Imagino, construyo y vivo mi mundo, a trav?s de la fantas?a de las artes y de la literatura

74 P?ginasRecurso Electr?nicoEl Proyecto trata sobre la importancia de las artes y la literatura como herramientas para fortalecer el aprendizaje significativo y la comunicaci?n, se aplic? en el Centro Educativo El Vergel ubicado en el corregimiento de San Antonio de Prado de la Ciudad de Medell?n. La propuesta surgi? ante la observaci?n de los comportamientos de los ni?os y el inter?s por las artes y la literatura como fortalecimiento de los procesos de ense?anza aprendizaje de lectura, el ejercicio escritural llam? la atenci?n de los docentes, iniciando as? la b?squeda de estrategias y t?cnicas para comenzar a interactuar con los ni?os/as a trav?s de actividades y herramientas sobre temas relacionados con educaci?n desde la primera infancia (educaci?n inicial) con el prop?sito de desarrollar habilidades, destrezas y generar nuevos espacios para profundizar las artes y la literatura. Se realizaron actividades frente al tema y surgi? gran impacto en los ni?os y padres de familias mediante la elaboraci?n de un cronograma de actividades, gu?as de trabajo las cuales se llevaron a cabo de manera eficaz en el grupo de estudio seleccionado. En diferentes dimensiones y en las fechas estipuladas se desarrollaron las actividades con los ni?os/as del centro educativo aplicando la encuesta (padres de familia y profesores), actividades sobre artes y literatura, lo cual despert? de forma positiva la utilidad de las herramientas para imaginar, crear cosas nuevas. Se tomaron elementos de los pedagogos Jean Piaget, Ausubel y Vigotsky.ABSTRACT. The research project is about the importance of arts and literature as tools to strengthen meaningful learning and communication , applied in the Education Center El Vergel located in the village of San Antonio de Prado of the City of Medellin. The proposal arose from the observation of the behaviors of children and interest in the arts and literature as strengthening the teaching and learning of reading the scriptural exercise , this factor attracted the attention of teachers , initiating search strategies and techniques to start interacting with children through activities and tools on topics related to education from early childhood care ( early childhood education ) in order to develop skills and generate new opportunities for deepening arts and literature. Activities were conducted on the issue and came up big impact on children and parents by developing a schedule of activities and working guidelines, which were carried out effectively in the selected study group. From the different dimensions and the dates, stipulated activities were developed with children of the school using a survey (parents and teachers), activities on the arts and literature, which woke positively the usefulness of tools to imagine and create new things. Elements pedagogues Jean Piaget, Ausubel and Vygotsky, stadiums, and meaningful sociocultural learning theories were taken.INTRODUCCI?N 17 1. PROBLEMA DE INVESTIGACI?N 18 1.1 ANTECEDENTES 18 1.2 PLANTEAMIENTO DEL PROBLEMA 18 1.3 PREGUNTA PROBLEMATIZADORA 19 2. JUSTIFICACI?N 20 3. OBJETIVOS 22 3.1 OBJETIVO GENERAL 22 3. 2 OBJETIVOS ESPEC?FICOS 22 4. MARCO TE?RICO 23 4.1 APRENDIZAJE SIGNIFICATIVO 25 4.2 APRENDIZAJE SIGNIFICATIVO Y APRENDIZAJE MEC?NICO 25 4.3 APRENDIZAJE POR DESCUBRIMIENTO Y APRENDIZAJE POR RECEPCI? 26 4.4 EL APRENDIZAJE POR DESCUBRIMIENTO 27 4.5 REQUISITOS PARA EL APRENDIZAJE SIGNIFICATIVO 27 4.6 PLANTEAMIENTO TE?RICO DE PIAGET 29 5. MARCO LEGAL 31 5.1 GENERALIDADES DE LOS LINEAMIENTOS EDUCATIVOS 32 5.2 COMPONENTES DE LOS LINEAMIENTOS EDUCATIVOS 32 Constituci?n Pol?tica de Colombia: 33 6. DISE?O METODOLOGICO 35 6.1 ?QU? ES INVESTIGACI?N CUALITATIVA? 36 6.2 TIPO DE INVESTIGACI?N 36 6.3 T?CNICAS DE INVESTIGACI?N 36 6.4 POBLACI?N 37 6.5 MUESTRA 37 6.6 INSTRUMENTOS DE RECOLECCI?N DE LA INFORMACI?N 38 7. AN?LISIS DE LA INFORMACI?N 40 7.1. ACTIVIDADES POR DESARROLLAR 41 8. CRONOGRAMA DE ACTIVIDADES 41 9. PRESUPUESTO 42 10. RECURSOS 44 11. CONCLUSIONES 45 RECOMENDACIONES 46 REFERENCIAS 47 ANEXOS 5

Estudio de las propiedades f?sico-mec?nicas de la especie Simarouba amara Aubl procedente del Bajo Calima, Buenaventura.

74 p. Recurso Electr?nicoEste estudio proporciona informaci?n pertinente sobre las propiedades f?sico-mec?nicas y usos posibles de la especie Simarouba amara Aubl procedente de la regi?n sur del litoral pac?fico colombiano. Se realizaron nueve pruebas diferentes, dos f?sicas y siete mec?nicas, con 30 probetas por ensayo, para un total de 270 probetas. Las dimensiones de las probetas y los procedimientos de los ensayos se basaron en la Norma T?cnica Colombiana. Para las propiedades f?sicas se determin? la densidad, contracciones transversales y longitudinales en los tres contenidos de humedad: verde, seca al aire y seca al horno. La densidad seca al aire arroj? un valor promedio de 0,45 g/cm2, clasific?ndola como bajo seg?n la norma ASTM; la contracci?n volum?trica normal fue peque?a (9,09 %) seg?n la norma DIN; y la relaci?n entre la contracci?n tangencial y radial tanto normal como total fueron moderadamente estables (2,14 y 1,81) seg?n la norman DIN. Para las pruebas mec?nicas, los valores se clasificaron seg?n la norma ASTM. El Esfuerzo en el Limite Proporcional para la flexi?n y la compresi?n paralela fue mediano (597 y 333 kg/cm2) al igual que el Modulo de Elasticidad (103 y 21.195 kg/cm2); mientras que para la compresi?n perpendicular el Esfuerzo en el L?mite Proporcional fue bajo (70 kg/cm2). La dureza, el cizallamiento y la extracci?n de clavos presentaron valores bajos. De acuerdo con los resultados de las propiedades f?sicas y mec?nicas de la madera de Simaruba amara Aubl. los usos posibles que se recomiendan para esta son: carpinter?a de obra y construcciones livianas. Otros usos posibles son para cerillas, juguetes, etc. Palabras claves: Simarouba amara Aubl, Pac?fico Colombiano, Propiedades f?sicas y mec?nicas, Usos de la madera.This study provides valuable information on the physico-mechanical properties and potential uses of the specie Simarouba amara Aubl from the southern region of the Colombian Pacific coast. Nine different test were performed, two physical and seven mechanical, with 30 test specimens, for a total of 270 specimens. The dimensions of the specimens and testing procedures were based on Colombian Technical Standard. For the physical properties density, transverse and longitudinal contractions are determined in the three moisture contents: green, air dried and oven dried. The dry air density is an average value of 0.45 g/cm2, classifying it as low according to the ware ASTM; normal volumetric contraction was small (9.09%) pursuant DIN standard; and the relationship between the tangential and radial contraction so much normal as total was moderately stable (2,14 and 1,81) in agreement with DIN standard. For mechanical test, the values were classified pursuant to ASTM standard. The effort in the limit determined for flexion and compression parallel was medium (597 and 333 kg/cm2), just like elastic modulus (103 and 21.195 kg/cm2); while for perpendicular compression was low (70 kg/cm2). The hardness, shear and nail pull had low values. According to the results of the physical and mechanical properties of wood Simaruba love Aubl properties. the possible uses that are recommended for this are: joinery and light construction . Other possible uses are for matches , toys, etc. Keywords: Simarouba amara Aubl, Colombian Pacific, physical and mechanical properties of wood and Uses of wood

Design, Manufacture and Characterization of an Acoustic Barrier Made of Multi-Phenomena Cylindrical Scatterers Arranged in a Fractal-Based Geometry

In this work we present the design and the manufacturing processes, as well as the acoustics standard-ization tests, of an acoustic barrier formed by a set of multi-phenomena cylindrical scatterers. Periodic arrangements of acoustic scatterers embedded in a fluid medium with different physical properties are usually called Sonic Crystals. The multiple scattering of waves inside these structures leads to attenuation bands related to the periodicity of the structure by means of Bragg scattering. In order to design the acoustic barrier, two strategies have been used: First, the arrangement of scatterers is based on fractal geometries to maximize the Bragg scattering; econd, multi-phenomena scatterers with several noise con- trol mechanisms, as resonances or absorption, are designed and used to construct the periodic array. The acoustic barrier reported in this work provides a high technological solution in the field of noise control.This work was supported by MCI Secretaria de Estado de Investigacion (Spanish government) and the FEDER funds, under Grant No. MAT2009-09438 and by Universitat Politecnica de Valencia (Programa INNOVA 2010) under grant "INNOVA 2010 PDC PANTALLA ACUSTICA". The authors would like to thank Applus+ (LGAI Technological Center S.A.) for their help. V.R.G. is grateful for the support of post-doctoral contracts of the UPV (CEI-01-11).Castiñeira Ibáñez, S.; Rubio Michavila, C.; Romero García, V.; Sánchez Pérez, JV.; García Raffi, LM. (2012). Design, Manufacture and Characterization of an Acoustic Barrier Made of Multi-Phenomena Cylindrical Scatterers Arranged in a Fractal-Based Geometry. Archives of Acoustics. 37(4):455-462. https://doi.org/10.2478/v10168-012-0057-9S45546237

Increased urinary markers of kidney damage in the institutionalized frail elderly due to recurrent urinary tract infections.

Objective: To characterize the impact on kidney injury of recurrent urinary tract infections (RUTI) in the frail elderly. Methods: Prospective observational study in 200 frail elderly subjects for 1 year. Groups: GA (n = 100): subjects without RUTI, GB (n = 100): subjects with RUTI. Variables: age, concomitant diseases, glomerular filtration rate (GFR), urine neutrophil gelatinase-associated lipocalin (NGAL) at the beginning (NGAL-1) and end (NGAL-2) of the study, urine N-acetyl glucosaminidase (NAG) at the beginning (NAG-1) and the end (NAG-2) of the study, urine transforming growth factor-beta 1 (TGFbeta-1). Descriptive statistics, Mann-Whitney test, Chi-squared test, Fisher's exact test, and multivariate analysis were used. Results: Mean age was 84.33 (65-99) years old, with no difference between GA and GB. Mean NGAL-1 was 1.29 ng/ml (0.04-8). There was lower in GA than in GB. Mean NGAL-2 was 1.41 ng/ml (0.02-9.22). NGAL-2 was lower in GA than in GB. Mean NAG-1 was 0.38 UU.II/ml (0.01-2.63. NAG-1 in GA was lower than in GB. Mean NAG-2 was 0.44 UU.II/ml (0-3.41). NAG-2 was lower in GA compared with GB. Mean TGFbeta-1 was 23.43 pg/ml (0.02-103.76). TGFbeta-1 was lower in GA than GB. There were no differences in the presence of secondary diagnoses between GA and GB. NAG-2 and NGAL-1 were the most determining factors of renal function; in GA it was NGAL-2, followed by NAG-1; in GB it was NGAL-1, followed by NAG-2. Conclusion: Frail elderly with RUTI have higher urinary levels of renal injury markers, specifically NGAL, NAG, and TGFbeta-1, chronically in periods between urinary tract infection (UTI). Urinary markers of renal injury, specifically NGAL, NAG, and TGFbeta-1, identify early deterioration of renal function, compared with serum creatinine, or albuminuria, in frail elderly with recurrent urinary infections

Phi-values in protein folding kinetics have energetic and structural components

Phi-values are experimental measures of how the kinetics of protein folding is changed by single-site mutations. Phi-values measure energetic quantities, but are often interpreted in terms of the structures of the transition state ensemble. Here we describe a simple analytical model of the folding kinetics in terms of the formation of protein substructures. The model shows that Phi-values have both structural and energetic components. In addition, it provides a natural and general interpretation of "nonclassical" Phi-values (i.e., less than zero, or greater than one). The model reproduces the Phi-values for 20 single-residue mutations in the alpha-helix of the protein CI2, including several nonclassical Phi-values, in good agreement with experiments.Comment: 15 pages, 3 figures, 1 tabl

LipoDDx: a mobile application for identification of rare lipodystrophy syndromes

BACKGROUND: Lipodystrophy syndromes are a group of disorders characterized by a loss of adipose tissue once other situations of nutritional deprivation or exacerbated catabolism have been ruled out. With the exception of the HIV-associated lipodystrophy, they have a very low prevalence, which together with their large phenotypic heterogeneity makes their identification difficult, even for endocrinologists and pediatricians. This leads to significant delays in diagnosis or even to misdiagnosis. Our group has developed an algorithm that identifies the more than 40 rare lipodystrophy subtypes described to date. This algorithm has been implemented in a free mobile application, LipoDDx(R). Our aim was to establish the effectiveness of LipoDDx(R). Forty clinical records of patients with a diagnosis of certainty of most lipodystrophy subtypes were analyzed, including subjects without lipodystrophy. The medical records, blinded for diagnosis, were evaluated by 13 physicians, 1 biochemist and 1 dentist. Each evaluator first gave his/her results based on his/her own criteria. Then, a second diagnosis was given using LipoDDx(R). The results were analysed based on a score table according to the complexity of each case and the prevalence of the disease. RESULTS: LipoDDx(R) provides a user-friendly environment, based on usually dichotomous questions or choice of clinical signs from drop-down menus. The final result provided by this app for a particular case can be a low/high probability of suffering a particular lipodystrophy subtype. Without using LipoDDx(R) the success rate was 17 +/- 20%, while with LipoDDx(R) the success rate was 79 +/- 20% (p < 0.01). CONCLUSIONS: LipoDDx(R) is a free app that enables the identification of subtypes of rare lipodystrophies, which in this small cohort has around 80% effectiveness, which will be of help to doctors who are not experts in this field. However, it will be necessary to analyze more cases in order to obtain a more accurate efficiency value

Continuous?Flow Synthesis of Orange Emitting Sn(II)?Doped CsBr Materials

An ongoing demand toward lead-free all-inorganic cesium metal halide perovskites has presented Sn(II) as an ideal substitute of Pb(II) for applications in optoelectronic devices. The major concern regarding Sn(II) is the instability due to the ambient oxidation to Sn(IV). To expand the scope of traditional perovskite and analogues, herein the synthesis and optical performance of Sn(II)-doped CsBr, a new material formed by interstitial doping of Sn(II) into the CsBr matrix, are reported for the first time. This material is prepared following an antisolvent mediated recrystallization method using a continuous flow reactor, which is beneficial for scaling up the production compared to traditional batch reactors. Sn(II)-doped CsBr exhibits broadband orange emission with full-width-half-maximum of 180 nm and a photoluminescence quantum yield of 21.5%. The emission turned to be highly stable over 7 months despite containing Sn(II). It is suggested that this is due to interstitial location of Sn(II) atoms in bulk of microcrystals. A broadband emission and high aerobic stability are attractive properties of the material for white-light emitting applications

Anti-tumour necrosis factor discontinuation in inflammatory bowel disease patients in remission: study protocol of a prospective, multicentre, randomized clinical trial

Background: Patients with inflammatory bowel disease who achieve remission with anti-tumour necrosis factor (anti-TNF) drugs may have treatment withdrawn due to safety concerns and cost considerations, but there is a lack of prospective, controlled data investigating this strategy. The primary study aim is to compare the rates of clinical remission at 1?year in patients who discontinue anti-TNF treatment versus those who continue treatment. Methods: This is an ongoing, prospective, double-blind, multicentre, randomized, placebo-controlled study in patients with Crohn?s disease or ulcerative colitis who have achieved clinical remission for ?6?months with an anti-TNF treatment and an immunosuppressant. Patients are being randomized 1:1 to discontinue anti-TNF therapy or continue therapy. Randomization stratifies patients by the type of inflammatory bowel disease and drug (infliximab versus adalimumab) at study inclusion. The primary endpoint of the study is sustained clinical remission at 1?year. Other endpoints include endoscopic and radiological activity, patient-reported outcomes (quality of life, work productivity), safety and predictive factors for relapse. The required sample size is 194 patients. In addition to the main analysis (discontinuation versus continuation), subanalyses will include stratification by type of inflammatory bowel disease, phenotype and previous treatment. Biological samples will be obtained to identify factors predictive of relapse after treatment withdrawal. Results: Enrolment began in 2016, and the study is expected to end in 2020. Conclusions: This study will contribute prospective, controlled data on outcomes and predictors of relapse in patients with inflammatory bowel disease after withdrawal of anti-TNF agents following achievement of clinical remission. Clinical trial reference number: EudraCT 2015-001410-1

Genome-wide association analysis of dementia and its clinical endophenotypes reveal novel loci associated with Alzheimer's disease and three causality networks: The GR@ACE project

INTRODUCTION: Large variability among Alzheimer's disease (AD) cases might impact genetic discoveries and complicate dissection of underlying biological pathways. METHODS: Genome Research at Fundacio ACE (GR@ACE) is a genome-wide study of dementia and its clinical endophenotypes, defined based on AD's clinical certainty and vascular burden. We assessed the impact of known AD loci across endophenotypes to generate loci categories. We incorporated gene coexpression data and conducted pathway analysis per category. Finally, to evaluate the effect of heterogeneity in genetic studies, GR@ACE series were meta-analyzed with additional genome-wide association study data sets. RESULTS: We classified known AD loci into three categories, which might reflect the disease clinical heterogeneity. Vascular processes were only detected as a causal mechanism in probable AD. The meta-analysis strategy revealed the ANKRD31-rs4704171 and NDUFAF6-rs10098778 and confirmed SCIMP-rs7225151 and CD33-rs3865444. DISCUSSION: The regulation of vasculature is a prominent causal component of probable AD. GR@ACE meta-analysis revealed novel AD genetic signals, strongly driven by the presence of clinical heterogeneity in the AD series