Foreword

Early Middle Cambrian bituminous coquinoid limestones from a tectonically isolated outcrop in southwestern Kyrgyzstan yield a remarkably diverse fauna, with stem-group cnidarians, trilobites, rhynchonelliformean brachiopods, and other shelly fossils. The fossil site is in the northern foothills of the Turkestan Range and thus forms part of the westernmost extension of the South Tien Shan. The fauna includes two fairly well known trilobite species, Glabrella ventrosa Lermontova, 1940 and Dorypyge richthofeniformis Lermontova, 1940, that provide confident support for an Amgan age of the rocks. New described taxa include the stem-group cnidarian Cambroctoconus kyrgyzstanicus Peel sp. nov., the trilobite Olenoides sagittatus Geyer sp. nov., and the helcionelloid Manasoconus bifrons Peel gen. et sp. nov. Additional fossils within the samples include the trilobites Olenoides sp. A, Kootenia sp., and Pseudoeteraspis? sp.; the rhynchonelliform brachiopods Narynella cf. ferganensis (Andreeva, 1962), Narynella? sp., Austrohedra? sp. nov., and two species of uncertain generic affinity; the tommotiid Tesella sp.; the hyolithelminth Hyolithellus sp.; and the palaeoscolecid Hadimopanella oezgueli Gedik, 1977. Of particular interest is Cambroctoconus kyrgyzstanicus with an octagonal corallum and a sparsely septate calyx

A CM construction for curves of genus 2 with p-rank 1

We construct Weil numbers corresponding to genus-2 curves with $p$-rank 1 over the finite field \F_{p^2} of $p^2$ elements. The corresponding curves can be constructed using explicit CM constructions. In one of our algorithms, the group of \F_{p^2}-valued points of the Jacobian has prime order, while another allows for a prescribed embedding degree with respect to a subgroup of prescribed order. The curves are defined over \F_{p^2} out of necessity: we show that curves of $p$-rank 1 over \F_p for large $p$ cannot be efficiently constructed using explicit CM constructions.Comment: 19 page

Continuous N-alkylation reactions of amino alcohols using γ-Al2O3 and supercritical CO2: unexpected formation of cyclic ureas and urethanes by reaction with CO2

The use of γ-Al2O3 as a heterogeneous catalyst in scCO2, has be successfully applied to the amination of alcohols for the synthesis of N-alkylated heterocycles. The optimal reaction conditions (temperature and substrate flow rate) were determined using an automated self-optimising reactor, resulting in moderate to high yields of the target products. Carrying out the reaction in scCO2 was shown to be beneficial, as higher yields were obtained in the presence of CO2 than in its absence. A surprising discovery is that, in addition to cyclic amines, cyclic ureas and urethanes could be synthesised by incorporation of CO2 from the supercritical solvent into the product

Проблеми впровадження методів профорієнтаційної роботи в середній школі

(uk) В статті розглядаються актуальні проблеми проведення профорієнтаційної роботи в середній школі, характеризуються основні методи цієї роботи.(en) In the article examined issues of the day of leadthrough professionally of orientation work at middle school, the basic methods of this work are characterized

Geriatric medicine learning objectives and entrustable professional activities in undergraduate medical curricula: a scoping review.

BACKGROUND entrustable professional activities (EPAs) have become an important component of competency-based medical education. The aim of this study is to evaluate how geriatric medicine learning objectives are addressed by undergraduate medical curricula including EPAs. METHODS we performed a scoping review following Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews guidelines to identify undergraduate medical curricula that include EPAs. A content analysis was conducted to examine how these curricula address the care of older individuals. In addition, we mapped the curricula to 19 geriatric medicine learning objectives identified from the European curriculum of undergraduate medical education. RESULTS we found nine curricula, each containing between 4 and 16 core EPAs. In the sections describing the EPAs, three of the nine curricula specify that all core EPAs apply to all age groups including older patients, whereas the remaining six curricula either only refer to older patients in selected EPAs or not at all. Mapping revealed that some geriatric medicine learning objectives are covered by most curricula (e.g. medication use, multidisciplinary team work), whereas others are lacking in the majority (e.g. normal ageing, geriatric assessment, cognitive assessment, nutrition assessment, decision-making capacity assessment, long-term care). Three curricula cover most geriatric learning objectives by using a matrix aligning EPAs with geriatric competencies. CONCLUSIONS geriatric learning objectives continue to be missing from undergraduate medical curricula, also from those adopting the novel approach of EPAs. However, this review also identified some curricula that might serve as models for how geriatric learning objectives can be successfully covered within future EPA frameworks

Trajectories of Changes in Renal Function in Patients with Acute Heart Failure

Aims: Changes in renal function have been associated with differential outcome in patients with acute heart failure (HF). However, individual trajectories of changes in renal function are unknown and it is unclear whether these relate to different clinical characteristics and clinical outcome. Our aim was to investigate the prognostic importance of individual trajectories of changes in renal function in acute HF. Methods and Results: This was a retrospective, observational analysis from the double-blind, randomized, placebo controlled PROTECT trial in acute HF patients. We identified and internally validated 8 different renal trajectories among 1897 patients by visual inspection of inhospital serum creatinine changes. The primary outcome measure was all-cause mortality at 180 days. Mean age was 70±12 years, 70% were male, and mean baseline eGFR was 49.0 mL/min/1.73m2. A total of eight different trajectories were established. The most prevalent trajectories were an inhospital bump (19.0%), a sustained increase (17.6%), and a dip (14.5%) in serum creatinine. Overall, clinical characteristics of patients within different trajectories were remarkably similar. Crude 180-day mortality rates ranged from 12.0% in the trajectory with no significant changes to 18.3% in trajectory of sustained increase without significant differences. Overall, after multivariable adjustment, there was no trajectory of changes in renal function that was associated with significantly better or worse outcomes. Conclusions: Trajectories of changes in renal function in acute HF differ considerably on patient level. Despite these differences, clinical characteristics and outcome were similar, therefore questioning the prognostic importance of changes in renal function in acute HF

Remote-controlled experiments with cloud chemistry

Developing cleaner chemical processes often involves sophisticated flow-chemistry equipment that is not available in many economically developing countries. For reactions where it is the data that are important rather than the physical product, the networking of chemists across the internet to allow remote experimentation offers a viable solution to this problem

Diabetes Mellitus and Right Ventricular Dysfunction in Heart Failure With Preserved Ejection Fraction

Diabetes mellitus is associated with left-sided myocardial remodeling in heart failure with preserved ejection fraction (HFpEF). Little is known about the impact of diabetes mellitus on right ventricular (RV) function in HFpEF. We therefore studied the relation between diabetes mellitus and RV dysfunction in HFpEF. We have examined patients with HFpEF who underwent simultaneous right-sided cardiac catheterization and echocardiography. RV systolic function was assessed using multiple established echocardiographic parameters, and systolic dysfunction was present if parameters were outside the normal range. RV diastolic function was assessed using the peak diastolic tissue velocity of the lateral tricuspid annulus (RV e') and was present if = 7.0 mmol/L, a positive glucose intolerance test result, or a glycated hemoglobin level of >= 6.5%. A total of 91 patients were studied (mean age 74 +/- 9 years, 69% women). A total of 37% had RV systolic dysfunction and 23% RV diastolic dysfunction. Thirty-seven percent of the patients had type 2 diabetes mellitus. These patients had higher pulmonary artery pressure (34 mm Hg vs 29 mm Hg, p = 0.004), more RV systolic dysfunction (57% vs 29%, p = 0.009), more RV diastolic dysfunction (46% vs 12%, p = 0.001), and lower RV e' (8.7 cm/s vs 11.5 cm/s, p = 0.006). The presence of diabetes mellitus was independently associated with RV systolic dysfunction (odds ratio 2.84, 95% confidence interval 1.09 to 7.40, p = 0.03) and with RV diastolic dysfunction (odds ratio 4.33, 95% confidence interval 1.25 to 15.07, p = 0.02), after adjustment for age, gender, and pulmonary pressures. In conclusion, diabetes mellitus is strongly associated with RV systolic and diastolic dysfunctions in patients with HFpEF, independent of RV afterload. (C) 2017 Elsevier Inc. All rights reserved