kukreja Anjanna
- Kumar Kuldeep
- Lacombe Karine
- Lambrecht Bart
- Lamontagne Francois
- Lampa Jon
- Landray Martin J
- Landray Martin J.
- Lawler Patrick
- Leal Lorna
- Lederer David J.
- Lee Cheng Siang
- LEITE RODRIGO T.
- Leon Rafael
- LEON RAFAEL
- Lim Wei Shen
- Lin Nina
- LISBOA THIAGO C.
- Litton Ed
- LOPES RENATO D.
- Lorenzi Elizabeth
- Lorenzi Elizabeth
- MACHADO DAVID J.B.
- MACHADO FLAVIA R.
- Maes Bastiaan
- Mafham Marion
- Mahevas Matthieu
- Malinis Maricar
- Malouf Jorge
- Mansour Michael K
- Mariette Xavier
- Mariette Xavier
- Marshall John
- Marshall John C.
- MARTIN JOSIANE
- Marttila Harri
- MartĂnez JosĂ© Antonio
- Mateo Gracia MarĂa
- McArthur Colin
- McAuley Daniel
- McGuinness Shay
- McVerry Bryan
- Megat Johari Bushra
- MejĂa-Abril Gina
- MERCHANTE NICOLAS
- Merchante Nicolas
- Millan Lucia
- Misnan Nor Arisah
- Misnan Nor Arisah
- Mohamed Gani Yasmin
- Mohan Shalini V.
- Mohd Abd Rahim Mohd Abd Hafiz
- Mohd Thabit Alif Adlan
- Molas Maria Ema
- Montgomery Alan
- Montgommery Stephanie
- Morpeth Susan
- Mouncey Paul
- Mukri Mohd Noor Azreet
- Mumford Andrew
- Mur Isabel
- Murthy Srinivas
- Murthy Srinivas
- Muñez Rubio Elena
- Muñoz Jessica
- Muñóz José
- Neelamegam Malinee
- Netea Mihai
- Ng Rong Xiang
- Nichol Alistair
- Nikiforow Sarah
- Nivens Michael C.
- Niward Katarina F
- Nordberg Marika
- Nowak Piotr
- Ogungbenro Kayode
- Oksi Jarmo
- Omar Sharifah Faridah
- Ong Hang Cheng
- PACHECO EDUARDO S.
- Pacheco IvĂĄn
- Paredes Roger
- Parke Rachael
- Parke Ă sa
- Parker Jane
- Patel Naomi J
- Pene Frédéric
- Perez-Molina Jose A
- Perez-Molina Jose A.
- Pettila Ville
- Pincus Michael D
- PINTĂO MARIA CAROLINA T.
- Pisano Jennifer
- Pizov Reuven
- Pizov Reuven
- Pomar Virginia
- Ponnampalavanar Sasheela
- Porcher Raphael
- Porcher Raphael
- Postma Simone
- Pourchet-Martinez Valérie
- PRATS JOĂO G.
- Price Christina
- Prieto Jose Carlos
- Prieto Sergio
- Raja Azwa Raja Iskandar Syah
- Raja Sureja Letchumi
- Rajasuriar Reena
- Rajasuriar Reena
- Ramanan Athimalaipet V.
- Ramos MartĂnez Antonio
- Rasmuson Johan
- Ratain Mark
- Ravaud Philippe
- Ravaud Philippe
- Reid Pankti D.
- Resche Rigon Matthieu
- Reyes Felipe
- RodrĂguez-GarcĂa Sebastian C
- ROJAS SALOMĂN S.O.
- ROSA REGIS G.
- Rosas Ivan O.
- Rowan Kathryn
- Ruiz-Antorån Belén
- Rutgers Abraham
- Sagar Manish
- Saito Hiroki
- Salama Carlos
- Sancho-Lopez Aranzazu
- SANDES ALEX R.
- Santos Marlene
- SANTOS SUELI V.
- Sanz Sanz Jesus
- Saravanamuttu Sujana
- Savovic Jelena
- SCHEINBERG PHILLIP
- Schlemmer Frédéric
- SCHNEIDER DANIEL
- Seto Todd B.
- Seymour Chris
- Shah Ruta
- Shankar-Hari Manu
- Shankar-Hari Manu
- Shrager Harry
- Sim Benedict
- SIQUEIRA SUELLEN R.R.
- Sivapalasingam Sumathi
- Skorup Paul
- Soin Arvinder Singh
- Soriano Alex
- Spiga Francesca
- Staplin Natalie
- Sterne Jonathan A. C.
- Stone John H.
- Strek Mary
- Strohbehn Garth W.
- Sulaiman Helmi
- Sunden-Cullberg Jonas
- Svensson Anna-Karin
- Syed Badaruddin Syarifah Nurul Ain
- Syed Mansor Syed Mukhtar
- Syed Omar Sharifah Faridah
- Sönnerborg Anders
- Tan Kok Tong
- Tay Kim Heng
- Thangavelu Suvintheran
- Tharaux Pierre Louis
- The WHO Rapid Evidence Appraisal for COVID-19 Therapies (REACT) Working Group [missing]
- Thwaites Guy
- Tibi Annick
- Tierney Jayne
- Tong Steve
- TORRE-CISNEROS JULIAN
- Torre-Cisneros Julian
- Torres Ferran
- Tsai Larry W.
- Tuang Wei Xuan
- Turgeon Alexis
- Turner Anne
- Uyeki Tim
- Vale Claire L.
- Valtonen Mika
- van Bentum-Puijk Wilma
- Van Damme Karel
- van de Veerdonk Frank
- van Hoogstraten Hubert
- van Meerten Tom
- VEIGA VIVIANE C.
- Veiga Viviane Cordeiro
- Vesterbacka Jan C.
- Villar Luisa M
- Vuorinen Tytti
- Webb Steve
- Westerweel Peter E.
- Wong Chee Kuan
- Wong Pui Li
- Woolley Ann E.
- Yazdanpanah Yazdan
- Youngstein Taryn
- ZAMPIERI FERNANDO G.
- Zarychanski Ryan
- Zulhaimi Nurul Syuhada
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 01/01/2021
- Field of study
IMPORTANCE Clinical trials assessing the efficacy of IL-6 antagonists in patients hospitalized for COVID-19 have variously reported benefit, no effect, and harm.
OBJECTIVE To estimate the association between administration of IL-6 antagonists compared with usual care or placebo and 28-day all-cause mortality and other outcomes.
DATA SOURCES Trials were identified through systematic searches of electronic databases between October 2020 and January 2021. Searches were not restricted by trial status or language. Additional trials were identified through contact with experts.
STUDY SELECTION Eligible trials randomly assigned patients hospitalized for COVID-19 to a group in whom IL-6 antagonists were administered and to a group in whom neither IL-6 antagonists nor any other immunomodulators except corticosteroids were administered. Among 72 potentially eligible trials, 27 (37.5%) met study selection criteria.
DATA EXTRACTION AND SYNTHESIS In this prospectivemeta-analysis, risk of biaswas assessed using the Cochrane Risk of Bias Assessment Tool. Inconsistency among trial results was assessed using the I-2 statistic. The primary analysis was an inverse variance-weighted fixed-effects meta-analysis of odds ratios (ORs) for 28-day all-cause mortality.
MAIN OUTCOMES AND MEASURES The primary outcome measurewas all-cause mortality at 28 days after randomization. There were 9 secondary outcomes including progression to invasive mechanical ventilation or death and risk of secondary infection by 28 days.
RESULTS A total of 10 930 patients (median age, 61 years [range of medians, 52-68 years]; 3560 [33%] were women) participating in 27 trials were included. By 28 days, there were 1407 deaths among 6449 patients randomized to IL-6 antagonists and 1158 deaths among 4481 patients randomized to usual care or placebo (summary OR, 0.86 [95% CI, 0.79-0.95]; P =.003 based on a fixed-effects meta-analysis). This corresponds to an absolute mortality risk of 22% for IL-6 antagonists compared with an assumed mortality risk of 25% for usual care or placebo. The corresponding summary ORs were 0.83 (95% CI, 0.74-0.92; P <.001) for tocilizumab and 1.08 (95% CI, 0.86-1.36; P =.52) for sarilumab. The summary ORs for the association with mortality compared with usual care or placebo in those receiving corticosteroids were 0.77 (95% CI, 0.68-0.87) for tocilizumab and 0.92 (95% CI, 0.61-1.38) for sarilumab. The ORs for the association with progression to invasive mechanical ventilation or death, compared with usual care or placebo, were 0.77 (95% CI, 0.70-0.85) for all IL-6 antagonists, 0.74 (95% CI, 0.66-0.82) for tocilizumab, and 1.00 (95% CI, 0.74-1.34) for sarilumab. Secondary infections by 28 days occurred in 21.9% of patients treated with IL-6 antagonists vs 17.6% of patients treated with usual care or placebo (OR accounting for trial sample sizes, 0.99; 95% CI, 0.85-1.16).
CONCLUSIONS AND RELEVANCE In this prospectivemeta-analysis of clinical trials of patients hospitalized for COVID-19, administration of IL-6 antagonists, compared with usual care or placebo, was associated with lower 28-day all-cause mortality