Modern submarine canyon feeder-system and deep-sea fan growth in a tectonically active margin (northern Sicily)

Widely used sequence stratigraphic models predict that specific facies assemblages alternate in the stratigraphy of deep-sea fans, depending on the cyclic nature of sea-level variations. Our work tests this assumption through facies reconstruction of submarine fans that are growing in a small basin along the tectonically active Sicilian margin. Connected canyons have heads close to the coastline; they can be river connected or littoral cell-connected, the first receiving sediment from hyperpycnal flows, the latter intercepting shelf sediment dispersal pathways. Hyperpycnal flows directly discharge river-born sediment into the head of the river-connected canyon and originate a large turbidite fan. A drift formed by the longshore redistribution of sediment of a nearby delta introduces sediment to the head of the littoral cell-connected canyon, forming turbidity currents that flow within the canyon to reach the basin plain. However, since sediment failure and landslide processes are common in the slope part of the system, a mixed fan, consisting of both turbidites and mass-transport deposits, is formed. Disconnected canyons, with heads at the shelf edge far from the coastline, are fed by canyon head and levee-wedge failures, resulting in mass-transport or mixed fan deposition, the latter developing when the seafloor gradient or the lithology of the failed sediment allows turbidity current formation. Connected canyons form in areas with high uplift rates, where the shelf is narrow and steep and the shelf edge is at a relatively shallow depth. Disconnected canyons develop where there are lower uplift rates or subsidence, where the shelf is large and relatively gentle with a deeper shelf edge. It is deduced that the relative vertical movements of fault-bound blocks control whether canyons are connected to the coast at the present day. The role of tectonics in controlling the canyon feeding processes and the facies of submarine fan growth during highstand periods is therefore highlighted. A further view that arises from our paper is that in active margins, the slope portion of fan systems, through seafloor instability and variations in channel gradient, is a key factor in determining the final deep-sea fan facies, regardless of the distance between the coast and the canyon. The concomitant growth of turbidites, mass-transport deposits, and mixed fans demonstrates that models that predict changes in submarine fan facies on the basis of sea-level cycles do not necessarily apply to systems developed along tectonically active margins

Pairing in Many-Fermion Systems: An Exact Renormalisation Group Treatment

We study the application of the exact renormalisation group to a many-fermion system with a short-range attractive force. We introduce a boson field to describe pairing effects, and take a simple ansatz for the effective action. We derive a set of approximate flow equations for the effective coupling including boson and fermionic fluctuations. The initial conditions are obtained by renormalising the interaction to fit the scattering length in vacuum. At some critical value of the running scale, the numerical solutions show a phase transition to a gapped phase. Standard results are recovered if we omit the boson loops. When boson fluctuations are included, we find that their contributions are significant only in the small-gap regime.Comment: 12 pages (RevTeX), 2 figures (eps

Forecasting the response of Earth's surface to future climatic and land use changes: a review of methods and research needs

In the future, Earth will be warmer, precipitation events will be more extreme, global mean sea level will rise, and many arid and semiarid regions will be drier. Human modifications of landscapes will also occur at an accelerated rate as developed areas increase in size and population density. We now have gridded global forecasts, being continually improved, of the climatic and land use changes (C&LUC) that are likely to occur in the coming decades. However, besides a few exceptions, consensus forecasts do not exist for how these C&LUC will likely impact Earth-surface processes and hazards. In some cases, we have the tools to forecast the geomorphic responses to likely future C&LUC. Fully exploiting these models and utilizing these tools will require close collaboration among Earth-surface scientists and Earth-system modelers. This paper assesses the state-of-the-art tools and data that are being used or could be used to forecast changes in the state of Earth's surface as a result of likely future C&LUC. We also propose strategies for filling key knowledge gaps, emphasizing where additional basic research and/or collaboration across disciplines are necessary. The main body of the paper addresses cross-cutting issues, including the importance of nonlinear/threshold-dominated interactions among topography, vegetation, and sediment transport, as well as the importance of alternate stable states and extreme, rare events for understanding and forecasting Earth-surface response to C&LUC. Five supplements delve into different scales or process zones (global-scale assessments and fluvial, aeolian, glacial/periglacial, and coastal process zones) in detail

A fleet of multiparameter observatories for geophysical and environmental monitoring at seafloor

Seafloor long-term, multiparameter, single-frame observatories have been developed within the framework of European Commission and Italian projects since 1995. A fleet of five seafloor observatories, built-up starting from 1995 within the framework of an effective synergy among research institutes and industries, have carried out a series of long-term sea experiments. The observatories are able to operate from shallow waters to deep sea, down to 4,000 m w.d., and to simultaneously monitor a broad spectrum of geophysical and environmental processes, including seismicity, geomagnetic field variations, water temperature, pressure, salinity, chemistry, currents, and gas occurrence. Moreover, they can transmit data in (near)-real-time that can be integrated with those of the on-land networks. The architecture of the seafloor observatories follows the criteria of modularity, interoperability and standardisation in terms of materials, components and communication protocols. This paper describes the technical features of the observatories, their experiments and data

A Granulin-Like Growth Factor Secreted by the Carcinogenic Liver Fluke, Opisthorchis viverrini, Promotes Proliferation of Host Cells

The human liver fluke, Opisthorchis viverrini, infects millions of people throughout south-east Asia and is a major cause of cholangiocarcinoma, or cancer of the bile ducts. The mechanisms by which chronic infection with O. viverrini results in cholangiocarcinogenesis are multi-factorial, but one such mechanism is the secretion of parasite proteins with mitogenic properties into the bile ducts, driving cell proliferation and creating a tumorigenic environment. Using a proteomic approach, we identified a homologue of human granulin, a potent growth factor involved in cell proliferation and wound healing, in the excretory/secretory (ES) products of the parasite. O. viverrini granulin, termed Ov-GRN-1, was expressed in most parasite tissues, particularly the gut and tegument. Furthermore, Ov-GRN-1 was detected in situ on the surface of biliary epithelial cells of hamsters experimentally infected with O. viverrini. Recombinant Ov-GRN-1 was expressed in E. coli and refolded from inclusion bodies. Refolded protein stimulated proliferation of murine fibroblasts at nanomolar concentrations, and proliferation was inhibited by the MAPK kinase inhibitor, U0126. Antibodies raised to recombinant Ov-GRN-1 inhibited the ability of O. viverrini ES products to induce proliferation of murine fibroblasts and a human cholangiocarcinoma cell line in vitro, indicating that Ov-GRN-1 is the major growth factor present in O. viverrini ES products. This is the first report of a secreted growth factor from a parasitic worm that induces proliferation of host cells, and supports a role for this fluke protein in establishment of a tumorigenic environment that may ultimately manifest as cholangiocarcinoma

Forecasting the Response of Earth\u27s Surface to Future Climatic and Land Use Changes: A Review of Methods and Research Needs

In the future, Earth will be warmer, precipitation events will be more extreme, global mean sea level will rise, and many arid and semiarid regions will be drier. Human modifications of landscapes will also occur at an accelerated rate as developed areas increase in size and population density. We now have gridded global forecasts, being continually improved, of the climatic and land use changes (C&LUC) that are likely to occur in the coming decades. However, besides a few exceptions, consensus forecasts do not exist for how these C&LUC will likely impact Earth-surface processes and hazards. In some cases, we have the tools to forecast the geomorphic responses to likely future C&LUC. Fully exploiting these models and utilizing these tools will require close collaboration among Earth-surface scientists and Earth-system modelers. This paper assesses the state-of-the-art tools and data that are being used or could be used to forecast changes in the state of Earth\u27s surface as a result of likely future C&LUC. We also propose strategies for filling key knowledge gaps, emphasizing where additional basic research and/or collaboration across disciplines are necessary. The main body of the paper addresses cross-cutting issues, including the importance of nonlinear/threshold-dominated interactions among topography, vegetation, and sediment transport, as well as the importance of alternate stable states and extreme, rare events for understanding and forecasting Earth-surface response to C&LUC. Five supplements delve into different scales or process zones (global-scale assessments and fluvial, aeolian, glacial/periglacial, and coastal process zones) in detail

Ror2 Enhances Polarity and Directional Migration of Primordial Germ Cells

The trafficking of primordial germ cells (PGCs) across multiple embryonic structures to the nascent gonads ensures the transmission of genetic information to the next generation through the gametes, yet our understanding of the mechanisms underlying PGC migration remains incomplete. Here we identify a role for the receptor tyrosine kinase-like protein Ror2 in PGC development. In a Ror2 mouse mutant we isolated in a genetic screen, PGC migration and survival are dysregulated, resulting in a diminished number of PGCs in the embryonic gonad. A similar phenotype in Wnt5a mutants suggests that Wnt5a acts as a ligand to Ror2 in PGCs, although we do not find evidence that WNT5A functions as a PGC chemoattractant. We show that cultured PGCs undergo polarization, elongation, and reorientation in response to the chemotactic factor SCF (secreted KitL), whereas Ror2 PGCs are deficient in these SCF-induced responses. In the embryo, migratory PGCs exhibit a similar elongated geometry, whereas their counterparts in Ror2 mutants are round. The protein distribution of ROR2 within PGCs is asymmetric, both in vitro and in vivo; however, this asymmetry is lost in Ror2 mutants. Together these results indicate that Ror2 acts autonomously to permit the polarized response of PGCs to KitL. We propose a model by which Wnt5a potentiates PGC chemotaxis toward secreted KitL by redistribution of Ror2 within the cell

The RESET project: constructing a European tephra lattice for refined synchronisation of environmental and archaeological events during the last c. 100 ka

This paper introduces the aims and scope of the RESET project (. RESponse of humans to abrupt Environmental Transitions), a programme of research funded by the Natural Environment Research Council (UK) between 2008 and 2013; it also provides the context and rationale for papers included in a special volume of Quaternary Science Reviews that report some of the project's findings. RESET examined the chronological and correlation methods employed to establish causal links between the timing of abrupt environmental transitions (AETs) on the one hand, and of human dispersal and development on the other, with a focus on the Middle and Upper Palaeolithic periods. The period of interest is the Last Glacial cycle and the early Holocene (c. 100-8 ka), during which time a number of pronounced AETs occurred. A long-running topic of debate is the degree to which human history in Europe and the Mediterranean region during the Palaeolithic was shaped by these AETs, but this has proved difficult to assess because of poor dating control. In an attempt to move the science forward, RESET examined the potential that tephra isochrons, and in particular non-visible ash layers (cryptotephras), might offer for synchronising palaeo-records with a greater degree of finesse. New tephrostratigraphical data generated by the project augment previously-established tephra frameworks for the region, and underpin a more evolved tephra 'lattice' that links palaeo-records between Greenland, the European mainland, sub-marine sequences in the Mediterranean and North Africa. The paper also outlines the significance of other contributions to this special volume: collectively, these illustrate how the lattice was constructed, how it links with cognate tephra research in Europe and elsewhere, and how the evidence of tephra isochrons is beginning to challenge long-held views about the impacts of environmental change on humans during the Palaeolithic. © 2015 Elsevier Ltd.RESET was funded through Consortium Grants awarded by the Natural Environment Research Council, UK, to a collaborating team drawn from four institutions: Royal Holloway University of London (grant reference NE/E015905/1), the Natural History Museum, London (NE/E015913/1), Oxford University (NE/E015670/1) and the University of Southampton, including the National Oceanography Centre (NE/01531X/1). The authors also wish to record their deep gratitude to four members of the scientific community who formed a consultative advisory panel during the lifetime of the RESET project: Professor Barbara Wohlfarth (Stockholm University), Professor Jørgen Peder Steffensen (Niels Bohr Institute, Copenhagen), Dr. Martin Street (Romisch-Germanisches Zentralmuseum, Neuwied) and Professor Clive Oppenheimer (Cambridge University). They provided excellent advice at key stages of the work, which we greatly valued. We also thank Jenny Kynaston (Geography Department, Royal Holloway) for construction of several of the figures in this paper, and Debbie Barrett (Elsevier) and Colin Murray Wallace (Editor-in-Chief, QSR) for their considerable assistance in the production of this special volume.Peer Reviewe