206 research outputs found
Deep GALEX Observations of the Coma Cluster: Source Catalog and Galaxy Counts
We present a source catalog from deep 26 ks GALEX observations of the Coma
cluster in the far-UV (FUV; 1530 A) and near-UV (NUV; 2310 A) wavebands. The
observed field is centered 0.9 deg (1.6 Mpc) south-west of the Coma core, and
has full optical photometric coverage with SDSS. The catalog consists of 9700
galaxies with GALEX and SDSS photometry, including 242
spectroscopically-confirmed Coma member galaxies that range from giant spirals
and elliptical galaxies to dwarf irregular and early-type galaxies. The full
multi-wavelength catalog (cluster plus background galaxies) is ~80% complete to
NUV=23 and FUV=23.5, and has a limiting depth at NUV=24.5 and FUV=25.0 which
corresponds to a star formation rate of ~0.001 Msun/yr at the distance of Coma.
Our deep GALEX observations required a two-fold approach to generating a source
catalog: we used a Bayesian deblending algorithm to measure faint and compact
sources (using SDSS coordinates as a position prior), and relied on the GALEX
pipeline catalog for bright/extended objects. We performed simulations to
assess the influence that systematic effects (e.g. object blends, source
confusion, Eddington Bias) have on source detection and photometry when using
both methods. The Bayesian deblending method roughly doubles the number of
source detections and provides reliable photometry to a few magnitudes deeper
than the GALEX pipeline catalog. This method is also free from source confusion
over the UV magnitude range studied here; conversely, we estimate that the
GALEX pipeline catalogs are confusion limited at magnitudes fainter than NUV~23
and FUV~24. We have measured the total UV galaxy counts using our catalog and
report a ~50% excess of counts across FUV=22-23.5 and NUV=21.5-23 relative to
previous GALEX measurements, which is not attributed to cluster member
galaxies. Our galaxy counts are a better match to deeper UV counts measured
with HST.Comment: 27 pages, 13 figures, 4 tables, accepted for publication in ApJ
The HST/ACS Coma Cluster Survey. II. Data Description and Source Catalogs
The Coma cluster was the target of a HST-ACS Treasury program designed for
deep imaging in the F475W and F814W passbands. Although our survey was
interrupted by the ACS instrument failure in 2007, the partially completed
survey still covers ~50% of the core high-density region in Coma. Observations
were performed for 25 fields that extend over a wide range of cluster-centric
radii (~1.75 Mpc) with a total coverage area of 274 arcmin^2. The majority of
the fields are located near the core region of Coma (19/25 pointings) with six
additional fields in the south-west region of the cluster. In this paper we
present reprocessed images and SExtractor source catalogs for our survey
fields, including a detailed description of the methodology used for object
detection and photometry, the subtraction of bright galaxies to measure faint
underlying objects, and the use of simulations to assess the photometric
accuracy and completeness of our catalogs. We also use simulations to perform
aperture corrections for the SExtractor Kron magnitudes based only on the
measured source flux and half-light radius. We have performed photometry for
~73,000 unique objects; one-half of our detections are brighter than the
10-sigma point-source detection limit at F814W=25.8 mag (AB). The slight
majority of objects (60%) are unresolved or only marginally resolved by ACS. We
estimate that Coma members are 5-10% of all source detections, which consist of
a large population of unresolved objects (primarily GCs but also UCDs) and a
wide variety of extended galaxies from a cD galaxy to dwarf LSB galaxies. The
red sequence of Coma member galaxies has a constant slope and dispersion across
9 magnitudes (-21<M_F814W<-13). The initial data release for the HST-ACS Coma
Treasury program was made available to the public in 2008 August. The images
and catalogs described in this study relate to our second data release.Comment: Accepted for publication in ApJS. A high-resolution version is
available at http://archdev.stsci.edu/pub/hlsp/coma/release2/PaperII.pd
Destruction of tumor vasculature and abated tumor growth upon VEGF blockade is driven by proapoptotic protein Bim in endothelial cells
VEGF deprivation induces Bim expression in tumor endothelial cells, and Bim is needed for anti-VEGF–driven endothelial cell death and tumor shrinkage
UNBOUND
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Many Labs 5:Testing pre-data collection peer review as an intervention to increase replicability
Replication studies in psychological science sometimes fail to reproduce prior findings. If these studies use methods that are unfaithful to the original study or ineffective in eliciting the phenomenon of interest, then a failure to replicate may be a failure of the protocol rather than a challenge to the original finding. Formal pre-data-collection peer review by experts may address shortcomings and increase replicability rates. We selected 10 replication studies from the Reproducibility Project: Psychology (RP:P; Open Science Collaboration, 2015) for which the original authors had expressed concerns about the replication designs before data collection; only one of these studies had yielded a statistically significant effect (p < .05). Commenters suggested that lack of adherence to expert review and low-powered tests were the reasons that most of these RP:P studies failed to replicate the original effects. We revised the replication protocols and received formal peer review prior to conducting new replication studies. We administered the RP:P and revised protocols in multiple laboratories (median number of laboratories per original study = 6.5, range = 3?9; median total sample = 1,279.5, range = 276?3,512) for high-powered tests of each original finding with both protocols. Overall, following the preregistered analysis plan, we found that the revised protocols produced effect sizes similar to those of the RP:P protocols (?r = .002 or .014, depending on analytic approach). The median effect size for the revised protocols (r = .05) was similar to that of the RP:P protocols (r = .04) and the original RP:P replications (r = .11), and smaller than that of the original studies (r = .37). Analysis of the cumulative evidence across the original studies and the corresponding three replication attempts provided very precise estimates of the 10 tested effects and indicated that their effect sizes (median r = .07, range = .00?.15) were 78% smaller, on average, than the original effect sizes (median r = .37, range = .19?.50)
Integrated genomic characterization of pancreatic ductal adenocarcinoma
We performed integrated genomic, transcriptomic, and proteomic profiling of 150 pancreatic ductal adenocarcinoma (PDAC) specimens, including samples with characteristic low neoplastic cellularity. Deep whole-exome sequencing revealed recurrent somatic mutations in KRAS, TP53, CDKN2A, SMAD4, RNF43, ARID1A, TGFβR2, GNAS, RREB1, and PBRM1. KRAS wild-type tumors harbored alterations in other oncogenic drivers, including GNAS, BRAF, CTNNB1, and additional RAS pathway genes. A subset of tumors harbored multiple KRAS mutations, with some showing evidence of biallelic mutations. Protein profiling identified a favorable prognosis subset with low epithelial-mesenchymal transition and high MTOR pathway scores. Associations of non-coding RNAs with tumor-specific mRNA subtypes were also identified. Our integrated multi-platform analysis reveals a complex molecular landscape of PDAC and provides a roadmap for precision medicine
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