Geological heterogeneity in landslides:characterization and flow modelling

Significant progress has been made these last decades in the development of hydrogeological numerical flow modelling for describing the hydrodynamic behaviour of landslides. However, these new sophisticated methods are still very seldom used in the problems of slope instability in particular because of the hydrogeological complexity which characterizes them; thin aquifers, discontinuous media, succession of saturated and unsaturated zones, low permeabilities, high hydraulic gradients, lithological heterogeneity, strong contrasts of permeabilities and heterogeneous infiltration. Predictive models of flow in the subsurface, which are often based on homogeneous porous media types of representation, are badly adapted to natural systems that are characterized by highly heterogeneous media such as landslides. These models are good and reliable on a landslide scale (regional scale), but their quality may be affected on a local scale by strong geological heterogeneities. Geological heterogeneities of the subsurface take part in determining the hydrodynamical and geomechanical behaviour of landslides. However, their spatial distribution is partially unknown. Thus, the principal objectives of this PhD thesis are: (i) To carry out an integrated multidisciplinary characterization study on the internal structure of landslides in flysch and Quaternary environments, in order to clarify the organisation of the geological heterogeneities and to identify the hydrodynamic implications. (ii) To propose a conceptual model representing the geological architecture and the hydrogeological functioning. (iii) To examine the effects of heterogeneity and anisotropy on flow systems. (iv) To better understand the influence of geological heterogeneities on the mechanical behaviour of large landslides by performing numerical sensitivity analyses, by means of different heterogeneity scenarios on the field parameters. (v) Finally, to test the incidences on slope stabilization techniques; evaluation of the efficiency of a drainage gallery work. The main test site of la Frasse landslide (VD, Switzerland) was chosen, and completed with additional landslide cases. The main results are the following: In most of the case studies, the landslide mass is composed of an old prehistoric stabilized mass, pinched between the active sliding mass and the bedrock, and playing an important hydrologic role. The stabilized mass and the bedrock form the substratum of the landslide. Landslides occurring in these types of media are defined by an organized heterogeneous environment with "fracture" flows and discontinuity porosity. The overall hydraulic conductivity is low, and locally high permeable zones exist. Regional groundwater circulations are limited and form local interconnected aquicludes organised in thin aquifers, and presenting saturated and unsaturated zones. The hydrogeological analyses showed that the system presents a bimodal permeability; (i) Low hydraulic conductivities characterizing the global matrix and defining the capacitive fraction, and (ii) high permeable features, with high hydraulic conductivities defining the conductive fraction, and favouring strong channelling effects. Besides, the observation shows that the aquifer system is generally very reactive with important magnitudes. Often, there is a straight correlation between water level variation and climatic conditions (rainy events). Landslides are characterized by two important inflows namely effective infiltration from the surface and lateral inflows from the neighbouring units. Water transfer between the stabilized mass and the active mass may be important and thus have to be considered. The existence of water transfer between the bedrock and the landslide mass (stabilized and active) is not well established. The bedrock and the landslide mass present a hydrological behavioural independence. Theoretical two- and three-dimensional flow models are used to investigate the effects of the spatial variability of the hydraulic conductivity on the underground flows. The role of the connectivity in generating flow channelling is examined thanks to the observation of close relations between the permeability and the hydraulic pressures. The sensitivity analysis shows clearly that the relation between local permeability and hydraulic pressures is not straight, and that the organization of the flows depends on the heterogeneity of the hydraulic properties and their spatial correlation. Strong channelling effects are observed in highly heterogeneous porous media. The development of flow channelling as a function of the variance of the natural log permeability values and the correlation lengths is demonstrated. The integrated multi-disciplinary geological characterization at the La Frasse test site combined with the hydrogeological and lithological data of several additional case studies led to the proposal of a global conceptual model. The following assumptions are considered to enable a subsequent quantification of flow components: The flow occurs under confined to leaky conditions, with leakage varying in space; The flow framework is controlled by a complex multi-layer system, isolated lenses or perched aquifer; The aquifer system is divided into interconnected hydrological zones presenting various degrees of saturation; Each hydrological zone may function individually from the others; Horizontally and vertically, the flow direction in the porous matrix is affected by prevailing structural patterns generating channeling effects; The flow is multidirectional, free and channelized, and is affected by temporal and spatial changes; The aquifer is under an unsteady flow regime due to seasonal variation of natural gradients; A conceptual model based on a simple reservoir approach is proposed. It allows the representation of most of the field observations and the main characteristics, namely the organized heterogeneity and the duality of the aquifers. The system is represented by various reservoirs more or less connected and saturated. Complex storage capacities and plug-flow effects may record past events and reactive sliding processes several months after the last important rainy event. The analysis shows that function of the capacity and the degree of saturation of the system, an important hydrological event is not necessarily associated to a reactivation. And, according to the degree of complexity of the system (saturation, connectivity...) a localized geological modification (variation of permeability, reservoir burst...) may produce a chain reaction, and generate failures in unexpected places. The conductive fraction favours the drainage of the system, whereas the capacitive fraction controls the distribution of the hydraulic heads. The role of the phreatic nappe, through the conductive fraction, is to drain and control the hydrologic equilibrium of the system. Therefore landslide remediation with the help of a deep drainage gallery is obviously the most valuable method for this type of landslide. It supports and enhances the natural effects of the conductive fraction in draining the system. Finally, in this context the efficiency of civil engineering works was evaluated according to the heterogeneity of the medium. This study describes transient hydrogeological and geomechanical models realized jointly in 2006 by the EPFL and GeoMod SA within the framework of the stabilization work of the La Frasse landslide. These models evaluate the impact of a deep drainage gallery with subvertical pipes towards the surface in terms of reduction of the deformation velocities and increase of the factor of safety of the landslide. Three variants consisting of different inter pipe spacings are tested. Considering the local heterogeneities, the results show that a mean spacing between the pipes of the order of 10 m is able to control the temporal head fluctuations between the wells within a range of some meters. Moreover, this solution induces a strong diminution of the predicted displacements during a specific crisis, from 101cm for the model without drainage to around 14 cm for the drained model, and a significant gain of security (from 1.05 to 1.30)

Simulations of Galaxy Cluster Collisions with a Dark Plasma Component

12 pages, 1 table, 6 figures now including two internal energy maps.Dark plasma is an intriguing form of self-interacting dark matter with an effective fluid-like behavior, which is well motivated by various theoretical particle physics models. We aim to find an explanation for an isolated mass clump in the Abell 520 system, which cannot be explained by traditional models of dark matter, but has been detected in weak lensing observations. We performed N-body smoothed particle hydrodynamics simulations of galaxy cluster collisions with a two component model of dark matter, which is assumed to consist of a predominant non-interacting dark matter component and a 10-40 percent mass fraction of dark plasma. The mass of a possible dark clump was calculated for each simulation in a parameter scan over the underlying model parameters. In two higher resolution simulations shock-waves and Mach cones were observed to form in the dark plasma halos. By choosing suitable simulation parameters, the observed distributions of dark matter in both the Bullet Cluster (1E 0657-558) and Abell 520 (MS 0451.5+0250) can be qualitatively reproduced.Peer reviewe

Assessment of blood cultures and antibiotic susceptibility testing for bacterial sepsis diagnosis and utilization of results by clinicians in Benin: A qualitative study

ObjectivesWe assessed the current status of blood culture and antibiotic susceptibility testing (AST) practices in clinical laboratories in Benin, and how the laboratory results are used by physicians to prescribe antibiotics.MethodsThe qualitative study covered twenty-five clinical laboratories with a bacteriology unit and associated hospitals and pharmacies. Altogether 159 laboratory staff, physicians and pharmacists were interviewed about their perceptions of the state of laboratory diagnostics related to sepsis and the use of antibiotics. Face-to-face interviews based on structured questionnaires were supported by direct observations when visiting five laboratories in across the country.ResultsOnly 6 laboratories (24%) conducted blood cultures, half of them with a maximum of 10 samples per month. The most common gram-negative bacteria isolated from blood cultures were: Escherichia coli, Salmonella spp. and Salmonella enterica serovar Typhi while the most common gram-positives were Enterococcus spp. and Staphylococcus aureus. None of the laboratories listed Klebsiella pneumoniae among the three most common bacteria isolated from blood cultures, although other evidence indicates that it is the most common cause of sepsis in Benin. Due to limited testing capacity, physicians most commonly use empirical antibiotic therapy.ConclusionsMore resources are needed to develop laboratory testing capacity, technical skills in bacterial identification, AST, quality assurance, and communication of results must be strengthened.Peer reviewe

Assessment of blood cultures and antibiotic susceptibility testing for bacterial sepsis diagnosis and utilization of results by clinicians in Benin: A qualitative study

ObjectivesWe assessed the current status of blood culture and antibiotic susceptibility testing (AST) practices in clinical laboratories in Benin, and how the laboratory results are used by physicians to prescribe antibiotics.MethodsThe qualitative study covered twenty-five clinical laboratories with a bacteriology unit and associated hospitals and pharmacies. Altogether 159 laboratory staff, physicians and pharmacists were interviewed about their perceptions of the state of laboratory diagnostics related to sepsis and the use of antibiotics. Face-to-face interviews based on structured questionnaires were supported by direct observations when visiting five laboratories in across the country.ResultsOnly 6 laboratories (24%) conducted blood cultures, half of them with a maximum of 10 samples per month. The most common gram-negative bacteria isolated from blood cultures were: Escherichia coli, Salmonella spp. and Salmonella enterica serovar Typhi while the most common gram-positives were Enterococcus spp. and Staphylococcus aureus. None of the laboratories listed Klebsiella pneumoniae among the three most common bacteria isolated from blood cultures, although other evidence indicates that it is the most common cause of sepsis in Benin. Due to limited testing capacity, physicians most commonly use empirical antibiotic therapy.ConclusionsMore resources are needed to develop laboratory testing capacity, technical skills in bacterial identification, AST, quality assurance, and communication of results must be strengthened

Isoform-Specific Regulation of the Actin-Organizing Protein Palladin during TGF-β1-Induced Myofibroblast Differentiation

Contractile myofibroblasts are responsible for remodeling of extracellular matrix during wound healing; however, their continued activity results in various fibrocontractive diseases. Conversion of fibroblasts into myofibroblasts is induced by transforming growth factor-beta1 (TGF-beta1) and is hallmarked by the neo-expression of alpha-smooth muscle actin (alpha-SMA), a commonly used myofibroblast marker. Moreover, myofibroblast differentiation and acquisition of the contractile phenotype involves functionally important alterations in the expression of actin-organizing proteins. We investigated whether myofibroblast differentiation is accompanied by changes in the expression of palladin, a cytoskeletal protein that controls stress fiber integrity. Palladin is expressed as several isoforms, including major 3Ig (90 kDa) and 4Ig (140 kDa) forms that differ in their N-terminal sequence. Expression of the 4Ig isoform is strongly induced in fibroblast stress fibers upon TGF-beta1 treatment preceding alpha-SMA upregulation. TGF-beta1 induced upregulation of palladin is mediated both by Smad and mitogen-activated protein kinase pathways. Furthermore, palladin 4Ig-isoform is co-expressed with alpha-SMA in vivo in experimental rat wounds and in human myofibroblast-containing lesions. Taken together these results identify palladin 4Ig as a novel marker of myofibroblast conversion in vitro and in vivo. They also provide for the first time information about the signaling cascades involved in the regulation of palladin expression

The MetNet vehicle : a lander to deploy environmental stations for local and global investigations of Mars

Investigations of global and related local phenomena on Mars such as atmospheric circulation patterns, boundary layer phenomena, water, dust and climatological cycles and investigations of the planetary interior would benefit from simultaneous, distributed in situ measurements. Practically, such an observation network would require low-mass landers, with a high packing density, so a large number of landers could be delivered to Mars with the minimum number of launchers. The Mars Network Lander (MetNet Lander; MNL), a small semi-hard lander/penetrator design with a payload mass fraction of approximately 17 %, has been developed, tested and prototyped. The MNL features an innovative Entry, Descent and Landing System (EDLS) that is based on inflatable structures. The EDLS is capable of decelerating the lander from interplanetary transfer trajectories down to a surface impact speed of 50-70 ms(-1) with a deceleration of <500 g for <20 ms. The total mass of the prototype design is approximate to 24 kg, with approximate to 4 kg of mass available for the payload. The EDLS is designed to orient the penetrator for a vertical impact. As the payload bay will be embedded in the surface materials, the bay's temperature excursions will be much less than if it were fully exposed on the Martian surface, allowing a reduction in the amount of thermal insulation and savings on mass. The MNL is well suited for delivering meteorological and atmospheric instruments to the Martian surface. The payload concept also enables the use of other environmental instruments. The small size and low mass of a MNL makes it ideally suited for piggy-backing on larger spacecraft. MNLs are designed primarily for use as surface networks but could also be used as pathfinders for high-value landed missions.Peer reviewe

HIDEA syndrome is caused by biallelic, pathogenic, rare or founder P4HTM variants impacting the active site or the overall stability of the P4H-TM protein

HIDEA syndrome is caused by biallelic pathogenic variants in P4HTM. The phenotype is characterized by muscular and central hypotonia, hypoventilation including obstructive and central sleep apneas, intellectual disability, dysautonomia, epilepsy, eye abnormalities, and an increased tendency to develop respiratory distress during pneumonia. Here, we report six new patients with HIDEA syndrome caused by five different biallelic P4HTM variants, including three novel variants. We describe two Finnish enriched pathogenic P4HTM variants and demonstrate that these variants are embedded within founder haplotypes. We review the clinical data from all previously published patients with HIDEA and characterize all reported P4HTM pathogenic variants associated with HIDEA in silico. All known pathogenic variants in P4HTM result in either premature stop codons, an intragenic deletion, or amino acid changes that impact the active site or the overall stability of P4H-TM protein. In all cases, normal P4H-TM enzyme function is expected to be lost or severely decreased. This report expands knowledge of the genotypic and phenotypic spectrum of the disease.publishedVersio

Sporadic naturally occurring melanoma in dogs as a preclinical model for human melanoma

Melanoma represents a significant malignancy in humans and dogs. Different from genetically engineered models, sporadic canine melanocytic neoplasms share several characteristics with human disease that could make dogs a more relevant preclinical model. Canine melanomas rarely arise in sun-exposed sites. Most occur in the oral cavity, with a subset having intra-epithelial malignant melanocytes mimicking the in situ component of human mucosal melanoma. The spectrum of canine melanocytic neoplasia includes benign lesions with some analogy to nevi, as well as invasive primary melanoma, and widespread metastasis. Growing evidence of distinct subtypes in humans, differing in somatic and predisposing germ-line genetic alterations, cell of origin, epidemiology, relationship to ultraviolet radiation and progression from benign to malignant tumors, may also exist in dogs. Canine and human mucosal melanomas appear to harbor BRAF, NRAS, and c-kit mutations uncommonly, compared with human cutaneous melanomas, although both species share AKT and MAPK signaling activation. We conclude that there is significant overlap in the clinical and histopathological features of canine and human mucosal melanomas. This represents opportunity to explore canine oral cavity melanoma as a preclinical model

Overview: Recent advances in the understanding of the northern Eurasian environments and of the urban air quality in China – a Pan-Eurasian Experiment (PEEX) programme perspective

The Pan-Eurasian Experiment (PEEX) Science Plan, released in 2015, addressed a need for a holistic system understanding and outlined the most urgent research needs for the rapidly changing Arctic-boreal region. Air quality in China, together with the long-range transport of atmospheric pollutants, was also indicated as one of the most crucial topics of the research agenda. These two geographical regions, the northern Eurasian Arctic-boreal region and China, especially the megacities in China, were identified as a "PEEX region". It is also important to recognize that the PEEX geographical region is an area where science-based policy actions would have significant impacts on the global climate. This paper summarizes results obtained during the last 5 years in the northern Eurasian region, together with recent observations of the air quality in the urban environments in China, in the context of the PEEX programme. The main regions of interest are the Russian Arctic, northern Eurasian boreal forests (Siberia) and peatlands, and the megacities in China. We frame our analysis against research themes introduced in the PEEX Science Plan in 2015. We summarize recent progress towards an enhanced holistic understanding of the land-atmosphere-ocean systems feedbacks. We conclude that although the scientific knowledge in these regions has increased, the new results are in many cases insufficient, and there are still gaps in our understanding of large-scale climate-Earth surface interactions and feedbacks. This arises from limitations in research infrastructures, especially the lack of coordinated, continuous and comprehensive in situ observations of the study region as well as integrative data analyses, hindering a comprehensive system analysis. The fast-changing environment and ecosystem changes driven by climate change, socio-economic activities like the China Silk Road Initiative, and the global trends like urbanization further complicate such analyses. We recognize new topics with an increasing importance in the near future, especially "the enhancing biological sequestration capacity of greenhouse gases into forests and soils to mitigate climate change" and the "socio-economic development to tackle air quality issues".Peer reviewe