2,332 research outputs found
Influence of surface passivation on ultrafast carrier dynamics and terahertz radiation generation in GaAs
The carrier dynamics of photoexcited electrons in the vicinity of the surface
of (NH4)2S-passivated GaAs were studied via terahertz (THz) emission
spectroscopy and optical-pump THz-probe spectroscopy. THz emission spectroscopy
measurements, coupled with Monte Carlo simulations of THz emission, revealed
that the surface electric field of GaAs reverses after passivation. The
conductivity of photoexcited electrons was determined via optical-pump
THz-probe spectroscopy, and was found to double after passivation. These
experiments demonstrate that passivation significantly reduces the surface
state density and surface recombination velocity of GaAs. Finally, we have
demonstrated that passivation leads to an enhancement in the power radiated by
photoconductive switch THz emitters, thereby showing the important influence of
surface chemistry on the performance of ultrafast THz photonic devices.Comment: 4 pages, 3 figures, to appear in Applied Physics Letter
Effect of various dopant elements on primary graphite growth
Five spheroidal graphite cast irons were investigated, a usual ferritic grade and four pearlitic alloys containing Cu and doped with Sb, Sn and Ti. These alloys were remelted in a graphite crucible, leading to volatilization of the magnesium added for spheroidization and to carbon saturation of the liquid. The alloys were then cooled down and maintained at a temperature above the eutectic temperature. During this step, primary graphite could develop showing various features depending on the doping elements added. The largest effects were that of Ti which greatly reduces graphite nucleation and growth, and that of Sb which leads to rounded agglomerates instead of lamellar graphite. The samples have been investigated with secondary ion mass spectrometry to enlighten distribution of elements in primary graphite. SIMS analysis showed almost even distribution of elements, including Mg and Al (from the inoculant) in the ferritic grade, while uneven distribution was evident in all doped alloys. Investigations are going on to clarify if the uneven distribution is associated with structural defects in the graphite precipitates
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Genome-wide analysis on Chlamydomonas reinhardtii reveals the impact of hydrogen peroxide on protein stress responses and overlap with other stress transcriptomes.
Reactive oxygen species (ROS) are produced by and have the potential to be damaging to all aerobic organisms. In photosynthetic organisms, they are an unavoidable byproduct of electron transfer in both the chloroplast and mitochondrion. Here, we employ the reference unicellular green alga Chlamydomonas reinhardtii to identify the effect of H2O2 on gene expression by monitoring the changes in the transcriptome in a time-course experiment. Comparison of transcriptomes from cells sampled immediately prior to the addition of H2O2 and 0.5 and 1 h subsequently revealed 1278 differentially abundant transcripts. Of those transcripts that increase in abundance, many encode proteins involved in ROS detoxification, protein degradation and stress responses, whereas among those that decrease are transcripts encoding proteins involved in photosynthesis and central carbon metabolism. In addition to these transcriptomic adjustments, we observe that addition of H2O2 is followed by an accumulation and oxidation of the total intracellular glutathione pool, and a decrease in photosynthetic O2 output. Additionally, we analyze our transcriptomes in the context of changes in transcript abundance in response to singlet O2 (O2*), and relate our H2O2 -induced transcripts to a diurnal transcriptome, where we demonstrate enrichments of H2O2 -induced transcripts early in the light phase, late in the light phase and 2 h prior to light. On this basis several genes that are highlighted in this work may be involved in previously undiscovered stress remediation pathways or acclimation responses
Activation of Autophagy by Metals in Chlamydomonas reinhardtii
Autophagy is an intracellular self-degradation pathway by which eukaryotic cells recycle their own material in response to specific stress conditions. Exposure to high concentrations of metals causes cell damage, although the effect of metal stress on autophagy has not been explored in photosynthetic organisms. In this study, we investigated the effect of metal excess on autophagy in the model unicellular green alga Chlamydomonas reinhardtii. We show in cells treated with nickel an upregulation of ATG8 that is independent of CRR1, a global regulator of copper signaling in Chlamydomonas. A similar effect on ATG8 was observed with copper and cobalt but not with cadmium or mercury ions. Transcriptome sequencing data revealed an increase in the abundance of the protein degradation machinery, including that responsible for autophagy, and a substantial overlap of that increased abundance with the hydrogen peroxide response in cells treated with nickel ions. Thus, our results indicate that metal stress triggers autophagy in Chlamydomonas and suggest that excess nickel may cause oxidative damage, which in turn activates degradative pathways, including autophagy, to clear impaired components and recover cellular homeostasisMinisterio de EconomĂa y Competitividad BFU2012-35913Junta de AndalucĂa CVI-7336National Institutes of Health GM42143, R24 GM09247
DNA nucleotide-specific modulation of \mu A transverse edge currents through a metallic graphene nanoribbon with a nanopore
We propose two-terminal devices for DNA sequencing which consist of a
metallic graphene nanoribbon with zigzag edges (ZGNR) and a nanopore in its
interior through which the DNA molecule is translocated. Using the
nonequilibrium Green functions combined with density functional theory, we
demonstrate that each of the four DNA nucleotides inserted into the nanopore,
whose edge carbon atoms are passivated by either hydrogen or nitrogen, will
lead to a unique change in the device conductance. Unlike other recent
biosensors based on transverse electronic transport through DNA nucleotides,
which utilize small (of the order of pA) tunneling current across a nanogap or
a nanopore yielding a poor signal-to-noise ratio, our device concept relies on
the fact that in ZGNRs local current density is peaked around the edges so that
drilling a nanopore away from the edges will not diminish the conductance.
Inserting a DNA nucleotide into the nanopore affects the charge density in the
surrounding area, thereby modulating edge conduction currents whose magnitude
is of the order of \mu A at bias voltage ~ 0.1 V. The proposed biosensor is not
limited to ZGNRs and it could be realized with other nanowires supporting
transverse edge currents, such as chiral GNRs or wires made of two-dimensional
topological insulators.Comment: 6 pages, 6 figures, PDFLaTe
COVID-19 publications: Database coverage, citations, readers, tweets, news, Facebook walls, Reddit posts
Š 2020 The Authors. Published by MIT Press. This is an open access article available under a Creative Commons licence.
The published version can be accessed at the following link on the publisherâs website: https://doi.org/10.1162/qss_a_00066The COVID-19 pandemic requires a fast response from researchers to help address biological,
medical and public health issues to minimize its impact. In this rapidly evolving context,
scholars, professionals and the public may need to quickly identify important new studies. In
response, this paper assesses the coverage of scholarly databases and impact indicators
during 21 March to 18 April 2020. The rapidly increasing volume of research, is particularly
accessible through Dimensions, and less through Scopus, the Web of Science, and PubMed.
Google Scholarâs results included many false matches. A few COVID-19 papers from the
21,395 in Dimensions were already highly cited, with substantial news and social media
attention. For this topic, in contrast to previous studies, there seems to be a high degree of
convergence between articles shared in the social web and citation counts, at least in the
short term. In particular, articles that are extensively tweeted on the day first indexed are
likely to be highly read and relatively highly cited three weeks later. Researchers needing wide
scope literature searches (rather than health focused PubMed or medRxiv searches) should
start with Dimensions (or Google Scholar) and can use tweet and Mendeley reader counts as
indicators of likely importance
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Effect of lead content on phase evolution and microstructural development in Ag-clad Bi-2223 composite conductors
A two powder process was used to prepare silver-sheathed monofilamentary Bi{sub 1.8}Pb{sub x}Sr{sub 1.98}Ca{sub 1.97}Cu{sub 3.08}O{sub y} (Bi-2223) tapes with varying lead contents, x, from 0.2 to 0.5. The resulting tapes were subjected to thermomechanical processing and then characterized by x-ray diffraction (XRD), scanning electron microscopy (SEM), and energy dispersive x-ray analysis (EDX). Layered phase texture was accessed using image analysis software on scanned SEM micrographs. Transport currents were measured at 77 K and zero field by the four-probe method. It was found that tapes with low lead content (X = 0.2 and 0.25) showed incomplete conversion to Bi-2223, had small grain size and poor c-axis texture. Tapes having higher lead content (x = 0.4 and 0.5) also showed incomplete conversion and the presence of lead-rich secondary phases. Tapes with lead content x = 0.3 and 0.35 showed complete conversion to Bi-2223, and had the least amount of secondary phases, the best c-axis texture, and the highest transport current (j{sub c}). The carbon content of the precursor powder also had a strong influence on secondary-phase chemistry
Rare coding SNP in DZIP1 gene associated with late-onset sporadic Parkinson's disease
We present the first application of the hypothesis-rich mathematical theory
to genome-wide association data. The Hamza et al. late-onset sporadic
Parkinson's disease genome-wide association study dataset was analyzed. We
found a rare, coding, non-synonymous SNP variant in the gene DZIP1 that confers
increased susceptibility to Parkinson's disease. The association of DZIP1 with
Parkinson's disease is consistent with a Parkinson's disease stem-cell ageing
theory.Comment: 14 page
Organizing Shared Digital Reading in Groups: Optimizing the Affordances of Text and Medium
Children develop their language when they explore and talk about literary texts. In this study, we explore the design of shared digital reading as a basis for critical reflection on the reading situation in an institutional context with its given opportunities and limitations. We examine six videotaped readings of one specific picture book app, with a focus on the strategies used by teachers in early childhood education and care institutions to control childrenâs access to the medium and the types of verbal engagement (about the story and about the medium) that are generated by these different strategies. We use qualitative and quantitative analysis of video data. A qualitative categorization of the readings reveals the strategies Show, Show & Share, and Share. In analyzing the participantsâ verbal and multisensory engagement, we find that the Show strategy generates more utterances, especially about the story, as well as more time spent on dialogue.publishedVersio
Metabolomics demonstrates divergent responses of two Eucalyptus species to water stress
Past studies of water stress in Eucalyptus spp. generally highlighted the role of fewer than five âimportantâ metabolites, whereas recent metabolomic studies on other genera have shown tens of compounds are affected. There are currently no metabolite profiling data for responses of stress-tolerant species to water stress. We used GCâMS metabolite profiling to examine the response of leaf metabolites to a long (2 month) and severe (Ψpredawn < â2 MPa) water stress in two species of the perennial tree genus Eucalyptus (the mesic Eucalyptus pauciflora and the semi-arid Eucalyptus dumosa). Polar metabolites in leaves were analysed by GCâMS and inorganic ions by capillary electrophoresis. Pressureâvolume curves and metabolite measurements showed that water stress led to more negative osmotic potential and increased total osmotically active solutes in leaves of both species. Water stress affected around 30â40% of measured metabolites in E. dumosa and 10â15% in E. pauciflora. There were many metabolites that were affected in E. dumosa but not E. pauciflora, and some that had opposite responses in the two species. For example, in E. dumosa there were increases in five acyclic sugar alcohols and four low-abundance carbohydrates that were unaffected by water stress in E. pauciflora. Re-watering increased osmotic potential and decreased total osmotically active solutes in E. pauciflora, whereas in E. dumosa re-watering led to further decreases in osmotic potential and increases in total osmotically active solutes. This experiment has added several extra dimensions to previous targeted analyses of water stress responses in Eucalyptus, and highlights that even species that are closely related (e.g. congeners) may respond differently to water stress and re-waterin
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