Internationalisation of a teaching experience: ToSCA UPC education for innovation workshop at UFPS, Colombia

[EN] ToSCA is an optional and intensive technical product innovation workshop that aims to include education for innovation of constructive solutions in the grade architecture programme, by applying a didactic structure based on problem solving skills, combined with cooperative learning structures and involving an industry of the sector every edition a client. The workshop has been held annually at the Vallès School of Architecture, Universitat Politècnica de Catalunya, since 2007 and the results of each edition can be found at: http://www.etsav.upc.edu/assignatures/tosca. After eleven editions of ToSCA_ETSAV and one edition in TUM Munich, with a very good outcomes and by the invitation of the School of Architecture of the Francisco de Paula Santander University in Cúcuta, Colombia, we assumed, between both institutions, the challenge of internationalizing the ToSCA experience, to carry out within the Deepening Course "the ceramics in the architectural project", a first educational workshop for the innovation of technical product, suggesting the adaptability of the ToSCA methodology, in a different socio-cultural environment.http://ocs.editorial.upv.es/index.php/HEAD/HEAD18Adroer Puig, M.; Díaz Fuentes, C.; Zamora I Mestre, J. (2018). Internationalisation of a teaching experience: ToSCA UPC education for innovation workshop at UFPS, Colombia. Editorial Universitat Politècnica de València. 1107-1115. https://doi.org/10.4995/HEAD18.2018.8154OCS1107111

Influencia de las variables de personalidad en la adicción al trabajo en un estudio con profesores universitarios

Novenes Jornades de Foment de la Investigació de la FCHS (Any 2003-2004)Este trabajo examina las relaciones entre la Adicción al trabajo (Workaholism) y las dimensiones de personalidad Energía (E), Estabilidad Emocional (EE), Tesón (T), Afabilidad (A) y Apertura Mental (AM). Para ello, se ha evaluado a 51 sujetos en dichas variables. Los resultados han mostrado que sí existen unas características típicas de los adictos al trabajo; así, los adictos presentan una baja estabilidad emocional, alta escrupulosidad, alta apertura mental, en especial apertura a la cultura, y baja amabilidad. Estos resultados son similares a los hallazgos de investigaciones y estudios precedentes

Buenas prácticas de Trabajo Social con redes de apoyo social

A partir de las conclusiones extraídas del Prácticum de investigación “Las redes de apoyo social de los nuevos pobres”, presentado en la Facultad de Ciencias Sociales y del Trabajo de Zaragoza, en enero de 2013, pretendemos averiguar si en las intervenciones de los profesionales del Trabajo Social de los Centros de Servicios Sociales Municipales del Ayuntamiento de Zaragoza se incorporan las redes de apoyo social de las personas usuarias. Tras estas averiguaciones, recopilaremos las buenas prácticas detectadas, así como las propuestas que los profesionales expongan, con el fin de elaborar un catálogo de buenas prácticas de intervención con redes de apoyo social

Low-cost ceramic membrane bioreactor: Effect of backwashing, relaxation and aeration on fouling. Protozoa and bacteria removal

Membrane biological reactors (MBR) constitute an alternative to conventional wastewater treatments for improved recovery, reuse, and recycling of water. MBRs have a smaller footprint, provide better biotreatment and achieve a high-quality effluent. This work analyses the use of MBRs innovative low-cost ceramic membranes for wastewater treatment. We propose low-cost ceramic membranes as an alternative to the more expensive commercial ceramic membranes. Low-cost membranes were made of clay, calcium carbonate, potato starch, almond shell and chamotte. We synthesized two different selective layers, from clay and/or TiO2. We characterized the membranes (pore diameter and water permeance) and their performance in a laboratory scale MBR. To mitigate membrane fouling and preserve the continued operation along time, the effect of different operating cycles was measured, considering two physical cleaning strategies: relaxation and backwashing. Cycles of 9 min of operation, 30 s of relaxation and 1 min of backwashing provided the lowest fouling rate. We investigated the effect of air scouring on fouling by operating with different air flow rates. Once experimental conditions were optimized, the overall performance of the different ceramic membranes was tested. The membrane with a TiO2 thin layer provided the best resistance to fouling, as well as a good retention capacity of E. coli, Cryptosporidium oocysts and Giardia cysts

Brain innate immunity in the regulation of neuroinflammation: therapeutic strategies by modulating cd200-cd200r interaction involve the cannabinoid system

The central nervous system (CNS) innate immune response includes an arsenal of molecules and receptors expressed by professional phagocytes, glial cells and neurons that is involved in host defence and clearance of toxic and dangerous cell debris. However, any uncontrolled innate immune responses within the CNS are widely recognized as playing a major role in the development of autoimmune disorders and neurodegeneration, with multiple sclerosis (MS) and Alzheimer´s disease (AD) being primary examples. Hence, it is important to identify the key regulatory mechanisms involved in the control of CNS innate immunity and which could be harnessed to explore novel therapeutic avenues. Neuroimmune regulatory proteins (NIReg) such as CD95L, CD200, CD47, sialic acid, complement regulatory proteins (CD55, CD46, fH, C3a), HMGB1, may control the adverse immune responses in health and diseases. In the absence of these regulators, when neurons die by apoptosis, become infected or damaged, microglia and infiltrating immune cells are free to cause injury as well as an adverse inflammatory response in acute and chronic settings. We will herein provide new emphasis on the role of the pair CD200-CD200R in MS and its experimental models: experimental autoimmune encephalomyelitis (EAE) and Theiler?s virus induced demyelinating disease (TMEV-IDD). The interest of the cannabinoid system as inhibitor of inflammation prompt us to introduce our findings about the role of endocannabinoids (eCBs) in promoting CD200-CD200 receptor (CD200R) interaction and the benefits caused in TMEV-IDD. Finally, we also review the current data on CD200-CD200R interaction in AD, as well as, in the aging brain.Fil: Hernangómez, Miriam. Consejo Superior de Investigaciones Cientificas; EspañaFil: Carrillo Salinas, Francisco. Consejo Superior de Investigaciones Cientificas; EspañaFil: Mecha, Miriam. Consejo Superior de Investigaciones Cientificas; EspañaFil: Correa, Fernando Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Mestre, Leyre. Consejo Superior de Investigaciones Cientificas; EspañaFil: Loría, Frida. Consejo Superior de Investigaciones Cientificas; EspañaFil: Feliú, Ana. Consejo Superior de Investigaciones Cientificas; EspañaFil: Docagne, Fabian. Inserm; FranciaFil: Guaza, Carmen. Consejo Superior de Investigaciones Cientificas; Españ

PROYECTO PARA LA PROMOCIÓN DEL PATRIMONIO CULTURAL ANGLO-CARIBEÑO DE MANATÍ: AVANCES Y PERSPECTIVAS

The investigation offers the analysis of the results reached until the present by the Project for the promotion of the anglo-caribbean cultural patrimony of Manatí, sustained in the promotion of the cultural patrimony as tool for its appraisement and that it recognizes the benefits of the promotion, in connection with the preservation of the patrimony starting from the development actions that they wake up favorable affective states in the cultural fellows of the community. It constitutes a contribution to the materialization of the strategic line of renew of values and identity of the municipality that it integrates knowledge of the culture and the local history, it ponders the participation of the community and the setting in practice of the knowledge and present values in the anglo-caribbean community, for the sake of the preservation and appraisement of their patrimony.La investigación ofrece el análisis de los resultados alcanzados hasta el presente por el Proyecto para la promoción del patrimonio cultural anglo-caribeño de Manatí, sustentado en la promoción del patrimonio cultural como herramienta para su valorización y que reconoce los beneficios de la promoción, en relación con la preservación del patrimonio a partir del desarrollo acciones que despierten estados afectivos favorables en los sujetos culturales de la comunidad. Constituye un aporte a la materialización de la línea estratégica de revitalización de valores e identidad del municipio, que integra conocimientos de la cultura y la historia local, pondera la participación de la comunidad y la puesta en práctica de los conocimientos y valores presentes en la comunidad anglo-caribeña, en aras de la preservación y valorización de su patrimoni

Anandamide inhibits Theiler's virus induced VCAM-1 in brain endothelial cells and reduces leukocyte transmigration in a model of blood brain barrier by activation of CB1 receptors

<p>Abstract</p> <p>Background</p> <p>VCAM-1 represents one of the most important adhesion molecule involved in the transmigration of blood leukocytes across the blood-brain barrier (BBB) that is an essential step in the pathogenesis of MS. Several evidences have suggested the potential therapeutic value of cannabinoids (CBs) in the treatment of MS and their experimental models. However, the effects of endocannabinoids on VCAM-1 regulation are poorly understood. In the present study we investigated the effects of anandamide (AEA) in the regulation of VCAM-1 expression induced by Theiler's virus (TMEV) infection of brain endothelial cells using <it>in vitro </it>and <it>in vivo </it>approaches.</p> <p>Methods</p> <p>i) <it>in vitro</it>: VCAM-1 was measured by ELISA in supernatants of brain endothelial cells infected with TMEV and subjected to AEA and/or cannabinoid receptors antagonist treatment. To evaluate the functional effect of VCAM-1 modulation we developed a blood brain barrier model based on a system of astrocytes and brain endothelial cells co-culture. ii) <it>in vivo</it>: CB₁receptor deficient mice (Cnr1^-/-) infected with TMEV were treated with the AEA uptake inhibitor UCM-707 for three days. VCAM-1 expression and microglial reactivity were evaluated by immunohistochemistry.</p> <p>Results</p> <p>Anandamide-induced inhibition of VCAM-1 expression in brain endothelial cell cultures was mediated by activation of CB₁receptors. The study of leukocyte transmigration confirmed the functional relevance of VCAM-1 inhibition by AEA. <it>In vivo </it>approaches also showed that the inhibition of AEA uptake reduced the expression of brain VCAM-1 in response to TMEV infection. Although a decreased expression of VCAM-1 by UCM-707 was observed in both, wild type and CB₁receptor deficient mice (Cnr1^-/-), the magnitude of VCAM-1 inhibition was significantly higher in the wild type mice. Interestingly, Cnr1^-/-mice showed enhanced microglial reactivity and VCAM-1 expression following TMEV infection, indicating that the lack of CB₁receptor exacerbated neuroinflammation.</p> <p>Conclusions</p> <p>Our results suggest that CB₁receptor dependent VCAM-1 inhibition is a novel mechanism for AEA-reduced leukocyte transmigration and contribute to a better understanding of the mechanisms underlying the beneficial role of endocannabinoid system in the Theiler's virus model of MS.</p

How oral probiotics affect the severity of an experimental model of progressive multiple sclerosis? Bringing commensal bacteria into the neurodegenerative process

A growing number of studies support that the bidirectional interactions between the gut microbiota, the immune system and the CNS are relevant for the pathophysiology of MS. Several studies have reported alterations in the gut microbiome of MS patients. In addition, a variety of studies in animal models of MS have suggested that specific members of the gut commensal microbiota can exacerbate or ameliorate neuroinflammation. Probiotics represent oral nontoxic immunomodulatory agents that would exert benefits when using in combination with current MS therapy. Here we investigate the effect of Vivomixx on the gut microbiome and central and peripheral immune responses in a murine model of primary progressive MS. Vivomixx administration was associated with increased abundance of many taxa such as Bacteroidetes, Actinobacteria, Tenericutes and TM7. This was accompanied by a clear improvement of the motor disability of Theiler's virus infected mice; in the CNS Vivomixx reduced microgliosis, astrogliosis and leukocyte infiltration. Notably, the presence of Breg cells (CD19 + CD5 + CD1d high) in the CNS was enhanced by Vivomixx, and while spinal cord gene expression of IL-1β and IL-6 was diminished, the probiotic promoted IL-10 gene expression. One of the most significant findings was the increased plasma levels of butyrate and acetate levels in TMEV-mice that received Vivomixx. Peripheral immunological changes were subtle but interestingly, the probiotic restricted IL-17 production by Th17-polarized CD4 + T-cells purified from the mesenteric lymph nodes of Theiler's virus infected mice. Our data reinforce the beneficial effects of oral probiotics that would be coadjuvant treatments to current MS therapies

CONCEPCIONES TEÓRICAS SOBRE PROMOCIÓN CULTURAL Y PATRIMONIO. SU IMPORTANCIA PARA LA PRESERVACIÓN DEL PATRIMONIO CULTURAL EN LAS COMUNIDADES

The theoretical conceptions on cultural promotion and patrimony are essential for the work in the communities, for the sake of understanding the wealth of these processes and their potentialities for the preservation of our cultural patrimony; from the development of actions with a cultural focus, where the center is in the man's analysis with the variety of customs, roots, traditions, habits and beliefs of those who is payee and creator.&nbsp; Las concepciones teóricas sobre promoción cultural y patrimonio son esenciales para el trabajo en las comunidades, en aras de entender la riqueza de estos procesos y sus potencialidades para la preservación de nuestro patrimonio cultural; desde el desarrollo de acciones con un enfoque cultorológico, donde el centro está en el análisis del hombre con la variedad de costumbres, raíces, tradiciones, hábitos y creencias de los que es portador y creador