Dynamic wavelet correlation analysis for multivariate climate time series

The wavelet local multiple correlation (WLMC) is introduced for the first time in the study of climate dynamics inferred from multivariate climate time series. To exemplify the use of WLMC with real climate data, we analyse Last Millennium (LM) relationships among several large‑scale reconstructed climate variables characterizing North Atlantic: i.e. sea surface temperatures (SST) from the tropical cyclone main developmental region (MDR), the El Niño‑Southern Oscillation (ENSO), the North Atlantic Multidecadal Oscillation (AMO), and tropical cyclone counts (TC). We examine the former three large‑scale variables because they are known to influence North Atlantic tropical cyclone activity and because their underlying drivers are still under investigation. WLMC results obtained for these multivariate climate time series suggest that: (1) MDRSST and AMO show the highest correlation with each other and with respect to the TC record over the last millennium, and: (2) MDRSST is the dominant climate variable that explains TC temporal variability. WLMC results confirm that this method is able to capture the most fundamental information contained in multivariate climate time series and is suitable to investigate correlation among climate time series in a multivariate contextJ.M.P.M was funded by the PIC 444/18 – EU Interreg project MOSES (EAPA 224/2016), FEDER funds and the SEPE (Spanish Public Service of Employment). J.F.M. acknowledges research funding received from UPV/EHU Econometrics Research Group (Basque Government Dpt. of Education grant IT-1359-19) and Spanish Ministry of Economy and Business (grant MTM2016-74931-P)

OPERACIÓN DE UNA ESTACIÓN DE BOMBEO CON GRUPOS ELECTRÓGENOS

[EN] During the months of May and June of 2011, electricity for pumping sector D (644 irrigated ha) of the Pisuerga Channel Irrigation Area (hereinafter ZR), in Palencia and Burgos, Spain, was supplied with generators (hereinafter GE) due to theft of the pumping station transformers. During the operation with GE, readings of energy consumed by pumps, energy consumed by the auxiliary circuits, pumped water, hours of operation and refueling volumes for each GE, and surfaces, volumes supplied and crops for hydrants operated, were taken during the period. With these data, total consumption, specific consumption and GE performance were determined; consumption per pumped cubic meter and per watered hectare; fixed and variable costs of operation with GE; and fixed and variable costs of operation with utility power. The main problem during the operation was limited autonomy of GE. The final cost of irrigation water for the analyzed period was 0.165 € m-3, compared with 0.026 € m-3 with utility power for that campaign.[ES] Durante los meses de mayo y junio de 2011, la energía eléctrica para el bombeo del sector D (644 ha regadas) de la Zona Regable del Canal del Pisuerga (en adelante, ZR), en Palencia y Burgos, fue suministrada con grupos electrógenos (en adelante GE) debido al robo de los transformadores de la estación. Durante el período de operación con GE se tomaron lecturas de energía consumida por las bombas, energía consumida por los circuitos auxiliares, agua bombeada, horas de funcionamiento y volúmenes de repostaje de cada uno de los GE, y superficies, volúmenes suministrados y cultivos para los hidrantes operados durante el período. Con estos datos, se determinaron los consumos totales, consumos específicos y rendimientos de los grupos; consumos por m3 bombeado y por ha regada; costes fijos y variables de operación con GE; y costes fijos y variables de operación con energía de la red. El principal problema durante la operación fue la limitada autonomía de los equipos. El coste final del agua de riego, para el período analizado, fue de 0,165 € m-3, frente a los 0,026 € m-3 con suministro de la red eléctrica para esa campaña.Ruiz Padín, A.; Medina Martínez, J. (2015). OPERACIÓN DE UNA ESTACIÓN DE BOMBEO CON GRUPOS ELECTRÓGENOS. En XXXIII CONGRESO NACIONAL DE RIEGOS. Valencia 16-18 junio de 2015. Editorial Universitat Politècnica de València. https://doi.org/10.4995/CNRiegos.2015.1466OC

Storing, reporting and comparing proteomics experiments using the miape generator tool

Comunicaciones a congreso

MODELIZACIÓN DE ACUÍFEROS PARA GARANTIZAR LOS RECURSOS EN EXPLOTACIONES CON DESTINO A RIEGO

[ES] Los modelos hidrogeológicos constituyen una herramienta básica de apoyo a las decisiones para la gestión de recursos hídricos y se utilizan para contabilizar las entradas y salidas de recursos hídricos en el espacio y en el tiempo, simulando la disponibilidad futura de recursos y por tanto la garantía en cantidad y calidad de los mismos. En este contexto, un modelo hidrogeológico, bien construido y calibrado, tiene la virtud de poder predecir el futuro de distintos escenarios posibles y por tanto poder actuar con suficiente antelación frente a situaciones críticas o de estrés prolongado. Por ejemplo, ante un periodo de estiaje prolongado (sequía) la posible entrada en explotación de nuevos pozos de bombeo o regeneración de los existentes, cómo afectaría al sistema hidrogeológico, ¿lo agotaría?, ¿en cuánto tiempo?, ¿aguantaría la explotación hasta el siguiente periodo húmedo?, ¿afectaría a la calidad del agua?, etc. Existen muchas cuestiones fundamentales que resuelve la modelización y que hasta ahora, únicamente la Administración, ha estado utilizando como herramienta fundamental para la gestión de la explotación de acuíferos.Martínez Arias, A.; Soto Venegas, J.; Beltrán Medina, P. (2015). MODELIZACIÓN DE ACUÍFEROS PARA GARANTIZAR LOS RECURSOS EN EXPLOTACIONES CON DESTINO A RIEGO. En XXXIII CONGRESO NACIONAL DE RIEGOS. Valencia 16-18 junio de 2015. Editorial Universitat Politècnica de València. https://doi.org/10.4995/CNRiegos.2015.1443OC

Re-use of construction and demolition residues and industrial wastes for the elaboration or recycled eco-efficient concretes

[EN] Production of residues from industries and construction and demolition sectors has increased during last years. The total amount of debris produced according to different estimations reaches values close to 42 million tonnes yr –1 . Much of this waste has been thrown to landfill, without considering its potential for reuse, recycling or valuation. The aim of this research is to describe some of the physical and mechanical properties of different laboratory-mixed concretes, using various proportions of additional materials recovered from industrial waste and demolition rubble. The added materials are included either as admixtures (forestry residues, cork dust, steel fibre) or in partial substitution of natural aggregates (wire from electrical residues, tyre rubber, white ceramic, sanitary porcelain or shale). The laboratory tests have followed the standard EN protocols. Assay results were variable according to the nature of the material added to the mix: organic materials and shale, despite the steel fibre reinforcement, reduce the compression strength, but are suitable for the manufacture of lightweight concrete for agricultural pavements, with certain flexion resistance and a relatively good behaviour to impact. The substitution of natural aggregates with ceramic and porcelain wastes produces a significant increase in compression resistance, making them suitable for the manufacture of concrete with characteristic resistances above 40 MPa, which can be used both for structures or other agricultural elements: separators, feeders, slat floors. As a conclusion can be stated the possibility of reuse these wastes for the production of structural or non-structural concrete, with different applications in agricultural engineerin

Pathogenesis of Penile Squamous Cell Carcinoma: Molecular Update and Systematic Review.

Penile squamous cell carcinoma (PSCC) is a rare but aggressive neoplasm with dual pathogenesis (human papillomavirus (HPV)-associated and HPV-independent). The development of targeted treatment is hindered by poor knowledge of the molecular landscape of PSCC. We performed a thorough review of genetic alterations of PSCC focused on somatic mutations and/or copy number alterations. A total of seven articles have been identified which, overall, include 268 PSCC. However, the series are heterogeneous regarding methodologies employed for DNA sequencing and HPV detection together with HPV prevalence, and include, in general, a limited number of cases, which results in markedly different findings. Reported top-ranked mutations involve TP53, CDKN2A, FAT1, NOTCH-1 and PIK3CA. Numerical alterations involve gains in MYC and EGFR, as well as amplifications in HPV integration loci. A few genes including TP53, CDKN2A, PIK3CA and CCND1 harbor both somatic mutations and copy number alterations. Notch, RTK-RAS and Hippo pathways are frequently deregulated. Nevertheless, the relevance of the identified alterations, their role in signaling pathways or their association with HPV status remain elusive. Combined targeting of different pathways might represent a valid therapeutic approach in PSCC. This work calls for large-scale sequencing studies with robust HPV testing to improve the genomic understanding of PSCC

The molecular basis and biologic significance of the β-dystroglycan-emerin interaction

β-dystroglycan (β-DG) assembles with lamins A/C and B1 and emerin at the nuclear envelope (NE) to maintain proper nuclear architecture and function. To provide insight into the nuclear function of β-DG, we characterized the interaction between β-DG and emerin at the molecular level. Emerin is a major NE protein that regulates multiple nuclear processes and whose deficiency results in Emery–Dreifuss muscular dystrophy (EDMD). Using truncated variants of β-DG and emerin, via a series of in vitro and in vivo binding experiments and a tailored computational analysis, we determined that the β-DG–emerin interaction is mediated at least in part by their respective transmembrane domains (TM). Using surface plasmon resonance assays we showed that emerin binds to β-DG with high affinity (KD in the nanomolar range). Remarkably, the analysis of cells in which DG was knocked out demonstrated that loss of β-DG resulted in a decreased emerin stability and impairment of emerin-mediated processes. β-DG and emerin are reciprocally required for their optimal targeting within the NE, as shown by immunofluorescence, western blotting and immunoprecipitation assays using emerin variants with mutations in the TM domain and B-lymphocytes of a patient with EDMD. In summary, we demonstrated that β-DG plays a role as an emerin interacting partner modulating its stability and function

Innovación y estrategias de intervención en acoso escolar

Los problemas de convivencia escolar, violencia escolar, bullying y cyberbullying, en los centros españoles son una realidad y, por tanto, es necesario que los futuros docentes cuenten con estrategias específicas para el abordaje de estas situaciones cuando se enfrenten a la realidad de las aulas. En este manual, profesionales del área de la convivencia escolar presentan las actuaciones, programas y herramientas disponibles que en estos momentos se están poniendo en práctica en los centros escolares con resultados positivos. Así, se pretende ampliar el conocimiento teórico-práctico en el ámbito de la convivencia, gestión de conflictos y violencia escolar.EducaciónPsicologí