Pharmacokinetics of cefquinome in goats after intramuscular administration alone and with meloxicam

Background: Nonsteroidal anti-inflammatory drugs and antibiotics are commonly prescribed together. We aimed to study the kinetic profile of cefquinome (2 mg/kg b.wt.) following intramuscular administration of it alone and co-administered with meloxicam (0.2 mg/kg b.wt.) in goats.Methods: Five Egyptian Baladi goats, each goat was injected intramuscularly at the dose rate of 2 mg/kg b.wt. Cefquinome into the deep gluteal muscle of hindquarter alone and then after fifteen days washout period, these animals also injected intramuscularly at the dose rate of 2 mg/kg b.wt. Cefquinome preceded with meloxicam at the dose rate of 0.2 mg/kg b.wt. The serum concentrations of cefquinome were detected by high performance liquid chromatography, two compartment model.Results: Following a single dose intramuscular administration of cefquinome alone, peak plasma concentration (1.71±0.0189 μg/ml) was obtained at 1.59±0.0038 h. The absorption half-life (t1/2ab), total body clearance (Cltot), elimination half-life (t1/2el) and area under curve (area under concentration (AUC(0-inf)) of cefquinome were 0.4±0.0028 h, 0.068±0.78 l/h/kg, 9.21±0.178h and 29.36±0.78 µg.h.ml-1, respectively. Following a single dose intramuscular co-administration of cefquinome and meloxicam, peak plasma concentration (1.60±0.0124 μg/ml) was obtained at 1.49±0.0092 h. The absorption half-life (t1/2ab), total body clearance (Cltot), elimination half-life (t1/2el) and area under curve (AUC(0-inf)) of cefquinome were 0.396±0.006 h, 0.094±0.25 l/h/kg, 6.5±0.221 h and 21.38±0.696 µg/h/ml, respectively. Non significant alters were reported in the parameters following co-administration of Cefquinome with meloxicam.Conclusions: From our results, may be concluded that intramuscular administration of meloxicam may be successfully co-administrated with cefquinome for combating bacterial infections with an inflammatory condition in goats without any antagonistic effect

Egyptian weddings: happily ever after?

A 9.30-minute audio documentary about the Egyptian wedding ceremonies and how they\u27ve dramatically changed throughout the years, since the 1960s until now. This is done by contrasting the old and new wedding ceremonies and featuring a young bride-to-be and her grandmother. A 9.30-minute audio documentary about the Egyptian wedding ceremonies and how they\u27ve dramatically changed throughout the years, since the 1960s until now. This is done by contrasting the old and new wedding ceremonies and featuring a young bride-to-be and her grandmother

Cubic BOI-ideal of BOI-algebra

In this paper, the notion of cubic BOI-ideal of BOI-algebra is introduced. Some characterization of cubic BOI-ideal of BOI-algebra is given. Several theorems are presented in this regard. Thehomomorphic image and inverse image of cubic BOI-ideal are studied

Doubt Fuzzy BOI-ideal of BOI-algebra

The aim of this paper is to introduce the notion of doubt fuzzy BOI-ideal of BOI-algebra and to study their properties. The homomorphic image and the inverse image of a doubt fuzzy BOI-ideal isstudied well. The Cartesian product of doubt fuzzy BOI-ideal is introduced and discussed

Economic aspects of houses and housing in Roman Egypt

The thesis consists of a general introduction and four chapters. Chapter I deals with the factors which influence the property market, such as: 1) reasons for selling or purchasing house property or building land, for enlarging or consolidating house property, other forms of acquisition of the property, 2) Factors which determine the price of house property (dimension, construction, building materials and labour costs, etc.). Chapter II is concerned with the prices of houses and building land. The documents are grouped by nome in chronological order. As far as the evidence allows, comparisons are between price levels in villages and cities, and between nomes. Chapter III surveys rented house property 1) houses, flats, rooms, 2) industrial and business premises. One particularly interesting problem is the abundance of antichretic loans (with the right of habitation in lieu of interest), which may be linked to the almost complete lack of contracts of rent in the first century of Roman rule. ii Chapter /V attempts a comparison between village houses in Roman Egypt and those in Modern Egypt. The conclusion: The building materials, the location, the dimension, the condition, construction, economic condition play an important part in determining the prices and rents of houses. The sizes of houses varied greatly, but most houses were small. The rural houses were generally larger than the urban houses. The average price in the first two centuries is lower than in the third century. It is also lower in villages than in cities. The level of rents in the first two centuries is lower than in the third century. The rents of houses in the first two centuries are very reasonable compared with the daily or monthly wages of the workers. The modern village houses are very similar to the houses of the Roman period

Design, implementation and evaluation of a QoS-aware transport protocol

In the context of a reconfigurable transport protocol framework, we propose a QoS-aware Transport Protocol (QSTP), specifically designed to operate over QoS-enabled networks with bandwidth guarantee. QSTP combines QoS-aware TFRC congestion control mechanism, which takes into account the network-level bandwidth reservations, with a Selective ACKnowledgment (SACK) mechanism in order to provide a QoS-aware transport service that fill the gap between QoS enabled network services and QoS constraint applications. We have developed a prototype of this protocol in the user-space and conducted a large range of measurements to evaluate this proposal under various network conditions. Our results show that QSTP allows applications to reach their negotiated QoS over bandwidth guaranteed networks, such as DiffServ/AF network, where TCP fails. This protocol appears to be the first reliable protocol especially designed for QoS network architectures with bandwidth guarantee

Ultrasound guided single injection caudal epidural anesthesia of isobaric bupivacaine with/without dexamethasone for geriatric patients undergoing total hip replacement surgery

AbstractBackgroundDexamethasone has anti-inflammatory properties that can affect postoperative analgesia when added to caudal bupivacaine.MethodsSeventy-two geriatric patients scheduled for elective total hip replacement under ultrasound guided caudal anesthesia were randomized blindly into two groups: Group BD received caudal isobaric bupivacaine 0.25% (20ml) and dexamethasone 8mg (2ml) and Group BS received caudal isobaric bupivacaine 0.25% (20ml) and normal saline (2ml). Postoperative analgesia was assessed by recording time to first rescue analgesia and the analgesic doses (paracetamol and meperidine hydrochloride) required during the first 24h postoperatively as a primary outcome. Secondary outcomes were the time taken to the onset of sensory analgesia at T10, time to the onset of complete motor block, VAS pain score at rest and on movement at 1, 2, 4, 6, 8, 12 and 24h, and postoperative adverse events.ResultsGroup BD had a significantly longer time to first rescue analgesia [402 (63) vs 213 (53)] min and significantly lower doses of paracetamol [3389 (728) vs 2833 (697)] mg meperidine hydrochloride [78 (30) vs 142 (28)] mg than Group BS. VAS scores were significantly lower in Group BD than Group BS both at rest and on movement respectively at 4, 6, 8, 12 and 24h.ConclusionAdding dexamethasone with isobaric bupivacaine caudal anesthesia prolongs the duration of postoperative analgesia and decreased postoperative analgesic requirement in geriatric patients undergoing total hip replacement surgery in comparison isobaric bupivacaine alone

Dental Pulp Cells Isolated from Teeth with Superficial Caries Retain an Inflammatory Phenotype and Display an Enhanced Matrix Mineralization Potential

We have isolated dental pulp cells (DPCs) from three healthy (hDPCs) and three carious (cDPCs) donors and shown that compared to hDPCs cells isolated from superficial carious lesions show higher clonogenic potential; show an equivalent proportion of cells with putative stem cell surface markers; show enhanced matrix mineralisation capability; have enhanced angiogenic marker expression and retain the inflammatory phenotype in vitro characteristic of superficial caries lesions in vivo. Our findings suggest that cDPCs may be used for further investigation of the cross talk between inflammatory, angiogenic and mineralisation pathways in repair of carious pulp. In addition cells derived from carious pulps (almost always discarded) may have potential for future applications in mineralized tissue repair and regeneration

Combination Chemotherapeutic Dry Powder Aerosols via Controlled Nanoparticle Agglomeration

The original publication is available at www.springerlink.comPurpose To develop an aerosol system for efficient local lung delivery of chemotherapeutics where nanotechnology holds tremendous potential for developing more valuable cancer therapies. Concurrently, aerosolized chemotherapy is generating interest as a means to treat certain types of lung cancer more effectively with less systemic exposure to the compound. Methods Nanoparticles of the potent anticancer drug, paclitaxel, were controllably assembled to form low density microparticles directly after preparation of the nanoparticle suspension. The amino acid, L-leucine, was used as a colloid destabilizer to drive the assembly of paclitaxel nanoparticles. A combination chemotherapy aerosol was formed by assembling the paclitaxel nanoparticles in the presence of cisplatin in solution. Results Freeze-dried powders of the combination chemotherapy possessed desirable aerodynamic properties for inhalation. In addition, the dissolution rates of dried nanoparticle agglomerate formulations (~60% to 66% after 8 h) were significantly faster than that of micronized paclitaxel powder as received (~18% after 8 h). Interestingly, the presence of the water soluble cisplatin accelerated the dissolution of paclitaxel. Conclusions Nanoparticle agglomerates of paclitaxel alone or in combination with cisplatin may serve as effective chemotherapeutic dry powder aerosols to enable regional treatment of certain lung cancers

Microbial-Physical Synthesis of Fe and Fe3O4 Magnetic Nanoparticles Using Aspergillus niger YESM1 and Supercritical Condition of Ethanol

Magnetic Fe and Fe3O4 (magnetite) nanoparticles are successfully synthesized using Aspergillus niger YESM 1 and supercritical condition of liquids. Aspergillus niger is used for decomposition of FeSO4 and FeCl3 to FeS and Fe2O3, respectively. The produced particles are exposed to supercritical condition of ethanol for 1 hour at 300∘ C and pressure of 850 psi. The phase structure and the morphology measurements yield pure iron and major Fe3O4 spherical nanoparticles with average size of 18 and 50 nm, respectively. The crystal size amounts to 9 nm for Fe and 8 nm for Fe3O4. The magnetic properties are measured to exhibit superparamagneticand ferromagnetic-like behaviors for Fe and Fe3O4 nanoparticles, respectively. The saturation magnetization amounts to 112 and 68 emu/g for Fe and Fe3O4, respectively. The obtained results open new route for using the biophysical method for large-scale production of highly magnetic nanoparticles to be used for biomedical applications