6 research outputs found
Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors
- Author
- Abdellaoui Abdel
- Abramova Liliya
- Adams Mark
- Adams Mark J.
- Adan Roger A. H.
- Adolfsson Rolf
- Adolfsson Rolf
- Adorjan Kristina
- Agartz Ingrid
- Agartz Ingrid
- Agerbo Esben
- Agerbo Esben
- Agerbo Esben
- Aguayo Samuel
- Ahuja Sunil
- Air Tracy M.
- Air Tracy M.
- Al Eissa Mariam
- Albani Diego
- Alda Martin
- Alda Martin
- Alfredsson Lars
- Alfredsson Lars
- Alfredsson Lars
- Alliey-Rodriguez Ney
- Als Thomas D.
- Andlauer Till F. M.
- Ando Tetsuya
- Andreassen Ole A.
- Andreassen Ole A.
- Andreassen Ole A.
- Anjorin Adebayo
- Anjorin Adebayo
- Antilla Verneri
- Antoniou Anastasia
- Appadurai Vivek
- Argyres Dean P.
- Arolt Volker
- Artigas Maria Soler
- Aschauer Harald
- Ashley-Koch Allison E.
- Aslan Mihaela
- Awasthi Swapnil
- Awasthi Swapnil
- Awasthi Swapnil
- Azevedo M. Helena
- Babadjanova Gulja
- Bacanu Silviu-Alin
- Backlund Lena
- Baek Ji Hyun
- Baker Jessica H.
- Ballas Zuhair
- Bass Nicholas
- Bass Nicholas
- Bau Claiton H. D.
- Bauer Michael
- Baune Bernhard T.
- Baune Bernhard T.
- Baune Bernhard T.
- Beckham Jean
- Beckham Jean
- Beckham Jean C.
- Beekman Aartjan T. F.
- Beins Eva C.
- Bellivier Frank
- Bellivier Frank
- Bencko Vladimir
- Bengesser Susanne
- Bergen Andrew W.
- Bergen Andrew W.
- Bergen Sarah E.
- Berger Klaus
- Berger Klaus
- Berrettini Wade H.
- Berrettini Wade H.
- Berrettini Wade H.
- Bhushan Sujata
- Biernacka Joanna M.
- Biernacka Joanna M.
- Bigdeli Tim B.
- Bigdeli Tim B.
- Bigdeli Tim B.
- Binder Elisabeth B.
- Binder Elisabeth B.
- Birgegård Andreas
- Birner Armin
- Blackwood Douglas H. R.
- Boden Joseph M.
- Boehm Ilka
- Boehnke Michael
- Boehnke Michael
- Bohus Martin
- Bohus Martin
- Boks Marco P.
- Boks Marco P.
- Boni Claudette
- Boomsma Dorret I.
- Bosch Rosa
- Bosch Rosa
- Boyko Edward
- Braff David L.
- Brandt Harry
- Brandt Harry
- Breeling James
- Breen Gerome
- Breen Gerome
- Breen Gerome
- Breen Gerome
- Brewer Jessica V.
- Brophy Mary T.
- Brum Murielle
- Brumpton Ben M.
- Brunkhorst-Kanaan Nathalie
- Bryant Richard
- Bryois Julien
- Bryois Julien
- Bryois Julien
- Budde Monika
- Budde Monika
- Buehren Katharina
- Bulik Cynthia M.
- Bulik Cynthia M.
- Burghardt Roland
- Buttenschøn Henriette N.
- Bybjerg-Grauholm Jonas
- Bybjerg-Grauholm Jonas
- Byerley William
- Byrne Enda M.
- Byrne Enda M.
- Bækvad-Hansen Marie
- Bækvad-Hansen Marie
- Bøen Erlend
- Børglum Anders D.
- Børglum Anders D.
- Børglum Anders D.
- Børte Sigrid
- Cahn Wiepke
- Cai Na
- Cairns Murray
- Campos Adrian I.
- Carlberg Laura
- Carr Vaughan J.
- Carter Bruce W.
- Casas Miguel
- Casas Miquel
- Cassina Matteo
- Castelao Enrique
- Castelao Enrique
- Catts Stanley
- Cervantes Pablo
- Cervilla Jorge A.
- Chang Kyong-Mi
- Chang Xiao
- Charney Alexander W.
- Chaumette Boris
- Chen Hsi-Chung
- Chen Wei J.
- Cho Kelly
- Cho Kelly
- Christensen Jane Hvarregaard
- Cichon Sven
- Cichon Sven
- Cichon Sven
- Cichon Sven
- Clarke Toni-Kim
- Clarke Toni-Kim
- Clementi Maurizio
- Cohen David
- Coleman Jonathan R. I.
- Coleman Jonathan R. I.
- Coleman Jonathan R. I.
- Coleman Jonathan R. I.
- Colodro-Conde Lucía
- Cone Roger D.
- Connor Todd
- Constans Joseph
- Coombes Brandon
- Coon Hilary
- Corvin Aiden
- Corvin Aiden
- Courtet Philippe
- Couvy-Duchesne Baptiste
- Craddock Nicholas
- Craddock Nicholas
- Craddock Nick
- Craig David
- Crawford Gregory E.
- Crawford Steven
- Crawford Steven
- Crivelli Silvia
- Crow Scott
- Crow Scott
- Crowley James J.
- Cruceanu Cristiana
- Cuellar-Barboza Alfredo
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- Curtis David
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- Dannlowski Udo
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- Dedoussis George
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- Dellitalia Louis
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- Dennis Michelle F.
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- DePaulo J. Raymond
- der Auwera Sandra Van
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- Dietl Lydie
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- Djurovic Srdjan
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- Do Nhan
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- Domenici Enrico
- Domschke Katharina
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- Duriez Philibert
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- Ha Kyooseob
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- Hwu Hai-Gwo
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- Imgart Hartmut
- Inoko Hidetoshi
- Iruvanti Pran
- Ising Marcus
- Ising Marcus
- Ivins Douglas
- Iwata Nakao
- Jablensky Assen V.
- Jacobson Daniel
- Jacono Frank
- Jain Sonia
- Jamain Stéphane
- Jamain Stéphane
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- Treutlein Jens
- Trubetskoy Vassily
- Trubetskoy Vassily
- Trzaskowski Maciej
- Trzaskowski Maciej
- Tsao Philip
- Tsao Philip S.
- Tsao Philip S.
- Tsao Philip S.
- Tsermpini Evangelia-Eirini
- Tsitsika Artemis
- Tsuang Ming T.
- Turecki Gustavo
- Turecki Gustavo
- Tyszkiewicz-Nwafor Marta
- Tziouvas Konstantinos
- Uher Rudolf
- Uitterlinden André G.
- Umbricht Daniel
- Ursano Robert J.
- Vaaler Arne E.
- Van der Auwera Sandra
- van Elburg Annemarie A.
- van Furth Eric F.
- van Hemert Albert M.
- Vawter Marquis P.
- Vedder Helmut
- Vieta Eduard
- Viktorin Alexander
- Vilar-Ribó Laura
- Villareal Gerardo
- Vincent John B.
- Vincent John B.
- Visscher Peter M.
- Völzke Henry
- Völzke Henry
- Wade Tracey D.
- Wagner Gudrun
- Waldman Irwin D.
- Wallbom Agnes
- Walters James T. R.
- Walters James T. R.
- Walton Esther
- Wang Yunpeng
- Ware Erin B.
- Wasserman Danuta
- Watson Hunna J.
- Watson Hunna J.
- Webb Bradley T.
- Weickert Cynthia Shannon
- Weickert Thomas W.
- Weickert Thomas W.
- Weinsheimer Shantel Marie
- Weissman Myrna M.
- Weissman Myrna M.
- Wellmann Jürgen
- Werge Thomas
- Werge Thomas
- Werge Thomas
- Werge Thomas
- Whitbourne Stacey B.
- Whiteman David C.
- Whiteman David C.
- Whittle Jeffrey
- Whooley Mary
- Wichmann H. Erich
- Widen Elisabeth
- Willemsen Gonneke
- Williams Leanne M.
- Willour Virginia
- Wilson Peter
- Winsvold Bendik S.
- Witt Stephanie H.
- Witt Stephanie H.
- Witt Stephanie H.
- Witt Stephanie H.
- Won Hong-Hee
- Woodside D. Blake
- Woodside D. Blake
- Wray Naomi R.
- Wray Naomi R.
- Wray Naomi R.
- Wu Yang
- Xi Hualin S.
- Xi Simon
- Xu Junzhe
- Xu Wei
- Yang Jian
- Yao Shuyang
- Yeh Shing Shing
- Yilmaz Zeynep
- Yilmaz Zeynep
- Young Allan H.
- Young Hannah
- Zablocki Clement J.
- Zai Clement C.
- Zandi Peter P.
- Zeggini Eleftheria
- Zerwas Stephanie
- Zhang Futao
- Zhao Hongyu
- Zhou Hang
- Zillich Lea
- Zillich Lea
- Zipfel Stephan
- Zwart John-Anker
- Świątkowska Beata
- Świątkowska Beata
- Świątkowska Beata
- Publication venue
- Publication date
- 01/01/2021
- Field of study
Background Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic etiology, which is partially shared and partially distinct from that of related psychiatric disorders. Methods We conducted a genome-wide association study (GWAS) of 29,782 suicide attempt (SA) cases and 519,961 controls in the International Suicide Genetics Consortium (ISGC). The GWAS of SA was conditioned on psychiatric disorders using GWAS summary statistics via multitrait-based conditional and joint analysis, to remove genetic effects on SA mediated by psychiatric disorders. We investigated the shared and divergent genetic architectures of SA, psychiatric disorders, and other known risk factors. Results Two loci reached genome-wide significance for SA: the major histocompatibility complex and an intergenic locus on chromosome 7, the latter of which remained associated with SA after conditioning on psychiatric disorders and replicated in an independent cohort from the Million Veteran Program. This locus has been implicated in risk-taking behavior, smoking, and insomnia. SA showed strong genetic correlation with psychiatric disorders, particularly major depression, and also with smoking, pain, risk-taking behavior, sleep disturbances, lower educational attainment, reproductive traits, lower socioeconomic status, and poorer general health. After conditioning on psychiatric disorders, the genetic correlations between SA and psychiatric disorders decreased, whereas those with nonpsychiatric traits remained largely unchanged. Conclusions Our results identify a risk locus that contributes more strongly to SA than other phenotypes and suggest a shared underlying biology between SA and known risk factors that is not mediated by psychiatric disorders.Peer reviewe
Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders.
- Author
- Abbott Liam
- Abdellaoui Abdel
- Adams Mark J
- Adolfsson Annelie Nordin
- Adolfsson Rolf
- Agartz Ingrid
- Agerbo Esben
- Agerbo Esben
- Air Tracy M
- Akil Huda
- Albani Diego
- Alda Martin
- Alliey-Rodriguez Ney
- Als Thomas D
- Andlauer Till F M
- Andlauer Till F M
- Andreassen Ole A
- Anjorin Adebayo
- Antilla Verneri
- Arolt Volker
- Auburger Georg
- Awasthi Swapnil
- Bacanu Silviu-Alin
- Backlund Lena
- Badner Judith A
- Barchas Jack D
- Bass Nicholas
- Bauer Michael
- Baune Bernhard T
- Baune Bernhard T
- Beekman Aartjan T F
- Belliveau Richard
- Bellivier Frank
- Bergen Sarah E
- Berger Klaus
- Berrettini Wade H
- Biernacka Joanna M
- Bigdeli Tim B
- Binder Elisabeth B
- Blackwood Douglas H R
- Boehnke Michael
- Boks Marco
- Boocock James
- Boomsma Dorret I
- Breen Gerome
- Breen Gerome
- Bryois Julien
- Budde Monika
- Bunney William
- Burmeister Margit
- Buttenschøn Henriette N
- Bybjerg-Grauholm Jonas
- Bybjerg-Grauholm Jonas
- Byerley William
- Byrne Enda M
- Bækvad-Hansen Marie
- Bækvad-Hansen Marie
- Bøen Erlend
- Børglum Anders D
- Børglum Anders D
- Cabaleiro Fabeiro Francisco J
- Cai Na
- Casas Miquel
- Castelao Enrique
- Cerrato Felecia
- Cervantes Pablo
- Chambert Kimberly
- Charney Alexander W
- Chen Danfeng
- Christensen Jane Hvarregaard
- Churchhouse Claire
- Cichon Sven
- Cichon Sven
- Cichon Sven
- Clair David St
- Clarke Toni-Kim
- Clarke Toni-Kim
- Coleman Jonathan R I
- Coleman Jonathan R I
- Colodro-Conde Lucía
- Corvin Aiden
- Coryell William
- Couvy-Duchesne Baptiste
- Craddock Nicholas
- Craddock Nick
- Craig David W
- Crawford Gregory E
- Cruceanu Cristiana
- Czerski Piotr M
- Dale Anders M
- Daly Mark J
- Dannlowski Udo
- Dannlowski Udo
- Davies Gail
- de Diego-Otero Yolanda
- de Geus E. J. C.
- de Jong Simone
- de Leeuw Christiaan A
- Deary Ian J
- Degenhardt Franziska
- Degenhardt Franziska
- Degenhardt Franziska
- Del Río Noriega Francisco
- Del-Favero Jurgen
- DePaulo J Raymond
- DePaulo J Raymond
- Derks Eske M
- Direk Nese
- Djurovic Srdjan
- Dobbyn Amanda L
- Dolan Conor V
- Domenici Enrico
- Domschke Katharina
- Dumont Ashley
- Dunn Erin C
- Edenberg Howard J
- Eley Thalia C
- Elvsåshagen Torbjørn
- Escott-Price Valentina
- Escott-Price Valentina
- Esko Tõnu
- Esko Tõnu
- Etain Bruno
- EThorgeirsson Thorgeir
- Fan Chun Chieh
- Finucane Hilary K
- Fischer Sascha B
- Flickinger Matthew
- Florio Arianna Di
- Foo Jerome C
- Foo Jerome C
- Foroud Tatiana M
- Forstner Andreas J
- Forstner Andreas J
- Forstner Andreas J
- Forty Liz
- Frank Josef
- Frank Josef
- Frank Josef
- Fraser Christine
- Freimer Nelson B
- Frisén Louise
- Frye Mark
- Fullerton Janice M
- Gade Katrin
- Gage Diane
- Garnham Julie
- Gaspar Héléna A
- Gaspar Héléna A
- Gershon Elliot S
- Giambartolomei Claudia
- Gil Flores Susana
- Gill Michael
- Gill Michael
- Goes Fernando
- Goes Fernando S
- Goldstein Jaqueline
- González Maria José
- Gordon Scott D
- Gordon Scott D
- Gordon-Smith Katherine
- Grabe Hans J
- Green Elaine K
- Green Melissa J
- Greenwood Tiffany A
- Grigoroiu-Serbanescu Maria
- Grove Jakob
- Grove Jakob
- Guan Weihua
- Guzman-Parra Jose
- Hall Lynsey S
- Hamilton Steven P
- Hamshere Marian L
- Hansen Christine Søholm
- Hansen Christine Søholm
- Hansen Thomas F
- Haro González Jesus
- Hauser Joanna
- Hautzinger Martin
- Hayward Caroline
- Heath Andrew C
- Heilbronner Urs
- Heilmann-Heimbach Stefanie
- Herms Stefan
- Herms Stefan
- Herms Stefan
- Hickie Ian B
- Hipolito Maria
- Hoffmann Per
- Hoffmann Per
- Hoffmann Per
- Holland Dominic
- Holmans Peter A
- Homuth Georg
- Horn Carsten
- Hottenga Jouke-Jan
- Hougaard David M
- Hougaard David M
- Howard David M
- Huckins Laura
- Hultman Christina M
- Ising Marcus
- Jamain Stéphane
- Jansen Rick
- Johnson Jessica S
- Jones Ian
- Jones Ian
- Jones Lisa A
- Jones Lisa A
- Jorgenson Eric
- Juréus Anders
- Kahn René S
- Kandaswamy Radhika
- Karlsson Robert
- Kelsoe John
- Kendler Kenneth S
- Kennedy James L
- Kiadeh Farnush Farhadi Hassan
- Kirov George
- Kittel-Schneider Sarah
- Kloiber Stefan
- Knowles James A
- Knowles James A
- Kogevinas Manolis
- Kogevinas Manolis
- Kohane Isaac S
- Koller Anna C
- Kraft Julia
- Kretzschmar Warren W
- Kupka Ralph
- Kutalik Zoltán
- Landén Mikael
- Lavebratt Catharina
- Lawrence Jacob
- Lawson William B
- Leber Markus
- Leboyer Marion
- Lee Phil H
- Levinson Douglas F
- Levy Shawn E
- Lewis Cathryn M
- Lewis Cathryn M
- Lewis Glyn
- Li Jun Z
- Li Qingqin S
- Li Qingqin S
- Li Yihan
- Lind Penelope A
- Lissowska Jolanta
- Liu Chunyu
- Loohuis Loes M Olde
- Lucae Susanne
- Lucae Susanne
- Maaser Anna
- MacIntyre Donald J
- MacIntyre Donald J
- MacKinnon Dean F
- Madden Pamela A F
- Magnusson Patrik K
- Mahon Pamela B
- Maier Robert M
- Maier Wolfgang
- Maier Wolfgang
- Marchini Jonathan
- Martin Nicholas G
- Martin Nicholas G
- Martinsson Lina
- Mattheisen Manuel
- Mattheisen Manuel
- Mayoral Fermin
- Mayoral Fermín
- Mbarek Hamdi
- McCarroll Steve
- McElroy Susan L
- McGrath Patrick
- McGuffin Peter
- McGuffin Peter
- McInnis Melvin G
- McIntosh Andrew M
- McIntosh Andrew M
- McKay James D
- McMahon Francis J
- McQuillin Andrew
- Medeiros Helena
- Medland Sarah E
- Medland Sarah E
- Mehta Divya
- Melle Ingrid
- Meng Fan
- Metspalu Andres
- Metspalu Andres
- Middeldorp Christel M
- Mihailov Evelin
- Milaneschi Yuri
- Milani Lili
- Milani Lili
- Mirza Saira Saeed
- Mitchell Philip B
- Mondimore Francis M
- Montgomery Grant W
- Montgomery Grant W
- Moreno-Küstner Berta
- Morken Gunnar
- Morris Derek W
- Mors Ole
- Mors Ole
- Mortensen Preben Bo
- Mortensen Preben Bo
- Mostafavi Sara
- Mullins Niamh
- Mullins Niamh
- Myers Richard M
- Mühleisen Thomas W
- Müller-Myhsok Bertram
- Müller-Myhsok Bertram
- Müller-Myhsok Bertram
- Nauck Matthias
- Neale Benjamin M
- Ng Bernard
- Nguyen Hoang
- Nievergelt Caroline M
- Nimgaonkar Vishwajit
- Nivard Michel G
- Nordentoft Merete
- Nordentoft Merete
- Nurnberger John I
- Nwulia Evaristus A
- Nyholt Dale R
- Nöthen Markus M
- Nöthen Markus M
- Nöthen Markus M
- O'Donovan Claire
- O'Donovan Michael C
- O'Donovan Michael C
- O'Reilly Paul F
- Oedegaard Ketil J
- Ophoff Roel A
- Ori Anil P S
- Orozco Diaz Guillermo
- Oruc Lilijana
- Oskarsson Hogni
- Owen Michael J
- Owen Michael J
- Paciga Sara A
- Paciga Sara A
- Painter Jodie N
- Parra José Guzman
- Pato Carlos
- Pato Michele T
- Pavlides Jennifer M Whitehead
- Pedersen Carsten Bøcker
- Pedersen Carsten Bøcker
- Pedersen Marianne Giørtz
- Pedersen Marianne Giørtz
- Pedersen Nancy L
- Penninx Brenda W J H
- Perez Fermin Perez
- Perlis Roy H
- Perlis Roy H
- Perry Amy
- Pers Tune H
- Peterson Roseann E
- Pettersson Erik
- Peyrot Wouter J
- Pfennig Andrea
- Pistis Giorgio
- Porteous David J
- Posthuma Danielle
- Posthuma Danielle
- Potash James B
- Potash James B
- Preisig Martin
- Purcell Shaun M
- Quiroz Jorge A
- Qvist Per
- Ramos-Quiroga Josep Antoni
- Regeer Eline J
- Reif Andreas
- Reinbold Céline S
- Ribasés Marta
- Rice John P
- Rice John P
- Richards Alexander L
- Rietschel Marcella
- Rietschel Marcella
- Rietschel Marcella
- Riley Brien P
- Ripke Stephan
- Ripke Stephan
- Rivas Fabio
- Rivas Fabio
- Rivera Margarita
- Rivera Margarita
- Rouleau Guy A
- Roussos Panos
- Ruderfer Douglas M
- Ryu Euijung
- Schaefer Catherine
- Schalling Martin
- Schatzberg Alan F
- Scheftner William A
- Schoevers Robert
- Schofield Peter R
- Schork Nicholas J
- Schulte Eva C
- Schulze Thomas G
- Schulze Thomas G
- Scott Laura J
- Serretti Alessandro
- Shehktman Tatyana
- Shen Ling
- Shi Jianxin
- Shilling Paul D
- Shyn Stanley I
- Sigurdsson Engilbert
- Sigurdsson Engilbert
- Sinnamon Grant C B
- Sklar Pamela
- Slaney Claire
- Smeland Olav B
- Smit Johannes H
- Smith Daniel J
- Smoller Jordan W
- Smoller Jordan W
- Sobell Janet L
- Spijker Anne T
- Stahl Eli A
- Stefansson Hreinn
- Stefansson Hreinn
- Stefansson Kari
- Stefansson Kari
- Steffens Michael
- Steinberg Stacy
- Steinberg Stacy
- Stordal Eystein
- Strauss John S
- Streit Fabian
- Streit Fabian
- Streit Fabian
- Strohmaier Jana
- Strohmaier Jana
- Strohmaier Jana
- Sullivan Patrick F
- Sullivan Patrick F
- Szelinger Szabolcs
- Sánchez-Mora Cristina
- Tansey Katherine E
- Teismann Henning
- Teumer Alexander
- Thompson Robert C
- Thompson Wesley
- Thomson Pippa A
- Thorgeirsson Thorgeir E
- Tiemeier Henning
- Traylor Matthew
- Treutlein Jens
- Treutlein Jens
- Treutlein Jens
- Trubetskoy Vassily
- Trubetskoy Vassily
- Trzaskowski Maciej
- Trzaskowski Maciej
- Turecki Gustavo
- Uher Rudolf
- Uitterlinden André G
- Umbricht Daniel
- Vaaler Arne E
- Van der Auwera Sandra
- van Hemert Albert M
- Vedde Helmut
- Vieta Eduard
- Viktorin Alexander
- Vincent John B
- Visscher Peter M
- Völzke Henry
- Wang Weiqing
- Wang Yunpeng
- Wang Yunpeng
- Watson Stanley J
- Webb Bradley T
- Weickert Cynthia Shannon
- Weickert Thomas W
- Weinsheimer Shantel Marie
- Weissman Myrna M
- Wellmann Jürgen
- Werge Thomas
- Werge Thomas
- Willemsen Gonneke
- Witt Stephanie H
- Witt Stephanie H
- Witt Stephanie H
- Wray Naomi R
- Wray Naomi R
- Wu Yang
- Xi Hualin S
- Xi Simon
- Xu Wei
- Yang Jian
- Young Allan H
- Zandi Peter
- Zhang Futao
- Zhang Peng
- Zollner Sebastian
- Ösby Urban
- Publication venue
- Mol Psychiatry
- Publication date
- 20/12/2018
- Field of study
Multiplex families with a high prevalence of a psychiatric disorder are often examined to identify rare genetic variants with large effect sizes. In the present study, we analysed whether the risk for bipolar disorder (BD) in BD multiplex families is influenced by common genetic variants. Furthermore, we investigated whether this risk is conferred mainly by BD-specific risk variants or by variants also associated with the susceptibility to schizophrenia or major depression. In total, 395 individuals from 33 Andalusian BD multiplex families (166 BD, 78 major depressive disorder, 151 unaffected) as well as 438 subjects from an independent, BD case/control cohort (161 unrelated BD, 277 unrelated controls) were analysed. Polygenic risk scores (PRS) for BD, schizophrenia (SCZ), and major depression were calculated and compared between the cohorts. Both the familial BD cases and unaffected family members had higher PRS for all three psychiatric disorders than the independent controls, with BD and SCZ being significant after correction for multiple testing, suggesting a high baseline risk for several psychiatric disorders in the families. Moreover, familial BD cases showed significantly higher BD PRS than unaffected family members and unrelated BD cases. A plausible hypothesis is that, in multiplex families with a general increase in risk for psychiatric disease, BD development is attributable to a high burden of common variants that confer a specific risk for BD. The present analyses demonstrated that common genetic risk variants for psychiatric disorders are likely to contribute to the high incidence of affective psychiatric disorders in the multiplex families. However, the PRS explained only part of the observed phenotypic variance, and rare variants might have also contributed to disease development
Rights Without Remedies: The Court Party Theory and the Demise of the Court Challenges Program
- Author
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- . L Isr
- . U Loy
- . U Loy
- ] S C J NO
- A J
- Ab Currie
- Ab Currie
- Adam Whitcombe
- Adam Whitcombe
- Alberta Government Of
- Alberta Government Of
- Allen &
- Andrews V
- Archibald H Kaiser
- Band V Sawridge Indian
- Bedford V
- Bedford V. The
- Beverley C J Mclachlin
- Brian &
- Brian Etherington
- Brian Laghi
- Brodie
- Brodie
- Brodie
- Bruce Porter
- Buckley
- C J Bauman
- Canada
- Canada
- Canada
- Carol Mceown
- Chaoulli V Quebec
- Charles Epp
- Chris Tollefson
- Christie
- Christie
- Christopher &
- Christopher Manfredi
- Claire E Choudhry
- Daved Muttart
- David E Smith
- David Gourlay
- David Mullan
- De Guzman V
- Dennis &
- Dennis R Hoover
- E Eid
- Egan V Canada
- F L Morton
- F L Morton
- F L Morton
- Faisal Bhabha
- Ford V Quebec
- Gordon V Goertz
- Gourlay
- Gourlay
- Grant V Canada
- Gregory Hein
- Gwen Brodsky
- Gwen Brodsky
- Gwen Brodsky
- H B Mccullough
- Heather Scoffield
- Herbert Kritzer
- Hindle &
- Hindle &
- Hogg
- Hugo Rojas
- Hugo Rojas
- Ian Binnie
- Ian Binnie
- Ian Brodie
- Ian Brodie
- Ian Brodie
- Ian Greene
- Ibid
- Ibid
- Ibid
- Ibid
- Ibid
- Ibid
- Ibid
- Ibid
- Ibid
- Ibid
- J Carpay
- J F Fletcher
- J F. &
- Jamie &
- Jane Taber
- Janet Hiebert
- Joseph &
- Karen &
- Karen Hindle
- Kent Roach
- Kerri Froc
- Kevin Marshall
- L J Mcgill
- L J Mcgill
- L J Mcgill
- L. -A Kloegman
- Lara Friedlander
- Larry M Fox
- Lavigne V
- Legal Aid Ontario
- Lisa Braverman
- Lorne Sossin
- Lorne Sossin
- Lorne Sossin
- Lorraine. -Canada&apos
- Louise Arbour
- M V H
- M V H
- Mandel Michael
- Mary Eberts
- Mcivor V Canada
- Mckay-Panos V. Air
- Melanie Randall
- Melina Buckley
- Michael &
- Michael Trebilcock
- Mike &
- Mike Desouza
- Miriam Smith
- Morton
- Morton
- Natalie Alcoba
- Nicholas Kittrie
- Okanagan
- Okanagan
- Osgoode Hall
- Patrick Monahan
- Patrick Monahan
- Peter H Russell
- Peter Hogg
- Philip Bryden
- Pro Bono Law Ontario
- R V Caron
- R V Conway
- R V Conway
- R V Daviault
- R V Daviault
- R V Gomboc
- Rainer &
- Ran Hirschl
- Richard A Goreham
- Roach
- Roach
- Roach
- Robert Bauman
- Robert C J Bauman
- Robert Martin
- Robert W Macaulay
- Robin Elliot
- Ronald Dworkin
- Roy Elliott
- Roy Elliott
- S C L R
- Sarah Armstrong
- See Buckley
- See Ibid Canada
- See Philip Bryden
- See Social Planning
- Shannon Salter
- Shannon Smithey
- Sheila Mcintyre
- Sheila. -Deference Mcintyre
- Social Planning
- Solis V Canada
- Steven Chase
- Steven Chase
- Tracey Tyler
- Tracey Tyler
- Tracey Tyler
- Treasury Board
- Tyler
- Tyler
- U B C L Rev
- V See Rjr Macdonald Inc
- Vicki Schmolka
- Vicki Schmolka
- Vicki Trerise
- Vriend
- W Robert
- Walter Tarnopolsky
- Whitcombe
- William. -Whither Conklin
- Y B Windsor
- Y Windsor
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2011
- Field of study
Rights Without Remedies: The Court Party Theory and the Demise of the Court Challenges Program
- Author
- &
- &
- &
- &
- &
- &
- &apos
- ---&
- . F Const
- . L Isr
- . U Loy
- . U Loy
- ] S C J NO
- A J
- Ab Currie
- Ab Currie
- Adam Whitcombe
- Adam Whitcombe
- Alberta Government Of
- Alberta Government Of
- Allen &
- Andrews V
- Archibald H Kaiser
- Band V Sawridge Indian
- Bedford V
- Bedford V. The
- Beverley C J Mclachlin
- Brian &
- Brian Etherington
- Brian Laghi
- Brodie
- Brodie
- Brodie
- Bruce Porter
- Buckley
- C J Bauman
- Canada
- Canada
- Canada
- Carol Mceown
- Chaoulli V Quebec
- Charles Epp
- Chris Tollefson
- Christie
- Christie
- Christopher &
- Christopher Manfredi
- Claire E Choudhry
- Daved Muttart
- David E Smith
- David Gourlay
- David Mullan
- De Guzman V
- Dennis &
- Dennis R Hoover
- E Eid
- Egan V Canada
- F L Morton
- F L Morton
- F L Morton
- Faisal Bhabha
- Ford V Quebec
- Gordon V Goertz
- Gourlay
- Gourlay
- Grant V Canada
- Gregory Hein
- Gwen Brodsky
- Gwen Brodsky
- Gwen Brodsky
- H B Mccullough
- Heather Scoffield
- Herbert Kritzer
- Hindle &
- Hindle &
- Hogg
- Hugo Rojas
- Hugo Rojas
- Ian Binnie
- Ian Binnie
- Ian Brodie
- Ian Brodie
- Ian Brodie
- Ian Greene
- Ibid
- Ibid
- Ibid
- Ibid
- Ibid
- Ibid
- Ibid
- Ibid
- Ibid
- Ibid
- J Carpay
- J F Fletcher
- J F. &
- Jamie &
- Jane Taber
- Janet Hiebert
- Joseph &
- Karen &
- Karen Hindle
- Kent Roach
- Kerri Froc
- Kevin Marshall
- L J Mcgill
- L J Mcgill
- L J Mcgill
- L. -A Kloegman
- Lara Friedlander
- Larry M Fox
- Lavigne V
- Legal Aid Ontario
- Lisa Braverman
- Lorne Sossin
- Lorne Sossin
- Lorne Sossin
- Lorraine. -Canada&apos
- Louise Arbour
- M V H
- M V H
- Mandel Michael
- Mary Eberts
- Mcivor V Canada
- Mckay-Panos V. Air
- Melanie Randall
- Melina Buckley
- Michael &
- Michael Trebilcock
- Mike &
- Mike Desouza
- Miriam Smith
- Morton
- Morton
- Natalie Alcoba
- Nicholas Kittrie
- Okanagan
- Okanagan
- Osgoode Hall
- Patrick Monahan
- Patrick Monahan
- Peter H Russell
- Peter Hogg
- Philip Bryden
- Pro Bono Law Ontario
- R V Caron
- R V Conway
- R V Conway
- R V Daviault
- R V Daviault
- R V Gomboc
- Rainer &
- Ran Hirschl
- Richard A Goreham
- Roach
- Roach
- Roach
- Robert Bauman
- Robert C J Bauman
- Robert Martin
- Robert W Macaulay
- Robin Elliot
- Ronald Dworkin
- Roy Elliott
- Roy Elliott
- S C L R
- Sarah Armstrong
- See Buckley
- See Ibid Canada
- See Philip Bryden
- See Social Planning
- Shannon Salter
- Shannon Smithey
- Sheila Mcintyre
- Sheila. -Deference Mcintyre
- Social Planning
- Solis V Canada
- Steven Chase
- Steven Chase
- Tracey Tyler
- Tracey Tyler
- Tracey Tyler
- Treasury Board
- Tyler
- Tyler
- U B C L Rev
- V See Rjr Macdonald Inc
- Vicki Schmolka
- Vicki Schmolka
- Vicki Trerise
- Vriend
- W Robert
- Walter Tarnopolsky
- Whitcombe
- William. -Whither Conklin
- Y B Windsor
- Y Windsor
- Publication venue
- Publication date
- 01/01/2011
- Field of study
The author argues that the Court Challenges Program’s 2006 cancellation was based on claims that judicial review is undemocratic, including those made by three academics, Rainer Knopff, F.L. Morton and Ian Brodie; the Court Party Theorists (the “CPT”). Through a study of Charter equality cases, this paper examines the CPT’s arguments regarding judicial activism, interest groups and interveners and finds they are largely unsupported by statistical evidence. Further, the debate about judicial review and democracy obscures judicial review’s important auditing function over the legislature’s constitutional adherence. This audit depends on individuals’ capacity to pursue Charter litigation, an ability compromised by the access to justice crisis. The author examines this crisis and the efforts to fill the funding gap left by the CCP’s cancellation and concludes that a publicly-funded program like the CCP is best-placed to ensure that the Charter remains a relevant tool for enforcing fundamental human rights in Canada.MAS
Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders
- Author
- Abbott Liam
- Abdellaoui Abdel
- Adams Mark J.
- Adams Mark J.
- Adolfsson Annelie Nordin
- Adolfsson Rolf
- Adolfsson Rolf
- Agartz Ingrid
- Agerbo Esben
- Agerbo Esben
- Agerbo Esben
- Air Tracy
- Air Tracy M.
- Akil Huda
- Albani Diego
- Albus Margot
- Alda Martin
- Alda Martin
- Alexander Madeline
- Alliey-Rodriguez Ney
- Als Thomas D.
- Als Thomas D.
- Amin Farooq
- Andlauer Till F. M.
- Andreassen Ole A.
- Andreassen Ole A.
- Anjorin Adebayo
- Antilla Verneri
- Arolt Volker
- Arranz Maria J.
- Awasthi Swapnil
- Bacanu Silviu A.
- Bacanu Silviu-Alin
- Badner Judith A.
- Bakker Steven
- Band Gavin
- Barchas Jack D.
- Barroso Ines
- Barroso Ines
- Bass Nicholas
- Bass Nicholas J.
- Bauer Michael
- Baune Bernhard T.
- Baune Bernhard T.
- Beekman Aartjan T. F.
- Begemann Martin
- Begemann Martin
- Bellenguez Céline
- Belliveau Richard
- Belliveau Richard A.
- Bellivier Frank
- Bender Stephan
- Bene Judit
- Bergen Sarah E.
- Bergen Sarah E.
- Berger Klaus
- Bevilacqua Elizabeth
- Biernacka Joanna M.
- Bigdeli Tim B.
- Bigdeli Tim B.
- Binder Elisabeth B.
- Black Donald W.
- Blackburn Hannah
- Blackwell Jenefer M.
- Blackwell Jenefer M.
- Blackwood Douglas H. R.
- Blokland Gabriëlla A. M.
- Blokland Gabriëlla A. M.
- Boks Marco P.
- Boocock James
- Boomsma Dorret I.
- Boomsma Dorret I.
- Bortolato Marco
- Bralten Janita
- Bramon Elvira
- Bramon Elvira
- Bramon Elvira
- Bramon Elvira
- Breen Gerome
- Breen Gerome
- Breen Gerome
- Breen Gerome
- Brown Matthew A.
- Brown Matthew A.
- Bruggeman Richard
- Bryois Julien
- Buccola Nancy G.
- Buckner Randy L.
- Budde Monika
- Bulik Cynthia M.
- Bulik-Sullivan Brendan
- Bumpstead Suzannah J.
- Bunney William
- Burmeister Margit
- Burton Christie L.
- Buttenschøn Henriette N.
- Buxbaum Joseph D.
- Buxbaum Joseph D.
- Bybjerg-Grauholm Jonas
- Bybjerg-Grauholm Jonas
- Byerley William
- Byerley William
- Byrne Enda M.
- Byrne Enda M.
- Byrne Enda M.
- Bækvad-Hansen Marie
- Bækvad-Hansen Marie
- Bøen Erlend
- Børglum Anders D.
- Børglum Anders D.
- Børglum Anders D.
- Børglum Anders D.
- Børglum Anders D.
- Cahn Wiepke
- Cai Guiqing
- Cai Na
- Cairns Murray J.
- Cairns Murray J.
- Campion Dominique
- Cantor Rita M.
- Carey Caitlin E.
- Carr Vaughan J.
- Carrera Noa
- Casas Juan P.
- Casas Miquel
- Castelao Enrique
- Catts Stanley V.
- Cerrato Felecia
- Cervantes Pablo
- Cervantes Pablo
- Chambert Kimberly
- Chambert Kimberly D.
- Chan Raymond C. K.
- Charney Alexander W.
- Chen Chia-Yen
- Chen Danfeng
- Chen Eric Y. H.
- Chen Ronald Y. L.
- Cheng Wei
- Cheung Eric F. C.
- Chong Siow Ann
- Christensen Jane Hvarregaard
- Churchhouse Claire
- Cichon Sven
- Cichon Sven
- Cichon Sven
- Clarke Toni-Kim
- Clarke Toni-Kim
- Cloninger C. Robert
- Cohen David
- Cohen Nadine
- Coleman Jonathan R. I.
- Coleman Jonathan R. I.
- Coleman Jonathan R. I.
- Collier David A.
- Collier David A.
- Colodro-Conde Lucía
- Comes Ashley L.
- Cormican Paul
- Corvin Aiden
- Corvin Aiden
- Corvin Aiden
- Corvin Aiden
- Coryell William
- Cotsapas Chris
- Couvy-Duchesne Baptiste
- Craddock Nick
- Craddock Nick
- Craig David W.
- Crawford Gregory E.
- Crespo-Facorro Benedicto
- Crowley James J.
- Cruceanu Cristiana
- Curtis David
- Curtis David
- Czerski Piotr M.
- Dale Anders M.
- Daly Mark J.
- Dannlowski Udo
- Darvasi Ariel
- Davidson Michael
- Davies Gail
- Davis Kenneth L.
- Davis Lea K.
- de Geus Eco J. C.
- de Geus Eco J. C.
- de Haan Lieuwe
- de Jong Simone
- de Leeuw Christiaan A.
- Deary Ian J.
- Degenhardt Franziska
- Degenhardt Franziska
- Degenhardt Franziska
- Degenhardt Franziska
- Del Favero Jurgen
- Del-Favero Jurgen
- Deloukas Panos
- Deloukas Panos
- Demontis Ditte
- Demontis Ditte
- DePaulo J. Raymond
- DePaulo J. Raymond
- Derks Eske M.
- Dikeos Dimitris
- Dinan Timothy
- Direk Nese
- Djurovic Srdjan
- Djurovic Srdjan
- Djurovic Srdjan
- Dobbyn Amanda L.
- Dolan Conor V.
- Domenici Enrico
- Domenici Enrico
- Domschke Katharina
- Donnelly Peter
- Donnelly Peter
- Donohoe Gary
- Drapeau Elodie
- Dronov Serge
- Duan Jubao
- Dudbridge Frank
- Dumont Ashley
- Duncan Laramie E.
- Duncanson Audrey
- Dunn Erin C.
- Durmishi Naser
- Edenberg Howard J.
- Edkins Sarah
- Ehrenreich Hannelore
- Ehrenreich Hannelore
- Eichhammer Peter
- Eley Thalia C.
- Elvsåshagen Torbjørn
- Erdman Lauren
- Eriksson Johan
- Escott-Price Valentina
- Escott-Price Valentina
- Escott-Price Valentina
- Esko Tõnu
- Esko Tõnu
- Esko Tõnu
- Essioux Laurent
- Etain Bruno
- Fan Chun Chieh
- Fanous Ayman H.
- Faraone Stephen V.
- Farh Kai-How
- Farrell Martilias S.
- Finucane Hilary K.
- Fischer Sascha B.
- Flickinger Matthew
- Foo Jerome C.
- Foroud Tatiana M.
- Forstner Andreas J.
- Forstner Andreas J.
- Forstner Andreas J.
- Forty Liz
- Frank Josef
- Frank Josef
- Frank Josef
- Franke Lude
- Fraser Christine
- Freedman Robert
- Freeman Colin
- Freimer Nelson B.
- Freimer Nelson B.
- Friedl Marion
- Friedman Joseph I.
- Fromer Menachem
- Frye Mark
- Fullerton Janice M.
- Gade Katrin
- Gage Diane
- Garnham Julie
- Gaspar Héléna A.
- Gaspar Héléna A.
- Gejman Pablo V.
- Gejman Pablo V.
- Genovese Giulio
- Georgieva Lyudmila
- Geschwind Daniel
- Giambartolomei Claudia
- Giannoulatou Eleni
- Giegling Ina
- Giegling Ina
- Gill Michael
- Gill Michael
- Gillman Matthew
- Giusti-Rodríguez Paola
- Godard Stephanie
- Goes Fernando S.
- Goldstein Jacqueline I.
- Goldstein Jaqueline
- Goldstein Jill M.
- Goldstein Jill M.
- Goleva Slavina B.
- Golimbet Vera
- Gopal Srihari
- Gordon Scott D.
- Gordon Scott D.
- Gordon-Smith Katherine
- Grabe Hans J.
- Grabe Hans J.
- Gratten Jacob
- Gray Emma
- Green Elaine K.
- Green Melissa J.
- Greenwood Tiffany A.
- Grigoroiu-Serbanescu Maria
- Grove Jakob
- Grove Jakob
- Grove Jakob
- Grove Jakob
- Guan Weihua
- Guo Wei
- Gurling Hugh
- Guzman-Parra José
- Guzman-Parra José
- Gwilliam Rhian
- Hall Jeremy
- Hall Lynsey S.
- Hamilton Steven P.
- Hamilton Steven P.
- Hammer Christian
- Hammond Naomi
- Hamshere Marian L.
- Hamshere Marian L.
- Hamshere Marian L.
- Handa Robert
- Hansen Christine Søholm
- Hansen Christine Søholm
- Hansen Mark
- Hansen Thomas
- Hansen Thomas F.
- Haroutunian Vahram
- Hartmann Annette M.
- Hartmann Annette M.
- Hassan Kiadeh Farnush Farhadi
- Hauser Joanna
- Hautzinger Martin
- Hayward Caroline
- Heath Andrew C.
- Heilbronner Urs
- Hellenthal Garrett
- Henskens Frans A.
- Herms Stefan
- Herms Stefan
- Herms Stefan
- Hickie Ian B.
- Hipolito Maria
- Hirschhorn Joel N.
- Hoffmann Per
- Hoffmann Per
- Hoffmann Per
- Hofman Andrea
- Holland Dominic
- Hollegaard Mads V.
- Holmans Peter A.
- Holmans Peter A.
- Homuth Georg
- Horn Carsten
- Hottenga Jouke-Jan
- Hottenga Jouke-Jan
- Hougaard David M.
- Hougaard David M.
- Hougaard David M.
- Hougaard David M.
- Howard David M.
- Huang Hailiang
- Huckins Laura
- Huckins Laura M.
- Hultman Christina M.
- Hunt Sarah E.
- Hübel Christopher
- Ikeda Masashi
- Ising Marcus
- Iwata Nakao
- Iwata Nakao
- Iyegbe Conrad
- Jablensky Assen V.
- Jablensky Assen V.
- Jamain Stéphane
- Jamain Stéphane
- Jankowski Janusz
- Jansen Rick
- Jayakumar Alagurevathi
- Joa Inge
- Johnson Jessica S.
- Jones Ian
- Jones Lisa A.
- Jorgenson Eric
- Julià Antonio
- Jönsson Erik G.
- Jönsson Erik G.
- Kahn René S.
- Kahn René S.
- Kalaydjieva Luba
- Kalaydjieva Luba
- Kandaswamy Radhika
- Karachanak-Yankova Sena
- Karjalainen Juha
- Karlsson Robert
- Kavanagh David
- Keller Matthew C.
- Kelly Brian
- Kelly Brian
- Kelsoe John
- Kendler Kenneth S.
- Kendler Kenneth S.
- Kennedy James L.
- Kennedy James L.
- Khramtsova Ekaterina A.
- Khrunin Andrey
- Kim Yunjung
- Kirov George
- Kirov George
- Kittel-Schneider Sarah
- Kloiber Stefan
- Klovins Janis
- Knight Jo
- Knowles James A.
- Knowles James A.
- Knowles James A.
- Knowles James A.
- Kogevinas Manolis
- Kogevinas Manolis
- Kohane Isaac S.
- Koller Anna C.
- Konte Bettina
- Konte Bettina
- Kraft Julia
- Kretzschmar Warren W.
- Kucinskas Vaidutis
- Kucinskiene Zita Ausrele
- Kupka Ralph
- Kutalik Zoltán
- Kuzelova-Ptackova Hana
- Kähler Anna K.
- Landén Mikael
- Langford Cordelia
- Laurent Claudine
- Lavebratt Catharina
- Lawrence Jacob
- Lawrie Stephen
- Lawson William B.
- Leber Markus
- Leboyer Marion
- Lee Chee Keong Jimmy
- Lee Jimmy
- Lee Phil
- Lee Phil H.
- Lee Phil H.
- Lee S. Hong
- Legge Sophie E.
- Lencz Todd
- Lencz Todd
- Lerer Bernard
- Levinson Douglas F.
- Levinson Douglas F.
- Levinson Douglas F.
- Levy Shawn E.
- Lewis Cathryn M.
- Lewis Cathryn M.
- Lewis Cathryn M.
- Lewis Glyn
- Li Jun Z.
- Li Miaoxin
- Li Qingqin S.
- Li Qingqin S.
- Li Tao
- Li Yihan
- Liang Kung-Yee
- Liddle Jennifer
- Lieberman Jeffrey
- Limborska Svetlana
- Lin Kuang
- Lind Penelope A.
- Linszen Don H.
- Lissowska Jolanta
- Liu Chunyu
- Liu Jianjun
- Loughland Carmel M.
- Lubinski Jan
- Lucae Susanne
- Lucae Susanne
- Lucae Susanne
- Lönnqvist Jouko
- Maaser Anna
- Macek Milan
- MacIntyre Donald J.
- MacIntyre Donald J.
- MacKinnon Dean F.
- Madden Pamela AF.
- Magnusson Patrik K.
- Magnusson Patrik K. E.
- Magnusson Patrik K. E.
- Maher Brion S.
- Mahon Pamela B.
- Maier Robert M.
- Maier Wolfgang
- Maier Wolfgang
- Maier Wolfgang
- Malhotra Anil K.
- Malhotra Anil K.
- Mallet Jacques
- Marchini Jonathan
- Markus Hugh S.
- Marsal Sara
- Martin Joanna
- Martin Nicholas G.
- Martin Nicholas G.
- Martinsson Lina
- Mata Ignacio
- Mathew Christopher G.
- Mathew Christopher G.
- Mathews Carol A.
- Mattheisen Manuel
- Mattheisen Manuel
- Mattheisen Manuel
- Mattheisen Manuel
- Mattingsdal Morten
- Mayoral Fermin
- Mbarek Hamdi
- McCann Owen T.
- McCarley Robert W.
- McCarroll Steve
- McCarroll Steven A.
- McCarthy Mark I.
- McDonald Colm
- McElroy Susan L.
- McGrath Patrick
- McGuffin Peter
- McGuffin Peter
- McInnis Melvin G.
- McIntosh Andrew M.
- McIntosh Andrew M.
- McIntosh Andrew M.
- McIntosh Andrew M.
- McKay James D.
- McQuillin Andrew
- McQuillin Andrew
- McQuillin Andrew
- Medeiros Helena
- Medland Sarah E.
- Medland Sarah E.
- Mehta Divya
- Mehta Divya
- Meier Sandra
- Meijer Carin J.
- Melegh Bela
- Melle Ingrid
- Melle Ingrid
- Meng Fan
- Mesholam-Gately Raquelle I.
- Metspalu Andres
- Metspalu Andres
- Michie Patricia T.
- Middeldorp Christel M.
- Mihailov Evelin
- Milaneschi Yuri
- Milaneschi Yuri
- Milani Lili
- Milani Lili
- Milani Lili
- Milani Lili
- Milanova Vihra
- Mill Jonathan
- Mirza Saira Saeed
- Mitchell Philip B.
- Mokrab Younes
- Molden Espen
- Mondimore Francis M.
- Montgomery Grant W.
- Montgomery Grant W.
- Moran Jennifer L.
- Morris Derek W.
- Morris Derek W.
- Mors Ole
- Mors Ole
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- Mors Ole
- Mortensen Preben B.
- Mortensen Preben B.
- Mortensen Preben Bo
- Mortensen Preben Bo
- Mostafavi Sara
- Mowry Bryan J.
- Mowry Bryan J.
- Mullins Niamh
- Mullins Niamh
- Mullins Niamh
- Murphy Kieran C.
- Murray Robin M.
- Murray Robin M.
- Murray Robin M.
- Myin-Germeys Inez
- Mühleisen Thomas W.
- Müller-Myhsok Bertram
- Müller-Myhsok Bertram
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- Nauck Matthias
- Neale Benjamin M.
- Neale Benjamin M.
- Nelis Mari
- Nenadic Igor
- Nertney Deborah A.
- Nestadt Gerald
- Ng Bernard
- Nguyen Hoang
- Nicodemus Kristin K.
- Nievergelt Caroline M.
- Nikitina-Zake Liene
- Nisenbaum Laura
- Nivard Michel G.
- Nordentoft Merete
- Nordentoft Merete
- Nordentoft Merete
- Nordin Annelie
- Nwulia Evaristus A.
- Nyholt Dale R.
- Nöthen Markus
- Nöthen Markus M.
- Nöthen Markus M.
- Nöthen Markus M.
- O'Donovan Claire
- O'Donovan Michael C.
- O'Reilly Paul F.
- Oh Sang-Yun
- Olde Loohuis Loes M.
- Olincy Ann
- Olsen Line
- Ophoff Roel A.
- Ophoff Roel A.
- Ophoff Roel A.
- Ori Anil P. S.
- Oruc Lilijana
- Oskarsson Hogni
- Owen Michael
- Owen Michael J.
- Owen Michael J.
- O’Callaghan Eadbhard
- O’Donovan Claire
- O’Donovan Michael C.
- O’Dushlaine Colm
- O’Neill F. Anthony
- Paciga Sara A.
- Painter Jodie N.
- Palmer Colin N. A.
- Palotie Aarno
- Palotie Aarno
- Pantelis Christos
- Papadimitriou George N.
- Papiol Sergi
- Parkhomenko Elena
- Pato Carlos N.
- Pato Michele T.
- Pato Michele T.
- Paunio Tiina
- Pearson Richard
- Pedersen Carsten Bøcker
- Pedersen Carsten Bøcker
- Pedersen Marianne Giørtz
- Pedersen Marianne Giørtz
- Pedersen Nancy L.
- Pejovic-Milovancevic Milica
- Penninx Brenda W. J. H.
- Penninx Brenda W. J. H.
- Periyasamy Sathish
- Periyasamy Sathish
- Perkins Diana O.
- Perlis Roy H.
- Perlis Roy H.
- Perlis Roy H.
- Perry Amy
- Pers Tune H.
- Pers Tune H.
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- Petryshen Tracey L.
- Petryshen Tracey L.
- Petryshen Tracey L.
- Peyrot Wouter J.
- Pfennig Andrea
- Pietiläinen Olli
- Pimm Jonathan
- Pirinen Matti
- Pistis Giorgio
- Plath Niels
- Plomin Robert
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- Porteous David J.
- Posthuma Danielle
- Posthuma Danielle
- Potash James B.
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- Potash James B.
- Potter Simon C.
- Powell John
- Powell John
- Preisig Martin
- Preisig Martin
- Price Alkes
- Pulver Ann E.
- Purcell Shaun M.
- Purcell Shaun M.
- Quested Digby
- Quiroz Jorge A.
- Qvist Per
- Rasmussen Henrik B.
- Rautanen Anna
- Ravindrarajah Radhi
- Regeer Eline J.
- Reichenberg Abraham
- Reif Andreas
- Reif Andreas
- Reimers Mark A.
- Reinbold Céline S.
- Rice John P.
- Rice John P.
- Richards Alexander L.
- Richards Alexander L.
- Ricketts Michelle
- Rietschel Marcella
- Rietschel Marcella
- Rietschel Marcella
- Riley Brien P.
- Riley Brien P.
- Riley Brien P.
- Ripke Stephan
- Ripke Stephan
- Ripke Stephan
- Rivas Fabio
- Rivera Margarita
- Rivera Margarita
- Robinson Elise
- Roffman Joshua L.
- Roussos Panos
- Roussos Panos
- Ruderfer Douglas M.
- Ruderfer Douglas M.
- Rujescu Dan
- Rujescu Dan
- Rujescu Dan
- Ryu Euijung
- Salomaa Veikko
- Sanders Alan R.
- Sanders Alan R.
- Sawcer Stephen J.
- Schaefer Catherine
- Schall Ulrich
- Schatzberg Alan F.
- Schaupp Sabrina
- Scheftner William A.
- Schoevers Robert
- Schofield Peter R.
- Schork Nicholas J.
- Schubert Christian R.
- Schulte Eva C.
- Schulze Thomas G.
- Schulze Thomas G.
- Schulze Thomas G.
- Schwab Sibylle G.
- Scolnick Edward M.
- Scott Laura J.
- Scott Rodney J.
- Seidman Larry J.
- Sham Pak C.
- Sham Pak C.
- Shehktman Tatyana
- Shen Ling
- Shi Jianxin
- Shi Jianxin
- Shi Jianxin
- Shilling Paul D.
- Shyn Stanley I.
- Sigurdsson Engilbert
- Sigurdsson Engilbert
- Sigurdsson Engilbert
- Silagadze Teimuraz
- Silverman Jeremy M.
- Sim Kang
- Sinnamon Grant C. B.
- Sirignano Lea
- Skajaa Kristjar
- Sklar Pamela
- Slaney Claire
- Slominsky Petr
- Smeland Olav B.
- Smeland Olav B.
- Smit Johannes H.
- Smith Daniel J.
- Smoller Jordan W.
- Smoller Jordan W.
- Smoller Jordan W.
- Smoller Jordan W.
- So Hon-Cheong
- Sobell Janet L.
- Spencer Chris C. A.
- Spencer Chris C. A.
- Spencer Chris C. A.
- Spijker Anne T.
- St Clair David
- St Clair David
- St Clair David
- Stahl Eli
- Stahl Eli A.
- Stahl Eli A.
- Stahl Eli A.
- Stefansson Hreinn
- Stefansson Hreinn
- Stefansson Kari
- Stefansson Kari
- Steffens Michael
- Steinberg Stacy
- Steinberg Stacy
- Steinberg Stacy
- Steixner-Kumar Agnes
- Stogmann Elisabeth
- Strange Amy
- Stranger Barbara E.
- Straub Richard E.
- Strauss John S.
- Streit Fabian
- Streit Fabian
- Streit Fabian
- Strengman Eric
- Strohmaier Jana
- Strohmaier Jana
- Strohmaier Jana
- Stroup T. Scott
- Su Zhan
- Subramaniam Mythily
- Sullivan Patrick F.
- Sullivan Patrick F.
- Sullivan Patrick F.
- Suvisaari Jaana
- Svrakic Dragan M.
- Szatkiewicz Jin P.
- Szelinger Szabolcs
- Sánchez-Mora Cristina
- Söderman Erik
- Tansey Katherine E.
- Tashakkori-Ghanbaria Avazeh
- Teismann Henning
- Teumer Alexander
- Teumer Alexander
- Thirumalai Srinivas
- Thompson Robert C.
- Thompson Wesley
- Thomson Pippa A.
- Thorgeirsson Thorgeir E.
- Thorgeirsson Thorgeir E.
- Tiemeier Henning
- Tiemeier Henning
- Tobet Stuart
- Toncheva Draga
- Tooney Paul A.
- Tooney Paul A.
- Tosato Sarah
- Traglia Michela
- Traylor Matthew
- Trembath Richard C.
- Treutlein Jens
- Treutlein Jens
- Trubetskoy Vassily
- Trubetskoy Vassily
- Trzaskowski Maciej
- Trzaskowski Maciej
- Uher Rudolf
- Uher Rudolf
- Uitterlinden André G.
- Umbricht Daniel
- Vaaler Arne E.
- Van der Auwera Sandra
- Van der Auwera Sandra
- van Hemert Albert M.
- Van Os Jim
- Van Os Jim
- Vedder Helmut
- Veijola Juha
- Viktorin Alexander
- Viktorin Alexander
- Vincent John B.
- Visscher Peter M.
- Visscher Peter M.
- Viswanathan Ananth C.
- Vukcevic Damjan
- Völker Uwe
- Völzke Henry
- Waddington John
- Waller Matthew
- Walsh Dermot
- Walshe Muriel
- Walters James T. R.
- Walters Raymond K.
- Wang Dai
- Wang Qiang
- Wang Weiqing
- Wang Yunpeng
- Wang Yunpeng
- Watson Stanley J.
- Webb Bradley T.
- Webb Bradley T.
- Weickert Cynthia Shannon
- Weickert Thomas W.
- Weinberger Daniel R.
- Weinberger Daniel R.
- Weinsheimer Shantel Marie
- Weisbrod Matthias
- Weiser Mark
- Weiss Lauren A.
- Weissman Myrna M.
- Weissman Myrna M.
- Wellmann Jürgen
- Wendland Jens R.
- Werge Thomas
- Werge Thomas
- Werge Thomas
- Werge Thomas
- Werge Thomas
- Weston Paul
- Whitehead Pavlides Jennifer M.
- Whittaker Pamela
- Widaa Sara
- Wiersma Durk
- Wildenauer Dieter B.
- Willemsen Gonneke
- Willemsen Gonneke
- Williams Nigel M.
- Williams Stephanie
- Winham Stacey J.
- Witt Stephanie H.
- Witt Stephanie H.
- Witt Stephanie H.
- Wolen Aaron R.
- Wong Emily H. M.
- Wood Nicholas W.
- Wormley Brandon K.
- Wray Naomi R.
- Wray Naomi R.
- Wray Naomi R.
- Wu Jing Qin
- Wu Jing Qin
- Wu Yang
- Xi Hualin S.
- Xi Hualin Simon
- Xi Simon
- Xu Wei
- Yang Jian
- Yao Yin
- Yolken Robert H.
- Young Allan H.
- Zai Clement C.
- Zandi Peter
- Zhang Futao
- Zhang Peng
- Zheng Xuebin
- Zimprich Fritz
- Zöllner Sebastian
- Ösby Urban
- Świątkowska Beata
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2022
- Field of study
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- Alliey-Rodriguez Ney
- Als Thomas D
- Andlauer Till F M
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- Andreassen Ole A
- Anjorin Adebayo
- Antilla Verneri
- Arolt Volker
- Auburger Georg
- Awasthi Swapnil
- Bacanu Silviu-Alin
- Backlund Lena
- Badner Judith A
- Barchas Jack D
- Bass Nicholas
- Bauer Michael
- Baune Bernhard T
- Beekman Aartjan T F
- Belliveau Richard
- Bellivier Frank
- Bergen Sarah E
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- Biernacka Joanna M
- Bigdeli Tim B
- Binder Elisabeth B
- Blackwood Douglas H R
- Boehnke Michael
- Boks Marco
- Boocock James
- Boomsma Dorret I
- Breen Gerome
- Bryois Julien
- Budde Monika
- Bunney William
- Burmeister Margit
- Buttenschøn Henriette N
- Bybjerg-Grauholm Jonas
- Byerley William
- Byrne Enda M
- Bækvad-Hansen Marie
- Bøen Erlend
- Børglum Anders D
- Cabaleiro Fabeiro Francisco J.
- Cai Na
- Casas Miquel
- Castelao Enrique
- Cerrato Felecia
- Cervantes Pablo
- Chambert Kimberly
- Charney Alexander W
- Chen Danfeng
- Christensen Jane Hvarregaard
- Churchhouse Claire
- Cichon Sven
- Clair David St
- Clarke Toni-Kim
- Coleman Jonathan R I
- Colodro-Conde Lucía
- Corvin Aiden
- Coryell William
- Couvy-Duchesne Baptiste
- Craddock Nicholas
- Craddock Nick
- Craig David W
- Crawford Gregory E
- Cruceanu Cristiana
- Czerski Piotr M
- Dale Anders M
- Daly Mark J
- Dannlowski Udo
- Davies Gail
- de Diego-Otero Yolanda
- de Geus E J C
- de Jong Simone
- de Leeuw Christiaan A
- Deary Ian J
- Degenhardt Franziska
- del Río Noriega Francisco
- Del-Favero Jurgen
- DePaulo J Raymond
- Derks Eske M
- Direk Nese
- Djurovic Srdjan
- Dobbyn Amanda L
- Dolan Conor V
- Domenici Enrico
- Domschke Katharina
- Dumont Ashley
- Dunn Erin C
- Edenberg Howard J
- Eley Thalia C
- Elvsåshagen Torbjørn
- Escott-Price Valentina
- Esko Tõnu
- Etain Bruno
- EThorgeirsson Thorgeir
- Fan Chun Chieh
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- Fischer Sascha B
- Flickinger Matthew
- Florio Arianna Di
- Foo Jerome C
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- Fraser Christine
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- Gade Katrin
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- Gershon Elliot S
- Giambartolomei Claudia
- Gil Flores Susana
- Gill Michael
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- Goes Fernando S
- Goldstein Jaqueline
- González Maria José
- Gordon Scott D
- Gordon-Smith Katherine
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- Green Melissa J
- Greenwood Tiffany A
- Grigoroiu-Serbanescu Maria
- Grove Jakob
- Guan Weihua
- Guzman-Parra Jose
- Hall Lynsey S
- Hamilton Steven P
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- Hansen Thomas F
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- Hauser Joanna
- Hautzinger Martin
- Hayward Caroline
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- Herms Stefan
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- Horn Carsten
- Hottenga Jouke-Jan
- Hougaard David M
- Howard David M
- Huckins Laura
- Hultman Christina M
- Ising Marcus
- Jamain Stéphane
- Jansen Rick
- Johnson Jessica S
- Jones Ian
- Jones Lisa A
- Jorgenson Eric
- Juréus Anders
- Kahn René S
- Kandaswamy Radhika
- Karlsson Robert
- Kelsoe John
- Kendler Kenneth S
- Kennedy James L
- Kiadeh Farnush Farhadi Hassan
- Kirov George
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- Kloiber Stefan
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- Kupka Ralph
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- Lucae Susanne
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- Mattheisen Manuel
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- Stefansson Hreinn
- Stefansson Kari
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- Steinberg Stacy
- Stordal Eystein
- Strauss John S
- Streit Fabian
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- Szelinger Szabolcs
- Sánchez-Mora Cristina
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- Thomson Pippa A
- Thorgeirsson Thorgeir E
- Tiemeier Henning
- Traylor Matthew
- Treutlein Jens
- Trubetskoy Vassily
- Trzaskowski Maciej
- Turecki Gustavo
- Uher Rudolf
- Uitterlinden André G
- Umbricht Daniel
- Vaaler Arne E
- Van der Auwera Sandra
- van Hemert Albert M
- Vedde Helmut
- Vieta Eduard
- Viktorin Alexander
- Vincent John B
- Visscher Peter M
- Völzke Henry
- Wang Weiqing
- Wang Yunpeng
- Watson Stanley J
- Webb Bradley T.
- Weickert Cynthia Shannon
- Weickert Thomas W
- Weinsheimer Shantel Marie
- Weissman Myrna M
- Wellmann Jürgen
- Werge Thomas
- Willemsen Gonneke
- Witt Stephanie H
- Witt Stephanie H.
- Wray Naomi R
- Wu Yang
- Xi Hualin S
- Xi Simon
- Xu Wei
- Yang Jian
- Young Allan H
- Zandi Peter
- Zhang Futao
- Zhang Peng
- Zollner Sebastian
- Ösby Urban
- Publication venue
- Molecular Psychiatry
- Publication date
- 22/03/2021
- Field of study
Abstract: Multiplex families with a high prevalence of a psychiatric disorder are often examined to identify rare genetic variants with large effect sizes. In the present study, we analysed whether the risk for bipolar disorder (BD) in BD multiplex families is influenced by common genetic variants. Furthermore, we investigated whether this risk is conferred mainly by BD-specific risk variants or by variants also associated with the susceptibility to schizophrenia or major depression. In total, 395 individuals from 33 Andalusian BD multiplex families (166 BD, 78 major depressive disorder, 151 unaffected) as well as 438 subjects from an independent, BD case/control cohort (161 unrelated BD, 277 unrelated controls) were analysed. Polygenic risk scores (PRS) for BD, schizophrenia (SCZ), and major depression were calculated and compared between the cohorts. Both the familial BD cases and unaffected family members had higher PRS for all three psychiatric disorders than the independent controls, with BD and SCZ being significant after correction for multiple testing, suggesting a high baseline risk for several psychiatric disorders in the families. Moreover, familial BD cases showed significantly higher BD PRS than unaffected family members and unrelated BD cases. A plausible hypothesis is that, in multiplex families with a general increase in risk for psychiatric disease, BD development is attributable to a high burden of common variants that confer a specific risk for BD. The present analyses demonstrated that common genetic risk variants for psychiatric disorders are likely to contribute to the high incidence of affective psychiatric disorders in the multiplex families. However, the PRS explained only part of the observed phenotypic variance, and rare variants might have also contributed to disease development