15 research outputs found
Catålogo de los hongos aislados en el polvo acumulado en colegios de Córdoba (España)
Catålogo de los hongos aislados en el polvo acumulado en colegios de Córdoba (España).
En este trabajo se ha analizado el polvo de 12 Colegios de E.G.B. de la ciudad de CĂłrdoba, con objeto de
identificar, cuantificar y catalogar la micoflora presente en Ă©l, asĂ como conocer su frecuencia y
estacionalidad. De esta manera hemos aislado 91 tĂĄxones, los cuales se relacionan en el presente catĂĄlogo,
indicando para cada uno de ellos si son potencialmente patogénicos, época del año en la que se han
detectado e incidencia en nuestros muestreos.Checklist of the fungi isolated from school dust in Cordoba (Spain). The micoflora presents
in dust of 12 schools of the city of Cordoba have been studied. A check list indicating seasonality,
frequency and incidence of the 91 taxa is included
Catålogo de los hongos presentes en silos de la provincia de Córdoba (España)
En este trabajo se realizĂł durante un año el estudio de la presencia de hongos en el ambiente de dos silos y dos almacenes de semillas de la provincia de CĂłrdoba. Para el muestreo del aire se utilizaron simultĂĄneamente un mĂ©todo volumĂ©trico y otro gravimĂ©trico, ambos sobre medio de cultivo. Paralelamente se tomaron muestras de grano almacenado, para conocer la micoflora que contenĂan. Con los resultados obtenidos se ha elaborado un catĂĄlogo que incluye los 70 tĂĄxones identificados. Para cada taxĂłn se indican, ecologĂa, patogenicidad potencial y anteriores citas en España
Catålogo de los hongos presentes en silos de la provincia de Córdoba (España)
The presence of fungi in two different silos and two stores located at CoÌrdoba province, has been studied during twelve months. Volumetric and gravimetric methods were used simultaneously for sampling the air, always on culture medium. At the same time the grain stored were sampled in order to know its associated mycoflora. From the results, a catalogue containing the 70 identified taxa in the silos and stores sampled (air and grain). The ecology, potential patogenicity and previous records in Spain is given for every taxa.En este trabajo se realizoÌ durante un anÌo el estudio de la presencia de hongos en el ambiente de dos silos y dos almacenes de semillas de la provincia de CoÌrdoba. Para el muestreo del aire se utilizaron simultaÌneamente un meÌtodo volumeÌtrico y otro gravimeÌtrico, ambos sobre medio de cultivo. Paralelamente se tomaron muestras de grano almacenado, para conocer la micoflora que conteniÌan. Con los resultados obtenidos se ha elaborado un cataÌlogo que incluye los 70 taÌxones identificados. Para cada tazoÌn se indican, ecologiÌa, patogenicidad potencial y anteriores citas en EspanÌa
Prediction of unplanned hospitalizations in older patients treated with chemotherapy
Purpose: To determine the incidence of unplanned hospitalization (UH) and to identify risk factors for UH in elderly patients with cancer who start chemotherapy. Methods: In all, 493 patients over 70 years starting new chemotherapy regimens were prospectively included. A pre-chemotherapy geriatric assessment was performed, and tumor and treatment variables were collected. The association between these factors and UH was examined by using multivariable logistic regression. Score points were assigned to each risk factor. Results: During the first 6 months of treatment, 37% of patients had at least one episode of UH. Risk factors were the use of combination chemotherapy at standard doses, a MAX2 index â„1, a Charlson comorbidity score â„2, albumin level <3.5 g/dL, falls in the past 6 months â„1, and weight loss >5%. Three risk groups for UH were established according to the score in all patients: 0â1: 17.5%; 2: 34%; and 3â7: 57% (p < 0.001). The area under receiver operation characteristic (ROC) curve was 0.72 (95% CI: 0.67â0.77). Conclusion: This simple tool can help to reduce the incidence of UH in elderly patients with cancer who are scheduled to initiate chemotherapy treatmen
Prediction of Chemotoxicity, Unplanned Hospitalizations and Early Death in Older Patients with Colorectal Cancer Treated with Chemotherapy
Simple Summary Chemotoxicity, unplanned hospitalizations (Uhs) and early death (ED) are common among older patients with cancer who receive chemotherapy. Our objective was to determine factors predicting these complications. A predictive score for these three complications based on geriatric, tumor and laboratory variables was developed in a series of 215 older patients with colorectal carcinoma receiving chemotherapy. The use of this score may reliably identify patients at risk to have excessive toxicity with chemotherapy, UH or ED, thus helping to plan treatment, implement adaptive measures, and intensify follow-up. Purpose: To identify risk factors for toxicity, unplanned hospitalization (UH) and early death (ED) in older patients with colorectal carcinoma (CRC) initiating chemotherapy. Methods: 215 patients over 70 years were prospectively included. Geriatric assessment was performed before treatment, and tumor and treatment variables were collected. The association between these factors and grade 3-5 toxicity, UH and ED (<6 months) was examined by using multivariable logistic regression. Score points were assigned to each risk factor. Results: During the first 6 months of treatment, 33% of patients developed grade 3-5 toxicity, 31% had UH and 23% died. Risk factors were, for toxicity, instrumental activities of daily living, creatinine clearance, weight loss and MAX2 index; for UH, Charlson Comorbidity Score, creatinine clearance, weight loss, serum albumin, and metastatic disease; and for ED, basic activities in daily living, weight loss, metastatic disease, and hemoglobin levels. Predictive scores were built with these variables. The areas under receiver operation characteristic (ROC) curves for toxicity, UH and ED were 0.70 (95% CI: 0.64-0.766), 0.726 (95% IC: 0.661-0.799) and 0.74 (95% IC: 0.678-0.809), respectively. Conclusion: Simple scores based on geriatric, tumor and laboratory characteristics predict severe toxicity, UH and ED, and may help in treatment planning
Development and Validation of an Early Mortality Risk Score for Older Patients Treated with Chemotherapy for Cancer
Background: Estimation of life expectancy in older patients is relevant to select the best treatment strategy. We aimed to develop and validate a score to predict early mortality in older patients with cancer. Patients and Methods: A total of 749 patients over 70 years starting new chemotherapy regimens were prospectively included. A prechemotherapy assessment that included sociodemographic variables, tumor/treatment variables, and geriatric assessment variables was performed. Association between these factors and early death was examined using multivariable logistic regression. Score points were assigned to each risk factor. External validation was performed on an independent cohort. Results: In the training cohort, the independent predictors of 6-month mortality were metastatic stage (OR 4.8, 95% CI [2.4-9.6]), ECOG-PS 2 (OR 2.3, 95% CI [1.1-5.2]), ADL †5 (OR 1.7, 95% CI [1.1-3.5]), serum albumin levels †3.5 g/dL (OR 3.4, 95% CI [1.7-6.6]), BMI < 23 kg/m2 (OR 2.5, 95% CI [1.3-4.9]), and hemoglobin levels < 11 g/dL (OR 2.4, 95% CI (1.2-4.7)). With these results, we built a prognostic score. The area under the ROC curve was 0.78 (95% CI, 0.73 to 0.84), and in the validation set, it was 0.73 (95% CI: 0.67-0.79). Conclusions: This simple and highly accurate tool can help physicians making decisions in elderly patients with cancer who are planned to initiate chemotherapy treatment
FamĂlies botĂ niques de plantes medicinals
Facultat de Farmà cia, Universitat de Barcelona. Ensenyament: Grau de Farmà cia, Assignatura: Botà nica FarmacÚutica, Curs: 2013-2014, Coordinadors: Joan Simon, CÚsar Blanché i
Maria Bosch.Els materials que aquĂ es presenten sĂłn els recull de 175 treballs dâuna famĂlia botĂ nica dâinterĂšs medicinal realitzats de manera individual. Els treballs han estat realitzat
per la totalitat dels estudiants dels grups M-2 i M-3 de lâassignatura BotĂ nica FarmacĂšutica
durant els mesos dâabril i maig del curs 2013-14. Tots els treballs sâhan dut a terme a travĂ©s de la plataforma de GoogleDocs i han estat tutoritzats pel professor de lâassignatura i revisats i finalment co-avaluats entre els propis estudiants. Lâobjectiu principal de lâactivitat ha estat fomentar lâaprenentatge autĂČnom i col·laboratiu en BotĂ nica farmacĂšutica
Design and baseline characteristics of the finerenone in reducing cardiovascular mortality and morbidity in diabetic kidney disease trial
Background: Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials.
Patients and Methods: The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate >= 25 mL/min/1.73 m(2) and albuminuria (urinary albumin-to-creatinine ratio >= 30 to <= 5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level alpha = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure.
Conclusions: FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen.
Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049
Estimation of chlorophyll in
âą The potential of a chlorophyll meter (CCM-200, Opti-Sciences, Tyngsboro, MA, USA) for
the estimation of total leaf chlorophyll contents was evaluated in leaves of different
developmental stages for Quercus pyrenaica Willd., Q. faginea
Lam., Q. suber L. and Q. ilex L. subsp.
ballota (Desf.) Samp.
âą For all species and leaf stages, a strong non-linear relationship (P
< 0.0001) was found between the chlorophyll content index (CCI) and leaf
chlorophyll content per unit area. In all species, the slope of the CCI-chlorophyll
content relationship varied during leaf development, suggesting that caution should be
exercised when using the CCM-200, since the interpretation of CCI readings should be
limited to samples of similar leaf age. Also, the data indicate that the models should
also be species-specific, owing to differences in the intercept and/or slope of the
equations.
âą The addition of fresh LMA as a complementary parameter improved the accuracy of
chlorophyll estimation in non-species-specific equations to a considerable extent when
leaf samples of similar development were considered.
âą After due consideration, it may be concluded that the CCM-200 chlorophyll meter is a
reliable method for acquiring an estimation of chlorophyll contents in Mediterranean
Quercus species, with potential use as an effective tool in forest
management