Flamingo Vol. II N 4

Chaparral. Taking It Seriously . Prose. 1. Whiz Bang. Our History Lesson . Prose. 1. Ubersax, Delmar. Untitled. Picture. 4. Mather, William G. Frozen Fields . Poem. 5. A.F.T. Open Season . Prose. 6. Anonymous. Bob . Poem. 6. Anonymous. Untitled. Poem. 6. Mather, William G. Untitled. Poem. 6. R. Song . Poem. 7. Q. Woman\u27s Love . Poem. 7. Holt, Kilburn. A Lost Art . Poem. 7. C.B. A Sonnet . Poem. 7. Keeler, Clyde. Untitled. Picture. 9. Keeler, Clyde. Mid-Years . Picture. 0. Anonymous. Inside Stuff . Prose. 9. Anonymous. Untitled. prose. 9. Keeler, Clyde. untitled. Picture. 10. Anonymous. Untitled. Prose. 10. Anonymous. The First One: A Flapper\u27s Lament . Prose. 11. Keeler, Clyde. Untitled. Picture. 11. Keeler, Clyde. Untitled. Prose. 11. Schmitz, Edward. Untitled. Picture. 11. W.A.V. The Microbes . Picture. 11. Williams, Grace. Heaven\u27s Bells! Picture. 12. Anonymous. Heaven\u27s Bells! Prose. 12. Anonymous. Tragedy Picture. 12. Anonymous. Untitled. Picture. 12. Anonymous. Famous Hells Picture. 12. Anonymous. Denison\u27s Hall of Fame: Uncle Sam Brierly . Prose. 13. Anonymous. Untitled. Prose. 14. Anonymous. Anxious Moments . Cartoon. 16. Keeler, Clyde. Untitled. Picture. 18. Anonymous. Untitled. Prose. 18. Williams, Grace. Just An ordinary C-Man . Picture. 18. Anonymous. As The Denisonian Reporter Would Have Done it . Prose. 19. Anonymous. Untitled. Prose. 19. Anonymous. Not The Morning After-But The Same Night . Prose. 20. Ubersax, Delmar. Untitled. Picture. 20. Anonymous. Untitled. Prose. 20. Anonymous. Untitled. Picture. 20. Anonymous. Not A Flirtation . Prose. 20. Anonymous. Crossing The Bar . Poem. 20. Anonymous. Untitled. Prose. 22. Williams, Grace. Untitled. Picture. 23. Anonymous. Untitled. Prose. 23. Williams, Grace. Untitled. Picture. 24. Anonymous. Untitled. Prose. 24. Anonymous. Benny Says . Prose. 25. Jester. Thy Name is Woman . Prose. 25. W.G.K. An Ode to A Rabbit . Poem. 26. Anonymous. Untitled. Poem. 26. Anonymous. Untitled. Poem. 27. Keeler, Clyde. Untitled. Picture. 27. Y. Catastrophe . Poem. 28. Ed. Untitled. Picture. 29. Beanpot. We Know Her, Too . Prose. 29. Puppet. Anonymous. Prose. 30. Benapot. Untitled. Prose. 30. Wasp. Untitled. Prose. 30. Whiz Bang. Untitled. Prose. 30. Chaparral. A Flapper . Poem. 31. Whiz Bang. Untitled. Prose. 31. Jester. Untitled. Prose. 31. Reel, Virginia. Untitled. Prose. 32. O\u27Lantern, Jack. Untitled. Prose. 32. Sun Dodger. Untitled. Prose. 32. Beanpot. Untitled. Prose. 32. Jester. Untitled. Prose. 32

Flamingo Vol. II N 3

Punch Bowl. A Previous Engagement . Prose. 1. Burr. Untitled. Prose. 1. Ubersax, Delmar. Untitled. Picture. 4. Mather, William G. Shelf 378C . Prose. 5. Bennett, G.W. Esotery . Poem. 6. W.A.V. Untitled. Poem. 6. Anonymous. Approved Subjects of Conversation . Poem. 7. Anonymous. Pipe Up . Prose. 7. Anonymous. Denison\u27s Hall of Fame: Francis W. Shepardson . Prose. 8 M.E. Percy . Poem. 9.; A.F.T. Triolet . Poem. 9. Anonymous. Untitled. Picture. 9. W.G.K. The Message of a Leader-Autobiographical . Prose. 9. Keeler, Clyde. Untitled. Picture. 10. Anonymous. Untitled. Prose. 10. Potter, W.M. Prose Fiction . Poem. 11. Keeler, Clyde. Untitled. Picture. 11. Anonymous. The Night After Christmas . Prose. 11. Anonymous. Untitled. Prose. 11. Anonymous. Popular Illusions Shattered . Prose. 11. Anonymous. Throw Him Into The Green River! . Poem. 12. Anonymous. Candid . Prose. 12. Holt, Kilburn. Favorite Poems (Revised Edition) . Poem. 12. Anonymous. Untitled. Prose. 14. Anonymous. Proof that Winter is Here . Cartoon. 16. F. The Inefficiency Medal . Prose. 18. Anonymous. Untitled. Picture. 18. Anonymous. Untitled. Prose. 18. Ed. A Pathetic Fallacy . Poem. 19. Ubersax, Delmar. Untitled. Picture. 19. Anonymous. Untitled. Prose. 19. Anonymous. Untitled. Picture. 19. Oh Min. The Baliff and The Bunk . Prose. 20. Anonymous. Reservoir . Prose. 20. Anonymous. Untitled. Prose. 20. Ed. and Delmar Ubersax. A Lass and a Lack . Picture. 20. Anonymous. Thrice Told Tales . Prose. 21. Anonymous. Untitled. Prose. 21. Anonymous. Untitled. Prose. 22. Keeler, Clyde. Untitled. Picture. 22. R. The Lover Sings . Poem. 23. Anonymous. Untitled. Prose. 23. Anonymous. Untitled. Picture. 23. Octopus. Untitled. Prose. 23. Anonymous. Untitled. Picture. 24. Anonymous. Untitled. Prose. 24. Keeler, Clyde. Untitled. Picture. 25. Anonymous. Untitled. Prose. 25. Punch Bowl. Untitled. Prose. 26. Orange Peel. Untitled. Prose. 26. Lampoon. Untitled. Prose. 26. Octopus. Untitled. Prose. 26. Sun Dodger. Untitled. Prose. 27. Phoenix. Untitled. Prose. 27. Dirge. Untitled. Prose. 27. Lampoon. Untitled. Prose. 27. Siren. Untitled. Prose. 27. Jester. Untitled. prose. 29. Frivol. Untitled. Prose. 29. Voo-Doo. Untitled. Prose. 29. Lampoon. Untitled. Prose. 29. Royal Gaboon. Untitled. Prose. 30. Octopus. Untitled. Prose. 30. Anonymous. Page Mr. Volstead . Prose. 30. Chaparral. Missing Cylinder . Prose. 30. Frivol. Untitled. Prose. 31. Widow. Bubbling over . Prose. 31. Juggler. The Order of The Bawth . Prose. 31. Tiger. Untitled. Prose. 31

Flamingo Vol. II N 2

Keeler, Clyde. Dad\u27s Day . Picture. 0. Puppet. Untitled. Prose. 1. Crescent. Untitled. Prose. 1. Williams, Charles L. As To Reading Biography . Prose. 5. Verlaine, Paul. Kyrie Eleison . Poem. 6. Anonymous. Mystery . Poem. 6. R. To You . Poem. 7. Q. The Passion Flower . Poem. 7. Bennett, G.W. November . Poem. 7. R. Storm . Poem. 7. Anonymous. Untitled.Prose. 8. Anonymous. No Doubt! . Poem. 8. Anonymous. Untitled. Picture. 8. McCutcheon, Dorothy. Ready-Made Reputations . Prose. 9. Anonymous. Untitled. Prose. 9. Anonymous. Untitled. Prose. 10. Ubersax, Delmar. Untitled. Prose. 10. Anonymous. Statistics From The Football Centers . Prose. 10. Anonymous. Our Own Handbook . Prose. 11. Anonymous. Real Reels . Prose. 12. Anonymous. Tire Trouble at The Round Table . Prose. 12. Anonymous. Untitled. Prose. 14. Anonymous. The Return From Dayton . Cartoon. 16. Anonymous. Untitled. Prose. 18. Anonymous. Down The Street . Poem. 18. Anonymous. The 7:30 . Poem. 18. Lord Jeff. In The Hole . Poem. 18. Anonymous. How It\u27s Done . Prose. 19. Anonymous. A Zoological Dream . Picture. 19. Anonymous. A Smooth Line . Prose. 20. Anonymous. Untitled. Prose. 20. Anonymous. You\u27ve Heart it . Prose. 20. Anonymous. Dog Gone! . Prose. 21. Anonymous. Untitled. Prose. 21. Cols Dis. Untitled. Poem. 21. Anonymous. Eddie Tor\u27s Lament . Poem. 22. Anonymous. Untitled. Prose. 22. Anonymous. The Long And Short of it. Prose. 22. Anonymous. Final Exam. In Zetetic Jactation 613 (You Look it up.) . Prose. 24. Pope of Fools. Love Letters of a Sceptic . Prose. 25. Anonymous. Untitled. Prose. 26. Williams, Grace. Untitled. Picture. 28. Anonymous. Untitled. Prose. 28. Goblin. It is a Wise Landlady . Prose. 28. Anonymous. Untitled. Prose. 28. Drexard. Untitled. Prose. 29. Chaparral. Untitled. Prose. 29. Punch Bowl. The Trifler . Prose. 29. Anonymous. His Finger Got Stuck in the Bowling Ball . Picture. 30. Chaparral. Untitled. Prose. 30. Banter. Untitled. Prose. 30. Tiger. Untitled. Prose. 30. Brown Jug. Untitled. Prose. 31. Octopus. Untitled. Prose. 31. Burr. Untitled. Prose. 31. Squib. Untitled. Prose. 31. Ubersax, Delmar. Untitled. Picture. 32. Purple Cow. Untitled. Prose. 32. Mather, William G. A Ditty . Poem. 12

Inhibition of sodium–glucose cotransporter-2 preserves cardiac function during regional myocardial ischemia independent of alterations in myocardial substrate utilization

The goal of the present study was to evaluate the effects of SGLT2i on cardiac contractile function, substrate utilization, and efficiency before and during regional myocardial ischemia/reperfusion injury in normal, metabolically healthy swine. Lean swine received placebo or canagliflozin (300 mg PO) 24 h prior to and the morning of an invasive physiologic study protocol. Hemodynamic and cardiac function measurements were obtained at baseline, during a 30-min complete occlusion of the circumflex coronary artery, and during a 2-h reperfusion period. Blood pressure, heart rate, coronary flow, and myocardial oxygen consumption were unaffected by canagliflozin treatment. Ventricular volumes remained unchanged in controls throughout the protocol. At the onset of ischemia, canagliflozin produced acute large increases in left ventricular end-diastolic and systolic volumes which returned to baseline with reperfusion. Canagliflozin-mediated increases in end-diastolic volume were directly associated with increases in stroke volume and stroke work relative to controls during ischemia. Canagliflozin also increased cardiac work efficiency during ischemia relative to control swine. No differences in myocardial uptake of glucose, lactate, free fatty acids or ketones, were noted between treatment groups at any time. In separate experiments using a longer 60 min coronary occlusion followed by 2 h of reperfusion, canagliflozin increased end-diastolic volume and stroke volume and significantly diminished myocardial infarct size relative to control swine. These data demonstrate that SGLT2i with canagliflozin preserves cardiac contractile function and efficiency during regional myocardial ischemia and provides ischemia protection independent of alterations in myocardial substrate utilization

Modeling the Mechanism of Action of a DGAT1 Inhibitor Using a Causal Reasoning Platform

Triglyceride accumulation is associated with obesity and type 2 diabetes. Genetic disruption of diacylglycerol acyltransferase 1 (DGAT1), which catalyzes the final reaction of triglyceride synthesis, confers dramatic resistance to high-fat diet induced obesity. Hence, DGAT1 is considered a potential therapeutic target for treating obesity and related metabolic disorders. However, the molecular events shaping the mechanism of action of DGAT1 pharmacological inhibition have not been fully explored yet. Here, we investigate the metabolic molecular mechanisms induced in response to pharmacological inhibition of DGAT1 using a recently developed computational systems biology approach, the Causal Reasoning Engine (CRE). The CRE algorithm utilizes microarray transcriptomic data and causal statements derived from the biomedical literature to infer upstream molecular events driving these transcriptional changes. The inferred upstream events (also called hypotheses) are aggregated into biological models using a set of analytical tools that allow for evaluation and integration of the hypotheses in context of their supporting evidence. In comparison to gene ontology enrichment analysis which pointed to high-level changes in metabolic processes, the CRE results provide detailed molecular hypotheses to explain the measured transcriptional changes. CRE analysis of gene expression changes in high fat habituated rats treated with a potent and selective DGAT1 inhibitor demonstrate that the majority of transcriptomic changes support a metabolic network indicative of reversal of high fat diet effects that includes a number of molecular hypotheses such as PPARG, HNF4A and SREBPs. Finally, the CRE-generated molecular hypotheses from DGAT1 inhibitor treated rats were found to capture the major molecular characteristics of DGAT1 deficient mice, supporting a phenotype of decreased lipid and increased insulin sensitivity

A Prospective Study to Establish a New-Onset Diabetes Cohort: From the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer

The National Cancer Institute and the National Institute for Diabetes and Digestive and Kidney Diseases initiated the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC) in 2015 (the CPDPC's origin, structure, governance, and research objectives are described in another article in this journal). One of the key objectives of CPDPC is to assemble a cohort of 10,000 subjects 50 years or older with new-onset diabetes, called the NOD cohort. Using a define, enrich, and find early detection approach, the aims of the NOD study are to (a) estimate the 3-year probability of pancreatic ductal adenocarcinoma (PDAC) in NOD (define), (b) establish a biobank of clinically annotated biospecimens from presymptomatic PDAC and control new-onset type 2 diabetes mellitus subjects, (c) conduct phase 3 validation studies of promising biomarkers for identification of incident PDAC in NOD patients (enrich), and (d) provide a platform for development of a future interventional screening protocol for early detection of PDAC in patients with NOD that incorporates imaging studies and/or clinical algorithms (find). It is expected that 85 to 100 incidences of PDAC will be diagnosed during the study period in this cohort of 10,000 patients

The Wide-field Infrared Survey Explorer (WISE): Mission Description and Initial On-orbit Performance

The all sky surveys done by the Palomar Observatory Schmidt, the European Southern Observatory Schmidt, and the United Kingdom Schmidt, the InfraRed Astronomical Satellite and the 2 Micron All Sky Survey have proven to be extremely useful tools for astronomy with value that lasts for decades. The Wide-field Infrared Survey Explorer is mapping the whole sky following its launch on 14 December 2009. WISE began surveying the sky on 14 Jan 2010 and completed its first full coverage of the sky on July 17. The survey will continue to cover the sky a second time until the cryogen is exhausted (anticipated in November 2010). WISE is achieving 5 sigma point source sensitivities better than 0.08, 0.11, 1 and 6 mJy in unconfused regions on the ecliptic in bands centered at wavelengths of 3.4, 4.6, 12 and 22 microns. Sensitivity improves toward the ecliptic poles due to denser coverage and lower zodiacal background. The angular resolution is 6.1, 6.4, 6.5 and 12.0 arc-seconds at 3.4, 4.6, 12 and 22 microns, and the astrometric precision for high SNR sources is better than 0.15 arc-seconds.Comment: 22 pages with 19 included figures. Updated to better match the accepted version in the A

Statewide Molecular Epidemiology of Mycobacterium tuberculosis Transmission in a Moderate- to Low-Incidence State: Are Contact Investigations Enough?

To assess the circumstances of recent transmission of tuberculosis (TB) (progression to active disease <2 years after infection), we obtained DNA fingerprints for 1,172 (99%) of 1,179 Mycobacterium tuberculosis isolates collected from Maryland TB patients from 1996 to 2000. We also reviewed medical records and interviewed patients with genetically matching M. tuberculosis strains to identify epidemiologic links (cluster investigation). Traditional settings for transmission were defined as households or close relatives and friends; all other settings were considered nontraditional. Of 436 clustered patients, 114 had recently acquired TB. Cluster investigations were significantly more likely than contact investigations to identify patients who recently acquired TB in nontraditional settings (33/42 vs. 23/72, respectively; p<0.001). Transmission from a foreign-born person to a U.S.-born person was rare and occurred mainly in public settings. The time from symptom onset to diagnosis was twice as long for transmitters as for nontransmitters (16.8 vs. 8.5 weeks, respectively; p<0.01). Molecular epidemiologic studies showed that eliminating diagnostic delays can prevent TB transmission in nontraditional settings, which elude contact investigations

The Wide-Field Infrared Survey Explorer (WISE): Mission Description and Initial On-Orbit Performance

The all sky surveys done by the Palomar Observatory Schmidt, the European Southern Observatory Schmidt, and the United Kingdom Schmidt, the InfraRed Astronomical Satellite and the 2 Micron All Sky Survey have proven to be extremely useful tools for astronomy with value that lasts for decades. The Wide-field Infrared Survey Explorer is mapping the whole sky following its launch on 14 December 2009. WISE began surveying the sky on 14 Jan 2010 and completed its first full coverage of the sky on July 17. The survey will continue to cover the sky a second time until the cryogen is exhausted (anticipated in November 2010). WISE is achieving 5 sigma point source sensitivities better than 0.08, 0.11, 1 and 6 mJy in unconfused regions on the ecliptic in bands centered at wavelengths of 3.4, 4.6, 12 and 22 micrometers. Sensitivity improves toward the ecliptic poles due to denser coverage and lower zodiacal background. The angular resolution is 6.1", 6.4", 6.5" and 12.0" at 3.4, 4.6, 12 and 22 micrometers, and the astrometric precision for high SNR sources is better than 0.15"

A comparison of responses to raised extracellular potassium and endothelium-derived hyperpolarizing factor (EDHF) in rat pressurised mesenteric arteries

The present study examined the hypothesis that potassium ions act as an endothelium-derived hyperpolarizing factor (EDHF) released in response to ACh in small mesenteric arteries displaying myogenic tone. Small mesenteric arteries isolated from rats were set up in a pressure myograph at either 60 or 90 mmHg. After developing myogenic tone, responses to raising extracellular potassium were compared to those obtained with ACh (in the presence of nitric oxide synthase and cyclo- oxygenase inhibitors). The effects of barium and ouabain, or capsaicin, on responses to raised extracellular potassium or ACh were also determined. The effects of raised extracellular potassium levels and ACh on membrane potential, were measured using sharp microelectrodes in pressurised arteries. Rat small mesenteric arteries developed myogenic tone when pressurised. On the background of vascular tone set by a physiological stimulus (i.e pressure), ACh fully dilated the small arteries in a concentration-dependent manner. This response was relatively insensitive to the combination of barium and ouabain, and insensitive to capsaicin. Raising extracellular potassium produced a more inconsistent and modest vasodilator response in pressurised small mesenteric arteries. Responses to raising extracellular potassium were sensitive to capsaicin, and the combination of barium and ouabain. ACh caused a substantial hyperpolarisation in pressurized arteries, while raising extracellular potassium did not. These data indicate that K+ is not the EDHF released in response to ACh in myogenically active rat mesenteric small arteries. Since the hyperpolarization produced by ACh was sensitive to carbenoxolone, gap junctions are the likely mediator of EDH responses under physiological conditions