Screening of the fruit pulp extract of Momordica balsamina for anti HIV property

Anti-HIV properties of the fruit pulp extract of Momordica balsamina, a plant of the cucurbitacea family commonly used in the Northern part of Nigeria for its anti-viral efficacy in poultry, was studied in vitro.Peripheral blood mononuclear cells (PBMCs) were prepared from both HIV sero positive and sero negative patients and categorized into group A (sero negative), group B (PBMC co-culture), group C (PBMC co-culture containing 3.12 mg/ml of the plant extract) and group D (only the enriched culture medium). The PBMCs were cultivated for 28 days using standard methods. CD4+ counts and virus detection assay (P24) were determined on the PBMC. Results showed that the plant extract treatmentsignificantly (

Anti-Trypanosomal Potential Of Momordica Balsamina Linn Fruit Pulp Extract Against Trypanosoma brucei brucei Infection

The search for new trypanocides has not been keenly pursued due to high cost of design and development with no promise of financial returns. Momordica balsamina fruit pulp extract was screened for antitrypanosomal activity in experimental Trypanosoma brucei brucei infection in rabbits. The extract was administered prior to parasite inoculation, 24 hours post parasite inoculation and on establishment of infection. The treatment was by oral administration of the extract at 500mg/kg body weight for 14 consecutive days. Parasitaemia was monitored daily while body weight and packed cell volume (PCV) were determined before commencement of studies and subsequently at weekly intervals for 28 days. The result showed a significant (

ANTI-TRYPANOSOMAL POTENTIAL OF MOMORDICA BALSAMINA LINN FRUIT PULP EXTRACT AGAINST TRYPANOSOMA BRUCEI BRUCEI INFECTION

The search for new trypanocides has not been keenly pursued due to high cost of design and development with no promise of financial returns. Momordica balsamina fruit pulp extract was screened for antitrypanosomal activity in experimental T. brucei brucei infection in rabbits. The extract was administered prior to parasite inoculation, 24 hours post parasite inoculation and on establishment of infection. The treatment was by oral administration of the extract at 500mg/kg body weight for 14 consecutive days. Parasitaemia was monitored daily while body weight and packed cell volume (PCV) were determined before commencement of studies and subsequently at weekly intervals for 28 days. The result showed a significant (

Roles and Mechanisms of Docosahexaenoic Acid (DHA) in Neurodevelopment, Neuronal Functions, Learning and Memory

Docosahexaenoic acid (DHA) is an omega-3 fatty acid which is a major constituent of the brain, retina and skin in terms of structure. DHA can be produced from the metabolic synthesis of alpha linolenic acid (ALA) or gotten from breast milk, fatty fishes, or oil from algae. Studies have shown that DHA is an essential nutrient for normal functioning of the brain. It is the major omega-3 fatty acid present in brain tissues and is known to have effects on neurotransmitters, synaptic transmission, and signal transduction. Also, certain DHA metabolites are biologically active molecules that protect the tissues from oxidative injury and stress. DHA is also known to carry out important membrane neuronal functions such as Phospholipid synthesis, membrane fluidity, neuronal survival, regulation of gene expression and modulation of enzyme activity in the brain. Therefore, DHA needs to be taken at developmental stages of human life such as period of pregnancy, lactation and even childhood for proper development and functioning of the brain.Docosahexaenoic acid (DHA) is an omega-3 fatty acid which is a major constituent of the brain, retina and skin in terms of structure. DHA can be produced from the metabolic synthesis of alpha linolenic acid (ALA) or gotten from breast milk, fatty fishes, or oil from algae. Studies have shown that DHA is an essential nutrient for normal functioning of the brain. It is the major omega-3 fatty acid present in brain tissues and is known to have effects on neurotransmitters, synaptic transmission, and signal transduction. Also, certain DHA metabolites are biologically active molecules that protect the tissues from oxidative injury and stress. DHA is also known to carry out important membrane neuronal functions such as Phospholipid synthesis, membrane fluidity, neuronal survival, regulation of gene expression and modulation of enzyme activity in the brain. Therefore, DHA needs to be taken at developmental stages of human life such as period of pregnancy, lactation and even childhood for proper development and functioning of the brain

Sports related injuries

As athletics on the collegiate level become more competitive, the need for professionally trained strength and conditioning coaches increases. Having qualified coaches enhances athletes' performance on the field, and have been shown to promote safety and prevent certain injuries. Organized injury databases are needed to support these athletic professionals in their quest to help prevent injuries. With the knowledge of sports medicine growing every day, it is important to have strength and conditioning coaches

Delivery Vehicle and Mechanism for Human Mesenchymal Stem Cells

Several studies have shown that human mesenchymal stem cells (hMSCs) have the potential to be the futute of regenerative medicine based on their ability to rebuild diseased or damaged tissues. The difficulty involved with hMSCs is delivering these cells to the injured tissue site. Injection is the preferred method, but it has been shown that simple injection of hMSCs in media results in extreme turbulent flow, thus killing the cells. Hydrogels have been researched as a form of vehicle for hMSC transport. However, the delivery of the gel and cell viability remain a problem.  This project aims to seek the best overall hydrogel to act as the vehicle as well as a delivery mechanism that allows for simple, safe and convenient transport of hMSCs