The social dimension of globalization: A review of the literature

With globalization affecting so many inter-connected areas, it is difficult to grasp its full impact. This literature review of over 120 sources considers the impact of globalization on wages and taxes, poverty, inequality, insecurity, child labour, gender, and migration. Opening with some stylized facts concerning globalization in 1985-2002, the authors then highlight recent findings on these areas, reporting on controversies and on emerging consensus where it exists. There follows a review of national and international policy responses designed to make globalization more sustainable and equitable and to deliver decent jobs, security and a voice in decision-making

The Changing Landscape for Stroke\ua0Prevention in AF: Findings From the GLORIA-AF Registry Phase 2

Background GLORIA-AF (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation) is a prospective, global registry program describing antithrombotic treatment patterns in patients with newly diagnosed nonvalvular atrial fibrillation at risk of stroke. Phase 2 began when dabigatran, the first non\u2013vitamin K antagonist oral anticoagulant (NOAC), became available. Objectives This study sought to describe phase 2 baseline data and compare these with the pre-NOAC era collected during phase 1. Methods During phase 2, 15,641 consenting patients were enrolled (November 2011 to December 2014); 15,092 were eligible. This pre-specified cross-sectional analysis describes eligible patients\u2019 baseline characteristics. Atrial fibrillation disease characteristics, medical outcomes, and concomitant diseases and medications were collected. Data were analyzed using descriptive statistics. Results Of the total patients, 45.5% were female; median age was 71 (interquartile range: 64, 78) years. Patients were from Europe (47.1%), North America (22.5%), Asia (20.3%), Latin America (6.0%), and the Middle East/Africa (4.0%). Most had high stroke risk (CHA2DS2-VASc [Congestive heart failure, Hypertension, Age  6575 years, Diabetes mellitus, previous Stroke, Vascular disease, Age 65 to 74 years, Sex category] score  652; 86.1%); 13.9% had moderate risk (CHA2DS2-VASc = 1). Overall, 79.9% received oral anticoagulants, of whom 47.6% received NOAC and 32.3% vitamin K antagonists (VKA); 12.1% received antiplatelet agents; 7.8% received no antithrombotic treatment. For comparison, the proportion of phase 1 patients (of N = 1,063 all eligible) prescribed VKA was 32.8%, acetylsalicylic acid 41.7%, and no therapy 20.2%. In Europe in phase 2, treatment with NOAC was more common than VKA (52.3% and 37.8%, respectively); 6.0% of patients received antiplatelet treatment; and 3.8% received no antithrombotic treatment. In North America, 52.1%, 26.2%, and 14.0% of patients received NOAC, VKA, and antiplatelet drugs, respectively; 7.5% received no antithrombotic treatment. NOAC use was less common in Asia (27.7%), where 27.5% of patients received VKA, 25.0% antiplatelet drugs, and 19.8% no antithrombotic treatment. Conclusions The baseline data from GLORIA-AF phase 2 demonstrate that in newly diagnosed nonvalvular atrial fibrillation patients, NOAC have been highly adopted into practice, becoming more frequently prescribed than VKA in Europe and North America. Worldwide, however, a large proportion of patients remain undertreated, particularly in Asia and North America. (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients With Atrial Fibrillation [GLORIA-AF]; NCT01468701

Inward-Looking Policies, Institutions, Autocrats, and Economic Growth in Latin America: An Empirical Exploration

This paper explores the institutional determinants of economic growth in Latin America by taking advantage of recent empirical research that employs subjective and objective measures to test for a possible Northian explanation that links institutional quality and economic growth. I provide a framework that helps better understand the policymakers` choices and persistence regarding inward-looking policies that were pursued between the 1930s and the 1980s by arguing that in the Latin American case Olson`s (1982) idea of encompassing interest should be expanded to cover not only the economic stakes of power holders, but also, their political stakes, somewhat along the lines of work by Robinson (1997)

The control and generation of technology in European food and beverage multinationals

32 págs.Using a sample of 59 major European food and beverage multinationals and their 8,432 subsidiaries worldwide, we study the characteristics and evolution over time of their inventions. In doing so, we analyse: i) 8,626 EPO applications filed by these companies between 1978 and 2005; ii) 3,650 US patents they applied for between 1978 and 2001; iii) more than 2,000 patent families of three different kinds; and iv) the location of their R&D entres of excellence. We find that the internationalisation of invention is in reality chiefly a European phenomenon for these companies, which also tend to retain their key R&D strategic assets within their home countries or in neighbouring countries. The innovations of EU-based companies which are most closely related to their core businesses tend to be located in EU countries; however, such companies do not display a geographical preference with regard to high value or technically complex innovations, which are generated at home and abroad and inside and outside the EU. From these findings we extract conclusions relevant to European R&D policy.Peer reviewe

Association study of nonsynonymous single nucleotide polymorphisms in schizophrenia.

BACKGROUND: Genome-wide association studies using several hundred thousand anonymous markers present limited statistical power. Alternatively, association studies restricted to common nonsynonymous single nucleotide polymorphisms (nsSNPs) have the advantage of strongly reducing the multiple testing problem, while increasing the probability of testing functional single nucleotide polymorphisms (SNPs). METHODS: We performed a case-control association study of common nsSNPs in Galician (northwest Spain) samples using the Affymetrix GeneChip Human 20k cSNP Kit, followed by a replication study of the more promising results. After quality control procedures, the discovery sample consisted of 5100 nsSNPs at minor allele frequency >5% analyzed in 476 schizophrenia patients and 447 control subjects. The replication sample consisted of 4069 cases and 15,128 control subjects of European origin. We also performed multilocus analysis, using aggregated scores of nsSNPs at liberal significance thresholds and cross-validation procedures. RESULTS: The 5 independent nsSNPs with false discovery rate q 64 .25, as well as 13 additional nsSNPs at p < .01 and located in functional candidate genes, were genotyped in the replication samples. One SNP, rs13107325, located at the metal ions transporter gene SLC39A8, reached significance in the combined sample after Bonferroni correction (trend test, p = 2.7 7 10(-6), allelic odds ratio = 1.32). This SNP presents minor allele frequency of 5% to 10% in many European populations but is rare outside Europe. We also confirmed the polygenic component of susceptibility. CONCLUSIONS: Taking into account that another metal ions transporter gene, SLC39A3, is associated to bipolar disorder, our findings reveal a role for brain metal homeostasis in psychosis

Measurement of CP violation and constraints on the CKM angle γ in B± → DK± with D → K0Sπ+π− decays

A model-dependent amplitude analysis of B± → DK± with D → K0 Sπ+π− decays is performed using proton–proton collision data, corresponding to an integrated luminosity of 1 fb−1, recorded by LHCb at a centre-of-mass energy of 7 TeV in 2011. Values of the CP violation observables x± and y±, which are sensitive to the CKM angle γ, are measured to be x− = +0.027 ± 0.044+0.010 −0.008 ± 0.001, y− = +0.013 ± 0.048+0.009 −0.007 ± 0.003, x+ = −0.084 ± 0.045 ± 0.009 ± 0.005, y+ = −0.032 ± 0.048+0.010 −0.009 ± 0.008, where the first uncertainty is statistical, the second systematic and the third arises from the uncertainty of the D → K0 Sπ+π− amplitude model. The value of γ is determined to be (84+49 −42)◦, including all sources of uncertainty. Neutral D meson mixing is found to have negligible effect