“Professionalization: Overview” & “Professionalization: Europe”

Two entries in a large encyclopedia of the social sciences

THE GERMAN MODEL FOR AMERICAN MEDICAL REFORM

The Flexner Report of 1910, which radically transformed American medical education and medical schools, may be seen not so much as a completely novel initiative as the culmination of a longer transfer of models from Germany, with which Flexner was intimately acquainted

American Reform Efforts: German Professional Education after World War II

An exploration of educational reform and specifically to three areas in which the American occupation of post-war Germany influenced the shape of professional education in the 1940s and beyond

Modern German Universities and their Historians since the Fall of the Wall

A critical collective evaluation of recently-published works on German universities

Inszenierte Weltgeltung einer prima inter pares? Die Berliner Universität und ihr Jubiläum 1910“ [Staged World Respect for a prima inter pares? Berlin University and its Jubilee in 1910]

Before the twin catastrophes of the Third Reich and World War II, Berlin was the intellectual epicenter of the world and the Humboldt [University] the university in Berlin.” But there were already signs at the celebration of its centenary in 1910 that its place at the pinnacle of world research universities had reached its apogee

Edward Thompson's Ethics and Activism 1956–1963: Reflections on the Political Formation of The Making of the English Working Class

As well as a work of history, E. P. Thompson's The Making of the English Class (London: Gollancz, 1963) was written as a strategic intervention in wider political debates of the late 1950s about working class consciousness, identity, agency and organisation, and as a sustained expression and application of ‘socialist humanism’ to historical subjects. This essay situates the book within these debates, moving between The Making and Thompson's writings within the New Left, to show how the characteristic themes of his work—moral choice and agency, the complexities of working-class consciousness and culture, the role of intellectuals and of an ‘organised minority’—were developed through both. This provides us with a richer context for understanding both the moral sensibility that animates the book and key elements of its historiographical standpoint

Analysis of Salmonella enterica Serotype Paratyphi A Gene Expression in the Blood of Bacteremic Patients in Bangladesh

Salmonella enterica serotype Paratyphi A is a significant and emerging global public health problem and accounts for one fifth of all cases of enteric fever in many areas of Asia. S. Paratyphi A only infects humans, and the lack of an appropriate animal model has limited the study of S. Paratyphi A infection. In this study, we report the application of an RNA analysis method, Selective Capture of Transcribed Sequences (SCOTS), to evaluate which S. Paratyphi A genes are expressed directly in the blood of infected humans. Our results provide insight into the bacterial adaptations and modifications that S. Paratyphi A may need to survive within infected humans and suggest that similar approaches may be applied to other pathogens in infected humans and animals

The state of the Martian climate

60°N was +2.0°C, relative to the 1981–2010 average value (Fig. 5.1). This marks a new high for the record. The average annual surface air temperature (SAT) anomaly for 2016 for land stations north of starting in 1900, and is a significant increase over the previous highest value of +1.2°C, which was observed in 2007, 2011, and 2015. Average global annual temperatures also showed record values in 2015 and 2016. Currently, the Arctic is warming at more than twice the rate of lower latitudes

Global Systems-Level Analysis of Hfq and SmpB Deletion Mutants in Salmonella: Implications for Virulence and Global Protein Translation

Using sample-matched transcriptomics and proteomics measurements it is now possible to begin to understand the impact of post-transcriptional regulatory programs in Enterobacteria. In bacteria post-transcriptional regulation is mediated by relatively few identified RNA-binding protein factors including CsrA, Hfq and SmpB. A mutation in any one of these three genes, csrA, hfq, and smpB, in Salmonella is attenuated for mouse virulence and unable to survive in macrophages. CsrA has a clearly defined specificity based on binding to a specific mRNA sequence to inhibit translation. However, the proteins regulated by Hfq and SmpB are not as clearly defined. Previous work identified proteins regulated by hfq using purification of the RNA-protein complex with direct sequencing of the bound RNAs and found binding to a surprisingly large number of transcripts. In this report we have used global proteomics to directly identify proteins regulated by Hfq or SmpB by comparing protein abundance in the parent and isogenic hfq or smpB mutant. From these same samples we also prepared RNA for microarray analysis to determine if alteration of protein expression was mediated post-transcriptionally. Samples were analyzed from bacteria grown under four different conditions; two laboratory conditions and two that are thought to mimic the intracellular environment. We show that mutants of hfq and smpB directly or indirectly modulate at least 20% and 4% of all possible Salmonella proteins, respectively, with limited correlation between transcription and protein expression. These proteins represent a broad spectrum of Salmonella proteins required for many biological processes including host cell invasion, motility, central metabolism, LPS biosynthesis, two-component regulatory systems, and fatty acid metabolism. Our results represent one of the first global analyses of post-transcriptional regulons in any organism and suggest that regulation at the translational level is widespread and plays an important role in virulence regulation and environmental adaptation for Salmonella