2,875 research outputs found
Accelerated return to sport after osteochondral autograft plug transfer
Background:Previous studies have reported varying return-to-sport protocols after knee cartilage restoration procedures.Purpose:To (1) evaluate the time for return to sport in athletes with an isolated chondral injury who underwent an accelerated return-to-sport protocol after osteochondral autograft plug transfer (OAT) and (2) evaluate clinical outcomes to assess for any consequences from the accelerated return to sport.Study Design:Case series; Level of evidence, 4.Methods:An institutional cohort of 152 OAT procedures was reviewed, of which 20 competitive athletes met inclusion and exclusion criteria. All patients underwent a physician-directed accelerated rehabilitation program after their procedure. Return to sport was determined for all athletes. Clinical outcomes were assessed using International Knee Documentation Committee (IKDC) and Tegner scores as well as assessment of level of participation on return to sport.Results:Return-to-sport data were available for all 20 athletes; 13 of 20 athletes (65%) were available for clinical evaluation at a mean 4.4-year follow-up. The mean time for return to sport for all 20 athletes was 82.9 ± 25 days (range, 38-134 days). All athletes were able to return to sport at their previous level and reported that they were satisfied or very satisfied with their surgical outcome and ability to return to sport. The mean postoperative IKDC score was 84.5 ± 9.5. The mean Tegner score prior to injury was 8.9 ± 1.7; it was 7.7 ± 1.9 at final follow-up.Conclusion:Competitive athletes with traumatic chondral defects treated with OAT managed using this protocol had reduced time to preinjury activity levels compared with what is currently reported, with excellent clinical outcomes and no serious long-term sequelae.</jats:sec
Multilocus phylogenetics in a widespread African anuran lineage (Brevicipitidae: Breviceps) reveals patterns of diversity reflecting geoclimatic change
AimTo investigate models assessing the influence of geomorphology and climatic shifts on species diversification in subâSaharan Africa by reconstructing the pattern and timing of phylogenetic relationships of rain frogs (Brevicipitidae: Breviceps).LocationSubâSaharan Africa, south of the Congo Basin.MethodsMultilocus sequence data were generated for near complete speciesâlevel sampling of the genus Breviceps. Phylogenetic relationships were inferred via Bayesian inference and maximum likelihood analyses on both concatenated and singleâgene datasets. Network analyses identified locusâspecific reticulate relationships among taxa. Bayesian methods were used to infer dates of divergence among Breviceps lineages, and niche modelling was used to identify possible adaptive divergence.ResultsBreviceps is monophyletic and comprised of two major, largely allopatric subclades. Diversity within each subclade is concentrated in two areas with contrasting geologic and climatic histories: the arid/semiarid winter rainfall zone in the southâwestern (SW) Cape, and the semitropical East Coast that receives predominantly summer rainfall. Recognized species diversity in the SW Cape based on phenotypic variation is consistent with observed genetic patterns whereas the East Coast is shown to harbour unexpectedly high genetic diversity and up to seven putative, cryptic species. Niche models show significant overlap between closely related species.Main conclusionsDating analyses indicate that diversification of Breviceps occurred rapidly within the Miocene, with only a moderate decline over the PlioâPleistocene, suggesting that this process might be slowed but ongoing. Our findings suggest that a combination of two models, a landscape barrier model and climate fluctuation model, can explain patterns of diversification in Breviceps. This demonstrates that Miocene epeirogenic events and climatic shifts may have had a considerable influence on contemporary patterns of biodiversity. Topographic complexity and relative geoclimatic stability in the East have promoted cryptic diversification in allopatry, and this area clearly harbours numerous undescribed taxa and is in need of detailed biotic investigation.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/145569/1/jbi13394.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/145569/2/jbi13394_am.pd
Defect accommodation in off-stoichiometric (SrTiO<sub>3</sub>)<i><sub>n</sub></i>SrO RuddlesdenâPopper superlattices studied with positron annihilation spectroscopy
Intermolecular Structure Determination of Amyloid Fibrils with 2 Magic-Angle Spinning and Dynamic Nuclear Polarization NMR
We describe magic-angle spinning NMR experiments designed to elucidate the interstrand architecture of amyloid fibrils. Three methods are introduced for this purpose, two being based on the analysis of long-range [superscript 13]Câ[superscript 13]C correlation spectra and the third based on the identification of intermolecular interactions in [superscript 13]Câ[superscript 15]N spectra. We show, in studies of fibrils formed by the 86-residue SH3 domain of PI3 kinase (PI3-SH3 or PI3K-SH3), that efficient [superscript 13]Câ[superscript 13]C correlation spectra display a resonance degeneracy that establishes a parallel, in-register alignment of the proteins in the amyloid fibrils. In addition, this degeneracy can be circumvented to yield direct intermolecular constraints. The [superscript 13]Câ[superscript 13]C experiments are corroborated by [superscript 15]Nâ[superscript 13]C correlation spectra obtained from a mixed [[superscript 15]N,[superscript 12]C]/[[superscript 14]N,[superscript 13]C] sample which directly quantify interstrand distances. Furthermore, when the spectra are recorded with signal enhancement provided by dynamic nuclear polarization (DNP) at 100 K, we demonstrate a dramatic increase (from 23 to 52) in the number of intermolecular [superscript 15]Nâ[superscript 13]C constraints detectable in the spectra. The increase in the information content is due to the enhanced signal intensities and to the fact that dynamic processes, leading to spectral intensity losses, are quenched at low temperatures. Thus, acquisition of low temperature spectra addresses a problem that is frequently encountered in MAS spectra of proteins. In total, the experiments provide 111 intermolecular [superscript 13]Câ[superscript 13]C and [superscript 15]Nâ[superscript 13]C constraints that establish that the PI3-SH3 protein strands are aligned in a parallel, in-register arrangement within the amyloid fibril.National Institutes of Health (U.S.) (Grant EB-003151)National Institutes of Health (U.S.) (Grant EB-002804)National Institutes of Health (U.S.) (Grant EB-002026
Social Preferences and the Efficiency of Bilateral Exchange
Under what conditions do social preferences, such as altruism or a concern for fair outcomes, generate efficient trade? I analyze theoretically a simple bilateral exchange game: Each player sequentially takes an action that reduces his own material payoff but increases the other playerâs. Each playerâs preferences may depend on both his/her own material payoff and the other playerâs. I identify necessary conditions and sufficient conditions on the playersâ preferences for the outcome of their interaction to be Pareto efficient. The results have implications for interpreting the rotten kid theorem, gift exchange in the laboratory, and gift exchange in the field
Baryons at the Edge of the X-ray Brightest Galaxy Cluster
Studies of the diffuse X-ray emitting gas in galaxy clusters have provided
powerful constraints on cosmological parameters and insights into plasma
astrophysics. However, measurements of the faint cluster outskirts have become
possible only recently. Using data from the Suzaku X-ray telescope, we
determined an accurate, spatially resolved census of the gas, metals, and dark
matter out to the edge of the Perseus Cluster. Contrary to previous results,
our measurements of the cluster baryon fraction are consistent with the
expected universal value at half of the virial radius. The apparent baryon
fraction exceeds the cosmic mean at larger radii, suggesting a clumpy
distribution of the gas, which is important for understanding the ongoing
growth of clusters from the surrounding cosmic web.Comment: Accepted for publicatio
Thermal Emission of WASP-14b Revealed with Three Spitzer Eclipses
Exoplanet WASP-14b is a highly irradiated, transiting hot Jupiter. Joshi et
al. calculate an equilibrium temperature Teq of 1866 K for zero albedo and
reemission from the entire planet, a mass of 7.3 +/- 0.5 Jupiter masses and a
radius of 1.28 +/- 0.08 Jupiter radii. Its mean density of 4.6 g/cm3 is one of
the highest known for planets with periods less than 3 days. We obtained three
secondary eclipse light curves with the Spitzer Space Telescope. The eclipse
depths from the best jointly fit model are +/- at 4.5
{\mu}m and +/- at 8.0 {\mu}m. The corresponding brightness
temperatures are 2212 +/- 94 K and 1590 +/- 116 K. A slight ambiguity between
systematic models suggests a conservative 3.6 {\mu}m eclipse depth of
+/- and brightness temperature of 2242 +/- 55 K. Although extremely
irradiated, WASP-14b does not show any distinct evidence of a thermal
inversion. In addition, the present data nominally favor models with day night
energy redistribution less than . The current data are generally
consistent with oxygen-rich as well as carbon-rich compositions, although an
oxygen-rich composition provides a marginally better fit. We confirm a
significant eccentricity of e = 0.087 +/- 0.002 and refine other orbital
parameters.Comment: 16 pages, 16 figure
The Balloon-Borne Large Aperture Submillimeter Telescope (BLAST) 2005: A 10 deg^2 Survey of Star Formation in Cygnus X
We present Cygnus X in a new multi-wavelength perspective based on an
unbiased BLAST survey at 250, 350, and 500 micron, combined with rich datasets
for this well-studied region. Our primary goal is to investigate the early
stages of high mass star formation. We have detected 184 compact sources in
various stages of evolution across all three BLAST bands. From their
well-constrained spectral energy distributions, we obtain the physical
properties mass, surface density, bolometric luminosity, and dust temperature.
Some of the bright sources reaching 40 K contain well-known compact H II
regions. We relate these to other sources at earlier stages of evolution via
the energetics as deduced from their position in the luminosity-mass (L-M)
diagram. The BLAST spectral coverage, near the peak of the spectral energy
distribution of the dust, reveals fainter sources too cool (~ 10 K) to be seen
by earlier shorter-wavelength surveys like IRAS. We detect thermal emission
from infrared dark clouds and investigate the phenomenon of cold ``starless
cores" more generally. Spitzer images of these cold sources often show stellar
nurseries, but these potential sites for massive star formation are ``starless"
in the sense that to date there is no massive protostar in a vigorous accretion
phase. We discuss evolution in the context of the L-M diagram. Theory raises
some interesting possibilities: some cold massive compact sources might never
form a cluster containing massive stars; and clusters with massive stars might
not have an identifiable compact cold massive precursor.Comment: 42 pages, 31 Figures, 6 table
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Energy and Electron Transfer Dynamics within a Series of Perylene Diimide/Cyclophane Systems.
Artificial photosynthetic systems for solar energy conversion exploit both covalent and supramolecular chemistry to produce favorable arrangements of light-harvesting and redox-active chromophores in space. An understanding of the interplay between key processes for photosynthesis, namely light-harvesting, energy transfer, and photoinduced charge separation and the design of novel, self-assembling components capable of these processes are imperative for the realization of multifunctional integrated systems. We report our investigations on the potential of extended tetracationic cyclophane/perylene diimide systems as components for artificial photosynthetic applications. We show how the selection of appropriate heterocycles, as extending units, allows for tuning of the electron accumulation and photophysical properties of the extended tetracationic cyclophanes. Spectroscopic techniques confirm energy transfer between the extended tetracationic cyclophanes and perylene diimide is ultrafast and quantitative, while the heterocycle specifically influences the energy transfer related parameters and the acceptor excited state.S.T.J.R. thanks the Cambridge Home and European Scholarship Scheme and the Robert Gardiner memorial scholarship. S.T.J.R., A.F. and O.A.S. thank the ERC starting investigator grant ASPiRe (project no. 240629) and the EPSRC (reference no. EP/G060649/1). Femtosecond and nanosecond spectroscopy (R.M.Y.), EPR spectroscopy (M.D.K.) and phosphorescence spectroscopy (Y.W.) were supported as part of the ANSER Center, an Energy Frontier Research Center funded by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences under award no. DE-SC0001059. J.F.S., J.J.H., N.H., N.A.V. and E.D.J. acknowledge the Joint Center of Excellence in Integrated Nano-Systems (JCIN) between KACST and Northwestern University (Project 34-946) for their continued financial support. E.J.D. acknowledges NSF and Ryan fellowships. A.H. and W.M.N. thank the COST Action CM1005 âSupramolecular Chemistry in Waterâ and the DFG (grant NA-686/5) for financial support.This is the author accepted manuscript. The final version is available from the American Chemical Society via http://dx.doi.org/10.1021/jacs.5b1032
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