644 research outputs found
Linking bone development on the caudal aspect of the distal phalanx with lameness during life
Claw horn disruption lesions (CHDL; sole hemorrhage, sole ulcer, and white line disease) cause a large proportion of lameness in dairy cattle, yet their etiopathogenesis remains poorly understood. Untreated CHDL may be associated with damage to the internal anatomy of the foot, including to the caudal aspect of the distal phalanx upon which bone developments have been reported with age and with sole ulcers at slaughter. The primary aim of this study was to assess whether bone development was associated with poor locomotion and occurrence of CHDL during a cow’s life. A retrospective cohort study imaged 282 hind claws from 72 Holstein-Friesian dairy cows culled from a research herd using X-ray micro–computed tomography (μ-CT; resolution: 0.11 mm). Four measures of bone development were taken from the caudal aspect of each distal phalanx, in caudal, ventral, and dorsal directions, and combined within each claw. Cow-level variables were constructed to quantify the average bone development on all hind feet (BD-Ave) and bone development on the most severely affected claw (BD-Max). Weekly locomotion scores (1–5 scale) were available from first calving. The variables BD-Ave and BD-Max were used as outcomes in linear regression models; the explanatory variables included locomotion score during life, age, binary variables denoting lifetime occurrence of CHDL and of infectious causes of lameness, and other cow variables. Both BD-Max and BD-Ave increased with age, CHDL occurrence, and an increasing proportion of locomotion scores at which a cow was lame (score 4 or 5). The models estimated that BD-Max would be 9.8 mm (SE 3.9) greater in cows that had been lame at >50% of scores within the 12 mo before slaughter (compared with cows that had been assigned no lame scores during the same period), or 7.0 mm (SE 2.2) greater if the cow had been treated for a CHDL during life (compared with cows that had not). Additionally, histology demonstrated that new bone development was osteoma, also termed “exostosis.” Age explained much of the variation in bone development. The association between bone development and locomotion score during life is a novel finding, and bone development appears specific to CHDL. Bone development on the most severely affected foot was the best explained outcome and would seem most likely to influence locomotion score. To stop irreparable anatomical damage within the foot, early identification of CHDL and effective treatment could be critical
A survey of primary and specialised health care provision to prisons in England and Wales
Background Prison health care in England, including primary care, is now incorporated into the National Health Service; the impetus for the change is in part due to concern about standards of health care within prisons. The demographic characteristics and health status of patients within prisons are relatively well understood, as are the problems faced by health care professionals. Less is known about current health care provision. Aims To describe the organisation of primary health care and specialised services in prisons and compare services available to different types of prison. Method A piloted questionnaire was sent to the governors of all prisons in England and Wales for completion by the health care manager. Findings Completed questionnaires were received from 122 (89%) of 138 prisons. The survey showed a low use of information technology (IT). Problems were reported with the recruitment and retention of general nurses in more than 50% of prisons. Prisoners in category A/B (higher security) prisons had available to them a greater range of health care services compared with those in other prisons. The results suggest that provision of services for chronic diseases and improvements in IT are needed. Problems with the recruitment and retention of general nurses need addressing. The reasons why lower-security prisoners are receiving a narrower range of specialised health care services compared with higher-security prisoners need justifying
Confined granular packings: structure, stress, and forces
The structure and stresses of static granular packs in cylindrical containers
are studied using large-scale discrete element molecular dynamics simulations
in three dimensions. We generate packings by both pouring and sedimentation and
examine how the final state depends on the method of construction. The vertical
stress becomes depth-independent for deep piles and we compare these stress
depth-profiles to the classical Janssen theory. The majority of the tangential
forces for particle-wall contacts are found to be close to the Coulomb failure
criterion, in agreement with the theory of Janssen, while particle-particle
contacts in the bulk are far from the Coulomb criterion. In addition, we show
that a linear hydrostatic-like region at the top of the packings unexplained by
the Janssen theory arises because most of the particle-wall tangential forces
in this region are far from the Coulomb yield criterion. The distributions of
particle-particle and particle-wall contact forces exhibit
exponential-like decay at large forces in agreement with previous studies.Comment: 11 pages, 11 figures, submitted to PRE (v2) added new references,
fixed typo
Novae Ejecta as Colliding Shells
Following on our initial absorption-line analysis of fifteen novae spectra we
present additional evidence for the existence of two distinct components of
novae ejecta having different origins. As argued in Paper I one component is
the rapidly expanding gas ejected from the outer layers of the white dwarf by
the outburst. The second component is pre-existing outer, more slowly expanding
circumbinary gas that represents ejecta from the secondary star or accretion
disk. We present measurements of the emission-line widths that show them to be
significantly narrower than the broad P Cygni profiles that immediately precede
them. The emission profiles of novae in the nebular phase are distinctly
rectangular, i.e., strongly suggestive of emission from a relatively thin,
roughly spherical shell. We thus interpret novae spectral evolution in terms of
the collision between the two components of ejecta, which converts the early
absorption spectrum to an emission-line spectrum within weeks of the outburst.
The narrow emission widths require the outer circumbinary gas to be much more
massive than the white dwarf ejecta, thereby slowing the latter's expansion
upon collision. The presence of a large reservoir of circumbinary gas at the
time of outburst is suggestive that novae outbursts may sometime be triggered
by collapse of gas onto the white dwarf, as occurs for dwarf novae, rather than
steady mass transfer through the inner Lagrangian point.Comment: 12 pages, 3 figures; Revised manuscript; Accepted for publication in
Astrophysics & Space Scienc
Partially filled stripes in the two dimensional Hubbard model: statics and dynamics
The internal structure of stripes in the two dimensional Hubbard model is
studied by going beyond the Hartree-Fock approximation. Partially filled
stripes, consistent with experimental observations, are stabilized by quantum
fluctuations, included through the Configuration Interaction method. Hopping of
short regions of the stripes in the transverse direction is comparable to the
bare hopping element. The integrated value of compares well
with experimental results.Comment: 4 page
Jamming at Zero Temperature and Zero Applied Stress: the Epitome of Disorder
We have studied how 2- and 3- dimensional systems made up of particles
interacting with finite range, repulsive potentials jam (i.e., develop a yield
stress in a disordered state) at zero temperature and applied stress. For each
configuration, there is a unique jamming threshold, , at which
particles can no longer avoid each other and the bulk and shear moduli
simultaneously become non-zero. The distribution of values becomes
narrower as the system size increases, so that essentially all configurations
jam at the same in the thermodynamic limit. This packing fraction
corresponds to the previously measured value for random close-packing. In fact,
our results provide a well-defined meaning for "random close-packing" in terms
of the fraction of all phase space with inherent structures that jam. The
jamming threshold, Point J, occurring at zero temperature and applied stress
and at the random close-packing density, has properties reminiscent of an
ordinary critical point. As Point J is approached from higher packing
fractions, power-law scaling is found for many quantities. Moreover, near Point
J, certain quantities no longer self-average, suggesting the existence of a
length scale that diverges at J. However, Point J also differs from an ordinary
critical point: the scaling exponents do not depend on dimension but do depend
on the interparticle potential. Finally, as Point J is approached from high
packing fractions, the density of vibrational states develops a large excess of
low-frequency modes. All of these results suggest that Point J may control
behavior in its vicinity-perhaps even at the glass transition.Comment: 21 pages, 20 figure
Analytic and Asymptotic Methods for Nonlinear Singularity Analysis: a Review and Extensions of Tests for the Painlev\'e Property
The integrability (solvability via an associated single-valued linear
problem) of a differential equation is closely related to the singularity
structure of its solutions. In particular, there is strong evidence that all
integrable equations have the Painlev\'e property, that is, all solutions are
single-valued around all movable singularities. In this expository article, we
review methods for analysing such singularity structure. In particular, we
describe well known techniques of nonlinear regular-singular-type analysis,
i.e. the Painlev\'e tests for ordinary and partial differential equations. Then
we discuss methods of obtaining sufficiency conditions for the Painlev\'e
property. Recently, extensions of \textit{irregular} singularity analysis to
nonlinear equations have been achieved. Also, new asymptotic limits of
differential equations preserving the Painlev\'e property have been found. We
discuss these also.Comment: 40 pages in LaTeX2e. To appear in the Proceedings of the CIMPA Summer
School on "Nonlinear Systems," Pondicherry, India, January 1996, (eds) B.
Grammaticos and K. Tamizhman
Diffusion of impurities in a granular gas
Diffusion of impurities in a granular gas undergoing homogeneous cooling
state is studied. The results are obtained by solving the Boltzmann--Lorentz
equation by means of the Chapman--Enskog method. In the first order in the
density gradient of impurities, the diffusion coefficient is determined as
the solution of a linear integral equation which is approximately solved by
making an expansion in Sonine polynomials. In this paper, we evaluate up to
the second order in the Sonine expansion and get explicit expressions for
in terms of the restitution coefficients for the impurity--gas and gas--gas
collisions as well as the ratios of mass and particle sizes. To check the
reliability of the Sonine polynomial solution, analytical results are compared
with those obtained from numerical solutions of the Boltzmann equation by means
of the direct simulation Monte Carlo (DSMC) method. In the simulations, the
diffusion coefficient is measured via the mean square displacement of
impurities. The comparison between theory and simulation shows in general an
excellent agreement, except for the cases in which the gas particles are much
heavier and/or much larger than impurities. In theses cases, the second Sonine
approximation to improves significantly the qualitative predictions made
from the first Sonine approximation. A discussion on the convergence of the
Sonine polynomial expansion is also carried out.Comment: 9 figures. to appear in Phys. Rev.
GC-MS Techniques Investigating Potential Biomarkers of Dying in the Last Weeks with Lung Cancer
Predicting when a patient with advanced cancer is dying is a challenge and currently no prognostic test is available. We hypothesised that a dying process from cancer is associated with metabolic changes and specifically with changes in volatile organic compounds (VOCs). We analysed urine from patients with lung cancer in the last weeks of life by headspace gas chromatography mass spectrometry. Urine was acidified or alkalinised before analysis. VOC changes in the last weeks of life were identified using univariate, multivariate and linear regression analysis; 12 VOCs increased (11 from the acid dataset, 2 from the alkali dataset) and 25 VOCs decreased (23 from the acid dataset and 3 from the alkali dataset). A Cox Lasso prediction model using 8 VOCs predicted dying with an AUC of 0.77, 0.78 and 0.85 at 30, 20 and 10 days and stratified patients into a low (median 10 days), medium (median 50 days) or high risk of survival. Our data supports the hypothesis there are specific metabolic changes associated with the dying. The VOCs identified are potential biomarkers of dying in lung cancer and could be used as a tool to provide additional prognostic information to inform expert clinician judgement and subsequent decision making
Randomised controlled trial to evaluate the effect of foot trimming before and after first calving on subsequent lameness episodes and productivity in dairy heifers
The objective of this study was to assess both independent and combined effects of routine foot trimming of heifers at 3 weeks pre-calving and 100 days post calving on the first lactation lameness and lactation productivity. A total of 419 pre-calving dairy heifers were recruited from one heifer rearing operation over a 10-month period. Heifers were randomly allocated into one of four foot trimming regimens; pre-calving foot trim and post-calving lameness score (Group TL), pre-calving lameness score and post-calving foot trim (Group LT), pre-calving foot trim and post-calving foot trim (Group TT), and pre-calving lameness score and post-calving lameness score (Group LL, control group). All heifers were scored for lameness at 24 biweekly time points for 1 year following calving, and first lactation milk production data were collected.
Following calving, 172/419 (41.1%) of heifers became lame during the study (period prevalence), with lameness prevalence at each time-point following calving ranging from 48/392 (12.2%) at 29–42 days post-calving to 4/379 (1.1%) between 295 and 383 days after calving. The effects of the four treatment groups were not significantly different from each other for overall lameness period prevalence, biweekly lameness point prevalence, time to first lameness event, type of foot lesion identified at dry off claw trimming, or the 4% fat corrected 305-day milk yield. However, increased odds lameness was significantly associated with a pre-calving trim alone (P = 0.044) compared to the reference group LL. The odds of heifer lameness were highest between 0 and 6 weeks post-partum, and heifer farm destination was significantly associated with lameness (OR 2.24), suggesting that even at high standard facilities, environment and management systems have more effect on heifer foot health than trimming
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