Vincenzo Consolo: punto de unión entre Sicilia y España. Los treinta años de Il sorriso dell'ignoto marinaio

Con ocasión del trigésimo aniversario de la publicación de Il sorriso dell’ignoto marinaio, hemos organizado las Jornadas Internacionales Vincenzo Consolo: punto de unión entre Sicilia y España. Los treinta años de Il sorriso dell’ignoto marinaio, que se celebraron en la Universitat de València los días 23 y 24 de octubre de 2006 y cuyas Actas ofrecemos en el presente volumen monográfico. De esta manera, cerramos el ciclo de dos años dedicado a la obra de Vincenzo Consolo, ciclo que iniciamos el año anterior con unas primeras Jornadas Internacionales, Lunaria vent’anni dopo, que también organizamos en la Universitat de València los días 24 y 25 de octubre de 2005, al cumplirse el vigésimo aniversario de su obra Lunaria

Xarxa de literatura catalana infantil (Grau d’Educació Infantil)

En aquesta memòria descrivim el treball en xarxa elaborat pels membres del projecte d’innovació docent “Xarxa de literatura catalana infantil (Grau d’Educació Infantil)” que, durant el curs 2014-2015, ha dut a terme diverses reunions presencials i virtuals per a modernitzar i millorar el procés d’ensenyament-aprenentatge relacionat amb la matèria objecte d’estudi. L’eix vertebral del projecte es basa l’ús de les TIC com a recurs motivador i dinàmic que cal implementar en la metodologia docent de les assignatures relacionades amb la literatura infantil del grau en Educació Infantil. En aquest sentit, s’hi descriuen els avantatges dels recursos relacionats amb l’univers Google (sobretot, Calendar, Sites, Drive i Youtube) i Prezi, la pàgina web que proporciona un entorn de presentacions en línia dinàmiques i interactives, molt en consonància amb les interessos de l’alumnat i els nous processos de comunicació i interacció docent. Per a il·lustrar el projecte, s’hi mostren imatges representatives dels materials que han sigut elaborats amb aquestos recursos

High incidence of clinical fragility fractures in postmenopausal women with rheumatoid arthritis. A case-control study.

Objectives: To estimate the incidence of clinical fragility fractures in postmenopausal women with rheumatoid arthritis (RA) and analyze risk factors for fracture. Methods: Incidence of clinical fragility fractures in 330 postmenopausal women with RA was compared to that of a control population of 660 age-matched postmenopausal Spanish women. Clinical fractures during the previous five years were recorded. We analyzed associations with risk factors for fracture in both populations and with disease-related variables in RA patients. Results: Median age of RA patients was 64 years; median RA duration was eight years. Sixty-nine percent were in remission or on low activity. Eighty-five percent had received glucocorticoids (GCs); 85 %, methotrexate; and 40 %, ≥1 biologic DMARD. Fifty-four patients and 47 controls had ≥1 major osteoporotic fracture (MOF). Incidence of MOFs was 3.55 per 100 patient-year in patients and 0.72 in controls (HR: 2.6). Risk factors for MOFs in RA patients were age, previous fracture, parental hip fracture, years since menopause, BMD, erosions, disease activity and disability, and cumulative dose of GCs. Previous fracture in RA patients was a strong risk for MOFs (HR: 10.37). Conclusion: Of every 100 postmenopausal Spanish women with RA, 3-4 have a MOF per year. This is more than double that of the general population. A previous fracture poses a high risk for a new fracture. Other classic risk factors for fracture, RA disease activity and disability, and the cumulative dose of GCs are associated with fracture development

Sobre el diseño y las exposiciones en la Sala Hall

Puyuelo Cazorla, M.; Pastor Castillo, FJ. (2021). Sobre el diseño y las exposiciones en la Sala Hall. En Todo sobre diseño/All about design. Una década de exposiciones de diseño en la Sala Hall/ A decade of design exhibitions in the Hall. Editorial Universitat Politècnica de València. http://hdl.handle.net/10251/16668

Ahora / Ara

La cinquena edició del microrelatari per l’eradicació de la violència contra les dones de l’Institut Universitari d’Estudis Feministes i de Gènere «Purificación Escribano» de la Universitat Jaume I vol ser una declaració d’esperança. Aquest és el moment en el qual les dones (i els homes) hem de fer un pas endavant i eliminar la violència sistèmica contra les dones. Ara és el moment de denunciar el masclisme i els micromasclismes començant a construir una societat més igualitària. Cadascun dels relats del llibre és una denúncia i una declaració que ens encamina cap a un món millor

First-in-class inhibitor of the T cell receptor for the treatment of autoimmune diseases

Modulating T cell activation is critical for treating autoimmune diseases but requires avoiding concomitant opportunistic infections. Antigen binding to the T cell receptor (TCR) triggers the recruitment of the cytosolic adaptor protein Nck to a proline-rich sequence in the cytoplasmic tail of the TCR's CD3e subunit. Through virtual screening and using combinatorial chemistry, we have generated an orally available, low-molecular weight inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activationwith an IC50 (median inhibitory concentration) ~1 nM. By modulating TCR signaling, the inhibitor prevented the development of psoriasis and asthma and, furthermore, exerted a long-lasting therapeutic effect in a model of autoimmune encephalomyelitis. However, it did not prevent the generation of a protective memory response against amouse pathogen, suggesting that the compound might not exert its effects through immunosuppression. These results suggest that inhibiting an immediate TCR signal has promise for treating a broad spectrumof human T cell-mediated autoimmune and inflammatory diseases.Peer Reviewe

GEODIVULGAR: Geología y Sociedad

Depto. de Geodinámica, Estratigrafía y PaleontologíaFac. de Ciencias GeológicasFALSEsubmitte

Assessment of plasma chitotriosidase activity, CCL18/PARC concentration and NP-C suspicion index in the diagnosis of Niemann-Pick disease type C : A prospective observational study

Niemann-Pick disease type C (NP-C) is a rare, autosomal recessive neurodegenerative disease caused by mutations in either the NPC1 or NPC2 genes. The diagnosis of NP-C remains challenging due to the non-specific, heterogeneous nature of signs/symptoms. This study assessed the utility of plasma chitotriosidase (ChT) and Chemokine (C-C motif) ligand 18 (CCL18)/pulmonary and activation-regulated chemokine (PARC) in conjunction with the NP-C suspicion index (NP-C SI) for guiding confirmatory laboratory testing in patients with suspected NP-C. In a prospective observational cohort study, incorporating a retrospective determination of NP-C SI scores, two different diagnostic approaches were applied in two separate groups of unrelated patients from 51 Spanish medical centers (n = 118 in both groups). From Jan 2010 to Apr 2012 (Period 1), patients with ≥2 clinical signs/symptoms of NP-C were considered 'suspected NP-C' cases, and NPC1/NPC2 sequencing, plasma chitotriosidase (ChT), CCL18/PARC and sphingomyelinase levels were assessed. Based on findings in Period 1, plasma ChT and CCL18/PARC, and NP-C SI prediction scores were determined in a second group of patients between May 2012 and Apr 2014 (Period 2), and NPC1 and NPC2 were sequenced only in those with elevated ChT and/or elevated CCL18/PARC and/or NP-C SI ≥70. Filipin staining and 7-ketocholesterol (7-KC) measurements were performed in all patients with NP-C gene mutations, where possible. In total across Periods 1 and 2, 10/236 (4%) patients had a confirmed diagnosis o NP-C based on gene sequencing (5/118 [4.2%] in each Period): all of these patients had two causal NPC1 mutations. Single mutant NPC1 alleles were detected in 8/236 (3%) patients, overall. Positive filipin staining results comprised three classical and five variant biochemical phenotypes. No NPC2 mutations were detected. All patients with NPC1 mutations had high ChT activity, high CCL18/PARC concentrations and/or NP-C SI scores ≥70. Plasma 7-KC was higher than control cut-off values in all patients with two NPC1 mutations, and in the majority of patients with single mutations. Family studies identified three further NP-C patients. This approach may be very useful for laboratories that do not have mass spectrometry facilities and therefore, they cannot use other NP-C biomarkers for diagnosis

Geodivulgar: Geología y Sociedad

Depto. de Geodinámica, Estratigrafía y PaleontologíaDepto. de Química InorgánicaDepto. de Didáctica de las Ciencias Experimentales , Sociales y MatemáticasFac. de Ciencias GeológicasFac. de Ciencias QuímicasFac. de EducaciónFALSEsubmitte