Reconstructing and understanding the impacts of storms and surges, southern North Sea

Coastal barriers are ubiquitous globally and provide a vital protective role to valuable landforms, habitats and communities located to landward. They are, however, vulnerable to extreme water levels and storm wave impacts. A detailed record of sub-annual to annual; decadal; and centennial rates of shoreline retreat in frontages characterized by both high (> 3 m) and low (< 1 m) dunes is established for a barrier island on the UK east coast. For four storms (2006–2013) we match still water levels and peak significant wave heights against shoreline change at high levels of spatial densification. The results suggest that, at least in the short-term, shoreline retreat, of typically 5–8 m, is primarily driven by individual events, separated by varying periods of barrier stasis. Over decadal timescales, significant inter-decadal changes can be seen in both barrier onshore retreat rates and in barrier extension rates alongshore. Whilst the alongshore variability in barrier migration seen in the short-term remains at the decadal scale, shoreline change at the centennial stage shows little alongshore variability between a region of barrier retreat (at 1.15 m a$^{−1}$) and one of barrier extension. A data-mining approach, synchronizing all the variables that drive shoreline change (still water level, timing of high spring tides and peak significant wave heights), is an essential requirement for validating models that predict future shoreline responses under changing sea level and storminess.This paper was completed while the first author (SB) was a recipient of a Leverhulme Research Fellowship (RF-2015-045) for a project entitled Development and Application of a shoreline response model. This paper is a contribution to NERC BESS Consortium grant A hierarchical approach to the examination of the relationship between biodiversity and ecosystem service flows across coastal margins (grant reference NE/J015423/1). Table 1 reports information gathered as part of an EU FP7 Collaborative Project (grant agreement no: 603458) Resilience-Increasing Strategies for Coasts – toolkit (http://www.risckit.eu).This is the final version of the article. It first appeared from Wiley via http://dx.doi.org/10.1002/esp.390

The effects of elevated CO2 and eutrophication on surface elevation gain in a European salt marsh.

Salt marshes can play a vital role in mitigating the effects of global environmental change by dissipating incident storm wave energy and, through accretion, tracking increasing water depths consequent upon sea level rise. Atmospheric CO2 concentrations and nutrient availability are two key variables that can affect the biological processes that contribute to marsh surface elevation gain. We measured the effects of CO2 concentrations and nutrient availability on surface elevation change in intact mixed-species blocks of UK salt marsh using six open-top chambers receiving CO2 -enriched (800 ppm) or ambient (400 ppm) air. We found more rapid surface elevation gain in elevated CO2 conditions: an average increase of 3.4 mm over the growing season relative to ambient CO2 . Boosted regression analysis to determine the relative influence of different parameters on elevation change identified that a 10% reduction in microbial activity in elevated CO2 -grown blocks had a positive influence on elevation. The biomass of Puccinellia maritima also had a positive influence on elevation, while other salt marsh species (e.g. Suaeda maritima) had no influence or a negative impact on elevation. Reduced rates of water use by the vegetation in the high CO2 treatment could be contributing to elevation gain, either directly through reduced soil shrinkage or indirectly by decreasing microbial respiration rates due to lower redox levels in the soil. Eutrophication did not influence elevation change in either CO2 treatment despite doubling aboveground biomass. The role of belowground processes (transpiration, root growth and decomposition) in the vertical adjustment of European salt marshes, which are primarily minerogenic in composition, could increase as atmospheric CO2 concentrations rise and should be considered in future wetland models for the region. Elevated CO2 conditions could enhance resilience in vulnerable systems such as those with low mineral sediment supply or where migration upwards within the tidal frame is constrained.Marie Curie Incoming International Fellowship (Grant ID: FP7-PEOPLE-IIF 623720 STORM)This is the author accepted manuscript. The final version is available from Wiley via https://doi.org/10.1111/gcb.1339

Genetic mechanisms of critical illness in COVID-19.

Host-mediated lung inflammation is present1, and drives mortality2, in the critical illness caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with critical illness may identify mechanistic targets for therapeutic development3. Here we report the results of the GenOMICC (Genetics Of Mortality In Critical Care) genome-wide association study in 2,244 critically ill patients with COVID-19 from 208 UK intensive care units. We have identified and replicated the following new genome-wide significant associations: on chromosome 12q24.13 (rs10735079, P = 1.65 × 10-8) in a gene cluster that encodes antiviral restriction enzyme activators (OAS1, OAS2 and OAS3); on chromosome 19p13.2 (rs74956615, P = 2.3 × 10-8) near the gene that encodes tyrosine kinase 2 (TYK2); on chromosome 19p13.3 (rs2109069, P = 3.98 ×  10-12) within the gene that encodes dipeptidyl peptidase 9 (DPP9); and on chromosome 21q22.1 (rs2236757, P = 4.99 × 10-8) in the interferon receptor gene IFNAR2. We identified potential targets for repurposing of licensed medications: using Mendelian randomization, we found evidence that low expression of IFNAR2, or high expression of TYK2, are associated with life-threatening disease; and transcriptome-wide association in lung tissue revealed that high expression of the monocyte-macrophage chemotactic receptor CCR2 is associated with severe COVID-19. Our results identify robust genetic signals relating to key host antiviral defence mechanisms and mediators of inflammatory organ damage in COVID-19. Both mechanisms may be amenable to targeted treatment with existing drugs. However, large-scale randomized clinical trials will be essential before any change to clinical practice

Multiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study

Introduction: The multiorgan impact of moderate to severe coronavirus infections in the post-acute phase is still poorly understood. We aimed to evaluate the excess burden of multiorgan abnormalities after hospitalisation with COVID-19, evaluate their determinants, and explore associations with patient-related outcome measures. Methods: In a prospective, UK-wide, multicentre MRI follow-up study (C-MORE), adults (aged ≥18 years) discharged from hospital following COVID-19 who were included in Tier 2 of the Post-hospitalisation COVID-19 study (PHOSP-COVID) and contemporary controls with no evidence of previous COVID-19 (SARS-CoV-2 nucleocapsid antibody negative) underwent multiorgan MRI (lungs, heart, brain, liver, and kidneys) with quantitative and qualitative assessment of images and clinical adjudication when relevant. Individuals with end-stage renal failure or contraindications to MRI were excluded. Participants also underwent detailed recording of symptoms, and physiological and biochemical tests. The primary outcome was the excess burden of multiorgan abnormalities (two or more organs) relative to controls, with further adjustments for potential confounders. The C-MORE study is ongoing and is registered with ClinicalTrials.gov, NCT04510025. Findings: Of 2710 participants in Tier 2 of PHOSP-COVID, 531 were recruited across 13 UK-wide C-MORE sites. After exclusions, 259 C-MORE patients (mean age 57 years [SD 12]; 158 [61%] male and 101 [39%] female) who were discharged from hospital with PCR-confirmed or clinically diagnosed COVID-19 between March 1, 2020, and Nov 1, 2021, and 52 non-COVID-19 controls from the community (mean age 49 years [SD 14]; 30 [58%] male and 22 [42%] female) were included in the analysis. Patients were assessed at a median of 5·0 months (IQR 4·2–6·3) after hospital discharge. Compared with non-COVID-19 controls, patients were older, living with more obesity, and had more comorbidities. Multiorgan abnormalities on MRI were more frequent in patients than in controls (157 [61%] of 259 vs 14 [27%] of 52; p&lt;0·0001) and independently associated with COVID-19 status (odds ratio [OR] 2·9 [95% CI 1·5–5·8]; padjusted=0·0023) after adjusting for relevant confounders. Compared with controls, patients were more likely to have MRI evidence of lung abnormalities (p=0·0001; parenchymal abnormalities), brain abnormalities (p&lt;0·0001; more white matter hyperintensities and regional brain volume reduction), and kidney abnormalities (p=0·014; lower medullary T1 and loss of corticomedullary differentiation), whereas cardiac and liver MRI abnormalities were similar between patients and controls. Patients with multiorgan abnormalities were older (difference in mean age 7 years [95% CI 4–10]; mean age of 59·8 years [SD 11·7] with multiorgan abnormalities vs mean age of 52·8 years [11·9] without multiorgan abnormalities; p&lt;0·0001), more likely to have three or more comorbidities (OR 2·47 [1·32–4·82]; padjusted=0·0059), and more likely to have a more severe acute infection (acute CRP &gt;5mg/L, OR 3·55 [1·23–11·88]; padjusted=0·025) than those without multiorgan abnormalities. Presence of lung MRI abnormalities was associated with a two-fold higher risk of chest tightness, and multiorgan MRI abnormalities were associated with severe and very severe persistent physical and mental health impairment (PHOSP-COVID symptom clusters) after hospitalisation. Interpretation: After hospitalisation for COVID-19, people are at risk of multiorgan abnormalities in the medium term. Our findings emphasise the need for proactive multidisciplinary care pathways, with the potential for imaging to guide surveillance frequency and therapeutic stratification

Freshwater Mussels as Biofilters

Freshwater mussels (Bivalvia: Unionidae) are filter feeders, removing phytoplankton and other suspended particulate matter from the water. The removal of suspended matter from water is often considered desirable, in order to reduce algal blooms and in the treatment of drinking water. This thesis investigates the potential role of freshwater mussels as living filters, or “biofilters”, in a variety of settings. Initial measurements of the filtration rates of British freshwater mussels showed that individual mussels can filter up to half a litre of water per hour. Calculations of the filtration rates of mussel populations in four British rivers indicate that mussel filtering removes between 7% and 30% of the particulate matter in a parcel of water travelling 10km downstream. This implies that mussels play an important role in the removal of suspended particulate matter in river ecosystems. In a large-scale experiment on the Ouse Washes RSPB reserve, mussels were placed in three eutrophic ditches to assess their potential use in the biomanipulation of these ditches. Although mussels suffered high mortality in two ditches, in the third ditch 70% of mussels survived, and the section of ditch containing mussels remained clear of floating macrophytes throughout the summer. However, mussels had little effect on the water quality in ditches, and further work is needed before they are used in future biomanipulations. The novel use of mussels in drinking water treatment was investigated by placing mussels in large flow-through tanks at Coppermills drinking water treatment plant (operated by Thames Water). Mussels reduced the concentration of chlorophyll a and suspended solids in the water flowing through tanks, and increased sedimentation through the production of faeces and pseudofaeces. Therefore mussels behaved as flocculators, and could be used in the early stages of drinking water treatment. In order to assess the feasibility of producing the large numbers of mussels needed for their use as biofilters, freshwater mussels were cultured in the laboratory. Juveniles of $\textit{Anodonta anatina}$ and $\textit{A. cygnea}$ were successfully reared for over a year, and reached 14mm in length (mean = 11.3mm, n = 17) with 20% survival. $\textit{Unio pictorum}$ and $\textit{Pseudanodonta complanata}$ were also reared for 274 and 100 days respectively, although they had lower survival and growth. The apparatus used in these rearing attempts was small and inexpensive, and could be scaled up to produce the required number of mussels for their use as biofilters. Additionally, the rearing of $\textit{P. complanata}$ is vital for the conservation of this rare mussel species, and offers the first opportunity to study its juvenile morphology and habitat requirements