A framework for the integration of mobile technology into adventure sport for the purpose of increasing participant safety

The sporting industry has seen incredible advancements with the use of information technology. Technology is used in the sporting industry for training, coaching and even as a deciding factor of a game result. There are certain sports which require individuals to venture into isolated environments, these sports have been termed adventure or extreme sports. Due to the extreme environmental factors that can occur with adventure sport, it is possible for an individual to experience an emergency situation. Emergency situations can occur at any time, and this is especially true in adventure sport. Adventure sport such as ocean and river kayaking require individuals to venture into isolated environments, where if an emergency situation occurs could result in an individual left stranded waiting for emergency rescue. Adventure sport participants and Event Organizers are aware of the dangers associated with this type of adventure sport, but there is currently no requirement to have a mobile technology device present during kayaking events. The main purpose of this dissertation was to evaluate the current use of mobile technology in adventure sport in the Eastern Cape province of South Africa. To accomplish this two literature reviews were conducted which identi_ed information on the two main themes which are adventure sport and mobile technology. To produce information from the ocean and river kayaking community an online questionnaire was distributed to several kayaking clubs in the Eastern Cape province of South Africa. This dissertation also presents a framework that proposes the use of mobile technology hardware and software by participants and event organisers in an attempt to increase the safety of events in this form of adventure sport. It is hoped that the framework for using mobile technology to increase the safety of adventure sport proposed in this research, may provide clear guidance for the achievement of a safer sporting experience for the participants of ocean and river kayaking

Review of the prevalence of diabetic retinopathy in Indigenous Australians

Author version made available in accordance with Publisher copyright policy.The purpose of this review is to compare the prevalence of diabetic retinopathy (DR) between Indigenous and non-Indigenous Australians with Diabetes Mellitus (DM). Australian DR prevalence data from 6 Indigenous studies (n = 2865) and 5 non-Indigenous studies (n = 9801) conducted between 1985 and 2013 were included for analysis. Estimated prevalence of any DR among Indigenous Australians with DM was 23.4% compared with 28.9% for non-Indigenous Australians (χ2 = 26.9, P < 0.001). In studies performed after 1990, a significantly higher rate of diabetic macular edema was found in Indigenous compared with non-Indigenous Australians with DM (7.6% versus 4.9%, χ2 = 6.67, P = 0.01). Although there are limitations in comparing these studies, one explanation for the observed data could be a model in which Indigenous Australians are relatively resistant to early stage DR, but with a subset progressing to sight threatening DR due to individual genetic and environmental susceptibility factors coupled with poor glycemic control

Does Collocation Inform the Impact of Collaboration?

Background It has been shown that large interdisciplinary teams working across geography are more likely to be impactful. We asked whether the physical proximity of collaborators remained a strong predictor of the scientific impact of their research as measured by citations of the resulting publications. Methodology/Principal Findings Articles published by Harvard investigators from 1993 to 2003 with at least two authors were identified in the domain of biomedical science. Each collaboration was geocoded to the precise three-dimensional location of its authors. Physical distances between any two coauthors were calculated and associated with corresponding citations. Relationship between distance of coauthors and citations for four author relationships (first-last, first-middle, last-middle, and middle-middle) were investigated at different spatial scales. At all sizes of collaborations (from two authors to dozens of authors), geographical proximity between first and last author is highly informative of impact at the microscale (i.e. within building) and beyond. The mean citation for first-last author relationship decreased as the distance between them increased in less than one km range as well as in the three categorized ranges (in the same building, same city, or different city). Such a trend was not seen in other three author relationships. Conclusions/Significance Despite the positive impact of emerging communication technologies on scientific research, our results provide striking evidence for the role of physical proximity as a predictor of the impact of collaborations.Ewing Marion Kauffman FoundationHarvard University. Office of the Provost (1992-

The androgen receptor controls expression of the cancer-associated sTn antigen and cell adhesion through induction of ST6GalNAc1 in prostate cancer

Patterns of glycosylation are important in cancer, but the molecular mechanisms that drive changes are often poorly understood. The androgen receptor drives prostate cancer (PCa) development and progression to lethal metastatic castration-resistant disease. Here we used RNA-Seq coupled with bioinformatic analyses of androgen-receptor (AR) binding sites and clinical PCa expression array data to identify ST6GalNAc1 as a direct and rapidly activated target gene of the AR in PCa cells. ST6GalNAc1 encodes a sialytransferase that catalyses formation of the cancer-associated sialyl-Tn antigen (sTn), which we find is also induced by androgen exposure. Androgens induce expression of a novel splice variant of the ST6GalNAc1 protein in PCa cells. This splice variant encodes a shorter protein isoform that is still fully functional as a sialyltransferase and able to induce expression of the sTn-antigen. Surprisingly, given its high expression in tumours, stable expression of ST6GalNAc1 in PCa cells reduced formation of stable tumours in mice, reduced cell adhesion and induced a switch towards a more mesenchymal-like cell phenotype in vitro. ST6GalNAc1 has a dynamic expression pattern in clinical datasets, beingsignificantly up-regulated in primary prostate carcinoma but relatively down-regulated in established metastatic tissue. ST6GalNAc1 is frequently upregulated concurrently with another important glycosylation enzyme GCNT1 previously associated with prostate cancer progression and implicated in Sialyl Lewis X antigen synthesis. Together our data establishes an androgen-dependent mechanism for sTn antigen expression in PCa, and are consistent with a general role for the androgen receptor in driving important coordinate changes to the glycoproteome during PCa progression

Unconditional care in academic emergency departments

Recent news stories have explicitly stated that patients with symptoms of COVID-19 were "turned away" from emergency departments. This commentary addresses these serious allegations, with an attempt to provide the perspective of academic emergency departments (EDs) around the Nation. The overarching point we wish to make is that academic EDs never deny emergency care to any person

LSST: from Science Drivers to Reference Design and Anticipated Data Products

(Abridged) We describe here the most ambitious survey currently planned in the optical, the Large Synoptic Survey Telescope (LSST). A vast array of science will be enabled by a single wide-deep-fast sky survey, and LSST will have unique survey capability in the faint time domain. The LSST design is driven by four main science themes: probing dark energy and dark matter, taking an inventory of the Solar System, exploring the transient optical sky, and mapping the Milky Way. LSST will be a wide-field ground-based system sited at Cerro Pach\'{o}n in northern Chile. The telescope will have an 8.4 m (6.5 m effective) primary mirror, a 9.6 deg$^2$ field of view, and a 3.2 Gigapixel camera. The standard observing sequence will consist of pairs of 15-second exposures in a given field, with two such visits in each pointing in a given night. With these repeats, the LSST system is capable of imaging about 10,000 square degrees of sky in a single filter in three nights. The typical 5$\sigma$ point-source depth in a single visit in $r$ will be $\sim 24.5$ (AB). The project is in the construction phase and will begin regular survey operations by 2022. The survey area will be contained within 30,000 deg$^2$ with $\delta<+34.5^\circ$, and will be imaged multiple times in six bands, $ugrizy$, covering the wavelength range 320--1050 nm. About 90\% of the observing time will be devoted to a deep-wide-fast survey mode which will uniformly observe a 18,000 deg$^2$ region about 800 times (summed over all six bands) during the anticipated 10 years of operations, and yield a coadded map to $r\sim27.5$. The remaining 10\% of the observing time will be allocated to projects such as a Very Deep and Fast time domain survey. The goal is to make LSST data products, including a relational database of about 32 trillion observations of 40 billion objects, available to the public and scientists around the world.Comment: 57 pages, 32 color figures, version with high-resolution figures available from https://www.lsst.org/overvie

Crop Updates 2007 - Weeds

This session covers thirty two papers from different authors: 1. ACKNOWLEDGEMENTS, Alexandra Douglas CONVENOR – WEEDS DEPARTMENT OF AGRICULTURE AND FOOD WILD RADISH MANAGEMENT 2. Decimate a wild radish seed bank in five years, Peter Newman, Sally Peltzer, Abul Hashem and Aik Cheam, Department of Agriculture and Food 3. High level of seed-set control in wild radish is achievable, Aik Cheam and Siew Lee,Department of Agriculture and Food 4. Wild radish: Best management practice, Aik Cheam and Siew Lee, Department of Agriculture and Food 5. Control of phenoxy resistant wild radish through the combined effects of wheat competition and phenoxy herbicides, Natalie Maguire and Michael Walsh, WAHRI, School of Plant Biology, University of Western Australia 6.Efficacy of florasulam on chlorsulfuron resistant and susceptible wild radish populations in Western Australia, Michael Walsh1 and Dan Cornally2, 1WAHRI, School of Plant Biology, University of Western Australia, 2Dow Agrosciences Australia 7. Does liming to increase soil pH limit the growth and development of wild radish (Raphanus raphanistrum)Matt Willis and Michael Walsh, WAHRI, School of Plant Biology, University of Western Australia IWM TECHNIQUES AND SEEDBANKS 8. Weed trimming – a potential technique to reduce weed seed set, Glen Riethmuller, Abul Hashem and Shahab Pathan, Department of Agriculture and Food 9. Burn narrow windrows in the wind, Peter Newman1and Michael Walsh2, 1Department of Agriculture and Food, 2Research Fellow, WA Herbicide Resistance Initiative 10. Winning the Weed War with the Weed Seed Wizard! Michael Renton, Sally Peltzer and Art Diggle, Department of Agriculture and Food HERBICIDE RESISTANCE AND GENE FLOW 11. Frequency of herbicide resistance in wild oat (Avena fatua) across the Western Australian wheatbelt, Mechelle Owen and Stephen Powles, WA Herbicide Resistance Initiative, School of Plant Biology, University of Western Australia 12. Pollen mediated gene flow of herbicide resistance can occur over long distances doe annual ryegrass (Lolium rigidum): Results of two years with different meteorological conditions, Roberto Busi, Robert Barrett-Lennard and Stephen B. Powles, Western Australian Herbicide Resistance Initiative, School of Plant Biology – University of Western Australia 13. Doublegee has developed resistance to metsulfuron-methyl within WA wheatbelt, Dr Abul Hashem1and Dr Shahab Pathan2, 1Senior Research Officer, and 2Research Officer, Department Agriculture and Food 14. Another case of glyphosate resistance in annual ryegrass confirmes within Western Australia, Dr Abul Hashem1and Dr Shahab Pathan2, 1Senior Research Officer, and 2Research Officer, Department Agriculture and Food 15. Glyphosate resistance in the northern NSW – implications for Western Australian farming systems, Andrew Storrie, Tamworth Agricultural Institute, NSW Department of Primary Industries ALTERNATIVES TO TRIFLURALIN, KNOCKDOWNS, TANK MIXES AND NOVEL USES 16. Alternative pre-emergent herbicides to trifluralin for annual ryegrass control, Mr David Minkey and Dr Abul Hashem, Department of Agriculture and Food, 17. Evaluation of a new pre-emergent herbicide alternative dor the control of trifluralin resistant Lolium rigidum Gaudin (annual ryegrass) in wheat and barley, Craig A. Ruchs, Syngenta Crop Protection Australia Pty Ltd and Dr Peter Boutsalis, University of Adelaide 18. Novel knockdown tank mixes: Results from 12 trials over four years, Shahab Pathan1, Abul Hashem2, Catherine Borger3, Nerys Wilkins and Julie Roche, Department of Agriculture and Food, Western Australia, and 3the University of Western Australia 19. Alternative herbicides for weed control in lupins, Peter Newman and Martin Harries, Department of Agriculture and Food 20. Novel use application of clopyealid in lupins, John Peirce, and Brad Rayner, Department of Agriculture and Food 21. A model to predict grass selective herbicide rates, John Moore, Department of Agriculture and Food CROP AND WEED MANAGEMENT 22. Inter-row weed control in wide row lupin using knockdown-based tank mixes, Dr Abul Hashem1, Ray Fulwood2 and Chris Roberts3, 1Senior Research Officer, Department of Agriculture and Food, 2Farmer, Meckering, WA, 3Technical Officer, Department of Agriculture and Food 23. Timing of weed removal in wide-row lupins, Sally Peltzer, Shahab Pathan and Paul Matson, Department of Agriculture and Food 24. The effect of row spacing and crop density on competitiveness of lupins with wild radish, Bob French and Laurie Maiolo, Department of Agriculture and Food 25. Is delayed sowing a good strategy for weed management in lupins? Bob French, Department of Agriculture and Food 26. Delayed sowing as a strategy to manage annual ryegrass, Department of Agriculture and Food HERBICIDE TOLERANCE 27. The effect of herbicides on nodulation in lupins, Lorne Mills1, Harmohinder Dhammu2 and Beng Tan1, 1Curtin University of Technology, and 2Department of Agriculture and Food 28. Response of new wheat varieties to herbicides, Harmohinder Dhammu, Department of Agriculture and Food 29. Herbicide tolerance of new barley varieties, Harmohinder Dhammu, Vince Lambert and Chris Roberts, Department of Agriculture and Food 30. Herbicide tolerance of new oat varieties, Harmohinder Dhammu, Vince Lambert and Chris Roberts, Department of Agriculture and Food OTHER WEEDY MATTERS 31. Research and extension need for wild radish and other cruciferous weeds, Aik Cheam, Department of Agriculture and Food 32. e-weed – an information resource of seasonal weed management issues, Vanessa Stewartand Julie Roche, Department of Agriculture and Foo

The Long-Baseline Neutrino Experiment: Exploring Fundamental Symmetries of the Universe

The preponderance of matter over antimatter in the early Universe, the dynamics of the supernova bursts that produced the heavy elements necessary for life and whether protons eventually decay --- these mysteries at the forefront of particle physics and astrophysics are key to understanding the early evolution of our Universe, its current state and its eventual fate. The Long-Baseline Neutrino Experiment (LBNE) represents an extensively developed plan for a world-class experiment dedicated to addressing these questions. LBNE is conceived around three central components: (1) a new, high-intensity neutrino source generated from a megawatt-class proton accelerator at Fermi National Accelerator Laboratory, (2) a near neutrino detector just downstream of the source, and (3) a massive liquid argon time-projection chamber deployed as a far detector deep underground at the Sanford Underground Research Facility. This facility, located at the site of the former Homestake Mine in Lead, South Dakota, is approximately 1,300 km from the neutrino source at Fermilab -- a distance (baseline) that delivers optimal sensitivity to neutrino charge-parity symmetry violation and mass ordering effects. This ambitious yet cost-effective design incorporates scalability and flexibility and can accommodate a variety of upgrades and contributions. With its exceptional combination of experimental configuration, technical capabilities, and potential for transformative discoveries, LBNE promises to be a vital facility for the field of particle physics worldwide, providing physicists from around the globe with opportunities to collaborate in a twenty to thirty year program of exciting science. In this document we provide a comprehensive overview of LBNE's scientific objectives, its place in the landscape of neutrino physics worldwide, the technologies it will incorporate and the capabilities it will possess.Comment: Major update of previous version. This is the reference document for LBNE science program and current status. Chapters 1, 3, and 9 provide a comprehensive overview of LBNE's scientific objectives, its place in the landscape of neutrino physics worldwide, the technologies it will incorporate and the capabilities it will possess. 288 pages, 116 figure

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts