26 research outputs found
Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries.
- Author
- Ab Majid MA
- Ab Rahman AS
- Ab Rahman R
- Abayasinghe C
- Abbott T
- Abdullah NH
- Abdur-Rahman L
- Abeloos J
- Abernethy C
- Abidin UN
- Abrunhosa A
- Absar M
- Adam S
- Adams D
- Adams G
- Adamson M
- Adekola O
- Adelaja Y
- Ademola A
- Adenekan A
- Adenike O
- Adeolu AA
- Adetoye A
- Adewale B
- Adigun T
- Adolfsson A
- Aflori L
- Africander C
- Afshari A
- Agarwal V
- Agodirin O
- Aguero Vera M
- Aguzzoli C
- Ahmad A
- Ahmad N
- Ahmad T
- Ahmad T
- Ahmad Y
- Ahmed A
- Ahmed J
- Ai Y
- Aignatoaie M
- Aimoniotou-Georgiou E
- Akanmu O
- Akerman N
- Akinwale M
- Akring I
- Al 'Amri K
- Al Anizi M
- Al hussaini S
- Al-Soudaine Y
- Aladin H
- Alagbe-Briggs O
- Alaman Laguarda G
- Albaj S
- Alcock D
- Alcock L
- Aldecoa C
- Aldecoa C
- Aleixo FB
- Alexander H
- Alexander M
- Alexander-Sefre F
- Alherz F
- Ali H
- Ali M
- Ali S
- Alias A
- Alias AH
- Alias RLR
- Alit MA
- Allen S
- Allen SJ
- Allison J
- Alloj C
- Allorto NL
- Allsop J
- Almeida W
- Alonso E
- Alphonsus C
- Alvares D
- Alves MJ
- Amador JCB
- Ameer Y
- Amendola CP
- Ami N
- Amstrup-Hansen L
- Anagnou A
- Andersen C
- Anderson C
- Anderson C
- Anderson F
- Anderson P
- Andreadaki E
- Andreou A
- Andreou P
- Andrew A
- Andrews E
- Angermair S
- Angus K
- Anillo V
- Antal O
- Antill P
- Antoniadou E
- Antonina W
- Apagaki E
- Apostolou K
- Applewhaite C
- Aquino LPG
- Ar P
- Arawwawala D
- Ardern D
- Argue R
- Arkalaki E
- Armaganidis A
- Armstrong J
- Armstrong R
- Arnaoutoglou C
- Arnaoutoglou E
- Arnold G
- Arrandale L
- Arrich J
- Arrigo M
- Arshad H
- Arshad MA
- Arumugam S
- Arustei M
- Arvaniti K
- Arya A
- Arya S
- Asimakos A
- Asudo F
- Athanasakis E
- Atiku M
- Attrill E
- Attwood C
- Auer P
- Avidan M
- Avila Sanchez FJ
- Avila EJD
- Avis J
- Awad H
- Axioti E
- Ayyaz H
- Azam UAA
- Azambuja P
- Azevedo C
- Aziz FZ
- Baas P
- Baghirzada L
- Bai H-P
- Bai Y
- Baillie S
- Baines D
- Baio TH
- Bairaktari A
- Baker G
- Baker K-A
- Baker P
- Balain B
- Balaji P
- Balajonda N
- Balanescu A
- Balasubramaniam M
- Baldisserotto S
- Baldwin J
- Baldwin M
- Balfoussia D
- Bali C
- Bandeira ME
- Banerjee R
- Bankewitz C
- Banner-Goodspeed V
- Bao Q
- Barcraft-Barnes H
- Barneto L
- Barnett A
- Baroselli A
- Barraclough J
- Barras J-P
- Barrett S
- Barrett WJ
- Basanth S
- Batchelor N
- Bateman B
- Bates A
- Bates S
- Batista HD
- Bauchmuller K
- Bauer M
- Baumgarten G
- Baxter L
- Beaton C
- Beattie S
- Beavis V
- Bechan S
- Bejia T
- Belciu I
- Belda MT
- Bell G
- Bell R
- Bell S
- Bellandi M
- Bello J
- Beloeil H
- Belskiy V
- Ben-Menachem E
- Benavent P
- Benevento A
- Bengeri S
- Bennett C
- Bennett M
- Bennett R
- Bennett V
- Bentley C
- Beretta L
- Berg A
- Bergin C
- Bernard A
- Berntsen E
- Bertram W
- Bester D
- Bester M
- Bettega F
- Bettinelli A
- Bhardwaj N
- Bhatia K
- Bhula C
- Bi Y
- Biais M
- Biccard BM
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- Bidgoli J
- Biffen A
- Bignami E
- Bilolikar A
- Bin Mustapha MT
- Birch J
- Bishop DG
- Biyase T
- Bizios C
- Blackwell C
- Blackwood D
- Blaj M
- Blakemore SP
- Bland M
- Blunt M
- Blyth K
- Bocchino S
- Bodansky D
- Bodger P
- Boer C
- Boereboom C
- Boggiano V
- Bogner G
- Bolaji B
- Bolton D
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- Boschi L
- Boshier P
- Botes M
- Botis I
- Bottini C
- Bottrill F
- Bouchez S
- Boulton K
- Bouris V
- Bourner L
- Boutsikos G
- Bouwman A
- Bouwman RA
- Bowrey S
- Boxall L
- Boyd C
- Bradburn M
- Bradley J
- Branagan G
- Branco T
- Brand B
- Brandsborg B
- Breitenstein S
- Brennan A
- Brennan E
- Brenner L
- Brincat M
- Briscoe R
- Bristogiannis S
- Brooke J
- Brookes J
- Brookes M
- Brooks C
- Broomby R
- Brotto AF
- Brown A
- Brown CW
- Brown G
- Brown J
- Brown J
- Brown L
- Brown R
- Brown R
- Browning J
- Bruma D
- Brunete T
- Brunswicker A
- Bryant H
- Bua E
- Buccimazza I
- Buckley S
- Buerkle C
- Buhre W
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- Buhrer T
- Builu PM
- Buise M
- Bullock C
- Bunwarie B
- Burns K
- Burrows L
- Burrows T
- Burston B
- Burtenshaw A
- Burton M
- Busuioc M
- Butryn I
- Butt G
- Byrne K
- Cabezuelo E
- Cabral R
- Cabral TDN
- Cabrini L
- Cacala S
- Cai F
- Cai Y
- Cain H
- Cairns C
- Cakova V
- Calderwood C
- Callaghan M
- Campbell D
- Campbell D
- Campbell D
- Campbell G
- Campbell G
- Campbell K
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- Campbell T
- Campey L
- Camsooksai J
- Cancho D
- Candido K
- Cang J
- Cannavo M
- Cao J
- Cao Y
- Cao Z
- Cardellino S
- Cardosa J
- Cardoso G
- Cardy J
- Carmino L
- Carp CP
- Carr A
- Carrera R
- Carroll C
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- Caser E
- Castano Moreira B
- Castano B
- Castle G
- Cavanagh S
- Cawthorn L
- Cernea DD
- Chaddock M
- Chaloulis P
- Chan A
- Chan HMH
- Chan M
- Chan P
- Chan V
- Chan WK
- Chan WKJ
- Chan YL
- Chande S
- Chandler B
- Chandra S
- Chandrasekharan S
- Chang YH
- Chaniotaki F
- Charitos E
- Charlalampidoy A
- Charles R
- Chatterjee D
- Chatterjee J
- Chatzimichali CA
- Chau S
- Chazova E
- Cheah C
- Cheah S
- Cheeseman M
- Cheing Y
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- Chen C
- Chen F
- Chen F
- Chen H
- Chen J
- Chen J
- Chen L
- Chen L
- Chen L-L
- Chen P
- Chen Q
- Chen R
- Chen S
- Chen S
- Chen S
- Chen Y
- Chen Y
- Chen Y
- Chen Y
- Chen Z
- Cheng B
- Cheng KH
- Cheng Z
- Cheong E
- Cherian R
- Cherrett V
- Chetty RR
- Chew M
- Chhabra A
- Chicken D-W
- Chilinciuc I
- Chin II
- Chirkut S
- Chisbert Cuenca V
- Chlorou D
- Choi H-MD
- Choi S
- Chow L
- Christian R
- Christiansen IC
- Christmas N
- Christodoulidis G
- Christodoulopoulou T
- Christofaki M
- Christoforidis D
- Chronis C
- Chu HM
- Chu S
- Chua P
- Chukkambotla S
- Chung CKE
- Cifra E
- Ciobanu C
- Ciobotaru OR
- Cirstea E
- Clark R
- Clarkson A
- Clarkson R
- Claxton A
- Clemmons K
- Cloro LM
- Clyde A
- Cobzaru I
- Codita A
- Colangelo A
- Colangelo C
- Colling K
- Collins H
- Collins M
- Collins N
- Colvin C
- Commey T
- Comptaer N
- Conde C
- Conradie A
- Constantin K
- Cook T
- Cooper L
- Cooper L
- Cooper M
- Cooper R
- Cooper S
- Copaciu E
- Cope J
- Copetti E
- Copley E
- Copotoiu SM
- Coppens M
- Corneci D
- Cornell J
- Cornish J
- Correia da Silva RFM
- Corti D
- Costanzo E
- Costelloe H
- Cotter R
- Cotterell S
- Cotterill D
- Coughlan E
- Coulter I
- Coulter S
- Coutinho F
- Cowton A
- Cox H
- Cozar OI
- Craig J
- Craven R
- Craw N
- Craw S
- Creary T
- Cripps H
- Critchley R
- Cronje L
- Cruickshank R
- Cruikshanks A
- Cruz S
- Cueva A
- Cunha P
- Curley G
- Currow H
- Czepanski C
- Czeslick E
- D'Andrea R
- da Costa Fischer BF
- Dafnios N
- Dai H
- Dai Q
- Dai Q
- Dai SY
- Daikou P
- Dalamagka M
- Dalampini E
- Dali-Kemmery L
- Dalton E
- Damant R
- Daniel C
- Daniel GD
- Daniel H
- Daniel H
- Daniel S
- Dankl D
- Darko J
- Darwish S
- Das S
- Dasrath A
- Datson A
- Daubeny T
- Daugaard M
- Davari M
- Dave T
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- Daya B
- De Andres Ibanez JA
- de Araujo DM
- De Baerdemaeker L
- de Beer J
- de Boer HD
- De Bruyne A
- de Campos Ferreira MF
- de Fretes J
- de Gasperi J
- De Hert S
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- De Kegel D
- De Meyer JN
- De Oliveira MC
- de Rudnicki S
- de Swardt M
- de Vasconcellos K
- de Villiers M
- de Wet J
- Deacon M
- Deblaere I
- Dedemadi G
- Deen T
- Deepak S
- Deighton K
- Deja M
- Delgado Garcia DR
- Delgado Navarro C
- Della Rocca G
- Dempsey G
- Dempster A
- den Hoedt M
- Denham S
- Dent K
- Dermitzaki D
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- Despotidis V
- Diaconescu C
- Dias F
- Dias S
- Dickson J
- Ditai J
- Divatia J
- Dixon L
- do Nascimento Junior P
- Dobson G
- Docherty P
- Dodiyi-Manuel A
- Dodsworth K
- Dolan R
- Dong B
- Donohue R
- Donovan A
- Douglas J
- Doumos R
- Downes C
- Doyle D
- Dragnea D
- Dragoescu NA
- Drake M
- Drimala M
- Drinkwater Z
- Drummond L
- Du F
- Du F
- Du X
- Duarte C
- Dube NZ
- Duca A
- Dudgeon L
- Dudson R
- Duenser M
- Dumitrascu CO
- Dumitrescu A
- Dunay A
- Dunk N
- Durant E
- Durodola A
- Dursin AN
- Durst A
- Duttchen K
- Dutu M
- Dwyer H
- Dylst D
- Dzhamullaev P
- Dzulkipli N
- Echem R
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- Edwards J
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- Egan T
- Eggleston C
- Eichwalder A
- Eikman J
- Ekelund K
- el Manser D
- El-Sayed A
- Elabib A
- Elena G
- Elferink-Vonk R
- Elgasim M
- Ellis J
- Ellis K
- Elna C
- Emma T
- Endersby S
- Eneje P
- Eng K
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- English R
- Epodoi J
- Eskildsen KZ
- Esteves S
- Ethgen S
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- Everingham K
- Ewe R
- Ezekiel E
- Ezike H
- Fagerlund MJ
- Faina L
- Falk E
- Fan H
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- Fan Y
- Fanfani LC
- Faponle F
- Faria e Maia D
- Faria F
- Farid N
- Farina Z
- Farrell H
- Farrow M
- Fasina O
- Fatungase OM
- Faulds M
- Fei Y
- Fellinger P
- Feng Y
- Fengas L
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- Ferrando C
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- Filippopoulos A
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- Fiorentza K
- Fischbach N
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- Flores AAA
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- Fragandreas G
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- Frantzeskos G
- Freeman D
- Freeman V
- Freethy A
- Freitas K
- Freschini A
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- Fritsch G
- Frost V
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- Fuad A
- Fuentes I
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- Furtado Paiva AA
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- Govindasamy V
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- Granum SN
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- Guizeline J
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- Kushakovsky V
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- Yan Y
- Yang J
- Yang L
- Yang Q
- Yang S
- Yang T
- Yang Y
- Yao S
- Yao Y
- Yap HL
- Yarwood J
- Yassaee A
- Ye H
- Ye H
- Yegnaram S
- Yeh E
- Yin N
- Yip CP
- Yong J
- Yu HC
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- Yuan D
- Yuan F
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- Yuliana A
- Zaimi D
- Zakynthinos S
- Zamudio D
- Zangrillo A
- Zapata DDM
- Zbitnew G
- Zeidan L
- Zeng Q
- Zerman L
- Zettergren J
- Zhang B
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- Zhang H
- Zhang H
- Zhang H
- Zhang J
- Zhang K
- Zhang L
- Zhang M
- Zhang M
- Zhang Q
- Zhang R
- Zhang S
- Zhang W
- Zhang X
- Zhang X
- Zhang X
- Zhang X
- Zhang Y
- Zhang Y
- Zhang Y
- Zhang Y
- Zhao B
- Zhao B
- Zhao C
- Zhao J
- Zhao J
- Zhao L
- Zhao L
- Zhao S
- Zhao T
- Zhao W
- Zhao W
- Zhao X
- Zhen J
- Zheng K
- Zheng L
- Zheng T
- Zhong Y
- Zhou C
- Zhou D
- Zhou H
- Zhou H
- Zhou J
- Zhou J
- Zhou J
- Zhou X-J
- Zhu X
- Zhu X
- Zhu Y
- Zhu Z
- Zhuang X
- Zilis G
- Zin NHM
- Zingerle N
- Zingg U
- Zoerner F
- Zonneveldt H
- Zou X
- Zoulamoglou M
- Zsisku L
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2016
- Field of study
BACKGROUND: As global initiatives increase patient access to surgical treatments, there remains a need to understand the adverse effects of surgery and define appropriate levels of perioperative care. METHODS: We designed a prospective international 7-day cohort study of outcomes following elective adult inpatient surgery in 27 countries. The primary outcome was in-hospital complications. Secondary outcomes were death following a complication (failure to rescue) and death in hospital. Process measures were admission to critical care immediately after surgery or to treat a complication and duration of hospital stay. A single definition of critical care was used for all countries. RESULTS: A total of 474 hospitals in 19 high-, 7 middle- and 1 low-income country were included in the primary analysis. Data included 44 814 patients with a median hospital stay of 4 (range 2-7) days. A total of 7508 patients (16.8%) developed one or more postoperative complication and 207 died (0.5%). The overall mortality among patients who developed complications was 2.8%. Mortality following complications ranged from 2.4% for pulmonary embolism to 43.9% for cardiac arrest. A total of 4360 (9.7%) patients were admitted to a critical care unit as routine immediately after surgery, of whom 2198 (50.4%) developed a complication, with 105 (2.4%) deaths. A total of 1233 patients (16.4%) were admitted to a critical care unit to treat complications, with 119 (9.7%) deaths. Despite lower baseline risk, outcomes were similar in low- and middle-income compared with high-income countries. CONCLUSIONS: Poor patient outcomes are common after inpatient surgery. Global initiatives to increase access to surgical treatments should also address the need for safe perioperative care. STUDY REGISTRATION: ISRCTN5181700
Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome : Insights from the LUNG SAFE study
- Author
- Abad Ricardo Diaz
- Abe Toshikazu
- Abroug Fekri
- Adams John C.
- Adamsson Richard O.
- Adolfsson Anne
- Aguilar Ronald Zumaran
- Aguirre Janet S.
- Aguirre-Bermeo Hernan
- Aisa Tharwat M.
- Aisiku Imo
- Ajetunmobi Olaitan O.
- Aker Mustafa
- Akyol Onat O.
- Al Dorzi Hasan M.
- Al Jabbary Ahmed S.
- Albaiceta Guillermo M.
- Albarrak Mohamad M.
- Albiero Daniela
- Alda Rosa S.
- Alejandro Risso V.
- Alexander Peter
- Algaba Ángela
- Aliaga Felipe A.
- Alisasis Alain U.
- Allan Russell M.
- Allue Raquel Montoiro
- Almekhlafi Ghaleb
- Alonso Javier G.
- Altaf Wahid
- Alvarez António M.
- Alvarez Javier
- Amin Pravin
- Amir Fahd
- Amor Abdellatif Benslama Mourad
- An Youzhong
- Andersen Finn H.
- Andoh Kohkichi
- Andruszkiewicz Pawel
- Aneman Anders
- Antonelli Massimo M.
- Antônio Ana Carolina P.
- Aoki Nobumasa
- Appelberg Henrik
- Arabi Yaasen
- Arabi Yaseen M.
- Araujo Ana M.
- Arizmendi Alfons
- Arnal Jean-Michel
- Artiga Maria Jose D.
- Artigas Antonio
- Ascoli Aline
- Au Siu-Ming
- Avila Luis E.
- Azad Raman
- Azevedo Luciano Cesar
- Baboi Loredana
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- Bailey Irene M.
- Bailey Mathew B.
- Bajwa Ed
- Balkhi Hicham
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- Woods Paul W.
- Wrathall David W.
- Wrigge Hermann
- Wu Ya Q.
- Xin-Hua Qiang
- Xu Yonghao
- Yamaguchi Osamu
- Yamaji Yoshihiro
- Yao Qingchun
- Ye Zheng L.
- Yeatts Dale J.
- Yu Rongguo
- Yu Tao
- Yu Wenkui
- Yumha Jacob S.
- Yuste Luis J.
- Zacharas Giannis A.
- Zacharowski Kai D.
- Zani Gianluca
- Zantua Kim S.
- Zazu Alan
- Zeggwagh Amine Ali
- Zein Salem Ould
- Zender Hervé O.
- Zhai Zhe
- Zhang Fan
- Zhang Xing Y.
- Zhao Huiying
- Zhao Jun
- Zhao Xian Y.
- Zheng Ruiqiang
- Zhou Fa C.
- Zhou Suming
- Zhu Bao H.
- Zhu Wei H.
- Zogheib Elie H.
- Ñamendys-Silva Silvio A.
- Ünal Necmettin
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2020
- Field of study
Publisher Copyright: © 2020 The Author(s). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.Background: Concerns exist regarding the prevalence and impact of unnecessary oxygen use in patients with acute respiratory distress syndrome (ARDS). We examined this issue in patients with ARDS enrolled in the Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) study. Methods: In this secondary analysis of the LUNG SAFE study, we wished to determine the prevalence and the outcomes associated with hyperoxemia on day 1, sustained hyperoxemia, and excessive oxygen use in patients with early ARDS. Patients who fulfilled criteria of ARDS on day 1 and day 2 of acute hypoxemic respiratory failure were categorized based on the presence of hyperoxemia (PaO2 > 100 mmHg) on day 1, sustained (i.e., present on day 1 and day 2) hyperoxemia, or excessive oxygen use (FIO2 ≥ 0.60 during hyperoxemia). Results: Of 2005 patients that met the inclusion criteria, 131 (6.5%) were hypoxemic (PaO2 < 55 mmHg), 607 (30%) had hyperoxemia on day 1, and 250 (12%) had sustained hyperoxemia. Excess FIO2 use occurred in 400 (66%) out of 607 patients with hyperoxemia. Excess FIO2 use decreased from day 1 to day 2 of ARDS, with most hyperoxemic patients on day 2 receiving relatively low FIO2. Multivariate analyses found no independent relationship between day 1 hyperoxemia, sustained hyperoxemia, or excess FIO2 use and adverse clinical outcomes. Mortality was 42% in patients with excess FIO2 use, compared to 39% in a propensity-matched sample of normoxemic (PaO2 55-100 mmHg) patients (P = 0.47). Conclusions: Hyperoxemia and excess oxygen use are both prevalent in early ARDS but are most often non-sustained. No relationship was found between hyperoxemia or excessive oxygen use and patient outcome in this cohort. Trial registration: LUNG-SAFE is registered with ClinicalTrials.gov, NCT02010073publishersversionPeer reviewe
The Use of Complementary and Alternative Medicine Therapies by Patients with Advanced Cancer and Pain in a Hospice Setting: A Multicentered, Descriptive Study
- Publication venue
- Mary Ann Liebert, Inc.
- Publication date
- Field of study
Eighteen-month outcomes of house dust mite avoidance and dietary fatty acid modification in the Childhood Asthma Prevention Study (CAPS) (vol 111, pg 162, 2003)
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Prevention of asthma during the first 5 years of life: a randomized controlled trial
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Nursing Home Resident Barriers to Effective Pain Management: Why Nursing Home Residents May Not Seek Pain Medication
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- 'Elsevier BV'
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Immunocompromised patients with acute respiratory distress syndrome: Secondary analysis of the LUNG SAFE database
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- Yu Tao
- Yu Wenkui
- Yumha Jacob S.
- Yuste Luis J.
- Zacharas Giannis
- Zacharowski Kai
- Zani Gianluca
- Zantua Kim
- Zazu Alan
- Zeggwagh Amine Ali
- Zein Salem Ould
- Zender Hervé
- Zhai Zhe
- Zhang Fan
- Zhang Xing Y.
- Zhao Huiying
- Zhao Jun
- Zhao Xian Y.
- Zheng Ruiqiang
- Zhou Fa C.
- Zhou Suming
- Zhu Bao
- Zhu Wei H.
- Zogheib Elie
- Ñamendys-Silva Silvio A.
- ünal Necmettin
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
Background: The aim of this study was to describe data on epidemiology, ventilatory management, and outcome of acute respiratory distress syndrome (ARDS) in immunocompromised patients. Methods: We performed a post hoc analysis on the cohort of immunocompromised patients enrolled in the Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG SAFE) study. The LUNG SAFE study was an international, prospective study including hypoxemic patients in 459 ICUs from 50 countries across 5 continents. Results: Of 2813 patients with ARDS, 584 (20.8%) were immunocompromised, 38.9% of whom had an unspecified cause. Pneumonia, nonpulmonary sepsis, and noncardiogenic shock were their most common risk factors for ARDS. Hospital mortality was higher in immunocompromised than in immunocompetent patients (52.4% vs 36.2%; p < 0.0001), despite similar severity of ARDS. Decisions regarding limiting life-sustaining measures were significantly more frequent in immunocompromised patients (27.1% vs 18.6%; p < 0.0001). Use of noninvasive ventilation (NIV) as first-line treatment was higher in immunocompromised patients (20.9% vs 15.9%; p = 0.0048), and immunodeficiency remained independently associated with the use of NIV after adjustment for confounders. Forty-eight percent of the patients treated with NIV were intubated, and their mortality was not different from that of the patients invasively ventilated ab initio. Conclusions: Immunosuppression is frequent in patients with ARDS, and infections are the main risk factors for ARDS in these immunocompromised patients. Their management differs from that of immunocompetent patients, particularly the greater use of NIV as first-line ventilation strategy. Compared with immunocompetent subjects, they have higher mortality regardless of ARDS severity as well as a higher frequency of limitation of life-sustaining measures. Nonetheless, nearly half of these patients survive to hospital discharge. Trial registration: ClinicalTrials.gov, NCT02010073. Registered on 12 December 2013
Kuluttajabarometri maakunnittain 2000, 2. neljännes
- Author
- Ab Majid MA
- Ab Rahman AS
- Ab Rahman R
- Abayasinghe C
- Abbott T
- Abdullah NH
- Abdur-Rahman L
- Abeloos J
- Abernethy C
- Abidin UN
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- Zamudio D
- Zangrillo A
- Zapata DDM
- Zbitnew G
- Zeidan L
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- Zhu X
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- Zhuang X
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- Zin NHM
- Zingerle N
- Zingg U
- Zoerner F
- Zonneveldt H
- Zou X
- Zoulamoglou M
- Zsisku L
- Publication venue
- Tilastokeskus
- Publication date
- 11/07/2000
- Field of study
Suomen virallinen tilasto (SVT
Use of failure-to-rescue to identify international variation in postoperative care in low-, middle- and high-income countries: a 7-day cohort study of elective surgery
- Author
- Ab Majid MA
- Ab Rahman AS
- Ab Rahman R
- Abayasinghe C
- Abbott T
- Abdullah NH
- Abdur-Rahman L
- Abeloos J
- Abernethy C
- Abidin UN
- Abrunhosa A
- Absar M
- Adam S
- Adams D
- Adams G
- Adamson M
- Adekola O
- Adelaja Y
- Ademola A
- Adenekan A
- Adenike O
- Adeolu AA
- Adetoye A
- Adewale B
- Adigun T
- Adolfsson A
- Aflori L
- Africander C
- Afshari A
- Agarwal V
- Agodirin O
- Aguero Vera M
- Aguzzoli C
- Ahmad A
- Ahmad N
- Ahmad T
- Ahmad T
- Ahmad Y
- Ahmed A
- Ahmed J
- Ai Y
- Aignatoaie M
- Aimoniotou-Georgiou E
- Akanmu O
- Akerman N
- Akinwale M
- Akring I
- Al 'Amri K
- Al Anizi M
- Al hussaini S
- Al-Soudaine Y
- Aladin H
- Alagbe-Briggs O
- Alaman Laguarda G
- Albaj S
- Alcock D
- Alcock L
- Aldecoa C
- Aldecoa C
- Aleixo FB
- Alexander H
- Alexander M
- Alexander-Sefre F
- Alherz F
- Ali H
- Ali M
- Ali S
- Alias A
- Alias AH
- Alias RLR
- Alit MA
- Allen S
- Allen SJ
- Allison J
- Alloj C
- Allorto NL
- Allsop J
- Almeida W
- Alonso E
- Alphonsus C
- Alvares D
- Alves MJ
- Amador JCB
- Ameer Y
- Amendola CP
- Ami N
- Amstrup-Hansen L
- Anagnou A
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- Anderson F
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- Andreadaki E
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- Angus K
- Anillo V
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- Cherrett V
- Chetty RR
- Chew M
- Chhabra A
- Chicken D-W
- Chilinciuc I
- Chin II
- Chirkut S
- Chisbert Cuenca V
- Chlorou D
- Choi H-MD
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- Christoforidis D
- Chronis C
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- Chung CKE
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- Cirstea E
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- Cloro LM
- Clyde A
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- Codita A
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- Comptaer N
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- Dumitrascu CO
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- Van Bommel J
- Van de Velde M
- van den Berg B
- Van Den Eynde N
- van der Merwe D
- van der Merwe L
- van Duivenvoorde Y
- Van Duyvenvoorde G
- van Klei W
- Van Liefland M
- Van Limmen J
- Van Mossevelde V
- van Rossum S
- van Vuuren AJ
- van Wyk S
- van Zaane B
- van Zeggeren L
- van Zundert T
- van Zyl R
- Vandenbempt P
- Vandenheuvel M
- Vanluchene A
- Vanpeteghem C
- Varden R
- Varley S
- Varma S
- Varsani N
- Vartic M
- Vasian H
- Vasileiou M
- Vazquez Vicente B
- Veerakumaran J
- Veevaete L
- Veit S
- Velaz Dominguez S
- Vele L
- Venara A
- Venner N
- Venugopal S
- Vercauteren M
- Verdoodt H
- Veroniki F
- Verroiotou M
- Ververidou O
- Vesely M
- Vetsiou E
- Vilela dos Santos AM
- Virdi P
- Visser L
- Visvalingam S
- Vivian M
- Vlachogianni G
- Vohra A
- Vohra R
- Voldaeva O
- Voloudakis N
- Volta CA
- Von Heymann C
- von Rhaden R
- Voruz F
- Wadams B
- Waggett H
- Walder B
- Walkden G
- Walker A
- Walker E
- Walker R
- Walker R
- Walker T
- Wallace A
- Wallace K
- Wallet F
- Walsgrove J
- Walsh D
- Wan X
- Wang D
- Wang D
- Wang F
- Wang G
- Wang H
- Wang H
- Wang J
- Wang J
- Wang J
- Wang J
- Wang J
- Wang K
- Wang L
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- Wang T
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- Wang X-L
- Wang Y
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- Wang Z
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- Ward J
- Wasmund C
- Wassall R
- Watanabe Oliveira HR
- Watson A
- Watson N
- Watt P
- Waugh D
- Waweru P
- Waworuntu N
- Waymouth E
- Weatherall L
- Weatherill J
- Webb S
- Weber E
- Wei J
- Weimann J
- Weller D
- Welsh S
- Wen XH
- Wen Y
- Wen Z
- Wendling PR
- Wessels JD
- Wetzel P
- Weyland A
- White S
- White S
- whitehouse A
- Whitman Z
- Whittle N
- Whitworth H
- Whysall K
- Wibrandt I
- Wickboldt N
- Wickenhauser R
- Wid WM
- Widmark C
- Wiegand-Loehnert C
- Wighton E
- Wigmore G
- Wijeysundera D
- Wikner M
- Wild J
- Wildes T
- Wildi S
- Williams A
- Williams M
- Williams S
- Wilscott-Davids C
- Wilson A
- Wilson D
- Wilson L
- Wilson N
- Wima S
- Winch D
- Winstone U
- Winterton D
- Wir WM
- Wise R
- Wittmann M
- Wolfer A
- Wollaston J
- Wong C
- Wong CW
- Wong JY
- Wong K
- Wong KWK
- Wong SM
- Wong T
- Wong WL
- Woodgate A
- Woolsey A
- Woon YL
- Worreth M
- Wouters P
- Wrench I
- Wright S
- Wu C
- Wu C
- Wu J
- Wu J
- Wu Q
- Wu S
- Wyffels P
- Wylie K
- Xia J
- Xia Y
- Xia Z-Y
- Xiao W
- Xiao W
- Xie G
- Xie J
- Xie J
- Xie K
- Xifara A
- Xiong X
- Xiong Y
- Xouplidis K
- Xu G-J
- Xu L
- Xu L
- Xu Q
- Xu S
- Xue R
- Yagnik A
- Yan Y
- Yang J
- Yang L
- Yang Q
- Yang S
- Yang T
- Yang Y
- Yao S
- Yao Y
- Yap HL
- Yarwood J
- Yassaee A
- Ye H
- Ye H
- Yegnaram S
- Yeh E
- Yin N
- Yip CP
- Yong J
- Yu HC
- Yu S
- Yu T
- Yu Y
- Yuan D
- Yuan F
- Yuan J
- Yuan J
- Yuan Y
- Yuliana A
- Zaimi D
- Zakynthinos S
- Zamudio D
- Zangrillo A
- Zapata DDM
- Zbitnew G
- Zeidan L
- Zeng Q
- Zerman L
- Zettergren J
- Zhang B
- Zhang E
- Zhang H
- Zhang H
- Zhang H
- Zhang J
- Zhang K
- Zhang L
- Zhang M
- Zhang M
- Zhang Q
- Zhang R
- Zhang S
- Zhang W
- Zhang X
- Zhang X
- Zhang X
- Zhang X
- Zhang Y
- Zhang Y
- Zhang Y
- Zhang Y
- Zhao B
- Zhao B
- Zhao C
- Zhao J
- Zhao J
- Zhao L
- Zhao L
- Zhao S
- Zhao T
- Zhao W
- Zhao W
- Zhao X
- Zhen J
- Zheng K
- Zheng L
- Zheng T
- Zhong Y
- Zhou C
- Zhou D
- Zhou H
- Zhou H
- Zhou J
- Zhou J
- Zhou J
- Zhou X-J
- Zhu X
- Zhu X
- Zhu Y
- Zhu Z
- Zhuang X
- Zilis G
- Zin NHM
- Zingerle N
- Zingg U
- Zoerner F
- Zonneveldt H
- Zou X
- Zoulamoglou M
- Zsisku L
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2017
- Field of study
This was an investigator-initiated study funded by Nestle Health Sciences through an unrestricted research grant and by a National Institute for Health Research (UK) Professorship held by R.P. The study was sponsored by Queen Mary University of London
Validation and utility of ARDS subphenotypes identified by machine-learning models using clinical data: an observational, multicohort, retrospective analysis
- Author
- 1amendys-Silva Silvio A
- Abad Ricardo Diaz
- Abe Toshikazu
- Abroug Fekri
- Adams John C
- Adamsson Richard O
- Adolfsson Anne
- Aguilar Ronald Zumaran
- Aguirre Janet S
- Aguirre-Bermeo Hernan
- Aisa Tharwat M
- Aisiku Imo
- Ajetunmobi Olaitan O
- Aker Mustafa
- Akyol Onat O
- Al Dorzi Hasan M
- Al Jabbary Ahmed S
- Albaiceta Guillermo M
- Albarrak Mohamad M
- Albiero Daniela
- Alda Rosa S
- Alejandro Risso V
- Alexander Peter
- Alfonso Alec A Tallet
- Algaba \uc1ngela
- Aliaga Felipe A
- Alisasis Alain U
- Allan Russell M
- Allue Raquel Montoiro
- Almekhlafi Ghaleb
- Alonso Javier G
- Altaf Wahid
- Alvarez Ant\uf3nio M
- Alvarez Javier
- Amin Pravin
- Amir Fahd
- Amor Mourad
- Ampinelli Adenilton M R
- An Youzhong
- Andersen Finn H
- Andoh Kohkichi
- Andruszkiewicz Pawel
- Aneman Anders
- Ant\uf4nio Ana Carolina P
- Antonelli Massimo M
- Aoki Nobumasa
- Appelberg Henrik
- Arabi Yaasen
- Arabi Yaseen M
- Araujo Ana M
- Arizmendi Alfons
- Arnal Jean-Michel
- Artiga Maria Jose D
- Artigas Antonio
- Ascoli Aline
- Au Siu-Ming
- Avila Luis E
- Azad Raman
- Azevedo Luciano C
- B\ue9duneau Gaetan
- Baboi Loredana
- Badie Julio C
- Bailey Irene M
- Bailey Mathew B
- Bajwa Ed
- Balkhi Hicham
- Baltus Thomas
- Banner-Goodspeed Valerie M
- Barberet Guillaume
- Baron Rebecca M
- Baronia Arvind K
- Barratt-Due Andreas
- Barros Filipa M
- Barros Nelson C
- Batra Hitesh
- Battle Ceri E
- Bauer Philippe R
- Beck Eduardo
- Beck Oliver
- Bedreag Ovidiu H
- Beegle Scott H
- Beitler Jeremy R
- Bellani Giacomo
- Bellani Giacomo
- Beloncle Francois
- Ben Souissi Asma
- Benslama Abdellatif
- Beraldo Daniel O
- Berghe Caroline
- Berkelmans Frantz
- Besset Sebastien L
- Bettini Lisandro R
- Beuret Pascal
- Bezzi Marco G
- Bhardwaj Vallish K
- Bhowmick Kaushik
- Biehler Jerome
- Bigot Charlene
- Bihari Shailesh
- Biondi Rodrigo S
- Biscione Roberto R
- Bisso Mariano Carboni
- Black Colin S
- Blakeman Thomas C
- Blanco Javier
- Blasco Navalpotro Miguel Angel
- Bolon Stefan
- Borello Silvina A
- Borotto Erika E
- Botteri Marco
- Bouchoucha Slaheddine
- Boukhazna Messabi
- Bouw Maria J
- Boyd Owen
- Bramall Jon
- Braschi Antonio
- Brazzi Luca
- Breen Dorothy M
- Briquet Anais
- Brito Vania A
- Brizuela Matias
- Broman Lars M
- Brown Christine
- Brown Samuel M
- Bruhn Alejandro R
- Brunettini Barbara
- Bruns Monique M
- Buensuseso Juan A
- Bugedo Guillermo
- Buise Marc P
- Bulpa Pierre A
- Bumbasierevic Vesna
- Bumbasirevic Vesna
- Burtenshaw Andrew J
- Burtin Philippe
- Buzancais Gautier
- Calfee Carolyn S
- Camsooksai Julie
- Canestrini Sergio
- Cani Alma
- Carbayo-Gorriz Cecilia
- Cardonnet Luis P
- Careless Jon P
- Carpentier Doroth\ue9e
- Carre\uf1o Nicol\ue1s G
- Carteaux Guillaume
- Casalena Paolo
- Casement Jonathan
- Castro Alejandro G
- Castro Silvia
- Catorze Nuno T
- Cazorla-Barranquero Francisca G
- Ceniceros-Barros Alexandra
- Cereijo Enrique
- Cerny Vladimir
- Cerrato Valeria I
- Cervantes Mavy Ramirez
- Cesar Palazon Sanchez
- Ceunen Helga
- Ceylan Ilkay
- Chabanne Russell
- Chapman Rhiannon
- Chau Simon K
- Chelly Jonathan
- Chen Kai
- Chena Ariel
- Chiche Jean-Daniel
- Chouchene Imed
- Choudry Shazia
- Christiansen Aage
- Churpek Matthew
- Cimic Nedim
- Cinnella Gilda
- Cirone Rob
- Cital\ue1n Johanna E
- Claraco-Vega Luis M
- Clarkson Kevin
- Clarkson Kevin P
- Claverias Laura
- cnal Necmettin
- Cohen Jason E
- Cole Jade M
- Collins Daniel V
- Collyer Thomas
- Colombo Riccardo
- Combaux Daniele M
- Combes Alain
- Cooper Raphael
- Coppadoro Andrea
- Corneci Dan E
- Cortegiani Andrea
- Cortez Cesar A
- Cowley R Adams
- Cox Cristina M
- Cracchiolo Andrea N
- Cranshaw Julius H
- Crapelli Giulia
- Crouch Daniel R
- Crova Philippe J
- Csabi Peter
- Curley Gerard
- Curto Elena Gallego
- D\ue9mpaire Gabriel
- Daldin Julio
- Dangers Laurence
- Danin Pierre-Eric
- Daubin C\ue9dric
- Daviaud Fabrice
- Davies Kyle G
- Dawson Heidi
- De Cima-Iglesias Sara
- De Gordoa Laura Ortiz-Ruiz
- De Haro Candelaria
- De Pablo Raul
- de Prost Nicolas
- Dean Michael N
- Declercq Pierre-Louis M
- Dector Dulce M
- Deicas Alberto
- Dellamonica Jean
- Dellera Christian
- Delsing Angela
- Delucchi Kevin L
- Demirkiran Oktay
- Demoule Alexandre
- Dempsey Ged
- Dendane Tarek
- Depuydt P
- Depuydt Pieter
- Derman Suleyman S
- Di Tomasso Nora N
- Di Yu D
- Diaz Juan Carlos J Sotillo
- Diaz-Rodriguez Esther
- Dive Alain M
- Dixit Subhal B
- do Vale Fernandes Antero
- Dolva Merete S
- Donnelly Adrian
- Dowling Anna T
- Doyen Denis
- Dres Martin
- Dreyer Kyle R
- Dunne Eimhin S
- Dupont Herve
- Duranteau Jacques
- Dwyer Rory
- Ebeid Alejandro
- Elatrous Souheil
- Elisabet Garcia M
- Elkhayari Mina
- Ellis Helen E
- Elmasri Mary
- Erbabacan Emre
- Eriksson Karin E
- Estenssoro Elisa
- Esteve Francisco
- Estilita Joana M
- Estrella Claudia R
- Eugenio Luis Palazon Sanchez
- Ezzouine Hanane
- Fan Eddy
- Far\uedas Pamela A
- Fartoukh Muriel
- Fawkes Danielle A
- Ferguson Andrew
- Ferguson Niall D
- Fernandez Adriana M
- Fernandez Ruben O
- Fierro Jonathan M
- Floris Leda
- Follin Arnaud
- Fontenele Danielle C
- Formenti Paolo
- Forteza Catalina
- Fossali Tommaso
- Foti Giuseppe
- Fran\ue7a Ana G.
- Franco Nieves
- Francois Guy M
- Frati Elena
- Frendl Gyorgy
- Frigyik Aniko D
- Fusari Maurizio
- Futami Satoru
- G\uf3mez Pilar Ricart Aroa
- Gally Josette
- Ganesan Deeban
- Gao Yan
- Gao Yuan N
- Garcia Patricio H
- Gazenkampf Andrey A
- Gel\ue9e Bruno
- George Fernando G
- Ghazi Mohammed
- Gianinetto Hernan
- Giarratano Antonino
- Gillis Sarah
- Girgin Nermin Kelebek
- Gjedsted Jakob
- Glietsch Rita
- Goldgran-Toledano Dany
- Goligher Ewan C
- Gomaa Dina
- Gomaa Dina
- Gomes Rui M
- Gomez Antonio
- Gomez Pablo E
- Gomez-Flores Saira S
- Gon\ue7alves Claudio H
- Gonz\ue1lez Rojas Manuel A
- Gonz\ue1lez-Salamanca \uc1ngela
- Gonzalez Daniel R
- Gonzalez Marcos
- Goodson Jennifer C
- Gordo Federico
- Gosselin Ryan J
- Goubaux Bernard
- Graziani Romano
- Grelon Fabien
- Griffin Ruth O
- Grigoriev Evgeny
- Grijalba Carolina Quintana
- Grissom Colin K
- Gritsan Alexey I
- Grubissich Nicolas
- Gu\ue9rin Claude
- Gueret Renaud M
- Gurjar Mohan
- Guttormsen Anne B
- Hacking Danielle J
- Haddad Youssef
- Hadfield Dan
- Hagan Samantha J
- Han Hui
- Han Yi
- Hang Ai Y
- Hanlon Gabrielle C
- Harasawa Tomofumi
- Harrois Anatole
- Hashemian S. M
- Hashida Tomoaki
- He June
- He Zhenyang
- Hedlund Lars
- Heidari Farshad
- Heines Serge J
- Helleberg Johan
- Henderson Galen
- Hendrickson Carolyn M
- Herbrecht Jean-Etienne
- Hermosa Cecilia
- Hessell Robert J
- Heunks Leo M
- Heunks Leo M
- Higashijima Ushio
- Hirata Akira
- Holzgraefe Bernhard
- Honda Hiroyuki
- Honrubia Teresa
- Hopf Hans-Bernd F
- Hopkins Phil
- Hormis Anil P
- Hou Peter C
- Hou Sen-Kuang
- Hraiech Sami
- Hua Ma X
- Huang Qing Q
- Huang Xiao B
- Huerta Francisco P
- Huff Nidhi G
- Humphreys Sally K
- Hunt Anna
- Hurtado Javier
- Hurtado Javier
- Hurtado Javier
- Hutchison Robyn A
- Hutton Paula J
- Iba\uf1ez-Santacruz Marcos
- Ichikado Kazuya
- Ilutovich Santiago
- Imai Hiroshi
- Imma Vallverdu P
- Imperio Mar\ueda C
- Insaurralde Carolina S
- Inskip Deborah M
- Ioannou Nicholas
- Iotti Giorgio A
- Irvine Donald A
- Ismail Dina
- Ismail Dk Maizatul Aiman B Pg Hj
- Ismail Mehvish
- Ito Fumihito
- Izawa Masayo
- Jaafar Rola F
- Jakubowska Karina
- Jamaati Hamidreza
- Jarquin-Badiola Yves D
- Jassal Mandeep
- Jauregui Alejandra
- Javeed Areej
- Jiang Liangyan
- Jibaja Manuel
- Jimenez Antonio G
- Jochmans S\ue9bastien
- Jog Sameer A
- Jovanovic Bojan
- Judy Claine
- Jurado M\uaa Teresa
- Kadaba Varsha
- Kajtor Istvan
- Kakar Vivek
- Kalaitzis Evangelos
- Kalkoff Michael
- Kamel Ghassan
- Kameyama Yoshinobu
- Kamoun Salma
- Kander Thomas
- Kangelaris Kirsten N
- Kannan Santhana G
- Kashiwa Yozo
- Ke Serena
- Kedelv Hans
- Kennedy Barry
- Khebbeb Samy
- Kheir Fayez M
- Kimura Hiroyasu
- Kiourtzieva Ellada V
- Kitch Barrett T
- Knapman Karl M
- Knoll Jenny
- Knowles Serena
- Kol Mark R
- Kong Jing
- Koyama Kansuke
- Kra fler Jens
- Krstevski Amanda
- Kulkarni Shreedhar
- Kumar Alek
- Kurahashi Kiyoyasu
- Kusumoto Kohei
- L\uf3pez-Messa Juan B
- Laake Jon H
- Laake Jon Henrik
- Labarca Eduardo F
- Laffey John
- Laffey John G
- Lamb Keith D
- Lanspa Michael J
- Larsson Anders
- Larsson Niklas
- Le Moal Charlene
- Lebbinck Herve
- Lee Jarone
- Leemann-Refondini Corinne
- Leligdowicz Aleksandra
- Lemiale Virginie
- Lemus Jordana S
- Li Bin
- Li Qingdong
- Li Qiong J
- Li Wenwen
- Li Xiao L
- Li Xinyu
- Li Yimin
- Li Yuan Y
- Li-Xin Zhou
- Liew Kong Y
- Ling Long L
- Liu Haitao
- Liu Jian
- Liu Jing L
- Liu Kathleen D
- Liu Ling
- Llano Miguel
- Lohner Ralph
- Loiacono Flavia A
- Lombardo Andrea
- Lopez Esther Bermejo
- Lopez-Delgado Juan C
- Lora Fredy S
- Lora Pilar
- Lorente Jose A
- Lorente Maria del Carmen
- Lovazzano Pablo
- Lu Weihua
- Lu Yuanhua
- Luo Xiaoming
- Lynch Joan M
- M\ue1ca Jan
- Maazouzi Wajdi
- Macfadyen Rosaleen
- MacFie Caroline C
- Maddali Manoj V
- Maeyama Hiroki N
- Maghrabi Khalid A
- Magret Monica
- Mahto Heera L
- Mancebo Jordi
- Manoharan Venika
- Marcos Diego Pastor
- Marcu Alexandra
- Marin Julien
- Marin Maria C
- Martinez Felipe T
- Martinho Aurelia M
- Marum Susan M
- Massa Eleni V
- Mataloun Sergio
- Matamis Dimitrios
- Matsumoto Shuhei
- Mattei Alessia
- Matthay Michael A
- May Martin M
- Mcarthur Colin
- McAuley Daniel F
- McAuley Danny
- Mccalman Katie H
- Mckechnie Stuart
- Mckee Raymond
- Mckenna Toni E
- Mcleod Alex
- McNamee Lia
- McNamee Lia
- McNeil J Brennan
- Meaney Edel A
- Meco Basak Ceyda
- Meersseman Philippe
- Mehta Sangeeta
- Mejia Francisco Javier Flores
- Mellis Clare
- Memon Mohammedfaruk
- Mercat Alain
- Mesar Tomaz
- Mesar Tomaz
- Messias Ant\uf3nio M
- Messika Jonathan
- Meybohm Patrick
- Michel Philippe
- Millar Rebecca T
- Miller Jennene J
- Miller Russel R
- Milstein Cesar
- Mirabella Lucia
- Mizuguchi Ichiko
- Mochizuki Katsunori
- Mohammadreza Hashemian Seyed
- Mohr Nicholas M
- Mojoli Francesco
- Moles Silvia Iglesias
- Molin Alexandre
- Montanha Gustavo M
- Monteiro Jorge M
- Montero Laura Alvarez
- Monti Giacomo
- Montiel Gonz\ue1lez Raquel
- Montini Luca M
- Moock Marcelo
- Morin Anna-Karin
- Mortaza Satar
- Morton Alex
- Mouloudi Eleni K
- Moya David D Llinares
- Mukkera Satyanarayana Reddy
- Mustafa Ghanem M
- Muthuchellappan Radhakrishnan
- Nagy Eva O
- Nakamura Tomoyuki
- Namih Miriam
- Nassar Jr Antonio P
- Nasu Michitaka
- Navarra Leanlove
- Navarro Gonzalo
- Neal John
- Negoita Silvius Ioan
- Newby Lynette
- Nichol Alistair
- Nielsen Jonas
- Nielsen Jonas
- Niimi Daisuke
- Nin Nicolas
- Nishikawa Erin
- Nitta Kenichi
- Nobrega Danielle
- Noremark Kim Andre L
- Nu\uf1ez Edgardo
- Nunci Lordian
- Nunes Silvia L
- Nunomiya Shin
- Nutt Christopher
- Nygren Ingela
- O'Croinin Donall
- O'Muircheartaigh Aogan C
- Occhipinti Giovanna
- Oetting Trevor W
- Ogino Yasuaki
- Oikonomou Marina A
- Okane Sinead C
- Okuda Nao
- Oldroyd Matthew G
- Olga Moreno F
- Oliveira Bruno S
- Oneill Orla
- Ortiz Claudia A
- Oscanoa Fredy A Montes
- Osman Emilio M
- Oss Peteris
- Ouanes Islem
- Ould Zein Salem
- Ourailogloy Vasilis
- Owens Robert L
- Ozcelik Menekse
- Palaniswamy Vijayanand
- Palma Daniela M
- Palmese Salvatore
- Palo Jose Emmanuel
- Panarello Giovanna
- Papanikolaou Metaxia N
- Papavasilopoulou Theonymfi G
- Papazian Laurent
- Papurica Marius
- Para Luis Herrera
- Parhar Ken
- Parotto Matteo
- Pasanting-Lim Rossini Abbie B
- Patroniti Nicol\uf2
- Pattarino Ilaria
- Pecci Elisabetta
- Pellegrini Carlos A
- Pelletier Nicolas
- Pellicer Ana M
- Penuelas Oscar
- Pere Cesar P
- Pereira Carlos S
- Perez Cheng Meisy
- Perez Losada Elena
- Perez Manuel P
- Persson Linnea
- Pham T\ue0i
- Pham Tai
- Pham Tai
- Phan Nga T
- Piacentini Enrique A
- Pillai Suresh
- Pintado Maria C
- Piquilloud Lise
- Piquilloud Lise
- Piras Claudio
- Pittini Gustavo
- Plotnikow Gustavo A
- Poblano Manuel
- Poli Michela M
- Pota Vincenzo
- Pozo Norberto C
- Pozzi Matteo
- Preez Pieter D
- Prieto-Gonz\ue1lez Miryam
- Pronovost Antoine
- Protti Alessandro
- Qin Bingyu
- Qin Junping
- Qin Shu H
- Qin Tie H
- Qiu Haibo
- Qiu Haibo
- Raaijmakers Monique
- Rafael S\ue1nchez I
- Raimondi Ferdinando
- Raj Ashok S
- Ramakrishnan Nagarajan
- Ramesh Venkatapura J
- Ramirez-Alfaro Christian M
- Ramirez-Gutierrez Alvaro
- Ranero Jorge Luis
- Raponi Francesco
- Recio Noelia N
- Reschreiter Henrik
- Reske Andreas W
- Reuter Danielle
- Reynolds Claire
- Rezoagli Emanuele
- Rhayakar Rachana V
- Rialp Gemma
- Richecoeur Jack R
- Ricome Sylvie
- Rigaud Jean-Philippe
- Rinia Myra
- Rios Fernando
- Riss Katharina C
- Rittayamai Nuttapol
- Roberts Brigit L
- Robine Adrien
- Robles Joanne B
- Roche-Campo Ferran
- Rodgers Helen J
- Rodriguez Lucia L
- Rodriguez Ruben
- Rosa Jonas I
- Roser Tomas P
- Rossi Anna
- Roux Damien
- rowne Troy S B
- Rugonfalvi Szabolcs
- Ruiz Silvia Rodriguez
- Ruiz-Aguilar Antonio L
- Rylander Christian C
- Ryosuke Sekine
- S\ue1nchez Roc\uedo Manzano
- S\ue1nchez-Ballesteros Jes\ufas
- S\uf8reide Eldar
- Sabelnikovs Olegs
- Sable Safal D
- Saenz Mar\ueda G
- Saez Alejandro A
- Sagar Sudha V
- Saito Koji
- Saito Shigeki
- Salahuddin Nawal
- Salas Javier E
- Sales Vanessa M
- Samkaoui Nacer
- Sanchez Roberto Jimenez
- Sanchez-Hurtado Luis A
- Sanchez-Medina Jorge R
- Sandesc Dorel
- Santoli Francesco L
- Santos Cristina
- Sarma Aartik
- Sauvadet Elise P
- Savioli Monica
- Scafetti Sergio
- Sch\ue4fer Susanne
- Schi\uf6ler Fredrik
- Schiavone Vincenzo
- Schiavoni Lorenzo
- Schlichting Adam B
- Schneider Francis
- Schomer Ashley
- Schouten Jeroen A
- Schuetz Michael
- Schultz Marcus J
- Scott Christopher J
- Seasman Colette
- Seethala Raghu
- Sellors Gareth P
- Seoane-Quiroga Leticia
- Serra Carolina
- Serra Isabel M
- Setten Mariano G
- Seven Aylin
- Shah Bhagyesh
- Shao Huanzhang
- Shen Juanhong
- Shenoy Anitha
- Sher Sara
- Shimizu Kazuyoshi
- Shindhe Suresh
- Shinn Iii John O
- Shiozaki Kyoko
- Silesky Jimenez Juan I
- Silesky Juan
- Sim Malcolm
- Simon Philipp
- Simonis Fabienne D
- Sinha Pratik
- Sivashanmugave Mageswaran
- Sj\uf8b\uf8 Brit \uc5
- Sklienka Peter
- Smith Mark J
- Smith Oliver
- Soler Juan Alfonso
- Solis-Quesada Jaime E
- Sottiaux T
- Spadaro Savino
- Srinivasa Latha
- Stamou Electra E
- Stansil Frank
- Staudinger Thomas
- Steinberg Jack
- Stephenson Lorraine
- Stewart Richard
- Stigler William
- Sula Hektor
- Sun Renhua
- Surbatovic Maja
- Suzuki Hiroyuki
- Symmonds Sophie
- Szakmany Tamas
- Tabhan Edgardo
- Tabhan Edgardo E
- Tainter Christopher
- Takaba Akihiro
- Takada Tadaaki
- Takagi Shunsuke
- Tan Beatriz C
- Tanaka Hiroyuki
- Tang Rui
- Tapponnier Romain
- Tarantino Fabio
- Temprano Susana
- Terragni Pierpaolo
- Terzi Nicolas
- Thibault Sandrine
- Thomas Rajeev R Jha Matthew
- Thompson Marlus M
- Tibblin Anna Oscarsson
- Tinnirello Andrea
- Tiribelli Norberto
- Todeschini Manuel
- Tomescu Dana R
- Toribio D\ue1cil Parrilla
- Toth-Tarsoly Piroska
- Treanor Nuala
- Trinder T John
- Trinidad Olivia A
- Tulaimat Aiman
- Twohey Linda
- Uchiyama Akinori
- Ueda Takeshi
- Ueno Keiko
- Umbrello Michele
- Unnikrishnan Ramesh
- Uppalapati Aditya
- Van Haren Frank
- Van Wezel Hellen M
- Vargas Monica P
- Vascotto Ettore R
- Vasquez Daniela N
- Vega Luis D
- Veljovic Milic
- Venti Aaron
- Vercueil Andre
- Vermassen Joris
- Verstraete Rik
- Vessel Kathryn
- Villagomez Asisclo
- Villagomez Asisclo J
- Villamagua Boris G
- Villar Veronica
- Vinzio Mauricio
- Virgilio Corcoles G
- Vitale Michela N
- Volta Carlo A
- Wang Chunting
- Wang Chunxue
- Wang Hua X
- Wang Shou H
- Wang Wei
- Ware Lorraine B
- Warren Jessica
- Watanabe Eizo
- Watt Philip
- Welters Ingeborg D
- Wenham Tim
- Wessbergh Joanna
- Whitehead Christina
- Wickersham Nancy
- Willett Emma L
- Williams Alexandra J
- Williams Karen E
- Wise Matt P
- Wittebole Xavier
- Wong Helen S
- Woods Paul W
- Wrathall David W
- Wrigge Hermann
- Wu Ya Q
- Xin-Hua Qiang
- Xu Yonghao
- Yamaguchi Osamu
- Yamaji Yoshihiro
- Yao Qingchun
- Ye Zheng L
- Yeatts Dale J
- Yoshido Hector H Leon
- Yu Rongguo
- Yu Tao
- Yu Wenkui
- Yumha Jacob S
- Yuste Luis J
- Zacharas Giannis A
- Zacharowski Kai D
- Zani Gianluca
- Zantua Kim S
- Zazu Alan
- Zeggwagh Amine Ali
- Zeggwagh Amine Ali
- Zender Herv\ue9 O.
- Zhai Zhe
- Zhang Fan
- Zhang Xing Y
- Zhao Huiying
- Zhao Jun
- Zhao Wendi
- Zhao Xian Y
- Zheng Ruiqiang
- Zhou Fa C
- Zhou Suming
- Zhu Bao H
- Zhu Wei H
- Zhuo Hanjing
- Zogheib Elie H
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2022
- Field of study
International audienceTwo acute respiratory distress syndrome (ARDS) subphenotypes (hyperinflammatory and hypoinflammatory) with distinct clinical and biological features and differential treatment responses have been identified using latent class analysis (LCA) in seven individual cohorts. To facilitate bedside identification of subphenotypes, clinical classifier models using readily available clinical variables have been described in four randomised controlled trials. We aimed to assess the performance of these models in observational cohorts of ARDS. Methods: In this observational, multicohort, retrospective study, we validated two machine-learning clinical classifier models for assigning ARDS subphenotypes in two observational cohorts of patients with ARDS: Early Assessment of Renal and Lung Injury (EARLI; n=335) and Validating Acute Lung Injury Markers for Diagnosis (VALID; n=452), with LCA-derived subphenotypes as the gold standard. The primary model comprised only vital signs and laboratory variables, and the secondary model comprised all predictors in the primary model, with the addition of ventilatory variables and demographics. Model performance was assessed by calculating the area under the receiver operating characteristic curve (AUC) and calibration plots, and assigning subphenotypes using a probability cutoff value of 0·5 to determine sensitivity, specificity, and accuracy of the assignments. We also assessed the performance of the primary model in EARLI using data automatically extracted from an electronic health record (EHR; EHR-derived EARLI cohort). In Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG SAFE; n=2813), a multinational, observational ARDS cohort, we applied a custom classifier model (with fewer variables than the primary model) to determine the prognostic value of the subphenotypes and tested their interaction with the positive end-expiratory pressure (PEEP) strategy, with 90-day mortality as the dependent variable. Findings: The primary clinical classifier model had an area under receiver operating characteristic curve (AUC) of 0·92 (95% CI 0·90–0·95) in EARLI and 0·88 (0·84–0·91) in VALID. Performance of the primary model was similar when using exclusively EHR-derived predictors compared with manually curated predictors (AUC=0·88 [95% CI 0·81–0·94] vs 0·92 [0·88–0·97]). In LUNG SAFE, 90-day mortality was higher in patients assigned the hyperinflammatory subphenotype than in those with the hypoinflammatory phenotype (414 [57%] of 725 vs 694 [33%] of 2088; p<0·0001). There was a significant treatment interaction with PEEP strategy and ARDS subphenotype (p=0·041), with lower 90-day mortality in the high PEEP group of patients with the hyperinflammatory subphenotype (hyperinflammatory subphenotype: 169 [54%] of 313 patients in the high PEEP group vs 127 [62%] of 205 patients in the low PEEP group; hypoinflammatory subphenotype: 231 [34%] of 675 patients in the high PEEP group vs 233 [32%] of 734 patients in the low PEEP group). Interpretation: Classifier models using clinical variables alone can accurately assign ARDS subphenotypes in observational cohorts. Application of these models can provide valuable prognostic information and could inform management strategies for personalised treatment, including application of PEEP, once prospectively validated. Funding: US National Institutes of Health and European Society of Intensive Care Medicine