Elementos de derecho natural : El derecho en la vida. Derecho privado

Obra que además de abordas temas como el Derecho Natural y la Filosofía del Derecho, trata la conducta humana en general y las leyes que la rigen, intentando comprender así la conducta y las leyes relativas al orden jurídico.Obra que además de abordas temas como el Derecho Natural y la Filosofía del Derecho, trata la conducta humana en general y las leyes que la rigen, intentando comprender así la conducta y las leyes relativas al orden jurídico

Los obreros, los propietarios y los holgazanes ante la justicia social / conferencia... Luis Mendizábal y Martín

Sesión del día 5 de marzo de 1920Copia Digital : Real Academia de Jurisprudencia y Legislación, 201

Cognitive impairment induced by delta9-tetrahydrocannabinol occurs through heteromers between cannabinoid CB1 and serotonin 5-HT2A receptors

Delta-9-tetrahydrocannabinol (THC), the main psychoactive compound of marijuana, induces numerous undesirable effects, including memory impairments, anxiety, and dependence. Conversely, THC also has potentially therapeutic effects, including analgesia, muscle relaxation, and neuroprotection. However, the mechanisms that dissociate these responses are still not known. Using mice lacking the serotonin receptor 5-HT2A, we revealed that the analgesic and amnesic effects of THC are independent of each other: while amnesia induced by THC disappears in the mutant mice, THC can still promote analgesia in these animals. In subsequent molecular studies, we showed that in specific brain regions involved in memory formation, the receptors for THC and the 5-HT2A receptors work together by physically interacting with each other. Experimentally interfering with this interaction prevented the memory deficits induced by THC, but not its analgesic properties. Our results highlight a novel mechanism by which the beneficial analgesic properties of THC can be dissociated from its cognitive side effects

Bioformulation of microbial biocontrol agents for a sustainable agriculture

The application of microbial based biopesticides has become a sustainable alternative to the use of chemicals to prevent yield losses due to plant pathogens. However, microbial based biopesticides are often unsuccessfully formulated and do not meet the demanding regulatory standards required by the agencies, which hinders their commercialization. Hence, an outline on the approaches to attain more effective formulations might be useful for the development of future more effective products. With this aim, this chapter reports the current state of biocontrol strategies and describes the principles of microbial biocontrol formulations. Emphasis is placed on techniques and tools available for the development and characterisation of microbial products. To provide glimpses on the possible formulations, the different existing additives, carriers, inoculation techniques and formulation types are exhaustively reviewed. Finally, requirements and principles for efficacy evaluation of plant protection products in the European Union are include

Dipstick Test for Rapid Diagnosis of Shigella dysenteriae 1 in Bacterial Cultures and Its Potential Use on Stool Samples

International audienceBACKGROUND: We describe a test for rapid detection of S. dysenteriae 1 in bacterial cultures and in stools, at the bedside of patients. METHODOLOGY/PRINCIPAL FINDINGS: The test is based on the detection of S. dysenteriae 1 lipopolysaccharide (LPS) using serotype 1-specific monoclonal antibodies coupled to gold particles and displayed on a one-step immunochromatographic dipstick. A concentration as low as 15 ng/ml of LPS was detected in distilled water and in reconstituted stools in 10 minutes. In distilled water and in reconstituted stools, an unequivocal positive reaction was obtained with 1.6×10⁶ CFU/ml and 4.9×10⁶ CFU/ml of S. dysenteriae 1, respectively. Optimal conditions to read the test have been determined to limit the risk of ambiguous results due to appearance of a faint yellow test band in some negative samples. The specificity was 100% when tested with a battery of Shigella and unrelated strains in culture. When tested on 328 clinical samples in India, Vietnam, Senegal and France by laboratory technicians and in Democratic Republic of Congo by a field technician, the specificity (312/316) was 98.7% (95% CI:96.6-99.6%) and the sensitivity (11/12) was 91.7% (95% CI:59.8-99.6%). Stool cultures and the immunochromatographic test showed concordant results in 98.4 % of cases (323/328) in comparative studies. Positive and negative predictive values were 73.3% (95% CI:44.8-91.1%) and 99.7% (95% CI:98-100%). CONCLUSION: The initial findings presented here for a simple dipstick-based test to diagnose S. dysenteriae 1 demonstrates its promising potential to become a powerful tool for case management and epidemiological surveys

Elementos de derecho natural : Principios de moral y Teoría general de derecho

Obra que además de abordas temas como el Derecho Natural y la Filosofía del Derecho, trata la conducta humana en general y las leyes que la rigen, intentando comprender así la conducta y las leyes relativas al orden jurídico.Obra que además de abordas temas como el Derecho Natural y la Filosofía del Derecho, trata la conducta humana en general y las leyes que la rigen, intentando comprender así la conducta y las leyes relativas al orden jurídico

Informe dado á las Cortes por el Secretario de Estado y del Despacho de Hacienda sobre si es o no conveniente reunir las funciones de los intendentes a las de los gefes politicos y las de los tesoreros a las de los administradores de las provincias

Obra perteneciente al Fondo Antiguo de la Biblioteca de la USA

Manifestación hecha a las Cortes por el Secretario del Despacho de Hacienda sobre el pago del semestre de intereses de la Deuda Extranjera que vence el 1º de Noviembre de este año

Copia digital. Madrid : Ministerio de Cultura. Subdirección General de Coordinación Bibliotecaria, 200