What's the best drug treatment for premature ejaculation?

Antidepressants--specifically clomipramine, fluoxetine, paroxetine, and sertraline--are best and have been shown to improve symptoms of premature ejaculation (strength of recommendation [SOR]: A, meta-analysis of randomized controlled trials [RCTs]). The topical application of prilocaine-lidocaine cream (trade name EMLA) improves intravaginal ejaculatory latency time (IELT), but penile numbness and loss of erection may occur (SOR: B, based on several small RCTs)

Foreign aid from a new perspective: a conversation with Dr. S.S. Regilme

History and International Relation

Recursos florales usados por dos especies de Bombus en un fragmento de bosque subandino (Pamplonita-Colombia)

It is present the results of a palynological analysis of two species of the genus Bombus in vicinity of Pamplonita-Norte of Santander. On feces samples were identified and counted (april and may of 2010) 1585 grains of pollen, within which Solanaceae, Asteraceae, Malvaceae and Fabaceae were the more abundat taxa. With regard to the diversity, April was the most rich, diverse and dominant month; however in B. pullatus we observed greater wealth and dominance. Finally, it was possible to determine that a large percentage of pollen grains that were identified as Solanaceae correspond to Solanum quitoense. The results of this study make clear the importance of palynology at the time of establishing the diet of these species, in addition to reflect its role of those species as possible provider in ecosistemic services either in wild plant as a crops in Solanaceae case.Se presentan los resultados de un análisis palinológico en dos especies del género Bombus en cercanías de Pamplonita (Norte de Santander-Colombia) durante los meses de abril y mayo de 2010. A partir de muestras coprológicas se identificaron y contaron un total de 1585 granos, dentro de los cuales Solanaceae, Asteraceae, Malvaceae y Fabaceae fueron los taxa mas abundantes. En términos de diversidad, en abril se encontraron los valores más altos con respecto a los tipos de polen para ambas especies, aunque en B. pullatus, se observó mayor riqueza y dominancia para ambos meses. Finalmente, se puedo determinar un gran porcentaje de los granos de polen que se identificación en Solanaceae corresponden a Solanum quitoense. Los resultados presentados en este estudio dejan claro la importancia de la palinología al momento de establecer la dieta de estos organismos, además de reflejar el papel de estas especies como posible prestador de servicios ecosistemicos tanto en plantas silvestres como cultivadas en el caso de Solanum

Weak charge form factor and radius of 208Pb through parity violation in electron scattering

We use distorted wave electron scattering calculations to extract the weak charge form factor F_W(q), the weak charge radius R_W, and the point neutron radius R_n, of 208Pb from the PREX parity violating asymmetry measurement. The form factor is the Fourier transform of the weak charge density at the average momentum transfer q=0.475 fm$^{-1}$. We find F_W(q) =0.204 \pm 0.028 (exp) \pm 0.001 (model). We use the Helm model to infer the weak radius from F_W(q). We find R_W= 5.826 \pm 0.181 (exp) \pm 0.027 (model) fm. Here the exp error includes PREX statistical and systematic errors, while the model error describes the uncertainty in R_W from uncertainties in the surface thickness \sigma of the weak charge density. The weak radius is larger than the charge radius, implying a "weak charge skin" where the surface region is relatively enriched in weak charges compared to (electromagnetic) charges. We extract the point neutron radius R_n=5.751 \pm 0.175 (exp) \pm 0.026 (model) \pm 0.005 (strange) fm$, from R_W. Here there is only a very small error (strange) from possible strange quark contributions. We find R_n to be slightly smaller than R_W because of the nucleon's size. Finally, we find a neutron skin thickness of R_n-R_p=0.302\pm 0.175 (exp) \pm 0.026 (model) \pm 0.005 (strange) fm, where R_p is the point proton radius.Comment: 5 pages, 1 figure, published in Phys Rev. C. Only one change in this version: we have added one author, also to metadat

Homology Modeling of Leishmanolysin (gp63) from Leishmania panamensis and Molecular Docking of Flavonoids

Leishmaniasis is a chronic disease caused by protozoa of the distinct Leishmania genus transmitted by sandflies of the genus Phlebotomus (old world) and Lutzomyia (new world). Among the molecular factors that contribute to the virulence and pathogenesis of Leishmania are metalloproteases, e.g., glycoprotein 63 (gp63), also known as leishmanolysin or major surface protease (MSP). This protease is a zinc-dependent metalloprotease that is found on the surface of the parasite, abundant in Leishmania promastigote and amastigote. This study describes the prediction of three-dimensional (3D) structures of leishmanolysin (UniProt ID A0A088RJX7) of Leishmania panamensis employing a homology modeling approach. The 3D structure prediction was performed using the SWISS-MODEL web server. The tools PROCHECK, Molprobyty, and Verify3D were used to check the quality of the model, indicating that they are reliable. Best docking configurations were identified applying AutoDock Vina in PyRx 0.8 to obtain a potential antileishmanial activity. Biflavonoids such as lanaroflavone, podocarpusflavone A, amentoflavone, and podocarpusflavone B showed good scores among these molecules. Lanaroflavone appears to be the most suitable compound from binding affinity calculations

Incidencia de microorganismos mesófilos en la producción del agua de bebida envasada

With the purpose, of determining the likely incidence of mesophilic microorganisms on bottled drinking-water (BDW), the most relevant factors involved in the water production were analyzed. In order to determine the quality, water was stored in several different containers (polycarbonate, glass, high-density polyethylene (HDP), low-density polyethylene (LDP), and polyethylene-coextruded polypropilene (PCP) containers), and subsequently total counts were analysed for mesophilic microorganisms and the most likely number for total coliforms and Pseudomona aeruginosa. The best results were achieved by using glass-containers. Subsequently the treatment of water (chlorination-ozonisation) was compared by using two types of containers (LDP and PCP) so as to determine which material and treatment best kept best the organoleptic and physicochemical features, as well as causing the lowest incidence of mesophilic microorganism during the span of product storage. The most adequate container turned out to be that made from 2.5 gauge PCP with 0.6 ppm chlorine treatment It was also concluded that bacterial growth was more an additional by-product of storage and typeof container since our sampling of the production methods showed that at al1 times the water was drinkable. Lastly, a tasting panel was held where 80% of the tasters selected chose the PCP.Con el fin de determinar una posible incidencia de microorganismos mesófilos en la producción del agua de bebida envasada, se analizaron los factores más importantes implicados en la producción. Para determinar la calidad del agua, se almacenó en diferentes tipos de envases (policarbonato, vidrio, polietileno de alta densidad (PAD), polietileno de baja densidad (PBD) y polipropileno coextruído con polietileno (PCP), y posteriormente se realizaron recuentos totales para microorganismos mesófilos y número más probable paracoliformes totales y Pseudomona aeruginosa obteniéndose menores recuentos en el agua envasada  en vidrio. Posteriormente, se compararon los tratamientos de descontaminación del agua (cloraciónozonización) utilizando dos tipos de envase (PBD y PCP), para determinar el material y tratamiento que conservan mejor las características organolépticas-fisicoquimicas y la menor incidencia de microorganismos mesófilos durante el tiempo de almacenamiento del producto. El envase más adecuado es el de PCP de calibre 2,5 con el tratamiento de cloro 0,6 pm; también se demostró que el crecimiento bacteria no fue un producto más del almacenamiento y el tipo de envase, ya que al realizar el muestre0 de los sistemas de producción, el agua fue siempre potable. Finalmente, se realizó un panel de saboreo, obteniéndose una preferencia del 80% de los encuestados, hacia el envase de PCP con el tratamiento de cloro

EUNOIA

EUNOIA started in February 2020 with strategic plans in starting up a business. It aimed to create a product that is affordable, innovative, eco-friendly, and unique. It belonged to the accessory/bag industry. Eunoia offers tote bags for only 518 Pesos; when accessories are added, it is 618 Pesos (Power-bank included) or 678 Pesos (Alcohol Mist included). The accessories can be sold separately at 100 Pesos and 150 Pesos, respectively.EUNOIA’s product diversification, Calla Lily, is being sold for only 99 Pesos, using the vast digital platform and aims to support environmental and mental health awareness. It operated using sole proprietorship to let everyone work latest: John Benedict Young II as the Owner, John Eliquiel Jose Austria as the Operations Head, Emjel Mercado as the Marketing Head with Catherine Calixtro as the Marketing Officer and Quality Control Head, Katriel Santos as the Finance Head, and John Matthew Hilbero as the Human Resource Head. The market is vast as it is in Digital Marketing. The main competitors of EUNOIA are the 20 groups in the ABM Department. All of the total investment came from EUNOIA\u27s parents and, as of now, is at ₱ 36,000.00. EUNOIA’s expenses amounted to ₱ 71,776.50 as of March 15, 2021

A global Carleman estimate in a transmission wave equation and application to a one-measurement inverse problem

We consider a transmission wave equation in two embedded domains in $R^2$, where the speed is $a1 > 0$ in the inner domain and $a2 > 0$ in the outer domain. We prove a global Carleman inequality for this problem under the hypothesis that the inner domain is strictly convex and $a1 > a2$ . As a consequence of this inequality, uniqueness and Lip- schitz stability are obtained for the inverse problem of retrieving a stationary potential for the wave equation with Dirichlet data and discontinuous principal coefficient from a single time-dependent Neumann boundary measurement

Short-term antigen presentation and single clonal burst limit the magnitude of the CD8(+) T cell responses to malaria liver stages.

Malaria sporozoites induce swift activation of antigen-specific CD8(+) T cells that inhibit the intracellular development of liver-stage parasites. The length of time of functional in vivo antigen presentation, estimated by monitoring the activation of antigen-specific CD8(+) T cells, is of short duration, with maximum T cell activation occurring within the first 8 h after immunization and lasting approximately 48 h. Although the magnitude of the CD8(+) T cell response closely correlates with the number of parasites used for immunization, increasing the time of antigen presentation by daily immunizations does not enhance the magnitude of this response. Thus, once a primary clonal burst is established, the CD8(+) T cell response becomes refractory or unresponsive to further antigenic stimulation. These findings strongly suggest that the most efficient strategy for the induction of primary CD8(+) T cell responses is the delivery of a maximal amount of antigen in a single dose, thereby ensuring a clonal burst that involves the largest number of precursors to become memory cells