11 research outputs found

    Association of the Kir6.2 E23K Variant with Reduced Acute Insulin Response in African-Americans

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    Context: ATP-sensitive potassium channels are composed of pore-forming (Kir6.x) and regulatory sulfonylurea receptor (SURx) subunits and have been implicated in the maintenance of glucose homeostasis. Kir6.2 and SUR1 are expressed in a broad range of tissues, and no contemporary studies have addressed the physiological impact of variants in Hispanic-Americans and African-Americans carefully phenotyped for components of glucose homeostasis

    Association of Plasma Vitamin D Levels with Adiposity in Hispanic and African Americans

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    Context: Previous studies have suggested vitamin D insufficiency is associated with increased obesity; however, the relationship between 25-hydroxyvitamin D (25[OH]D) and 1,25-dihydroxyvitamin D (1,25[OH]2D) and measures of adiposity has not been well characterized in minority populations
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