We present the first application of the hypothesis-rich mathematical theory
to genome-wide association data. The Hamza et al. late-onset sporadic
Parkinson's disease genome-wide association study dataset was analyzed. We
found a rare, coding, non-synonymous SNP variant in the gene DZIP1 that confers
increased susceptibility to Parkinson's disease. The association of DZIP1 with
Parkinson's disease is consistent with a Parkinson's disease stem-cell ageing
theory.Comment: 14 page

A Lerner

A Ruepp

AA Merchant

AM Glazer

B Bakir-Gungor

B Dass

C Wolff

CB Do

CH Hawkes

D Subramaniam

DAD Monte

DI Chasman

E Eskin

FL Moore

H-C Fung

HR Kim

J Simón-Sánchez

K Lai

K Roeder

K Sekimizu

K Tsuboi

L Lum

LA Hindorff

LM Bekris

M Bak

M Plaisant

M Saad

M-X Li

N Miao

O Bragina

P Mill

P Whitton

PA Beachy

PW Ingham

RE Lamont

S Purcell

SM Chambers

SY Tay

TA Manolio

TH Hamza

TL Edwards

TS Keshava Prasad

V Palma

VF Rafuse

W Satake

Y Katoh

Scientific Reports

English

arXiv

An association between a rare, coding, non-synonymous SNP variant in the gene DZIP1 and Parkinson's disease was found, based on an analysis of the existing NGRC genome-wide association study dataset. The statistical analysis utilized the hypothesis-rich, targeted search unbiased assessment approach, rather than the hypothesis-free, genome-wide agnostic search paradigm. The association of DZIP1 with Parkinson's disease is discussed in the context of a Parkinson's disease stem-cell ageing theory

Valente, André X. C. N.

Shin, Joo H.

Sarkar, Abhijit

Gao, Yuan

Estudo Geral

Rare coding SNP in DZIP1 gene associated with late-onset sporadic Parkinson's disease

André X. C. N. Valente

Joo H. Shin

Abhijit Sarkar

Yuan Gao

Crossref

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Wehavereportedanon-synonymousSNPintheDZIP1genethat confers increased susceptibility to PD. We emphasize that this result is based on a single population cohort of mixed European ancestry, the Hamza et al. dataset

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3277088

Rare coding SNP in DZIP1 gene associated with late-onset sporadic
  Parkinson's disease

Rare coding SNP in DZIP1 gene associated with late-onset sporadic Parkinson's disease

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