[CII] 158μ\mum and [NII] 205μ\mum emission from IC 342 - Disentangling the emission from ionized and photo-dissociated regions

Aims: We investigate how much of the [CII] emission in the nucleus of the nearby spiral galaxy IC 342 is contributed by PDRs and by the ionized gas. We examine the spatial variations of starburst/PDR activity and study the correlation of the [CII] line with the [NII] 205{\textmu}m emission line coming exclusively from the HII regions. Methods: We present small maps of [CII] and [NII] lines recently observed with the GREAT receiver on board SOFIA. In particular we present a super-resolution method to derive how unresolved, kinematically correlated structures in the beam contribute to the observed line shapes. Results: We find that the emission coming from the ionized gas shows a kinematic component in addition to the general Doppler signature of the molecular gas. We interpret this as the signature of two bi-polar lobes of ionized gas expanding out of the galactic plane. We then show how this requires an adaptation of our understanding of the geometrical structure of the nucleus of IC~342. Examining the starburst activity we find ratios $I([CII])/I(^{12}\mathrm{CO} (1-0))$ between 400 and 1800 in energy units. Applying predictions from numerical models of HII and PDR regions to derive the contribution from the ionized phase to the total [CII] emission we find that 35-90% of the observed [CII] intensity stems from the ionized gas if both phases contribute. Averaged over the central few hundred parsec we find for the [CII] contribution a HII-to-PDR ratio of 70:30. Conclusions: The ionized gas in the center of IC 342 contributes more strongly to the overall [CII] emission than is commonly observed on larger scales and than is predicted. Kinematic analysis shows that the majority of the [CII] emission is related to the strong but embedded star formation in the nuclear molecular ring and only marginally emitted from the expanding bi-polar lobes of ionized gas.Comment: 20 pages spectra available online: http://cdsweb.u-strasbg.fr/cgi-bin/qcat?J/A+A/ submitted to and accepted by A&

What does data stewardship mean in physics?

This article expands on the considerations on data stewardship in physics the authors have presented as a poster at the “Data Stewardship goes Germany” workshop held in Brunswick in October 2022. We start from the observation that despite the close links between research in physics and scientific computing as a tenet of research data management (RDM), currently, the research data produced by physicists are not as FAIR (findable, accessible, interoperable, and reusable) as they could and should be. Physics research groups in Germany as of now do not feature explicitly designated data stewards. Building on a survey on RDM in physics conducted among researchers in 2020, we lay out a clear case and a mission for more explicitly defined and acknowledged data stewardship in physics. We argue that because of the closeness between data stewardship and genuine research, ample domain knowledge is indispensable: Data stewards in physics should ideally be trained physicists themselves! Data stewards are going to face a heterogeneous research landscape in terms of group size and resources, defined by the pressure to “publish or perish”. We consider that the introduction of data stewardship presents an opportunity to the physics community to self-organize research support infrastructures where they are missing. Data stewards from the physics community would be ideally skilled to transform the existing data handling solutions into the RDM systems needed to achieve a future of FAIR data from physics. We envision them to contribute to scientific projects both as advisors and as active role models of good scientific practice and reproducibility

Visualization of coronary arteries in paediatric patients using whole-heart coronary magnetic resonance angiography: comparison of image-navigation and the standard approach for respiratory motion compensation

Aims: To investigate the use of respiratory motion compensation using image-based navigation (iNAV) with constant respiratory efficiency using single end-expiratory thresholding (CRUISE) for coronary magnetic resonance angiography (CMRA), and compare it to the conventional diaphragmatic navigator (dNAV) in paediatric patients with congenital or suspected heart disease. Methods: iNAV allowed direct tracking of the respiratory heart motion and was generated using balanced steady state free precession startup echoes. Respiratory gating was achieved using CRUISE with a fixed 50% efficiency. Whole-heart CMRA was acquired with 1.3mm isotropic resolution. For comparison, CMRA with identical imaging parameters were acquired using dNAV. Scan time, visualization of coronary artery origins and mid-course, imaging quality and sharpness was compared between the two sequences. Results: Forty patients (13 females; median weight: 44 kg; median age: 12.6, range: 3 months–17 years) were enrolled. 25 scans were performed in awake patients. A contrast agent was used in 22 patients. The scan time was significantly reduced using iNAV for awake patients (iNAV 7:48 ± 1:26 vs dNAV 9:48 ± 3:11, P = 0.01) but not for patients under general anaesthesia (iNAV = 6:55 ± 1:50 versus dNAV = 6:32 ± 2:16; P = 0.32). In 98% of the cases, iNAV image quality had an equal or higher score than dNAV. The visual score analysis showed a clear difference, favouring iNAV (P = 0.002). The right coronary artery and the left anterior descending vessel sharpness was significantly improved (iNAV: 56.8% ± 10.1% vs dNAV: 53.7% ± 9.9%, P < 0.002 and iNAV: 55.8% ± 8.6% vs dNAV: 53% ± 9.2%, P = 0.001, respectively). Conclusion: iNAV allows for a higher success-rate and clearer depiction of the mid-course of coronary arteries in paediatric patients. Its acquisition time is shorter in awake patients and image quality score is equal or superior to the conventional method in most cases.Medical Engineering at King’s College London WT 088641/Z/09/ZBHF Centre of Excellence RE/08/0

Gas and dust cooling along the major axis of M 33 (HerM33es). Herschel/PACS [C II] and [O I] observations

Open Access article, published by EDP Sciences, under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Context. M 33 is a gas rich spiral galaxy of the Local Group. Its vicinity allows us to study its interstellar medium (ISM) on linear scales corresponding to the sizes of individual giant molecular clouds. Aims. We investigate the relationship between the two major gas cooling lines and the total infrared (TIR) dust continuum. Methods. We mapped the emission of gas and dust in M 33 using the far-infrared lines of [CII] and [OI](63 mu m) and the total infrared continuum. The line maps were observed with the PACS spectrometer on board the Herschel Space Observatory. These maps have 50 pc resolution and form a similar to 370 pc wide stripe along its major axis covering the sites of bright HII regions, but also more quiescent arm and inter-arm regions from the southern arm at 2 kpc galacto-centric distance to the south out to 5.7 kpc distance to the north. Full-galaxy maps of the continuum emission at 24 mu m from Spitzer/MIPS, and at 70 mu m, 100 mu m, and 160 mu m from Herschel/PACS were combined to obtain a map of the TIR. Results. TIR and [CII] intensities are correlated over more than two orders of magnitude. The range of TIR translates to a range of far ultraviolet (FUV) emission of G(0, obs)similar to 2 to 200 in units of the average Galactic radiation field. The binned [CII]/TIR ratio drops with rising TIR, with large, but decreasing scatter. The contribution of the cold neutral medium to the [CII] emission, as estimated from VLA HI data, is on average only 10%. Fits of modified black bodies to the continuum emission were used to estimate dust mass surface densities and total gas column densities. A correction for possible foreground absorption by cold gas was applied to the [OI] data before comparing it with models of photon dominated regions. Most of the ratios of [CII]/[OI] and ([CII]+[OI])/TIR are consistent with two model solutions. The median ratios are consistent with one solution at n similar to 2x10(2) cm(-3), G(0)similar to 60, and a second low-FUV solution at n similar to 10(4) cm(-3), G(0)similar to 1.5. Conclusions. The bulk of the gas along the lines-of-sight is represented by a low-density, high-FUV phase with low beam filling factors similar to 1. A fraction of the gas may, however, be represented by the second solution. © C. Kramer et al. 2020M.R. and S.V. acknowledge support by the research projects AYA2014-53506-P and AYA2017-84897-P from the Spanish Ministerio de Economia y Competitividad, from the European Regional Development Funds (FEDER) and the Junta de Andalucia (Spain) grants FQM108. This study has been partially financed by the Consejeria de Conocimiento, Investigacion y Universidad, Junta de Andalucia and European Regional Development Fund (ERDF), ref. SOMM17/6105/UGR. FST thanks the Spanish Ministry of Economy and Competitiveness (MINECO) for support under grant number AYA2016-76219-P.Peer reviewe

A Foundation Model for Cell Segmentation

Cells are the fundamental unit of biological organization, and identifying them in imaging data - cell segmentation - is a critical task for various cellular imaging experiments. While deep learning methods have led to substantial progress on this problem, models that have seen wide use are specialist models that work well for specific domains. Methods that have learned the general notion of "what is a cell" and can identify them across different domains of cellular imaging data have proven elusive. In this work, we present CellSAM, a foundation model for cell segmentation that generalizes across diverse cellular imaging data. CellSAM builds on top of the Segment Anything Model (SAM) by developing a prompt engineering approach to mask generation. We train an object detector, CellFinder, to automatically detect cells and prompt SAM to generate segmentations. We show that this approach allows a single model to achieve state-of-the-art performance for segmenting images of mammalian cells (in tissues and cell culture), yeast, and bacteria collected with various imaging modalities. To enable accessibility, we integrate CellSAM into DeepCell Label to further accelerate human-in-the-loop labeling strategies for cellular imaging data. A deployed version of CellSAM is available at https://label-dev.deepcell.org/

Synergy between CD26/DPP-IV Inhibition and G-CSF Improves Cardiac Function after Acute Myocardial Infarction

SummaryIschemic cardiomyopathy is one of the main causes of death, which may be prevented by stem cell-based therapies. SDF-1α is the major chemokine attracting stem cells to the heart. Since SDF-1α is cleaved and inactivated by CD26/dipeptidylpeptidase IV (DPP-IV), we established a therapeutic concept—applicable to ischemic disorders in general—by combining genetic and pharmacologic inhibition of DPP-IV with G-CSF-mediated stem cell mobilization after myocardial infarction in mice. This approach leads to (1) decreased myocardial DPP-IV activity, (2) increased myocardial homing of circulating CXCR-4+ stem cells, (3) reduced cardiac remodeling, and (4) improved heart function and survival. Indeed, CD26 depletion promoted posttranslational stabilization of active SDF-1α in heart lysates and preserved the cardiac SDF-1-CXCR4 homing axis. Therefore, we propose pharmacological DPP-IV inhibition and G-CSF-based stem cell mobilization as a therapeutic concept for future stem cell trials after myocardial infarction

THE UNIQUENESS THEOREM FOR ROTATING BLACK HOLE SOLUTIONS OF SELF-GRAVITATING HARMONIC MAPPINGS

We consider rotating black hole configurations of self-gravitating maps from spacetime into arbitrary Riemannian manifolds. We first establish the integrability conditions for the Killing fields generating the stationary and the axisymmetric isometry (circularity theorem). Restricting ourselves to mappings with harmonic action, we subsequently prove that the only stationary and axisymmetric, asymptotically flat black hole solution with regular event horizon is the Kerr metric. Together with the uniqueness result for non-rotating configurations and the strong rigidity theorem, this establishes the uniqueness of the Kerr family amongst all stationary black hole solutions of self-gravitating harmonic mappings.Comment: 18 pages, latex, no figure

A Self-Reference False Memory Effect in the DRM Paradigm: Evidence from Eastern and Western Samples

It is well established that processing information in relation to oneself (i.e., selfreferencing) leads to better memory for that information than processing that same information in relation to others (i.e., other-referencing). However, it is unknown whether self-referencing also leads to more false memories than other-referencing. In the current two experiments with European and East Asian samples, we presented participants the Deese-Roediger/McDermott (DRM) lists together with their own name or other people’s name (i.e., “Trump” in Experiment 1 and “Li Ming” in Experiment 2). We found consistent results across the two experiments; that is, in the self-reference condition, participants had higher true and false memory rates compared to those in the other-reference condition. Moreover, we found that selfreferencing did not exhibit superior mnemonic advantage in terms of net accuracy compared to other-referencing and neutral conditions. These findings are discussed in terms of theoretical frameworks such as spreading activation theories and the fuzzytrace theory. We propose that our results reflect the adaptive nature of memory in the sense that cognitive processes that increase mnemonic efficiency may also increase susceptibility to associative false memories

COL4A2 is associated with lacunar ischemic stroke and deep ICH: Meta-analyses among 21,500 cases and 40,600 controls

Objective: To determine whether common variants in familial cerebral small vessel disease (SVD) genes confer risk of sporadic cerebral SVD. Methods: We meta-analyzed genotype data from individuals of European ancestry to determine associations of common single nucleotide polymorphisms (SNPs) in 6 familial cerebral SVD genes (COL4A1, COL4A2, NOTCH3, HTRA1, TREX1, and CECR1) with intracerebral hemorrhage (ICH) (deep, lobar, all; 1,878 cases, 2,830 controls) and ischemic stroke (IS) (lacunar, cardioembolic, large vessel disease, all; 19,569 cases, 37,853 controls). We applied data quality filters and set statistical significance thresholds accounting for linkage disequilibrium and multiple testing. Results: A locus in COL4A2 was associated (significance threshold p , 3.5 3 1024) with both lacunar IS (lead SNP rs9515201: odds ratio [OR] 1.17, 95%confidence interval [CI] 1.11-1.24, p 56.62 31028) and deep ICH (lead SNP rs4771674: OR 1.28, 95%CI 1.13-1.44, p 55.76 3 1025). A SNP in HTRA1 was associated (significance threshold p , 5.5 3 1024) with lacunar IS (rs79043147: OR 1.23, 95%CI 1.10-1.37, p 5 1.90 3 1024) and less robustly with deep ICH. There was no clear evidence for association of common variants in either COL4A2 or HTRA1 with non-SVD strokes or in any of the other genes with any stroke phenotype