CNES and ESA CAROLS Airborne Campaigns at the Valencia Anchor Station and Los Monegros Site in the Framework of SMOS Validation

1 copia .pdf con Figs.Poster presentado en la European Geophysical Union. General Assembly 2011 celebrada en Viena del 03 al 08 de abril 2011. Session GI-1 on Geoscience Instrumentation.This communication will present the main results of a series of airborne campaigns conducted at the Valencia Anchor Station (VAS) and Los Monegros site using the CAROLS (Combined Airborne Radio-instruments for Ocean and Land Studies) radiometer on board the ATR 42 aircraft from M¶et¶eo-France. The main objective was to contribute to the implementation of the SMOS emission model L-MEB (L-band Microwave Emission model of the Biosphere) in the framework of the validation of SMOS land data and products. Speci¯cally, the objectives of the CAROLS campaigns were the following: Soil Moisture Validation Studies: Previous °ights at the VAS area took place in 2008 in the context of the ESA SMOS Validation Rehearsal Campaign 2008 (EMIRAD radiometer, L-band) over a control area of 10km£10km where intensive soil moisture data was acquired concurrently to airborne L-band measurements. One of the objectives of that campaign was to establish homogeneous units to characterize the average soil moisture of that area, and to investigate the possibility of extending the methodology to the whole SMOS validation pixel at the VAS site. The `homogeneous units' characterisation was studied and extended further in the context of CAROLS 2009, and validated during the CAROLS 2010 campaign. Radiometric Characterisation & SMOS Data Validation: The 10km £ 10km mentioned above is part of a larger area of » 50km £ 50km within the VAS SMOS validation pixel. For CAROLS 2009, °ights were performed over a 30km £ 50km area in order to examine the ra- diometric signature of other surfaces that are present in the VAS SMOS pixel but not in the 10km £ 10km control area examined in 2008 (mostly dense forests, matorral, and non-°at sur- faces). Main results of CAROLS 2009 will be presented in this communication, and the emphasis will be on comparing local to regional scale results given that CAROLS °ights were performed at 4000m above the surface. For 2010, lower altitude °ights (» 2200m a.s.l.) over an area of 20km£20km containing a large number of homogeneous units (`environmental units'), were used for validation of SMOS microwave model L-MEB. The preliminary results of this campaign will be presented in this communication, and the emphasis will be on the validation of the L-MEB model. In addition to the activities at the VAS site, °ights over Los Monegros' salt pans near Zaragoza were performed in the 2010 CAROLS Campaign to study their emissivity at L-band. Three playa-lakes (Guallar, La Playa, and Salineta) were sampled to measure gravimetric soil moisture and electrical conductivity.Peer reviewe

Morfología Fluvial.-The ESA SMOS Mission: Validation Activities at the Valencia Anchor Station

SUMMARY Since 2001, the Valencia Anchor Station (VAS) is being used for validation activities in the context of low spatial resolution Earth Observation Missions such as CERES (Clouds and the Earth’s Radiant Energy System), GERB (Geostationary Earth Radiation Budget), EPS (EUMETSAT Polar System), and is also being prepared for SMOS (Soil Moisture and Ocean Salinity). These missions have in common the low spatial resolution of their respective footprints (~50x50 km2) and the necessity of a well characterised and instrumented large scale area. The VAS has been selected as a primary validation site by the SMOS Mission. The reasonable homogeneous characteristics of the area make this site appropriate to undertake the validation of SMOS Level 2 land products (soil moisture (SM) and vegetation water content) during the Mission Commissioning Phase. A control area of 10x10 km2 was chosen to develop a network of ground SM measuring stations based on the definition of homogeneous physio-hydrological units attending to climatic, soil type, lithology, elevation, slope and vegetation cover conditions. The stations are linked via a wireless communication system to a central post accessible via internet. Area SM estimations are presently being compared to modelling products from ISBA – SURFEX. This paper shows the validation activities currently carried out at the VAS, especially the ESA SMOS Validation Rehearsal Campaign and the CNES CAROLS Scientific Airborne Campaign

Adipose tissue mitochondrial dysfunction in human obesity is linked to a specific DNA methylation signature in adipose-derived stem cells

Background: A functional population of adipocyte precursors, termed adipose-derived stromal/stem cells (ASCs), is crucial for proper adipose tissue (AT) expansion, lipid handling, and prevention of lipotoxicity in response to chronic positive energy balance. We previously showed that obese human subjects contain a dysfunctional pool of ASCs. Elucidation of the mechanisms underlying abnormal ASC function might lead to therapeutic interventions for prevention of lipotoxicity by improving the adipogenic capacity of ASCs. Methods: Using epigenome-wide association studies, we explored the impact of obesity on the methylation signature of human ASCs and their differentiated counterparts. Mitochondrial phenotyping of lean and obese ASCs was performed. TBX15 loss- and gain-of-function experiments were carried out and western blotting and electron microscopy studies of mitochondria were performed in white AT biopsies from lean and obese individuals. Results: We found that DNA methylation in adipocyte precursors is significantly modified by the obese environment, and adipogenesis, inflammation, and immunosuppression were the most affected pathways. Also, we identified TBX15 as one of the most differentially hypomethylated genes in obese ASCs, and genetic experiments revealed that TBX15 is a regulator of mitochondrial mass in obese adipocytes. Accordingly, morphological analysis of AT from obese subjects showed an alteration of the mitochondrial network, with changes in mitochondrial shape and number. Conclusions: We identified a DNA methylation signature in adipocyte precursors associated with obesity, which has a significant impact on the metabolic phenotype of mature adipocytes

Safety of hospital discharge before return of bowel function after elective colorectal surgery

Background: Ileus is common after colorectal surgery and is associated with an increased risk of postoperative complications. Identifying features of normal bowel recovery and the appropriateness for hospital discharge is challenging. This study explored the safety of hospital discharge before the return of bowel function. Methods: A prospective, multicentre cohort study was undertaken across an international collaborative network. Adult patients undergoing elective colorectal resection between January and April 2018 were included. The main outcome of interest was readmission to hospital within 30 days of surgery. The impact of discharge timing according to the return of bowel function was explored using multivariable regression analysis. Other outcomes were postoperative complications within 30 days of surgery, measured using the Clavien–Dindo classification system. Results: A total of 3288 patients were included in the analysis, of whom 301 (9·2 per cent) were discharged before the return of bowel function. The median duration of hospital stay for patients discharged before and after return of bowel function was 5 (i.q.r. 4–7) and 7 (6–8) days respectively (P < 0·001). There were no significant differences in rates of readmission between these groups (6·6 versus 8·0 per cent; P = 0·499), and this remained the case after multivariable adjustment for baseline differences (odds ratio 0·90, 95 per cent c.i. 0·55 to 1·46; P = 0·659). Rates of postoperative complications were also similar in those discharged before versus after return of bowel function (minor: 34·7 versus 39·5 per cent; major 3·3 versus 3·4 per cent; P = 0·110). Conclusion: Discharge before return of bowel function after elective colorectal surgery appears to be safe in appropriately selected patients

Predictive Factors and Risk Model for Positive Circumferential Resection Margin Rate after Transanal Total Mesorectal Excision in 2653 Patients with Rectal Cancer

The aim of this study was to determine the incidence of, and preoperative risk factors for, positive circumferential resection margin (CRM) after transanal total mesorectal excision (TaTME). Background: TaTME has the potential to further reduce the rate of positive CRM for patients with low rectal cancer, thereby improving oncological outcome. Methods: A prospective registry-based study including all cases recorded on the international TaTME registry between July 2014 and January 2018 was performed. Endpoints were the incidence of, and predictive factors for, positive CRM. Univariate and multivariate logistic regressions were performed, and factors for positive CRM were then assessed by formulating a predictive model. Results: In total, 2653 patients undergoing TaTME for rectal cancer were included. The incidence of positive CRM was 107 (4.0%). In multivariate logistic regression analysis, a positive CRM after TaTME was significantly associated with tumors located up to 1 cm from the anorectal junction, anterior tumors, cT4 tumors, extra-mural venous invasion (EMVI), and threatened or involved CRM on baseline MRI (odds ratios 2.09, 1.66, 1.93, 1.94, and 1.72, respectively). The predictive model showed adequate discrimination (area under the receiver-operating characteristic curve >0.70), and predicted a 28% risk of positive CRM if all risk factors were present. Conclusion: Five preoperative tumor-related characteristics had an adverse effect on CRM involvement after TaTME. The predicted risk of positive CRM after TaTME for a specific patient can be calculated preoperatively with the proposed model and may help guide patient selection for optimal treatment and enhance a tailored treatment approach to further optimize oncological outcomes

Timing of nasogastric tube insertion and the risk of postoperative pneumonia: an international, prospective cohort study

Aim: Aspiration is a common cause of pneumonia in patients with postoperative ileus. Insertion of a nasogastric tube (NGT) is often performed, but this can be distressing. The aim of this study was to determine whether the timing of NGT insertion after surgery (before versus after vomiting) was associated with reduced rates of pneumonia in patients undergoing elective colorectal surgery. Method: This was a preplanned secondary analysis of a multicentre, prospective cohort study. Patients undergoing elective colorectal surgery between January 2018 and April 2018 were eligible. Those receiving a NGT were divided into three groups, based on the timing of the insertion: routine NGT (inserted at the time of surgery), prophylactic NGT (inserted after surgery but before vomiting) and reactive NGT (inserted after surgery and after vomiting). The primary outcome was the development of pneumonia within 30 days of surgery, which was compared between the prophylactic and reactive NGT groups using multivariable regression analysis. Results: A total of 4715 patients were included in the analysis and 1536 (32.6%) received a NGT. These were classified as routine in 926 (60.3%), reactive in 461 (30.0%) and prophylactic in 149 (9.7%). Two hundred patients (4.2%) developed pneumonia (no NGT 2.7%; routine NGT 5.2%; reactive NGT 10.6%; prophylactic NGT 11.4%). After adjustment for confounding factors, no significant difference in pneumonia rates was detected between the prophylactic and reactive NGT groups (odds ratio 1.03, 95% CI 0.56\u20131.87, P = 0.932). Conclusion: In patients who required the insertion of a NGT after surgery, prophylactic insertion was not associated with fewer cases of pneumonia within 30 days of surgery compared with reactive insertion

Safety of hospital discharge before return of bowel function after elective colorectal surgery

Background: Ileus is common after colorectal surgery and is associated with an increased risk of postoperative complications. Identifying features of normal bowel recovery and the appropriateness for hospital discharge is challenging. This study explored the safety of hospital discharge before the return of bowel function. Methods: A prospective, multicentre cohort study was undertaken across an international collaborative network. Adult patients undergoing elective colorectal resection between January and April 2018 were included. The main outcome of interest was readmission to hospital within 30 days of surgery. The impact of discharge timing according to the return of bowel function was explored using multivariable regression analysis. Other outcomes were postoperative complications within 30 days of surgery, measured using the Clavien\u2013Dindo classification system. Results: A total of 3288 patients were included in the analysis, of whom 301 (9\ub72 per cent) were discharged before the return of bowel function. The median duration of hospital stay for patients discharged before and after return of bowel function was 5 (i.q.r. 4\u20137) and 7 (6\u20138) days respectively (P < 0\ub7001). There were no significant differences in rates of readmission between these groups (6\ub76 versus 8\ub70 per cent; P = 0\ub7499), and this remained the case after multivariable adjustment for baseline differences (odds ratio 0\ub790, 95 per cent c.i. 0\ub755 to 1\ub746; P = 0\ub7659). Rates of postoperative complications were also similar in those discharged before versus after return of bowel function (minor: 34\ub77 versus 39\ub75 per cent; major 3\ub73 versus 3\ub74 per cent; P = 0\ub7110). Conclusion: Discharge before return of bowel function after elective colorectal surgery appears to be safe in appropriately selected patients