Morphological and Histopathological Changes in Orofacial Structures of Experimentally Developed Acromegaly-Like Rats: An Overview

Tongue enlargement and mandibular prognathism are clinically recognized in almost all patients with acromegaly. An acromegaly-like rat model recently developed by exogenous administration of insulin-like growth factor I (IGF-I) was used to investigate morphological and histopathological changes in orofacial structures and to clarify whether these changes were reversible. Exogenous administration of IGF-I evoked specific enlargement of the tongue with identifiable histopathological changes (increased muscle bundle width, increased space between muscle bundles, and increased epithelial thickness), elongation of the mandibular alveolar bone and ascending ramus, and lateral expansion of the mandibular dental arch. Regarding histopathological changes in the mandibular condyle, the cartilaginous layer width, bone matrix ratio, and number of osteoblasts were all significantly greater in this rat model. After normalization of the circulating IGF-I level, tongue enlargement and histopathological changes in the tongue and mandibular condyle were reversible, whereas morphological skeletal changes in the mandible remained

英仏の形容詞修飾構造

n this paper, we analyze a syntactic structure of attributive adjectives (épithète) in French by the previous study, Cinque (2010). Cinque (2010) analyzed the phenomena of adjectival modifications in Italian (Romance) with the universal structure via NP-movement and snowballing-movement. We hypothesize that adnominal adjectives in French are direct modification in a hierarchical order including quantity, quality, and size, and postnominal adjectives in French areindirect modification including quality, size, shape, color, and nationality. Moreover, we propose that quality and size are lower than shape, color and nationality in a reduced relative clause. We can analyze the structure of French adjectival modifications without optional NP-movement in direct modification AP and snowballing-movement. Finally, we propose that quality and size must be either in a reduced relative clause from some syntactic phenomena.研究ノー

Identification of 45 New Neutron-Rich Isotopes Produced by In-Flight Fission of a 238U Beam at 345 MeV/nucleon

A search for new isotopes using in-flight fission of a 345 MeV/nucleon 238U beam has been carried out at the RI Beam Factory at the RIKEN Nishina Center. Fission fragments were analyzed and identified by using the superconducting in-flight separator BigRIPS. We observed 45 new neutron-rich isotopes: 71Mn, 73,74Fe, 76Co, 79Ni, 81,82Cu, 84,85Zn, 87Ga, 90Ge, 95Se, 98Br, 101Kr, 103Rb, 106,107Sr, 108,109Y, 111,112Zr, 114,115Nb, 115,116,117Mo, 119,120Tc, 121,122,123,124Ru, 123,124,125,126Rh, 127,128Pd, 133Cd, 138Sn, 140Sb, 143Te, 145I, 148Xe, and 152Ba

看護師の摂食・嚥下訓練に関するイメージ

原著論文Original Paper脳血管障害後遺症として摂食・嚥下障害を持つ患者と日常的に接している病棟に勤務する看護師とその他の病棟に勤務する看護師に対し、摂食・嚥下訓練に対するイメージ調査をSD法の測定尺度を用いて行った。今回の調査では、専門病棟に勤務する看護師の方が他の病棟に勤務する看護師よりも摂食・嚥下訓練に対して「日常的な」イメージが強いこと、また、「親しみにくくない」「消極的ではない」「あいまいではない」「抽象的ではない」「難しくはない」という、プラスにもマイナスにも偏らないイメージがあり、専門病棟に勤務する看護師も、摂食・嚥下訓練において、専門性を発揮できているとは感じていないことが分かった。今後、看護師が専門性を発揮しながら摂食・嚥下訓練を展開できるように環境を整えることが必要と考えた

基礎看護技術の自己学習支援システム(第2報) : ホームページ教材の開発

学生の基礎看護技術の学習環境を整備し、自己学習を促進するように学内LANを活用し『看護の基礎』ホームページを作成した。その有用性を評価するために、学生にアンケートを実施した。アンケート結果によると、学生は『看護の基礎』のホームページは必要であり、基礎看護技術の学習に役立つと答えている。しかし、改善すべき点があることもわかった。『看護の基礎』のホームページが学生にとってさらに活用され、学生の自己学習支援に役立つためには、「情報の発信と交流」「技術学習支援のための教育環境整備」「エビデンスに基づいた看護技術の知識の学習支援」「自己学習の促進」という課題が明らかになった

基礎看護技術の自己学習支援システム(第1報) : ビデオ教材を作成して

筆者らは、看護技術の修得には不可欠な学生の自己学習を支援する目的で、授業の中のデモンストレーションを撮影・編集し、ビデオ教材を作成している。これまで市販のビデオ教材ではなく自作のビデオ教材にこだわってきた。今回アンケート調査により、学生達は、自主練習の過程で有効にビデオ教材を利用していることが明らかになり、学生の自己学習支援のひとつとして、自作のビデオ教材必要とされていることが分かった。また、今後の課題としては、ビデオ教材だけでなく、他の教材も使い総合的に学生の自己学習支援をしていく必要があることが明らかになった

ApoSense: a novel technology for functional molecular imaging of cell death in models of acute renal tubular necrosis

Purpose: Acute renal tubular necrosis (ATN), a common cause of acute renal failure, is a dynamic, rapidly evolving clinical condition associated with apoptotic and necrotic tubular cell death. Its early identification is critical, but current detection methods relying upon clinical assessment, such as kidney biopsy and functional assays, are insufficient. We have developed a family of small molecule compounds, ApoSense, that is capable, upon systemic administration, of selectively targeting and accumulating within apoptotic/necrotic cells and is suitable for attachment of different markers for clinical imaging. The purpose of this study was to test the applicability of these molecules as a diagnostic imaging agent for the detection of renal tubular cell injury following renal ischemia. Methods: Using both fluorescent and radiolabeled derivatives of one of the ApoSense compounds, didansyl cystine, we evaluated cell death in three experimental, clinically relevant animal models of ATN: renal ischemia/reperfusion, radiocontrast-induced distal tubular necrosis, and cecal ligature and perforation-induced sepsis. Results: ApoSense showed high sensitivity and specificity in targeting injured renal tubular epithelial cells in vivo in all three models used. Uptake of ApoSense in the ischemic kidney was higher than in the non-ischemic one, and the specificity of ApoSense targeting was demonstrated by its localization to regions of apoptotic/necrotic cell death, detected morphologically and by TUNEL staining. Conclusion: ApoSense technology should have significant clinical utility for real-time, noninvasive detection of renal parenchymal damage of various types and evaluation of its distribution and magnitude; it may facilitate the assessment of efficacy of therapeutic interventions in a broad spectrum of disease states

Immense Essence of Excellence: Marine Microbial Bioactive Compounds

Oceans have borne most of the biological activities on our planet. A number of biologically active compounds with varying degrees of action, such as anti-tumor, anti-cancer, anti-microtubule, anti-proliferative, cytotoxic, photo protective, as well as antibiotic and antifouling properties, have been isolated to date from marine sources. The marine environment also represents a largely unexplored source for isolation of new microbes (bacteria, fungi, actinomycetes, microalgae-cyanobacteria and diatoms) that are potent producers of bioactive secondary metabolites. Extensive research has been done to unveil the bioactive potential of marine microbes (free living and symbiotic) and the results are amazingly diverse and productive. Some of these bioactive secondary metabolites of microbial origin with strong antibacterial and antifungal activities are being intensely used as antibiotics and may be effective against infectious diseases such as HIV, conditions of multiple bacterial infections (penicillin, cephalosporines, streptomycin, and vancomycin) or neuropsychiatric sequelae. Research is also being conducted on the general aspects of biophysical and biochemical properties, chemical structures and biotechnological applications of the bioactive substances derived from marine microorganisms, and their potential use as cosmeceuticals and nutraceuticals. This review is an attempt to consolidate the latest studies and critical research in this field, and to showcase the immense competence of marine microbial flora as bioactive metabolite producers. In addition, the present review addresses some effective and novel approaches of procuring marine microbial compounds utilizing the latest screening strategies of drug discovery

生活援助方法論の教育方法とその考え方

教育活動Educational Activity授業科目「生活援助方法論I・II」の教育目標・教育内容および科目構造、授業の展開にあたって基盤としている考え方、生活援助方法論Iの具体的な授業計画を紹介した。また、最初の授業の導入方法はその後の学修に大きな影響を及ぼすといわれるが、入学直後の学生に実施した授業の導入と、学生の気づきや学びについて報告する