The Role of Scientific Evidence in Canada\u27s West Coast Energy Conflicts

With salience, credibility, and legitimacy as organizing themes, we investigated how opposing communities engaged with scientific information for two contentious proposed energy projects in western Canada, and how their perceptions of science influenced its use in decision-making. The Trans Mountain pipeline expansion, to carry diluted bitumen from northern Alberta’s oil sands to tankers on British Columbia’s (BC) south coast, was expected to adversely impact biodiversity and contribute to climate change. The Bute Inlet hydroelectric project, a large renewable energy project planned for BC’s Central Coast, was anticipated to impact biodiversity but was largely seen as climate-friendly. Based on surveys and interviews with 68 participants who had made one or more personal or professional decisions pertaining to the projects, we discovered that values, cultural cognition, and media effects permeated all aspects of using scientific evidence—from commissioning scientific research to selecting, assessing, and weighing it with other forms of information. As a result, science was developed and used to support positions rather than to inform decisions. We discuss ways to improve the use of science in environmental assessments and other planning and development processes where engaged communities are divided by oppositional positions. We hope this research will lead to community-university partnerships that identify broadly salient, credible, and legitimate sources of information about energy and climate issues, and foster knowledge mobilization across conflict divides

L’éducation relative à l’environnement dans la Réserve de biosphère du mont Saint-Hilaire : observations et tensions

Le Programme sur l’Homme et la Biosphère (Programme MAB) de l’UNESCO vise à établir une base scientifique pour améliorer les relations entre l’humanité et la nature à l’échelle mondiale. Après presque 50 ans d’existence, l’expression la plus tangible du Programme MAB est un réseau de réserves de biosphère dont l’un des principaux objectifs est l’éducation. Puisque l’éducation relative à l’environnement a pour visée l’harmonisation du réseau de relations personne-société-environnement, nous avons effectué une analyse critique des actions suggérées à cet effet par le Programme MAB. Cet exercice a été réalisé dans le cadre du 3e examen périodique de la Réserve de biosphère du mont Saint-Hilaire (RBMSH), prévu par le cadre statutaire des réserves de biosphère dans une perspective d’amélioration des pratiques éducatives. Au bilan, nous formulons cinq observations relatives aux visées de l’ERE, au cadre non formel, à l’axiologie des pratiques, à la pertinence d’élaborer un modèle-cadre et à celle d’adopter des approches d’évaluation formative des pratiques pour favoriser la prise en compte de la diversité des relations entre les humains et la biosphère au sein de la RBMSH et dans le Réseau mondial des réserves de biosphère.UNESCO's Man and the Biosphere (MAB) Program aims to establish a scientific basis for improving human-nature relations on a global scale. After almost 50 years of existence, the most tangible expression of MAB is a network of biosphere reserves, one of whose main objectives is education. Since environmental education (EE) sets out to harmonize the relations between person-society-environment, we have carried out a critical analysis of the actions suggested for this purpose by the MAB. This exercise was carried out as part of the 3rd periodic review of the Mont Saint-Hilaire Biosphere Reserve (RBMSH), in compliance with the Statutory Framework of Biosphere Reserves and with the intention of providing insights into EE practices. In summary, we present five observations concerning the aims of EE, the non-formal framework in which EE is conducted, the axiology of practices, the relevance of developing an EE framework model, and the adoption of formative evaluation approaches during periodic reviews to take into account the diversity of human-biosphere relations within the RBMSH and the World Network of Biosphere Reserves

Reduced body weight is a common effect of gene knockout in mice

<p>Abstract</p> <p>Background</p> <p>During a search for obesity candidate genes in a small region of the mouse genome, we noticed that many genes when knocked out influence body weight. To determine whether this was a general feature of gene knockout or a chance occurrence, we surveyed the Jackson Laboratory Mouse Genome Database for knockout mouse strains and their phenotypes. Body weights were not available for all strains so we also obtained body weight information by contacting a random sample of investigators responsible for a knockout strain.</p> <p>Results</p> <p>We classified each knockout mouse strain as (1) lighter and smaller, (2) larger and heavier, or (3) the same weight, relative to control mice. We excluded knockout strains that died early in life, even though this type of lethality is often associated with a small embryo or reduced body size. Based on a dataset of 1,977 knockout strains, we found that that 31% of viable knockout mouse strains weighed less and an additional 3% weighed more than did controls.</p> <p>Conclusion</p> <p>Body weight is potentially a latent variable in about a third of experiments that use knockout mice and should be considered in interpreting experimental outcomes, e.g., in studies of hypertension, drug and hormone metabolism, organ development, cell proliferation and apoptosis, digestion, heart rate, or atherosclerosis. If we assume that the knockout genes we surveyed are representative then upward of 6,000 genes are predicted to influence the size of a mouse. Body weight is highly heritable, and numerous quantitative trait loci have been mapped in mice, but "multigenic" is an insufficient term for the thousands of loci that could contribute to this complex trait.</p

Social learning for enhancing social-ecological resilience to disaster-shocks : a policy Delphi approach

Publisher Copyright: © 2021, Emerald Publishing Limited.Purpose: The plethora of contributions to social learning has resulted in a wide range of interpretations, meanings and applications of social learning, both within and across disciplines. However, advancing the concept and using social learning methods and tools in areas like disaster-shocks requires interdisciplinary consolidation of understandings. In this context, the primary focus of this paper is on the contributions of social learning to disaster risk reduction (DRR). Design/methodology/approach: By applying a three-round policy Delphi process involving 18 purposefully selected scholars and expert-practitioners, the authors collected data on the meanings of social learning for two groups of professionals, DRR and social-ecological resilience. The survey instruments included questions relating to the identification of the core elements of social learning and the prospects for enhancing social-ecological resilience. Findings: The results revealed strong agreement that (1) the core elements of social learning indicate a collective, iterative and collaborative process that involves sharing/networking, changes in attitudes and knowledge and inclusivity; (2) social learning from disasters is unique; and (3) linkages between disciplines can be built by promoting interdisciplinarity, networks and knowledge platforms; collaboration and coordination at all levels; and teaching and practicing trust and respect. Social learning is useful in preparing for and responding to specific disaster events through communication; sharing experience, ideas and resources; creating synergies for collective action and promoting resilience. Research limitations/implications: The policy Delphi process involved a limited number of participants to control the quality of the data. To the best of the authors’ knowledge, this paper is the first of its kind to identify the core elements of social learning, specifically, in the disaster-shock context. It also makes significant contributions to the interdisciplinary integration issues. Practical implications: The practical implications of this study are related to pre-disaster planning and mitigation through the application of social learning on disaster-shocks. Social implications: The social implications of this study are related to valuing social learning for the improvement of disaster planning, management, and policy formulation and implementation in reducing disaster risks. Originality/value: The study provides a consensus view on the core elements of social learning and its role in DRR and resilience building. Relevant to all stages of DRR, social learning is best characterized as a collective, iterative and collaborative process. It can be promoted by enhancing networking and interdisciplinarity.Peer reviewe

Associations between human leukocyte antigen class I variants and the Mycobacterium tuberculosis subtypes causing disease

BACKGROUND. The development of active tuberculosis disease has been shown to be multifactorial. Interactions between host and bacterial genotype may influence disease outcome, with some studies indicating the adaptation of M. tuberculosis strains to specific human populations. Here we investigate the role of the human leukocyte antigen (HLA) class I genes in this biological process. METHODS. Three hundred patients with tuberculosis from South Africa were typed for their HLA class I alleles by direct sequencing. Mycobacterium tuberculosis genotype classification was done by IS6110 restriction fragment length polymorphism genotyping and spoligotyping. RESULTS. We showed that Beijing strain occurred more frequently in individuals with multiple disease episodes (P < .001) with the HLA-B27 allele lowering the odds of having an additional episode (odds ratio, 0.21; P = .006). Associations were also identified for specific HLA types and disease caused by the Beijing, LAM, LCC, and Quebec strains. HLA types were also associated with disease caused by strains from the Euro-American or East Asian lineages, and the frequencies of these alleles in their sympatric human populations identified potential coevolutionary events between host and pathogen. CONCLUSIONS. This is the first report of the association of human HLA types and M. tuberculosis strain genotype, highlighting that both host and pathogen genetics need to be taken into consideration when studying tuberculosis disease development.Web of Scienc

The ROS Scavenger, NAC, Regulates Hepatic Vα14iNKT Cells Signaling during Fas mAb-Dependent Fulminant Liver Failure

Uncontrolled systemic activation of the immune system is an early initiating event that leads to development of acute fulminant liver failure (FLF) in mice after treatment with agonistic Fas mAb. In this study, we demonstrate that treatment of mice with N-acetylcysteine (NAC), an ROS scavenger and glutathione (GSH) precursor, almost completely abolished Fas mAb-induced FLF through suppression of Vα14iNKT cell activation, IFN-γ signaling, apoptosis and nitrotyrosine formation in liver. In addition, enrichment of the liver with GSH due to Vα14iNKT cells deficiency, induced an anti-inflammatory response in the liver of Jα18−/− mice that inhibited apoptosis, nitrotyrosine formation, IFN-γ signaling and effector functions. In summary, we propose a novel and previously unrecognized pro-inflammatory and pro-apoptotic role for endogenous ROS in stimulating Th1 signaling in Vα14iNKT cells to promote the development of FLF. Therefore, our study provides critical new insights into how NAC, a ROS scavenger, regulates Th1 signaling in intrahepatic Vα14iNKT cells to impact inflammatory and pathological responses

‘Never waste a crisis’: a commentary on the COVID‐19 pandemic as a driver for innovation in maternity care

Abstract unavailable