Herd It in the Gobi: Deserting pastoralism?

Global drylands host more than USD 1 trillion in resource extraction investments, which serve to reconfigure communities and landscapes. In Mongolia’s Gobi Desert mega-mining brings social challenges and environmental changes that question if nomadic herding and mining can coexist. Whilst company and community conflict are common, nascent frameworks and mediation models suggest alternate ways to resolve the mining–community conundrum. Here we investigate environmental transformations that herders encounter in the presence of the Oyu Tolgoi mega-mine in Mongolia’s Khanbogd soum (district). Using socio-economic and physical data collected through interviews, field studies and climate records, we assessed local engagement and adaptation to largescale mining. Combining qualitative and quantitative methods enabled us to examine the implications of mining for herder lives and lands in an integrated way. This study presents a holistic assessment of the roles of herders, governments and mines in reshaping pastoralism. In our chosen case study, we find that—contrary to common narratives—mining and herding can, and do, coexist in Khanbogd soum, though ongoing challenges exist which deserve critical attention.info:eu-repo/semantics/publishedVersio

Deterioration risk of dryland earthen heritage sites facing future climatic uncertainty

Uncertainties over future climatic conditions pose significant challenges when selecting appropriate conservation strategies for heritage sites. Choosing effective strategies is especially important for earthen heritage sites located in dryland regions, as many are experiencing rapid environmentally-driven deterioration. We use a newly developed cellular automaton model (ViSTA-HD), to evaluate the environmental deterioration risk, over a 100-year period, under a range of potential climate and conservation scenarios. Results show increased wind velocities could substantially increase the overall deterioration risk, implying the need for wind-reducing conservation strategies. In contrast, predicted increases in rainfall are not likely to increase the overall deterioration risk, despite greater risk of rain-driven deterioration features. Of the four conservation strategies tested in our model, deterioration risk under all climatic scenarios was best reduced by increasing the coverage of natural, randomly-distributed vegetation to 80%. We suggest this approach could be an appropriate long-term conservation strategy for other earthen sites in dryland regions

Optimising the management of vaginal discharge syndrome in Bulgaria: cost effectiveness of four clinical algorithms with risk assessment

OBJECTIVES: To evaluate the performance and cost effectiveness of the WHO recommendations of incorporating risk-assessment scores and population prevalence of Neisseria gonorrhoeae (NG) and Chlamydia trachomatis (CT) into vaginal discharge syndrome (VDS) algorithms. METHODS: Non-pregnant women presenting with VDS were recruited at a non-governmental sexual health clinic in Sofia, Bulgaria. NG and CT were diagnosed by PCR and vaginal infections by microscopy. Risk factors for NG/CT were identified in multivariable analysis. Four algorithms based on different combinations of behavioural factors, clinical findings and vaginal microscopy were developed. Performance of each algorithm was evaluated for detecting vaginal and cervical infections separately. Cost effectiveness was based on cost per patient treated and cost per case correctly treated. Sensitivity analysis explored the influence of NG/CT prevalence on cost effectiveness. RESULTS: 60% (252/420) of women had genital infections, with 9.5% (40/423) having NG/CT. Factors associated with NG/CT included new and multiple sexual partners in the past 3 months, symptomatic partner, childlessness and >or=10 polymorphonuclear cells per field on vaginal microscopy. For NG/CT detection, the algorithm that relied solely on behavioural risk factors was less sensitive but more specific than those that included speculum examination or microscopy but had higher correct-treatment rate and lower over-treatment rates. The cost per true case treated using a combination of risk factors, speculum examination and microscopy was euro 24.08. A halving and tripling of NG/CT prevalence would have approximately the inverse impact on the cost-effectiveness estimates. CONCLUSIONS: Management of NG/CT in Bulgaria was improved by the use of a syndromic approach that included risk scores. Approaches that did not rely on microscopy lost sensitivity but were more cost effective

Gonorrhoea: tackling the global epidemic in the era of rising antimicrobial resistance.

This Special Issue of Sexual Health aims to collate the latest evidence base focussed on understanding the current epidemic and transmission of gonorrhoea, choice of treatment, molecular epidemiology application, concerns about antimicrobial resistance and alternative prevention and control for gonorrhoea

The population impact of herpes simplex virus type 2 (HSV-2) vaccination on the incidence of HSV-2, HIV and genital ulcer disease in South Africa: a mathematical modelling study

BACKGROUND: Evidence suggests HSV-2 infection increases HIV acquisition risk and HIV/HSV-2 coinfection increases transmission risk of both infections. We analysed the potential impact of HSV-2 vaccination in South Africa, a high HIV/HSV-2 prevalence setting. METHODS: We adapted a dynamic HIV transmission model for South Africa to incorporate HSV-2, including synergistic effects with HIV, to evaluate the impact of: (i) cohort vaccination of 9-year-olds with a prophylactic vaccine that reduces HSV-2 susceptibility; (ii) vaccination of symptomatically HSV-2-infected individuals with a therapeutic vaccine that reduces HSV shedding. FINDINGS: An 80% efficacious prophylactic vaccine offering lifetime protection with 80% uptake could reduce HSV-2 and HIV incidence by 84.1% (95% Credibility Interval: 81.2-86.0) and 65.4% (56.5-71.6) after 40 years, respectively. This reduces to 57.4% (53.6-60.7) and 42.1% (34.1-48.1) if efficacy is 50%, 56.1% (53.4-58.3) and 41.5% (34.2-46.9) if uptake is 40%, and 29.4% (26.0-31.9) and 24.4% (19.0-28.7) if protection lasts 10 years. An 80% efficacious therapeutic vaccine offering lifetime protection with 40% coverage among symptomatic individuals could reduce HSV-2 and HIV incidence by 29.6% (21.8-40.9) and 26.4% (18.5-23.2) after 40 years, respectively. This reduces to 18.8% (13.7-26.4) and 16.9% (11.7-25.3) if efficacy is 50%, 9.7% (7.0-14.0) and 8.6% (5.8-13.4) if coverage is 20%, and 5.4% (3.8-8.0) and 5.5% (3.7-8.6) if protection lasts 2 years. INTERPRETATION: Prophylactic and therapeutic vaccines offer promising approaches for reducing HSV-2 burden and could have important impact on HIV in South Africa and other high prevalence settings. FUNDING: WHO, NIAID

Coronal mass ejections, magnetic clouds, and relativistic magnetospheric electron events: ISTP

The role of high-speed solar wind streams in driving relativistic electron acceleration within the Earth\u27s magnetosphere during solar activity minimum conditions has been well documented. The rising phase of the new solar activity cycle (cycle 23) commenced in 1996, and there have recently been a number of coronal mass ejections (CMEs) and related “magnetic clouds” at 1 AU. As these CME/cloud systems interact with the Earth\u27s magnetosphere, some events produce substantial enhancements in the magnetospheric energetic particle population while others do not. This paper compares and contrasts relativistic electron signatures observed by the POLAR, SAMPEX, Highly Elliptical Orbit, and geostationary orbit spacecraft during two magnetic cloud events: May 27–29, 1996, and January 10–11, 1997. Sequences were observed in each case in which the interplanetary magnetic field was first strongly southward and then rotated northward. In both cases, there were large solar wind density enhancements toward the end of the cloud passage at 1 AU. Strong energetic electron acceleration was observed in the January event, but not in the May event. The relative geoeffectiveness for these two cases is assessed, and it is concluded that large induced electric fields (∂B/∂t) caused in situ acceleration of electrons throughout the outer radiation zone during the January 1997 event

Herpes Simplex Virus Type-2 Cervicovaginal Shedding Among Women Living With HIV-1 and Receiving Antiretroviral Therapy in Burkina Faso: An 8-Year Longitudinal Study.

BACKGROUND: The impact of antiretroviral therapy (ART) on herpes simplex virus type-2 (HSV-2) replication is unclear. The aim of this study was to assess factors associated with cervicovaginal HSV-2 DNA shedding and genital ulcer disease (GUD) in a cohort of women living with human immunodeficiency virus type-1 (HIV-1) in Burkina Faso. METHODS: Participants were screened for cervicovaginal HSV-2 DNA, GUD, cervicovaginal and systemic HIV-1 RNA, and reproductive tract infections every 3-6 months over 8 years. Associations with HSV-2 shedding and quantity were examined using random-effects logistic and linear regression, respectively. RESULTS: Of the 236 women with data on HSV-2 shedding, 151 took ART during the study period. Cervicovaginal HSV-2 DNA was detected in 42% of women (99 of 236) in 8.2% of visits (151 of 1848). ART was associated with a reduction in the odds of HSV-2 shedding, which declined for each year of ART use (odds ratio [OR], 0.74; 95% confidence interval [CI], .59-.92). In the multivariable model, the impact of ART was primarily associated with suppression of systemic HIV-1 RNA (adjusted OR, 0.32; 95% CI, .15-.67). A reduction in the odds of GUD was also observed during ART, mainly in those with HIV-1 suppression (adjusted OR, 0.53; 95% CI, .25-1.11). CONCLUSIONS: ART is strongly associated with a decrease in cervicovaginal HSV-2 shedding, and the impact was sustained over several years

Atmospheric temperature responses to solar irradiance and geomagnetic activity

The relative effects of solar irradiance and geomagnetic activity on the atmospheric temperature anomalies (Ta) are examined from the monthly to interdecadal timescales. Geomagnetic Ap (Ap) signals are found primarily in the stratosphere, while the solar F10.7-cm radio flux (Fs) signals are found in both the stratosphere and troposphere. In the troposphere, 0.1–0.4 K increases in Ta are associated with Fs. Enhanced Fs signals are found when the stratospheric quasi-biennial oscillation (QBO) is westerly. In the extrapolar region of the stratosphere, 0.1–0.6 and 0.1–0.7 K increases in Ta are associated with solar irradiance and with geomagnetic activity, respectively. In this region, Fs signals are strengthened when either the QBO is easterly, or geomagnetic activity is high, while Ap signals are strengthened when either the QBO is westerly, or solar irradiance is high. High solar irradiance and geomagnetic activity tend to enhance each other's signatures either making the signals stronger and symmetric about the equator or extending the signals to broader areas, or both. Positive Ap signals dominate the middle Arctic stratosphere and are two to five times larger than those of Fs. When solar irradiance is low, the signature of Ap in Ta is asymmetric about the equator, with positive signals in the Arctic stratosphere and negative signals at midlatitudes of the NH stratosphere. Weaker stratospheric QBO signals are associated with high Ap and Fs, suggesting possible disturbances on the QBO. The signals of Ap and Fs are distinct from the positive temperature anomalies resulting from volcanic eruptions