Hydrodynamic stress on fractal aggregates of spheres

We calculate the average hydrodynamic stress on fractal aggregates of spheres using Stokesian dynamics. We find that for fractal aggregates of force-free particles, the stress does not grow as the cube of the radius of gyration, but rather as the number of particles in the aggregate. This behavior is only found for random aggregates of force-free particles held together by hydrodynamic lubrication forces. The stress on aggregates of particles rigidly connected by interparticle forces grows as the radius of gyration cubed. We explain this behavior by examining the transmission of the tension along connecting lines in an aggregate and use the concept of a persistance length in order to characterize this stress transmission within an aggregate

Using the Sun to estimate Earth-like planets detection capabilities. III. Impact of spots and plages on astrometric detection

Stellar activity is a potential important limitation to the detection of low mass extrasolar planets with indirect methods (RV, photometry, astrometry). In previous papers, using the Sun as a proxy, we investigated the impact of stellar activity (spots, plages, convection) on the detectability of an Earth-mass planet in the habitable zone (HZ) of solar-type stars with RV techniques. We extend here the detectability study to the case of astrometry. We used the sunspot and plages properties recorded over one solar cycle to infer the astrometric variations that a Sun-like star seen edge-on, 10 pc away, would exhibit, if covered by such spots/bright structures. We compare the signal to the one expected from the astrometric wobble (0.3 {\mu}as) of such a star surrounded by a one Earth-mass planet in the HZ. We also briefly investigate higher levels of activity. The activity-induced astrometric signal along the equatorial plane has an amplitude of typ. less than 0.2 {\mu}as (rms=0.07 {\mu}as), smaller than the one expected from an Earth-mass planet at 1 AU. Hence, for this level of activity, the detectability is governed by the instrumental precision rather than the activity. We show that for instance a one Earth-mass planet at 1 AU would be detected with a monthly visit during less than 5 years and an instrumental precision of 0.8 {\mu}as. A level of activity 5 times higher would still allow such a detection with a precision of 0.35 {\mu}as. We conclude that astrometry is an attractive approach to search for such planets around solar type stars with most levels of stellar activity.Comment: Letter accepted by A&

Effects of zinc supplementation on cognitive function in healthy middle-aged and older adults: the ZENITH study

A randomised double-blind placebo-controlled design was employed to investigate the effects of Zn supplementation on cognitive function in 387 healthy adults aged 55–87 years. Several measures of visual memory, working memory, attention and reaction time were obtained using the Cambridge Automated Neuropsychological Test Battery at baseline and then after 3 and 6 months of 0 (placebo), 15 or 30 mg Zn/d. Younger adults (70 years), and performance improved with practice on some measures. For two out of eight dependent variables, there were significant interactions indicating a beneficial effect (at 3 months only) of both 15 and 30 mg/d on one measure of spatial working memory and a detrimental effect of 15 mg/d on one measure of attention. Further work is required to establish whether these findings generalise to older adults in poorer mental and physical health and with less adequate Zn intake and status than the present sample

Impact of the European Clinical Trials Directive on prospective academic clinical trials associated with BMT

The European Clinical Trials Directive (EU 2001; 2001/20/EC) was introduced to improve the efficiency of commercial and academic clinical trials. Concerns have been raised by interested organizations and institutions regarding the potential for negative impact of the Directive on non-commercial European clinical research. Interested researchers within the European Group for Blood and Marrow Transplantation (EBMT) were surveyed to determine whether researcher experiences confirmed this view. Following a pilot study, an internet-based questionnaire was distributed to individuals in key research positions in the European haemopoietic SCT community. Seventy-one usable questionnaires were returned from participants in different EU member states. The results indicate that the perceived impact of the European Clinical Trials Directive has been negative, at least in the research areas of interest to the EBMT

The multiple vehicle balancing problem

This paper deals with the multiple vehicle balancing problem (MVBP). Given a fleet of vehicles of limited capacity, a set of vertices with initial and target inventory levels and a distribution network, the MVBP requires to design a set of routes along with pickup and delivery operations such that inventory is redistributed among the vertices without exceeding capacities, and routing costs are minimized. The MVBP is NP\u2010hard, generalizing several problems in transportation, and arising in bike\u2010sharing systems. Using theoretical properties of the problem, we propose an integer linear programming formulation and introduce strengthening valid inequalities. Lower bounds are computed by column generation embedding an ad\u2010hoc pricing algorithm, while upper bounds are obtained by a memetic algorithm that separate routing from pickup and delivery operations. We combine these bounding routines in both exact and matheuristic algorithms, obtaining proven optimal solutions for MVBP instances with up to 25 stations

Dynamic reconfiguration of human brain networks during learning

Human learning is a complex phenomenon requiring flexibility to adapt existing brain function and precision in selecting new neurophysiological activities to drive desired behavior. These two attributes -- flexibility and selection -- must operate over multiple temporal scales as performance of a skill changes from being slow and challenging to being fast and automatic. Such selective adaptability is naturally provided by modular structure, which plays a critical role in evolution, development, and optimal network function. Using functional connectivity measurements of brain activity acquired from initial training through mastery of a simple motor skill, we explore the role of modularity in human learning by identifying dynamic changes of modular organization spanning multiple temporal scales. Our results indicate that flexibility, which we measure by the allegiance of nodes to modules, in one experimental session predicts the relative amount of learning in a future session. We also develop a general statistical framework for the identification of modular architectures in evolving systems, which is broadly applicable to disciplines where network adaptability is crucial to the understanding of system performance.Comment: Main Text: 19 pages, 4 figures Supplementary Materials: 34 pages, 4 figures, 3 table

Evaluation of Cellular-level Haversian Bone Resorption in Human Hyperparathyroid States: A Preliminary Report

Cellular-level bone resorption was evaluated in 16 patients undergoing renal dialysis and in two with primary hyperparathyroidism, by quantitative histological means using tissue time markers. When averaged over periods greater than two weeks, the individual osteoclasts in these patients resorbed less bone in unit time than normal

Root hairs enable high transpiration rates in drying soils

What processes facilitate the ability of roots to take up water from the soil? Are root hairs advantageous for water uptake? Despite the well documented role of root hairs in phosphate uptake, their role in water extraction is controversial and the experimental data contradictory. We proposed a novel experimental method to address this question. We grew barley (Hordeum vulgare L. cv. Pallas) and its root-hairless mutant in a pressure chamber whereby the transpiration rate could be varied while monitoring the suction in the xylem. We monitored xylem water potential as function of different transpiration rate during a drying cycle. The relationship between transpiration rate and xylem suction linearly increased in wet soils and did not differ between genotypes. The slope of this increase was equal to the plant hydraulic resistance. When the soil dried the xylem water suction rapidly increased, particularly at high transpiration rates. The root-hairless mutant showed a more marked increase in the xylem suction, indicative of a lower capacity to take up water. Interestingly, the high rise in xylem suction at high transpiration rates did not quickly decrease as the transpiration rate was reduced. To quantitatively understand the relationship between transpiration rate and xylem suction and the role of root hairs, we employed a 3D root architectural model coupled with water flow in soils. The model was parametrized based on measured root architecture and soil hydraulic properties. The role of the root hairs was simulated by extending the root radius in presence of root hairs. This implicitly simulates the ability of root hairs to take up water from their tips, potential softening the drops in water potential across the rhizosphere. The simulations predicted that that as the soil dries a bigger drop in water potential develop around the roots of the root-hairless mutant. Extension of the root radius by 0.7 mm (to simulate the uptake of root hairs) reduced the drop in water potential around the roots and softened the decrease in the xylem water potential, particularly at high transpiration rates. We conclude that the root-soil interface plays a key role in root water uptake and that root hairs reduce the gradient in water potential around the roots and enable plants to sustain high transpiration rates in drying soils

Laser-chemical vapor deposition of W Schottky contacts on GaAs\ud using WF6 and SiH4

Reports on the deposition of tungsten on gallium arsenide (GaAs) using a low-temperature laser-chemical vapor deposition process. Induction of metallic W formation from a gas mixture; Columnar structure shown by scanning electron microscopy of the W films; Schottky diodes obtained during a laser based resistless projection patterning process on GaAs