Electrical Impedance of Surface Modified Porous Titanium Implants with Femtosecond Laser

The chemical composition and surface topography of titanium implants are essential to improve implant osseointegration. The present work studies a non-invasive alternative of electrical impedance spectroscopy for the characterization of the macroporosity inherent to the manufacturing process and the effect of the surface treatment with femtosecond laser of titanium discs. Osteoblasts cell culture growths on the titanium surfaces of the laser-treated discs were also studied with this method. The measurements obtained showed that the femtosecond laser treatment of the samples and cell culture produced a significant increase (around 50%) in the absolute value of the electrical impedance module, which could be characterized in a wide range of frequencies (being more relevant at 500 MHz). Results have revealed the potential of this measurement technique, in terms of advantages, in comparison to tiresome and expensive techniques, allowing semi-quantitatively relating impedance measurements to porosity content, as well as detecting the effect of surface modification, generated by laser treatment and cell culture.Ministry of Science and Innovation of Spain grant PID2019-109371GB-I00Junta de Andalucía–FEDER (Spain) Project US-1259771Junta de Andalucía-Proyecto de Excelencia (Spain) P18-FR-203

Formación de líderes juveniles en Cuba: una propuesta estratégica para la política de cuadros

training management becomes the levels of development: initiation, application, demonstration, systematization, consolidation and demonstration of managerial suitability. This should generate a process of promotion to the position in a natural way. The article proposes a strategy for the integrated training management of youth leadership cadres, which generates seedbeds of leaders from an early age, which is the objective of the article. The type of research is qualitative, for which surveys, document review and participant observation were carried out. As a result, it was confirmed that the training of leading managers from the proposed strategy can constitute a viable alternative for the coherent and objective development of the processes of recruitment, selection, promotion, training and improvement of cadres in compliance with the cadre policy. established in Cuba. ​Una dinámica sistematizada de la relación formación de líderes – superación de cuadros – gestión formativa integrada deviene en los niveles de desarrollo: iniciación, aplicación, demostración, sistematización, consolidación y demostración de idoneidad directiva. Ello debe generar un proceso de promoción al cargo de manera natural. El artículo propone una estrategia para la gestión formativa integrada de cuadros líderes juveniles, que genere semilleros de líderes desde edades tempranas, lo que constituye el objetivo del artículo. El tipo de investigación es cualitativa, para lo cual se realizaron encuestas, revisión de documentos y observación participante. Como resultado se corroboró que la formación de directivos líderes desde la estrategia que se propone puede constituir una alternativa viable para el desarrollo coherente y objetivo de los procesos de reclutamiento, selección, promoción, formación y superación de los cuadros en cumplimiento de la política de cuadros establecida en Cub

Perceived parental rearing styles in eating disorders

El objetivo ha sido poner a prueba un modelo estructural para determinar cómo pueden estar afectando los estilos de crianza percibidos al desarrollo personal y emocional, así como a la aparición de conductas directamente relacionadas con los trastornos de la conducta alimentaria (TCA). La muestra estuvo formada por 168 mujeres con criterios diagnósticos para alguno de los tipos de TCA. El modelo estimado se ajustó satisfactoriamente. Los resultados muestran que la calidez emocional percibida del padre desempeña un importante papel frente a la percepción de rechazo de la madre, en el desarrollo personal y emocional, así como en la aparición de conductas relacionadas con los TCA. Además, se comprueba la relevancia de las variables personales y emocionales para el desarrollo de los TCA, en especial de la baja autoestima, más allá de la influencia directa de los estilos de crianza parentales, percibidos como disfuncionales.The aim of this study was to test a structural model designed to determine how perceived parenting styles may, in women with eating disorders (ED), affect their personal development and the emotional disturbances they experience, and also to explore how these styles may influence the emergence of behaviors directly related to ED. EMBU, BSQ, EAT-40, EDI-2, BDI, STAI, and BITE were administered to 168 women with some type of ED. The estimated model showed a satisfactory fit. The results show that perceived emotional warmth in the father plays an important role in mitigating perceived rejection by the mother. The analysis also highlights the relevance of personal and emotional variables, particularly low self-esteem, in the development of ED, above and beyond the direct influence of parental rearing styles that are perceived as dysfunctional

Titanocene–gold complexes containing N-heterocyclic carbene ligands inhibit growth of prostate, renal, and colon cancers in vitro

We report on the synthesis, characterization, and stability studies of new titanocene complexes containing a methyl group and a carboxylate ligand (mba = −OC(O)-p-C6H4-S−) bound to gold(I)−N-heterocyclic carbene fragments through the thiolate group: [(η5 -C5H5)2TiMe(μ-mba)Au(NHC)]. The cytotoxicities of the heterometallic compounds along with those of novel monometallic gold−N-heterocyclic carbene precursors [(NHC)Au(mbaH)] have been evaluated against renal, prostate, colon, and breast cancer cell lines. The highest activity and selectivity and a synergistic effect of the resulting heterometallic species was found for the prostate and colon cancer cell lines. The colocalization of both titanium and gold metals (1:1 ratio) in PC3 prostate cancer cells was demonstrated for the selected compound 5a, indicating the robustness of the heterometallic compound in vitro. We describe here preliminary mechanistic data involving studies on the interaction of selected mono- and bimetallic compounds with plasmid (pBR322) used as a model nucleic acid and the inhibition of thioredoxin reductase in PC3 prostate cancer cells. The heterometallic compounds, which are highly apoptotic, exhibit strong antimigratory effects on the prostate cancer cell line PC3

Manual de procedimientos del sistema de gestión de la calidad por procesos en una universidad

The quality management systems in higher education based on the ISO 9001:2015 standard, integrated with the requirements of Internal Control and the National Accreditation Board constitutes a Strategy adopted by Higher School of State and Government Cadres (ESCEG) for the fulfillment of its mission. The article aims to present the design of the Procedures Manual of the ESCEG Quality Management System, based on four stages, referring to the theoretical referential framework, the integral diagnosis with a focus on processes and risks, the design of the Manual, aligned to the strategic objectives, compliance with regulations and requirements, as well as the control and improvement of the procedures for the fulfillment of the goals of the indicators outlined in the strategic projection of the university.Los sistemas de gestión de la calidad en la educación superior basados en la norma ISO 9001:2015, integrados a los requerimientos del Control Interno y de la Junta de Acreditación Nacional constituye una Estrategia adoptada por la Escuela Superior de Cuadros del Estado y del Gobierno (ESCEG) para el cumplimiento de su misión. El artículo tiene como objetivo exponer el diseño del Manual de Procedimientos del Sistema de Gestión de la Calidad de la ESCEG, basado en cuatro etapas, referidas al marco teórico referencial, el diagnóstico integral con enfoque a procesos y a riesgos, el diseño del Manual, alineado a los objetivos estratégicos, el cumplimiento de las normativas y requerimientos, así como el control y la mejora de los procedimientos para el cumplimiento de las metas de los indicadores trazados en la proyección estratégica de la universidad

DC electrical stimulation enhances proliferation and differentiation on N2a and MC3T3 cell lines

Background: Electrical stimulation is a novel tool to promote the differentiation and proliferation of precursor cells. In this work we have studied the effects of direct current (DC) electrical stimulation on neuroblastoma (N2a) and osteoblast (MC3T3) cell lines as a model for nervous and bone tissue regeneration, respectively. We have developed the electronics and encapsulation of a proposed stimulation system and designed a setup and protocol to stimulate cell cultures. Methods: Cell cultures were subjected to several assays to assess the effects of electrical stimulation on them. N2a cells were analyzed using microscope images and an inmunofluorescence assay, differentiated cells were counted and neurites were measured. MC3T3 cells were subjected to an AlamarBlue assay for viability, ALP activity was measured, and a real time PCR was carried out. Results: Our results show that electrically stimulated cells had more tendency to differentiate in both cell lines when compared to non-stimulated cultures, paired with a promotion of neurite growth and polarization in N2a cells and an increase in proliferation in MC3T3 cell line. Conclusions: These results prove the effectiveness of electrical stimulation as a tool for tissue engineering and regenerative medicine, both for neural and bone injuries. Bone progenitor cells submitted to electrical stimulation have a higher tendency to differentiate and proliferate, filling the gaps present in injuries. On the other hand, neuronal progenitor cells differentiate, and their neurites can be polarized to follow the electric field applied.Universidad de Sevilla US-1380661Junta de Andalucía P18-FR-2038. 2020–202

Worldwide impact of economic cycles on suicide trends over 3 decades: Differences according to level of development. A mixed effect model study

Objectives: To investigate the trends and correlations of gross domestic product (GDP) adjusted for purchasing power parity (PPP) per capita on suicide rates in 10 WHO regions during the past 30 years. Design: Analyses of databases of PPP-adjusted GDP per capita and suicide rates. Countries were grouped according to the Global Burden of Disease regional classification system. Data sources: World Bank’s official website and WHO’s mortality database. Statistical analyses: After graphically displaying PPP-adjusted GDP per capita and suicide rates, mixed effect models were used for representing and analysing clustered data. Results: Three different groups of countries, based on the correlation between the PPP-adjusted GDP per capita and suicide rates, are reported: (1) positive correlation: developing (lower middle and upper middle income) Latin-American and Caribbean countries, developing countries in the South East Asian Region including India, some countries in the Western Pacific Region (such as China and South Korea) and high-income Asian countries, including Japan; (2) negative correlation: high-income and developing European countries, Canada, Australia and New Zealand and (3) no correlation was found in an African country. Conclusions: PPP-adjusted GDP per capita may offer a simple measure for designing the type of preventive interventions aimed at lowering suicide rates that can be used across countries. Public health interventions might be more suitable for developing countries. In high-income countries, however, preventive measures based on the medical model might prove more usefulAll authors have completed the Unified Competing Interest form. Dr. Blasco-Fontecilla acknowledges the Spanish Ministry of Health (Rio Hortega CMO8/00170; SAF2010-21849), Alicia Koplowitz Foundation and Conchita Rabago Foundation for funding his post-doctoral stage at CHRU, Montpellier, France

Preocupación por la apariencia física y alteraciones emocionales en mujeres con trastornos alimentarios con autoestima baja

The aim of the present study was to investigate differences in age, nutritional state (Body Mass Index or BMI), anxiety, depression and body dissatisfaction in eating disorder (ED) patients with low, medium and high self-esteem. We also attempted to identify discrepancies between the real and desired nutritional state. A total of 146 women with EDs (anorexia nervosa and bulimia nervosa; DSM-IV-TR criteria) were evaluated. The Body Shape Questionnaire (BSQ), Hospital Anxiety and Depression Scale (HADS) and Rosenberg Self-Esteem Scale (RSES) were used as measure-ment instruments. The results showed significant differences between the low, medium and high self-esteem patients regarding anxiety, depression, body dissatisfaction, desired BMI and the relationship between real and desired BMI. The women with low self-esteem presented higher levels of anxiety, depression and body dissatisfaction than the other groups. Furthermore, ED patients with low self-esteem have a stronger desire to achieve their ideal BMI. We suggest including self-esteem techniques in ED prevention and treatment programs in order to decrease anxiety and depression symptoms.El objetivo del presente estudio fue investigar las diferencias de edad, estado nutricional (Índice de Masa Corporal o IMC), ansiedad, depresión e insatisfacción corporal en pacientes con trastornos de la conducta alimentaria (TCA.), con una autoestima baja, media y alta. Además, intentamos distinguir las discrepancias entre el estado nutricional real y el estado nutricional deseado. Se evaluaron un total de 146 mujeres con TCA (Anorexia nerviosa y Bulimia nerviosa según el DSM-IV-TR). Los cuestionarios utilizados fueron el Body Shape Questionnaire (BSQ), el Hospital Anxiety and Depression Scale (HADS) y la Rosenberg Self-Esteem Scale (RSES). Los resultados reflejan diferencias significativas entre los tres subtipos de pacientes de baja, media y alta autoestima en cuanto a la ansiedad, depresión, insatisfacción corporal, IMC deseado y la relación dentro de IMC real y el IMC deseado. Estos hallazgos indican que las mujeres de baja autoestima presentan altos niveles en insatisfacción corporal, ansiedad y depresión en comparación con los otros grupos. Además, los pacientes con TCA con baja autoestima mostraban un mayor IMC deseado. Sugerimos que se incluyan técnicas de autoestima en la prevención y el tratamiento relacionados con programas de TCA para disminuir los síntomas de ansiedad y depresión

Global Entrepreneurship Monitor. Provincia de Córdoba. Informe 2020/21

El Global Entrepreneruship Monitor de la provincia de Córdoba es un informe sobre el estado del emprendimiento en la provincia que usa una metodología internacional y consistente en el tiempo y que permite, por lo tanto, realizar comparaciones entre diferentes ecosistemas de emprendimiento a nivel regional, nacional e internacional