Late Cretaceous post-rift magma emplacement offshore the West Iberian Margin [Abstract]

ABSTRACT: The West Iberian Margin is a prime example of a magma-poor hyperextended continental margin. However, the margin is punctuated by three discrete Mesozoic magmatic events, from which the last, occurring 20-40 M.a. after complete lithospheric breakup of the Iberia-Newfoundland conjugate margin, is related to the late Cretaceous Atlantic Alkaline Province. It is characterised onshore by multiple outcropping intrusive (Sintra, Sines and Monchique) and extrusive (e.g., the Lisbon Volcanic Complex) alkaline suites of magmatism, and offshore by conspicuous and enigmatic magnetic anomalies, suggesting additional magmatic features.N/

Nature, timing and magnitude of buried Late Cretaceous magmatism on the central West Iberian Margin

The magma-poor West Iberian Margin, as part of the Peri-Atlantic alkaline province, records multiple evidence for intra-plate post-rift magmatism. Based on high-resolution multichannel seismic data, this work discusses the presence of large volcanic and intrusive features in the Estremadura Spur, providing evidence for important magmatic activity during the drifting of the continental margin. Our observations reveal distinct voluminous fissure-fed effusive sequences and the details of the 2800 m-high Fontanelas compound volcano, including its external and internal architecture, secondary vents and associated lava flows, all of which were probably extruded at intermediate water depths. Numerous and morphologically diverse sills and sill complexes are also described, attesting to the presence of a Late Cretaceous shallow magmatic plumbing system in the area. Magmatism in this region is interpreted as having occurred during two main pulses and types of activity: 1) Coniacian to lower Campanian(?) age, characterized by fissural and fault-controlled volcanism, which mostly extruded massive lobate/sheet lava flows; and 2) a second voluminous intrusive and extrusive event of mid to late Campanian age, which includes the intrusion of the Estremadura Spur laccolith and the prominent Fontanelas compound volcano with associated dendritic lava flows. The inferred volumes of the first fissure-fed effusive event suggest a large eruption magnitude, comparable to some of the largest historical effusive eruptions. The second magmatic pulse led to the emplacement of discrete clusters of sills and sill complexes, as well as the construction of the ~2.8 km-high Fontanelas volcano, suggesting a syn-rift structural inheritance that controlled the location of the Estremadura Spur Intrusion and the Fontanelas volcanic area. Altogether, a total volume of rock exceeding 1.452 km3 is estimated to have been emplaced or extruded in this region in a relatively short period, attesting to the prominence of the magmatism in this sector of the West Iberian Margin

Sexual propagation of Abies religiosa (Kunth) Cham, by immersion in water at different temperatures and periods

Objective: To increase the percentage of germination in Abies religiosa by immersion in water at different temperatures and times that the seeds will be soaked. Design/methodology/approach: A completely randomized factorial experiment was carried oud with five temperatures (10, Ta, 30, 40 and 50 °C) and 13 times expressed in seconds (10, 20, 40, 60, 600, 1200, 1800, 2400, 3000, 3600, 7200, 14400 and 2160) with a total of 65 treatments and 30 replications of each treatment. The seed were immersed in water at different temperatures and times corresponded to each treatment in order to obtain the best treatment that generated the highest percentage. Results: The best pre-germinative treatment that generated the highest germination percentage was the combination of temperature of 40 °C and a time of 7200s, obtaining 73% germination, and 14% germination as the lowest percentage in the combinations (10 °C x 20s and 10 °C x 40s), generating 26 treatments with percentages higher than 50% germination, registering a peak value of 8.56 and 11.7 days to reach the peak value. Limitations on study/implications: In the experiment, it was important to maintain the different temperatures constant, being those of longer time, lower temperature and higher temperature the most difficult to control and maintain Findings/conclusions: Abies religiosa is able to tolerate and generate acceptable germination percentages with the highest temperature used (50 °C), being one of the best temperatures, which was supposed to generate low germination percentages. Keywords: Germination, Temperature, Time, Peak valueObjective: To increase the germination percentage of Abies religiosa by immersion in water with different temperatures and periods.Design/Methodology/Approach: A completely randomized factorial experiment was carried out with five temperatures (10, Room temperature (Rt), 30, 40, and 50°C) and 13 periods expressed in seconds (10, 20, 40, 60, 600, 1200, 1800, 2400, 3000, 3600, 7200, 14400, and 21600), with a total of 65 treatments and 30 repetitions per treatment. The seeds were dipped in water with the temperatures and periods of each treatment to obtain the highest germination percentage.Results: The best pre-germination treatment (73% germination) was obtained with the combination of 40 °C and 7,200 s. Meanwhile, the treatments with the lowest percentage (14%) were the combinations 10 °C × 20 s and 10 °C × 40 s. Twenty-six treatments recorded a >50% germination, reaching a peak value of 8.56 at 11.7days. Study Limitations/Implications: Keeping the water temperature and theimmersion period constant during the experiment was more difficult in the longer treatments, with the lowest and highest temperatures.Findings/Conclusions: Abies religiosa registers acceptable germination percentages with the highest temperature (50 °C)

PomBase – the scientific resource for fission yeast

The fission yeast Schizosaccharomyces pombe has become well established as a model species for studying conserved cell-level biological processes, especially the mechanics and regulation of cell division. PomBase integrates the S. pombe genome sequence with traditional genetic, molecular and cell biological experimental data as well as the growing body of large datasets generated by emerging high-throughput methods. This chapter provides insight into the curation philosophy and data organization at PomBase, and provides a guide to using PomBase for infrequent visitors and anyone considering exploring S. pombe in their research

Morphological Study and Dielectric Behavior of Nonisothermally Crystallized Poly(ethylene naphthalate) Nanocomposites as a Function of Graphene Content

Morphological evolution and dielectric properties of poly(ethylene naphthalate)- (PEN-) graphene nanocomposites nonisothermally crystallized have been investigated. PEN-graphene nanocomposites containing 0.01, 0.025, 0.05, 0.075, and 0.1 wt% of graphene were prepared by melt blending in a mini twin screw extruder. The results showed that graphene exhibited a superior influence on morphological and conformational structure of PEN during nonisothermal crystallization at low graphene contents. Crystallization temperature (Tc) was found to be increased up to 18°C supporting the high nucleating activity of graphene layers. Wide angle X-ray diffraction (WAXD) and Fourier Transform Infrared Spectroscopy (FTIR) indicated that graphene modifies the conformation of PEN chains promoting crystallinity and favoring the evolution from α to β crystalline form with homogeneous lamellar thickness. It may be attributed to the structural similarity between naphthalene rings and graphene structure and to π-π interactions during nucleation. Dielectric behavior was found to be a function of graphene content where the nanocomposites changed from dielectric to low conducting material when passing from 0.075 to 0.1 wt% of graphene content. This phenomenon permits having a wide range of properties to fit a wide variety of applications required to store electrical energy of low voltage

Pooled analysis of WHO Surgical Safety Checklist use and mortality after emergency laparotomy

Background The World Health Organization (WHO) Surgical Safety Checklist has fostered safe practice for 10 years, yet its place in emergency surgery has not been assessed on a global scale. The aim of this study was to evaluate reported checklist use in emergency settings and examine the relationship with perioperative mortality in patients who had emergency laparotomy. Methods In two multinational cohort studies, adults undergoing emergency laparotomy were compared with those having elective gastrointestinal surgery. Relationships between reported checklist use and mortality were determined using multivariable logistic regression and bootstrapped simulation. Results Of 12 296 patients included from 76 countries, 4843 underwent emergency laparotomy. After adjusting for patient and disease factors, checklist use before emergency laparotomy was more common in countries with a high Human Development Index (HDI) (2455 of 2741, 89.6 per cent) compared with that in countries with a middle (753 of 1242, 60.6 per cent; odds ratio (OR) 0.17, 95 per cent c.i. 0.14 to 0.21, P <0001) or low (363 of 860, 422 per cent; OR 008, 007 to 010, P <0.001) HDI. Checklist use was less common in elective surgery than for emergency laparotomy in high-HDI countries (risk difference -94 (95 per cent c.i. -11.9 to -6.9) per cent; P <0001), but the relationship was reversed in low-HDI countries (+121 (+7.0 to +173) per cent; P <0001). In multivariable models, checklist use was associated with a lower 30-day perioperative mortality (OR 0.60, 0.50 to 073; P <0.001). The greatest absolute benefit was seen for emergency surgery in low- and middle-HDI countries. Conclusion Checklist use in emergency laparotomy was associated with a significantly lower perioperative mortality rate. Checklist use in low-HDI countries was half that in high-HDI countries.Peer reviewe

Salivary Markers for Oral Cancer Detection

Oral cancer refers to all malignancies that arise in the oral cavity, lips and pharynx, with 90% of all oral cancers being oral squamous cell carcinoma. Despite the recent treatment advances, oral cancer is reported as having one of the highest mortality ratios amongst other malignancies and this can much be attributed to the late diagnosis of the disease. Saliva has long been tested as a valuable tool for drug monitoring and the diagnosis systemic diseases among which oral cancer. The new emerging technologies in molecular biology have enabled the discovery of new molecular markers (DNA, RNA and protein markers) for oral cancer diagnosis and surveillance which are discussed in the current review

Maternal dietary patterns and acute leukemia in infants: results from a case control study in Mexico

BackgroundChildhood cancer is the leading cause of disease-related mortality among children aged 5–14 years in Mexico, with acute leukemia being the most common cancer among infants. Examining the overall dietary patterns allows for a comprehensive assessment of food and nutrient consumption, providing a more predictive measure of disease risk than individual foods or nutrients. This study aims to evaluate the association between maternal dietary patterns during pregnancy and the risk of acute leukemia in Mexican infants.MethodsA hospital-based case–control study was conducted, comparing 109 confirmed acute leukemia cases with 152 age-matched controls. All participants (≤24 months) were identified at hospitals in Mexico City between 2010 and 2019. Data on a posteriori dietary patterns and other relevant variables were collected through structured interviews and dietary questionnaires. Multivariate logistic regression was employed to estimate the association between maternal dietary patterns during pregnancy and the risk of acute leukemia in infants.ResultsThe “Balanced &amp; Vegetable-Rich” pattern, characterized by a balanced consumption of various food groups and higher vegetable intake, exhibited a negative association with acute leukemia when compared to the “High Dairy &amp; Cereals” Pattern (adjusted odds ratio [OR] = 0.51; 95% confidence interval [CI]: 0.29, 0.90). We observed that mothers who gave birth to girls and adhered to a healthy dietary pattern during pregnancy exhibited significantly lower odds of their children developing AL compared to those who gave birth to boys [OR = 0.32 (95% CI 0.11, 0.97)]. Our results underscore the significance of maternal nutrition as a modifiable factor in disease prevention and the importance of prenatal health education

Familial hypercholesterolaemia in children and adolescents from 48 countries: a cross-sectional study

Background: Approximately 450 000 children are born with familial hypercholesterolaemia worldwide every year, yet only 2·1% of adults with familial hypercholesterolaemia were diagnosed before age 18 years via current diagnostic approaches, which are derived from observations in adults. We aimed to characterise children and adolescents with heterozygous familial hypercholesterolaemia (HeFH) and understand current approaches to the identification and management of familial hypercholesterolaemia to inform future public health strategies. Methods: For this cross-sectional study, we assessed children and adolescents younger than 18 years with a clinical or genetic diagnosis of HeFH at the time of entry into the Familial Hypercholesterolaemia Studies Collaboration (FHSC) registry between Oct 1, 2015, and Jan 31, 2021. Data in the registry were collected from 55 regional or national registries in 48 countries. Diagnoses relying on self-reported history of familial hypercholesterolaemia and suspected secondary hypercholesterolaemia were excluded from the registry; people with untreated LDL cholesterol (LDL-C) of at least 13·0 mmol/L were excluded from this study. Data were assessed overall and by WHO region, World Bank country income status, age, diagnostic criteria, and index-case status. The main outcome of this study was to assess current identification and management of children and adolescents with familial hypercholesterolaemia. Findings: Of 63 093 individuals in the FHSC registry, 11 848 (18·8%) were children or adolescents younger than 18 years with HeFH and were included in this study; 5756 (50·2%) of 11 476 included individuals were female and 5720 (49·8%) were male. Sex data were missing for 372 (3·1%) of 11 848 individuals. Median age at registry entry was 9·6 years (IQR 5·8-13·2). 10 099 (89·9%) of 11 235 included individuals had a final genetically confirmed diagnosis of familial hypercholesterolaemia and 1136 (10·1%) had a clinical diagnosis. Genetically confirmed diagnosis data or clinical diagnosis data were missing for 613 (5·2%) of 11 848 individuals. Genetic diagnosis was more common in children and adolescents from high-income countries (9427 [92·4%] of 10 202) than in children and adolescents from non-high-income countries (199 [48·0%] of 415). 3414 (31·6%) of 10 804 children or adolescents were index cases. Familial-hypercholesterolaemia-related physical signs, cardiovascular risk factors, and cardiovascular disease were uncommon, but were more common in non-high-income countries. 7557 (72·4%) of 10 428 included children or adolescents were not taking lipid-lowering medication (LLM) and had a median LDL-C of 5·00 mmol/L (IQR 4·05-6·08). Compared with genetic diagnosis, the use of unadapted clinical criteria intended for use in adults and reliant on more extreme phenotypes could result in 50-75% of children and adolescents with familial hypercholesterolaemia not being identified. Interpretation: Clinical characteristics observed in adults with familial hypercholesterolaemia are uncommon in children and adolescents with familial hypercholesterolaemia, hence detection in this age group relies on measurement of LDL-C and genetic confirmation. Where genetic testing is unavailable, increased availability and use of LDL-C measurements in the first few years of life could help reduce the current gap between prevalence and detection, enabling increased use of combination LLM to reach recommended LDL-C targets early in life