Measuring the desire for control: a Spanish version of Burger and Cooper's Scale

The following study will present findings on the validity of the adaptation of the Burger and Cooper’s Desirability of Control Scale into Spanish. Two samples are present: the first involving 1,999 people to study their psychometric properties. In the second sample, 111 people were included to estimate test/ retest reliability. Cultural adaptation was performed using the translation & back-translation method. Item analysis, internal consistency and test/retest reliability were assessed, then evidence of the validity of the internal structure was determined by using exploratory and confirmatory factor analysis. Subject recruitment was performed to gather the 1,999 subjects stratified by age, gender quotas as designed in the sampling plan. Of the subjects, 51% were female, average age of 45 years old (SD = 17.5). All items from the original scale were understood correctly, while five items presented ceiling effect. Cronbach’s alpha = .736 and a test-retest correlation r = .713 were obtained. The factor structure indicated the presence of four dimensions: forecast, autonomy, power and influence and reactance which were reassured in the confirmatory analysis (χ2/df = 4.805, CFI =.932, TLI =.954, RMSEA = .062). The basic dimensions of the scale have shown to be stable and well-defined, though not perfect. The scope, possible applications of the scale and further research are later proposed and discussed.Se presenta la adaptación y validación al español de la Escala de Deseo de Control de Burger y Cooper. Se emplearon dos muestras. Para estudiar las propiedades psicométricas de la escala se contó con una primera muestra de 1999 (Medad = 45 años, DS = 17,5; 51% mujeres). Para estimar la fiabilidad test-retest se contó con una segunda muestra de 111 personas. La adaptación cultural se llevó a cabo mediante el procedimiento de traducción–retrotraducción. Se presentan las evidencias de validez de la estructura interna de la escala mediante los resultados de sendos análisis factoriales, exploratorio y confirmatorio. El análisis de ítems reveló que todos los elementos presentaron unos valores aceptables, aunque cinco de ellos mostraron efecto techo. El Alfa de Cronbach fue de .736 y la Fiabilidad test–retest fue de .713. La estructura factorial indicó la presencia de cuatro dimensiones: previsión, autonomía, poder e influencia y reactancia. La estructura fue corroborada en el análisis confirmatorio (χ2/df = 4.805, CFI = .932, TLI = .954, RMSEA = .062). Las dimensiones de la escala son estables y específicas, aunque no perfectas. Se discute el alcance y posibles aplicaciones de la escala y se proponen futuras investigaciones

Effects of dietary inclusions of red beet and betaine on the acute stress response and muscle lipid peroxidation in rainbow trout

[EN] This study evaluates the effects of red beet (RB) and betaine on rainbow trout submitted to an acute stress challenge. A control diet was compared with four experimental diets in which red beet (14 and 28%) and betaine (0.9 and 1.63%) were incorporated in different concentrations according to a factorial design. Cortisol in plasma and fin, glucose and lactate plasma levels, and malondialdehide (MDA) in muscle were all measured before the stress challenge and 30 min and 6 and 12 h after the stress challenge as parameters to determine the diet effects. RB and betaine had no effect on cortisol, glucose, and MDA basal levels. However, lactate basal levels were significantly lower on fish fed with RB and betaine. Thirty minutes after the stress challenge, there was a significant increase in plasma and fin cortisol, glucose and lactate concentrations, although fish fed with diets containing RB and betaine showed significantly higher plasma cortisol values. MDA values of fish fed with 14% RB and 0.9% betaine were significantly higher than MDA values from fish fed with 28% RB and 1.63% betaine. After 6 and 12 h, plasma and fin cortisol and lactate levels recovered in a similar trend. Glucose plasma levels recovered in almost all groups 12 h after the stress. Also, MDA values recovered basal levels after 6 and 12 h. RB and betaine did not enhance the tolerance to the stress challenge compared to the control group, although the presence of these ingredients had no negative effect on any of the stress indicators.Pinedo-Gil, J.; Martín-Diana, AB.; Bertotto, D.; Sanz-Calvo, MÁ.; Jover Cerda, M.; Tomas-Vidal, A. (2018). Effects of dietary inclusions of red beet and betaine on the acute stress response and muscle lipid peroxidation in rainbow trout. Fish Physiology and Biochemistry. 44(3):939-948. doi:10.1007/s10695-018-0483-3S939948443Aluru N, Vijayan MM (2006) Aryl hydrocarbon receptor activation impairs cortisol response to stress in rainbow trout by disrupting the rate limiting steps in steroidogenesis. Endocrinology 147:1895–1903Ashley PJ (2007) Fish welfare: current issues in aquaculture. Appl Anim Behav Sci 104:199–235Barton BA, Iwama GK (1991) Physiological changes in fish from stress in aquaculture with emphasis on the response and effects of corticosteroids. Annu Rev Fish Dis 1:3–26Bertotto D, Poltronieri C, Negrato E, Majolini D, Radaelli G, Simontacchi C (2010) Alternative matrices for cortisol measurement in fish. Aquac Res 41:1261–1267Bertotto D, Poltronieri C, Negrato E, Richard J, Pascoli F, Simontacchi C, Radaelli G (2011) Whole body cortisol and expression of HSP70, IGF-I and MSTN in early development of sea bass subjected to heat shok. 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J Exp Biol 216:4435–4442Gesto M, López-Patiño MA, Hernández J, Soengas JL, Míguez JM (2015) Gradation of the stress response in rainbow trout exposed to stressors of different severity: the role of brain serotonergic and dopaminergic systems. J Neuroendocrinol 27:131–141Hemre GI, Mommsen TP, Krogdahl Å (2002) Carbohydrates in fish nutrition: effects on growth, glucose metabolism and heptic enzymes. Aquac Nutr 8:175–194Ings JS, Vijayan MM, Servos MR (2012) Tissue-specific metabolic changes in response to an acute handling disturbance in juvenile rainbow trout exposed to municipal wastewater effluent. Aquat Toxicol 108:53–59Janssens PA, Waterman J (1988) Hormonal regulation of gluconeogenesis and glycogenolysis in carp (Cyprinus carpio) liver pieces cultured in vitro. Comp Biochem Physiol 91A:451–457Jeney G, Galeotti M, Volpatti D, Anderson DP (1997) Prevention of stress in rainbow trout (Oncorhynchus mykiss) fed diets containing different doses of glucan. Aquaculture 154:1–15Kaplan LA, Pesce AJ (1984) Clinical chemistry: theory, analysis and correlation. Mosby, St. Louis, pp 1032–1036Krogdahl Å, Sundby A, Olli JJ (2004) Atlantic salmon (Salmon salar) and rainbow trout (Oncorhynchus mykiss) digest and metabolize nutrients differently. Effects of water salinity and dietary starch levels. Aquaculture 229:335–360Kujala TS, Vienola MS, Klika KD, Loponen JM, Pihlaja K (2002) Betalain and phenolic composition of four beetroot (Beta vulgaris) cultivars. Eur Food Res Technol 214:505–510Kumar N, Jadhao SB, Chandan NK, Kumar K, Jha AK, Bhushan S, Kumar S, Rana RS (2012) Dietary choline, betaine and lecithin mitigate endosulfan-induced stress in Labeo rohita fingerlings. Fish Physiol Biochem 38:989–1000Leveelahti L, Rytkönen KT, Renshaw GMC, Nikinmaa M (2014) Revisiting redox-active antioxidant defences in response to hypoxic challenge in both hypoxia-tolerant and hypoxia-sensitive fish species. Fish Physiol Biochem 40:183–191Lushchak VI, Bagnyukova TV, Lushchak OV, Storey JM, Storey KB (2005) Hypoxia and recovery perturb free radical processes and antioxidant potential in common carp (Cyprinus carpio) tissues. Int J Bichem Cell Biol 37:1319–1330Lushchak VI, Bagnyukova TV (2006) Temperature increase results in oxidative stress in goldfish tissues. 1. Indices of oxidative stress. Comp Biochem Physiol C 143:30–35Madaro A, Olsen RE, Kristiansen TS, Ebbeson LOE, Nilsen TO, Flik G, Gorissen M (2015) Stress in Atlantic salmon: response to unpredictable chronic stress. J Exp Biol 218:2538–2550Ming J, Xie J, Xu P, Ge X, Liu W, Ye J (2012) Effects of emodin and vitamin C on growth performance, biochemical parameters and two HSP70s mRNA expression of Wuchang bream (Megalobrama amblycephala Yih) under high temperature stress. Fish Shellfish Immunol 32:651–661Mommsen TP, Vijayan MM, Moon TW (1999) Cortisol in teleosts: dynamics, mechanisms of action, and metabolic regulation. Rev Fish Biol Fish 9:211–268Montero D, Tort L, Robaina L, Vergara JM, Izquierdo MS (2001) Low vitamin E in diet reduces stress resistance of gilthead seabream (Sparus aurta) juveniles. Fish Shellfish Immunol 11:473–490Ortuño J, Esteban MA, Meseguer J (2003) Effect of dietary intake of vitamins C and E on the stress response of gilthead seabream (Sparus aurata L.) Fish Shellfish Immunol 14:145–156Øverli Ø, Sørensen C, Kiessling A, Pottinger TG, Gjøen HM (2006) Selection for improved stress tolerance in rainbow trout (Oncorhynchus Mykiss) leads to reduced feed waste. Aquaculture 261:776–781Pérez-Jiménez A, Peres H, Rubio VC, Oliva-Teles A (2012) The effect of hypoxia on intermediary metabolism and oxidative status in gilthead sea bream (Sparus aurata) fed on diets supplemented with methionine and white tea. Comp Biochem Physiol C 155:506–516Pichavant K, Maxime V, Thébault MT, Ollivier H, Garnier JP, Bousquet B, Diouris M, Boeuf G, Nonnotte G (2002) Effects of hypoxia and subsequent recovery on turbot (Scophthalmus maximus): hormonal changes and anaerobic metabolism. Mar Ecol Prog Ser 225:275–285Pinedo-Gil J, Tomás-Vidal A, Larrán-García AM, Tomás-Almenar C, Jover-Cerdá M, Sanz-Calvo MA, Martín-Diana AB (2017a) Enhancement of quality of rainbow trout (Oncorhynchus mykiss) flesh incorporating barley on diet without negative effect on rearing parameters. Aquacult Int 25:1005–1023. https://doi.org/10.1007/s10499-016-0091-0Pinedo-Gil J, Tomás-Vidal A, Jover-Cerdá M, Tomás-Almenar C, Sanz-Calvo MA, Martín-Diana AB (2017b) Red beet and betaine as ingredients in diets of rainbow trout (Oncorhynchus mykiss): effects on growth performance, nutrient retention and flesh quality. Arch Anim Nutr 71:486–505. https://doi.org/10.1080/1745039X.2017.1391503Rabeh NM (2015) Effect of red beetroot (Beta vulgaris L.) and its fresh juice against carbon tetrachloride induced hepatotoxicity in rats. World Appl Sci J 33(6):931–938Rollo A, Sulpizio R, Nardi M, Silvi S, Orpianesi C, Caggiano M, Cresci A, Carnevalli O (2006) Live microbial feed supplement in aquaculture for improvement of stress tolerance. Fish Physiol Biochem 32:167–177Sadoul B, Leguen I, Colson V, Friggens NC, Prunet P (2015) A multivariate analysis using physiology and behaviour to characterize robustness in two isogenic lines of rainbow trout exposed to a confinement stress. Physiol Behav 140:139–147Tan Q, Xie S, Zhu X, Lei W, Yang Y (2006) Effect of dietary carbohydrates sources on growth performance and utilization for gibel carp (Carassius auratus) and Chinese longsnout catfish (Leiocassis Longirostris Günther). 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Toxicol Appl Pharmacol 208:87–97Zeng L, Wang YH, Ai CX, Zheng JL, Wu CW, Cai R (2016) Effects of β-glucan on ROS production and energy metabolism in yellow croaker (Pseudosciaena crocea) under acute hypoxic stress. Fish Physiol Biochem 42:1395–1405Zolderdo AJ, Algera DA, Lawrence MJ, Gilmour KM, Fast MD, Thuswaldner J, Willmore WG, Cooke SJ (2016) Stress, nutrition and parental care in a teleost fish: exploring mechanisms with supplemental feeding and cortisol manipulation. J Exp Biol 219:1237–124

RESOCIALIZACIÓN Y ENCUESTAS DE CALIDAD DE VIDA PENITENCIARIA

This paper presents and analyzes statistical results obtained from 454 self-report surveys aimed at evaluating the quality of prison life of inmates. These have been completed by over ten percent of the prison population of five prisons in the south of the Spain, four of them in eastern Andalusia, plus the penitentiary center of Melilla. The research is based on an independent version of the the original survey developed by Alison Liebling, Measuring the Quality of Prison Life (MQPL).The main general objective of this paper is to contribute to deepening the knowledge of the reality of Spanish prisons. In more specific terms, to inquire into the validity of the hypothesis on which prison sentences are still formally based in Spain: re-education and social reintegration of the convicted person (article 25.2 of the Spanish Constitution). For this purpose, we have analyzed the current state of prison ‘morals’ from the answers of the surveyed prisoners to a questionnaire that includes, among others, some questions connectedwith the following three issues: (1) their relationship with prison staff; (2) their relationship with other inmates; (3) the effectiveness or ineffectiveness of prison treatment in terms of their reintegration into society.The research will allow not only to detect possible differences in the prison life of the five penitentiaries analyzed, but also to confirm or not the initial hypothesis raised, namely, the current validity of what is established in the aforementioned artículo 25.2 of the Spanish Constitution.En el presente artículo se presentan y analizan los resultados estadísticos obtenidos de 454 encuestas de autoinforme dirigidas a evaluar la calidad de vida en prisión que han sido completadas por algo más del diez por ciento de la población penitenciaria de cinco centros del sur de España, cuatro de ellas en Andalucía oriental, más el centro penitenciario de Melilla. Se trata de una investigación realizada a partir de una versión independiente de la encuesta original desarrollada por Alison Liebling Measuring the Quality of Prison Life (MQPL). El principal objetivo general es contribuir a profundizar en el conocimiento de la realidad de las prisiones españolas. En términos más específicos, verificar si se confirma, o no, el fundamento constitucional con el que se sigue concibiendo la pena de prisión en España: la reeducación y reinserción social del condenado (artículo 25.2 CE). Para ello se analizan las respuestas a una serie de preguntas que se enmarcan en tres variables o dimensiones: (1) la relación de los internos con el personal de prisión; (2) la relación de los reclusos entre sí; (3) la eficacia o no del tratamiento penitenciario de cara a su reincorporación a la sociedad. El análisis permite no sólo vislumbrar diferencias en cuanto al régimen de vida de los centros penitenciarios analizados sino, además, evaluar la validez de la hipótesis de partida, a saber, la vigencia actual de lo establecido en el mencionado precepto constitucional.This paper presents and analyzes statistical results obtained from 454 self-report surveys aimed at evaluating the quality of prison life of inmates. These have been completed by over ten percent of the prison population of five prisons in the south of the Spain, four of them in eastern Andalusia, plus the penitentiary center of Melilla. The research is based on an independent version of the the original survey developed by Alison Liebling, Measuring the Quality of Prison Life (MQPL).The main general objective of this paper is to contribute to deepening the knowledge of the reality of Spanish prisons. In more specific terms, to inquire into the validity of the hypothesis on which prison sentences are still formally based in Spain: re-education and social reintegration of the convicted person (article 25.2 of the Spanish Constitution). For this purpose, we have analyzed the current state of prison ‘morals’ from the answers of the surveyed prisoners to a questionnaire that includes, among others, some questions connectedwith the following three issues: (1) their relationship with prison staff; (2) their relationship with other inmates; (3) the effectiveness or ineffectiveness of prison treatment in terms of their reintegration into society.The research will allow not only to detect possible differences in the prison life of the five penitentiaries analyzed, but also to confirm or not the initial hypothesis raised, namely, the current validity of what is established in the aforementioned artículo 25.2 of the Spanish Constitution

Red beet and betaine as ingredients in diets of rainbow trout (Oncorhynchus mykiss): effects on growth performance, nutrient retention and flesh quality

[EN] The objective of the study was to evaluate the impact of different concentrations of dietary red beet and betaine on the growth performance and fish flesh quality of rainbow trout. Therefore, a control diet was compared with four diets in which two levels of red beet (14% and 28%) and betaine (0.9% and 1.63%) were incorporated in combination. The study was set up with an average body weight of 69 ± 2.2 g and finished when fish reached commercial weight (175¿250 g) after 105 d. The impact of the diets was studied based on the growth performance, biometric indexes, proximal composition, protein and fat retention efficiencies and apparent nutrient digestibility by fish reared on a recirculation system. Further estimates were the effect of red beet and betaine on the flesh proximate composition and quality of the final product (water activity, colour, texture, thiobarbituric acid reactive substances and sensory characteristics). Results showed that inclusion of 14% red beet and 0.9% betaine did not affect growth, nutritive or biometric parameters and nutrient retention when compared with the control diet. However, higher levels of red beet and betaine had negative effects on growth and nutritive parameters. The tested ingredients enhanced quality parameters regardless of the concentration used. After feeding the red beet and betaine, fish flesh showed lower water activity and better textural and colour properties than the control and also a dose-dependent effect on lipid oxidation was observed.This work has been co-funded with FEDER and INIA funds. Julia Pinedo has been granted with the FPI-INIA grant number 21 [call 2012, BOE-2012-13337].Pinedo-Gil, J.; Tomas-Vidal, A.; Jover Cerda, M.; Tomás-Almenar, C.; Sanz-Calvo, MÁ.; Martín-Diana, AB. (2017). Red beet and betaine as ingredients in diets of rainbow trout (Oncorhynchus mykiss): effects on growth performance, nutrient retention and flesh quality. Archives of Animal Nutrition. 71(6):486-505. doi:10.1080/1745039X.2017.1391503S48650571

Effect of Barley on Liver Histology of Rainbow Trout, Oncorhynchus mykiss

[EN] This study investigated the effects of the incorporation of barley instead of wheat to study fish growth and biometrics parameters, body composition, retention efficiency and liver histology of rainbow trout Oncorhynchus mykiss. Experimental diets were used containing different barley concentrations (0-16%) randomly assigned to four groups per treatment. Results showed a significant change on liver histological parameters. Liver cell vacuolization was significantly lower on fish fed with 16B diets compared to control diet and revealed some degeneration. Those fish also showed more regular hepatocytes than in control diet.This work has been co-funded with FEDER and INIA funds (call 2012, BOE-2012-13337).Pinedo-Gil, J.; Martín-Diana, AB.; Caballero-Cansino, MJ.; Sanz-Calvo, MÁ.; Jover Cerda, M.; Tomas-Vidal, A. (2017). Effect of Barley on Liver Histology of Rainbow Trout, Oncorhynchus mykiss. Journal of Aquaculture & Marine Biology. 5(3). https://doi.org/10.15406/jamb.2017.05.00123S5

Effects on Lipid Oxidation and Bioactive Properties of Rainbow Trout Fillets Fed with Barley

[EN] Barley concentrations ranging from 0% to 32% were incorporated into rainbow trout (Oncorhynchus mykiss) diets. The effect of barley concentration on lipid peroxidation and antioxidant activity of fish fillets were analyzed. Results showed that the inclusion of barley in rainbow trout diets had an inhibitory effect on lipid oxidation, probably associated with certain bioactive compounds in barley that could interact with scavenging and reducing metabolites involved in lipid oxidation. Concentrations up to 8% of barley produced fish fillets with high antioxidant activity and higher levels of alpha-tocopherol.This work was carried out with fundings from INIA and ITACyL and cofounded by FEDER funds. Julia Pinedo has been granted with the FPI-INIA grant number 21 [call 2012, BOE-2012-13337].Pinedo-Gil, J.; Tomas-Vidal, A.; Rico, D.; Tiwaric, B.; Álvarez García, C.; Jover Cerda, M.; Sanz-Calvo, MÁ.... (2019). Effects on Lipid Oxidation and Bioactive Properties of Rainbow Trout Fillets Fed with Barley. Journal of Aquatic Food Product Technology. 28(5):495-504. https://doi.org/10.1080/10498850.2019.1604596S49550428

Formación en Nuevas Tecnologías e Intercambio de Experiencias Innovadoras en la Facultad de Geografía e Historia

Con este Proyecto de Innovación y Mejora de la Calidad Docente, de carácter institucional, se pretende dar continuidad a la etapa de innovación y formación docente que se inició el pasado Curso 2018-2019 en la Facultad de Geografía e Historia de la Universidad Complutense de Madrid. Así como a las anteriores iniciativas de la Facultad de Geografía e Historia en materia de nuevas tecnologías. El objetivo de este proyecto, siguiendo la metodología del año anterior, ha pretendido promover en nuestra Facultad una formación en el ámbito de la innovación educativa y de las nuevas tecnologías basada en: (i) la formación del Profesorado, del Personal de Administración y Servicios, y del Alumnado de nuestro Centro y (ii) en el intercambio de experiencias innovadoras entre representantes de estos colectivos, para poder hacer uso de las mismas en su desempeño docente, administrativo y formativo, respectivamente. El Proyecto, dirigido por el Vicedecano de Innovación, Nuevas Tecnologías y Comunicación de la Facultad, se adecua a las líneas prioritarias de la convocatoria Innova-Gestión Calidad, puesto que ha servido para profundizar en la innovación y en la mejora de la calidad docente-investigadora a través de programas formativos que, en la actualidad, constituyen objetivos prioritarios de la Estrategia UCM2020 de Investigación

Marco activo de recursos de innovación docente: Madrid

Una guía de espacios e instituciones para actividades educativas complementarias en enseñanza secundaria y Formación Profesional

Role of age and comorbidities in mortality of patients with infective endocarditis

[Purpose]: The aim of this study was to analyse the characteristics of patients with IE in three groups of age and to assess the ability of age and the Charlson Comorbidity Index (CCI) to predict mortality. [Methods]: Prospective cohort study of all patients with IE included in the GAMES Spanish database between 2008 and 2015.Patients were stratified into three age groups:<65 years,65 to 80 years,and ≥ 80 years.The area under the receiver-operating characteristic (AUROC) curve was calculated to quantify the diagnostic accuracy of the CCI to predict mortality risk. [Results]: A total of 3120 patients with IE (1327 < 65 years;1291 65-80 years;502 ≥ 80 years) were enrolled.Fever and heart failure were the most common presentations of IE, with no differences among age groups.Patients ≥80 years who underwent surgery were significantly lower compared with other age groups (14.3%,65 years; 20.5%,65-79 years; 31.3%,≥80 years). In-hospital mortality was lower in the <65-year group (20.3%,<65 years;30.1%,65-79 years;34.7%,≥80 years;p < 0.001) as well as 1-year mortality (3.2%, <65 years; 5.5%, 65-80 years;7.6%,≥80 years; p = 0.003).Independent predictors of mortality were age ≥ 80 years (hazard ratio [HR]:2.78;95% confidence interval [CI]:2.32–3.34), CCI ≥ 3 (HR:1.62; 95% CI:1.39–1.88),and non-performed surgery (HR:1.64;95% CI:11.16–1.58).When the three age groups were compared,the AUROC curve for CCI was significantly larger for patients aged <65 years(p < 0.001) for both in-hospital and 1-year mortality. [Conclusion]: There were no differences in the clinical presentation of IE between the groups. Age ≥ 80 years, high comorbidity (measured by CCI),and non-performance of surgery were independent predictors of mortality in patients with IE.CCI could help to identify those patients with IE and surgical indication who present a lower risk of in-hospital and 1-year mortality after surgery, especially in the <65-year group

Effectiveness of an intervention for improving drug prescription in primary care patients with multimorbidity and polypharmacy:Study protocol of a cluster randomized clinical trial (Multi-PAP project)

This study was funded by the Fondo de Investigaciones Sanitarias ISCIII (Grant Numbers PI15/00276, PI15/00572, PI15/00996), REDISSEC (Project Numbers RD12/0001/0012, RD16/0001/0005), and the European Regional Development Fund ("A way to build Europe").Background: Multimorbidity is associated with negative effects both on people's health and on healthcare systems. A key problem linked to multimorbidity is polypharmacy, which in turn is associated with increased risk of partly preventable adverse effects, including mortality. The Ariadne principles describe a model of care based on a thorough assessment of diseases, treatments (and potential interactions), clinical status, context and preferences of patients with multimorbidity, with the aim of prioritizing and sharing realistic treatment goals that guide an individualized management. The aim of this study is to evaluate the effectiveness of a complex intervention that implements the Ariadne principles in a population of young-old patients with multimorbidity and polypharmacy. The intervention seeks to improve the appropriateness of prescribing in primary care (PC), as measured by the medication appropriateness index (MAI) score at 6 and 12months, as compared with usual care. Methods/Design: Design:pragmatic cluster randomized clinical trial. Unit of randomization: family physician (FP). Unit of analysis: patient. Scope: PC health centres in three autonomous communities: Aragon, Madrid, and Andalusia (Spain). Population: patients aged 65-74years with multimorbidity (≥3 chronic diseases) and polypharmacy (≥5 drugs prescribed in ≥3months). Sample size: n=400 (200 per study arm). Intervention: complex intervention based on the implementation of the Ariadne principles with two components: (1) FP training and (2) FP-patient interview. Outcomes: MAI score, health services use, quality of life (Euroqol 5D-5L), pharmacotherapy and adherence to treatment (Morisky-Green, Haynes-Sackett), and clinical and socio-demographic variables. Statistical analysis: primary outcome is the difference in MAI score between T0 and T1 and corresponding 95% confidence interval. Adjustment for confounding factors will be performed by multilevel analysis. All analyses will be carried out in accordance with the intention-to-treat principle. Discussion: It is essential to provide evidence concerning interventions on PC patients with polypharmacy and multimorbidity, conducted in the context of routine clinical practice, and involving young-old patients with significant potential for preventing negative health outcomes. Trial registration: Clinicaltrials.gov, NCT02866799Publisher PDFPeer reviewe