La utilización del feedback en disminución progresiva en el aprendizaje de la respuesta de reacción

La frecuencia relativa del conocimiento de los resultados (CR) consiste en la proporción de información en relación al número total de ensayos. Una frecuencia baja de CR provoca un buen aprendizaje, pero suele ser perjudicial para la ejecución. En el siguiente trabajo se pone a prueba una forma de distribuir la información en disminución progresiva, siendo alta al principio y baja al final de la práctica, ayudando al sujeto en la adquisición de la tarea y evitando los efectos nocivos de una guía excesiva. Se compararon cuatro grupos en el aprendizaje de la salida de atletismo, utilizando el mismo sistema automatizado que Oña y sus colaboradores exponen en diversos trabajos.The relative frequency of knowledge of results (KR) is the proportion of information to the total number of trials. A lower frequency of KR causes a good learning, but uses to be detrimental to practice performance. In this work, a way of distributing the information in progressive decrease is examined, being high at the beginning and low at the end of the practice, helping the subject in the acquisition of the task and avoiding the noxious effects of an excessive guide. Four groups were compared in the learning of the exit of athletics, using the same automated system that Oña and col. expose in different works

Propuesta de enseñanza innovadora en Educación Infantil a través de la creatividad: La resolución de conflictos en la vida cotidiana.

[SPA] La propuesta que presentamos tiene como objetivo desarrollar la creatividad en la etapa escolar infantil. Abordamos la creatividad como la aptitud innata para producir ideas y soluciones nuevas, centrando la atención en el desarrollo de uno de sus componentes fundamentales: el pensamiento divergente. Basamos nuestra propuesta de trabajo en autores como Guilford y Robinson, defendiendo la creatividad como concepto central no sólo vinculado a la educación sino a todos los aspectos de la vida. Esta aptitud se debe potenciar y desarrollar con la práctica educativa, para ello presentamos una serie de talleres que parten del aprendizaje significativo, de situaciones cotidianas en la vida del estudiante. Evitando estereotipos, el alumnado comprobará cómo existen varias soluciones a un mismo problema siendo todas válidas. Promovemos con nuestra práctica docente el fomento de actitudes y valores como la tolerancia y el respeto, implementando una metodología flexible y participativa en la que el alumno es el protagonista y el docente guía el deseo natural de aprender. [ENG] Our study focuses in the development of creativity in early childhood education. We study creativity as an innate ability to produce ideas and new solutions, centering the educational plan on developing one of its main components: the divergent thinking. Our project is based on authors such as Guilford and Robinson, defending creativity as a main concept, and not only linked to education but to all aspects in life. This ability should be strengthened and developed in the classroom by practical activities; our methodology defends this meaningful and functional learning linking teaching tolearner’s everyday life and personal needs. Avoiding stereotypes, students will find that there are several solutions for a given task and all of them are acceptable. Our teaching practice promote the development of attitudes and values such as tolerance and respect, implementing a flexible and participatory approach, transforming the student in the leader and the teacher in the guide that shapes their natural desire to learn

Flora de interés corológico para Andalucía occidental

Flora of chorologycal interest for Western AndalusiaPalabras clave. Corología, Biogeografía, Andalucía Occidental, España.Key words. Chorology, Biogeography, Western Andalusia, Spain

Bisphenol A Induces Accelerated Cell Aging in Murine Endothelium.

Bisphenol A (BPA) is a widespread endocrine disruptor affecting many organs and systems. Previous work in our laboratory demonstrated that BPA could induce death due to necroptosis in murine aortic endothelial cells (MAECs). This work aims to evaluate the possible involvement of BPA-induced senescence mechanisms in endothelial cells. The β-Gal assays showed interesting differences in cell senescence at relatively low doses (100 nM and 5 µM). Western blots confirmed that proteins involved in senescence mechanisms, p16 and p21, were overexpressed in the presence of BPA. In addition, the UPR (unfolding protein response) system, which is part of the senescent phenotype, was also explored by Western blot and qPCR, confirming the involvement of the PERK-ATF4-CHOP pathway (related to pathological processes). The endothelium of mice treated with BPA showed an evident increase in the expression of the proteins p16, p21, and CHOP, confirming the results observed in cells. Our results demonstrate that oxidative stress induced by BPA leads to UPR activation and senescence since pretreatment with N-acetylcysteine (NAC) in BPA-treated cells reduced the percentage of senescent cells prevented the overexpression of proteins related to BPA-induced senescence and reduced the activation of the UPR system. The results suggest that BPA participates actively in accelerated cell aging mechanisms, affecting the vascular endothelium and promoting cardiovascular diseases.post-print3206 K

Educlick Portal Services (EPS): enseñanza interactiva a través de plataformas virtuales

A la vista de los excelentes resultados alcanzados con el sistema tradicional de mandos de respuesta interactiva en la docencia universitaria, la Facultad de Turismo y Finanzas de la Universidad de Sevilla, pionera en esta herramienta, ha desarrollado un nuevo proyecto de innovación docente. El mismo ha consistido en la integración del sistema de mandos interactivos y la plataforma de enseñanza virtual WebCT. Después de varios meses de trabajo durante el curso 2009/10, el sistema está siendo actualmente utilizado en la asignatura Dirección y Gestión de la Producción II, impartida en la Diplomatura de Empresariales. En este trabajo presentamos su funcionamiento, nuestra experiencia y las numerosas ventajas que, tanto para el docente como para los alumnos, se derivan del mismo. La herramienta ya está pues configurada, diseñada y convenientemente testada, quedando disponible para ser usada por las asignaturas de este centro y del resto de la Universidad de Sevilla durante el curso 2010/11.Considering the excellent results reached with the use of an interactive response system in university teaching, the Tourism and Finance Faculty of the University of Seville, pioneer in the use of this tool, has developed a new educational innovation project. It consisted on the integration of both, the interactive response system and the virtual learning environment (WebCT). After several months of working during the academic year 2009/10, the system is currently being used in the subject Dirección y Gestión de la Producción II, taught in the Diploma in Business Studies. In this project we present how the system works, how our experience has been done and the advantages, so much for the teacher as for the own students, that are derived from it. The tool is already formed, designed and suitably tested, remaining available for its use by all the subjects of this Faculty and the rest of subjects of the University of Seville for the 2010/11 academic year

Influence of root canal instrumentation and obturation techniques on intra-operative pain during endodontic therapy

Objective: To analyse the influence of root canal instrumentation and obturation techniques on intra-operative pain experienced by patients during endodontic therapy. Method and Materials: A descriptive cross-sectional study was carried out in Ponferrada and Sevilla, Spain, including 80 patients (46 men and 34 women), with ages ranged from 10 to 74 years, randomly recruited. Patient gender and age, affected tooth, pulpal diagnosis, periapical status, previous NSAID or antibiotic (AB) treatment, and root canal instrumentation and obturation techniques were recorded. After root canal treatment (RCT), patients completed a 10-cm visual analogue scale (VAS) that ranked the level of pain. Results were analysed statistically using the Chi-square and ANOVA tests and logistic regression analysis. Results: The mean pain level during root canal treatment was 2.9 ± 3.0 (median = 2) in a VAS between 0 and 10. Forty percent of patients experienced no pain. Gender, age, arch, previous NSAIDs or AB treatment and anaesthetic type did not influence significantly the pain level (p > 0.05). Pain during root canal treatment was significantly greater in molar teeth (OR = 10.1; 95% C.I. = 1.6 - 63.5; p = 0.013). Root canal instrumentation and obturation techniques did not affect significantly patient?s pain during root canal treatment (p > 0.05). Conclusion: Patients feel more pain when RCT is carried out on molar teeth. The root canal instrumentation and obturation techniques do not affect significantly the patients? pain during RCT

MICa/b-dependent activation of natural killer cells by CD64+ inflammatory type 2 dendritic cells contributes to autoimmunity

Artículo escrito por un elevado número de autores, solo se referencian el que aparece en primer lugar, el nombre del grupo de colaboración, si le hubiere, y los autores pertenecientes a la UAMPrimary Sjögren's syndrome (pSS) is an inflammatory autoimmune disorder largely mediated by type I and II interferon (IFN). The potential contribution of innate immune cells, such as natural killer (NK) cells and dendritic cells (DC), to the pSS pathology remains understudied. Here, we identified an enriched CD16+ CD56hi NK cell subset associated with higher cytotoxic function, as well as elevated proportions of inflammatory CD64+ conventional dendritic cell (cDC2) subtype that expresses increased levels of MICa/b, the ligand for the activating receptor NKG2D, in pSS individuals. Circulating cDC2 from pSS patients efficiently induced activation of cytotoxic NK cells ex vivo and were found in proximity to CD56+ NK cells in salivary glands (SG) from pSS patients. Interestingly, transcriptional activation of IFN signatures associated with the RIG-I/DDX60 pathway, IFN I receptor, and its target genes regulate the expression of NKG2D ligands on cDC2 from pSS patients. Finally, increased proportions of CD64hi RAE-1+ cDC2 and NKG2D+CD11b+CD27+ NK cells were present in vivo in the SG after poly I:C injection. Our study provides novel insight into the contribution and interplay of NK and cDC2 in pSS pathology and identifies new potential therapy targetsRTI2018-097485-A-I00, PID2021-127899OB-I0

Integrin-Linked Kinase Expression in Human Valve Endothelial Cells Plays a Protective Role in Calcific Aortic Valve Disease.

Calcific aortic valve disease (CAVD) is highly prevalent during aging. CAVD initiates with endothelial dysfunction, leading to lipid accumulation, inflammation, and osteogenic transformation. Integrin-linked kinase (ILK) participates in the progression of cardiovascular diseases, such as endothelial dysfunction and atherosclerosis. However, ILK role in CAVD is unknown. First, we determined that ILK expression is downregulated in aortic valves from patients with CAVD compared to non-CAVD, especially at the valve endothelium, and negatively correlated with calcification markers. Silencing ILK expression in human valve endothelial cells (siILK-hVECs) induced endothelial-to-mesenchymal transition (EndMT) and promoted a switch to an osteoblastic phenotype; SiILK-hVECs expressed increased RUNX2 and developed calcified nodules. siILK-hVECs exhibited decreased NO production and increased nitrosative stress, suggesting valvular endothelial dysfunction. NO treatment of siILK-hVECs prevented VEC transdifferentiation, while treatment with an eNOS inhibitor mimicked ILK-silencing induction of EndMT. Accordingly, NO treatment inhibited VEC calcification. Mechanistically, siILK-hVECs showed increased Smad2 phosphorylation, suggesting a TGF-β-dependent mechanism, and NO treatment decreased Smad2 activation and RUNX2. Experiments performed in eNOS KO mice confirmed the involvement of the ILK-eNOS signaling pathway in valve calcification, since aortic valves from these animals showed decreased ILK expression, increased RUNX2, and calcification. Our study demonstrated that ILK endothelial expression participates in human CAVD development by preventing endothelial osteogenic transformationpost-print4615 K

Assessment strategies of palliative care development: A systematic review

Introducción. Dada la alta carga de enfermedades crónicas no transmisibles y el sufrimiento grave es importante estudiar los cuidados paliativos en los sistemas de salud pública. Objetivo. Analizar las estrategias de evaluación del desarrollo de los cuidados paliativos. Material y métodos. Se realizó una revisión sistemática de la literatura utilizando dos motores de búsqueda: pubMed y Embase, se seleccionaron artículos que evalúan el desarrollo en cuidados paliativos en al menos dos países. Se evaluó la calidad de los estudios según las fuentes de información utilizadas para la construcción de las estrategias de evaluación. Los resultados se presentan en una síntesis narrativa. Resultados. Se identificaron 15 estrategias de evaluación de los cuidados paliativos que comparten una estructura en común y se estableció una clasificación según su metodología en cuatro grupos: de registro, clasificación nominal, clasificación numérica y estrategias mixtas. Conclusiones. La clasificación de las estrategias de evaluación de los cuidados paliativos facilitará la elección del modelo más adecuado para las necesidades de cada contexto así como también la identificación de los medios necesarios para asegurar la implementación universal en los sistemas de salud.Introduction. Due to the high rate of chronic non-transmissible illnesses and the serious suffering they cause, it is important to study palliative care in public health systems. Objective. Analyze the strategies for the evaluation of the development of palliative care. Material and methods. A systematic review was made of the literature using two search engines: pubMed and Embase, and articles were selected that evaluate development in palliative care in at least two countries. The quality of the studies was evaluated according to the information source used to build the assessment strategies. The results are presented in a narrative synthesis. Results. Fifteen palliative care strategies that share a common structure were identified, and a classification was established according to their methodology in four groups: registration, nominal classification, numerical classification and mixed strategies. Conclusions. The classification of palliative care assessment strategies facilitates the choice of the most appropriate model for the needs of each context, as well as identification of the means necessary to ensure their universal implementation in health systems

Modelling barrier beaches under storms with XBEACH: The case of the Trabucador bar

Postprint (updated version