Analysis of skin blood microflow oscillations in patients with rheumatic diseases

Laser Doppler flowmetry (LDF) has been applied for the assessment of variation in blood microflows in patients with rheumatic diseases and healthy volunteers. Oscillations of peripheral blood microcirculation observed by LDF have been analyzed utilizing a wavelet transform. A higher amplitude of blood microflow oscillations has been observed in a high frequency band (over 0.1 Hz) in patients with rheumatic diseases. Oscillations in the high frequency band decreased in healthy volunteers in response to the cold pressor test, whereas lower frequency pulsations prevailed in patients with rheumatic diseases. A higher perfusion rate at normal conditions was observed in patients, and a weaker response to cold stimulation was observed in healthy volunteers. Analysis of blood microflow oscillations has a high potential for evaluation of mechanisms of blood flow regulation and diagnosis of vascular abnormalities associated with rheumatic diseases

Influence of blood pulsation on diagnostic volume in pulse oximetry and photoplethysmography measurements

Recent advances in the development of ultra-compact semiconductor lasers and technology of printed flexible hybrid electronics have opened broad perspectives for the design of new pulse oximetry and photoplethysmography devices. Conceptual design of optical diagnostic devices requires careful selection of various technical parameters, including spectral range; polarization and intensity of incident light; actual size, geometry, and sensitivity of the detector; and mutual position of the source and detector on the surface of skin. In the current study utilizing a unified Monte Carlo computational tool, we explore the variations in diagnostic volume due to arterial blood pulsation for typical transmitted and back-scattered probing configurations in a human finger. The results of computational studies show that the variations in diagnostic volumes due to arterial pulse wave are notably (up to 45%) different in visible and near-infrared spectral ranges in both transmitted and back-scattered probing geometries. While these variations are acceptable for relative measurements in pulse oximetry and/or photoplethysmography, for absolute measurements, an alignment normalization of diagnostic volume is required and can be done by a computational approach utilized in the framework of the current study

Spectral analysis of the blood flow in the foot microvascular bed during thermal testing in patients with diabetes mellitus

Timely diagnostics of microcirculatory system abnormalities, which are the most severe diabetic complications, is one of the major problems facing modern health care. Functional abnormalities manifest themselves earlier than the structural ones, and therefore their assessment is the issue of primary importance. In this study Laser Doppler flowmetry, a noninvasive technique for the cutaneous blood flow monitoring, was utilized together with local temperature tests and wavelet analysis. The study of the blood flow in the microvascular bed of toes was carried out in the control group of 40 healthy subjects and in two groups of 17 type 1 and 23 type 2 diabetic patients. The local temperature tests demonstrated that the diabetic patients have impaired vasodilation in response to local heating. The tendency for impaired low frequency pulsations of the blood flow associated with endothelial and neurogenic activities in both diabetes groups was observed. Local thermal tests induced variations in perfusion and its spectral characteristics, which were different in the groups under study. In our opinion, the obtained preliminary results can be a basis for further research and provide a deeper understanding of pathological processes that drive microvascular abnormalities caused by diabetes mellitus

Simulated SKA maps from Galactic 3D-emission models

(Abridged) We present maps for various Galactic longitudes and latitudes at 1.4 GHz, which is the frequency where deep SKA surveys are proposed. The maps are about 1.5 deg in size and have an angular resolution of about 1.6 arcsec. We analyse the maps in terms of their probability density functions (PDFs) and structure functions. Total intensity emission is more smooth in the plane than at high latitudes due to the different contributions from the regular and random magnetic field. The high latitude fields show more extended polarized emission and RM structures than those in the plane, where patchy emission structures on very small scales dominate. The RM PDFs in the plane are close to Gaussians, but clearly deviate from that at high latitudes. The RM structure functions show smaller amplitudes and steeper slopes towards high latitudes. These results emerge from the fact that much more turbulent cells are passed through by the line-of-sights in the plane. Although the simulated random magnetic field components distribute in 3D, the magnetic field spectrum extracted from the structure functions of RMs conforms to 2D in the plane and approaches 3D at high latitudes. This is partly related to the outer scale of the turbulent magnetic field, but mainly to the different lengths of the line-of-sights.Comment: 19 pages, 15 figures, accepted for publication in Astronomy and Astrophysics. The sizes of figures have been significantly reduced. For the version with full resolution, see ftp://ftp.mpifr-bonn.mpg.de/outgoing/p098wre/sun-reich.pd

Faraday caustics: Singularities in the Faraday spectrum and their utility as probes of magnetic field properties

We describe singularities in the distribution of polarized intensity as a function of Faraday depth (i.e. the Faraday spectrum) caused by line-of-sight (LOS) magnetic field reversals. We call these features Faraday caustics because of their similarity to optical caustics. They appear as sharply peaked and asymmetric profiles in the Faraday spectrum, that have a tail that extends to one side. The direction in which the tail extends depends on the way in which the LOS magnetic field reversal occurs (either changing from oncoming to retreating or vice versa). We describe how Faraday caustics will form three-dimensional surfaces that relate to boundaries between regions where the LOS magnetic field has opposite polarity. We present examples from simulations of the predicted polarized synchrotron emission from the Milky Way. We derive either the probability or luminosity distribution of Faraday caustics produced in a Gaussian magnetic field distribution as a function of their strength, F, and find that for strong Faraday caustics P(F)\proptoF^{-3} . If fully resolved, this distribution is also shown to depend on the Taylor microscale, which relates to the largest scale over which dissipation is important in a turbulent flow.Comment: 14 pages, 9 figures, Accepted for publication in Astronomy & Astrophysic