4 research outputs found
Trends in urinary tract infection hospitalization in older adults in Spain from 2000-2015
- Author
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/09/2021
- Field of study
Objective: To analyze trends in urinary tract infection hospitalization (cystitis, pyelonephritis, prostatitis and non-specified UTI) among patients over 65 years in Spain from 2000-2015. Methods: We conducted a retrospective observational study using the Spanish Hospitalization Minimum Data Set (CMBD), with codifications by the International Classification of Diseases (ICD-9). We collected data on sex, age, type of discharge, main diagnosis, comorbid diagnosis, length of stay, and global cost. All the hospitalizations were grouped by age into three categories: 65-74 years old, 75-84 years old, and 85 years old and above. In the descriptive statistical analysis, crude rates were defined as hospitalizations per 1,000 inhabitants aged ≥65. To identify trends over time, we performed a Joinpoint regression. Results: From 2000-2015, we found 387,010 hospitalizations coded as UTIs (54,427 pyelonephritis, 15,869 prostatitis, 2643 cystitis and 314,071 non-specified UTI). The crude rate of hospitalization for UTIs between 2000 and 2015 ranged from 2.09 in 2000 to 4.33 in 2015 Rates of hospitalization were higher in men than in women, except with pyelonephritis. By age group, higher rates were observed in patients aged 85 years or older, barring prostatitis-related hospitalizations. Joinpoint analyses showed an average annual percentage increase (AAPC) in incidence rates of 4.9% (95% CI 3.2;6.1) in UTI hospitalizations. We observed two joinpoints, in 2010 and 2013, that found trends of 5.5% between 2000 and 2010 (95% CI 4.7;6.4), 1.5% between 2010 and 2013 (95% CI -6.0;9.6) and 6.8% between 2013 and 2015 (95% CI -0.3;14.4). Conclusions: The urinary infection-related hospitalization rate in Spain doubled during the period 2000-2015. The highest hospitalization rates occurred in men, in the ≥85 years old age group, and in non-specified UTIs. There were increases in all types of urinary tract infection, with non-specified UTIs having the greatest growth. Understanding these changing trends can be useful for health planning.This study has been funded by Instituto de Salud Carlos III through the project “PI19/01700”, as part of the Plan Estatal de I+D+I 2017-2020 co-funded by European Regional Development Fund (ERDF) “A way of shaping Europe”. In addition, the principal investigator JRS received support to increase his research activities and to publish this manuscript from the 2020 funding program of the Fundación de Investigación e Innovación Biosanitaria en Atención Primaria (FIIBAP), Community of Madrid.S
Ticagrelor in patients with diabetes and stable coronary artery disease with a history of previous percutaneous coronary intervention (THEMIS-PCI) : a phase 3, placebo-controlled, randomised trial
- Author
- Abbott J
- Abe Mitsuru
- Abouglila Kamal
- Abrahamovych Orest
- Abu-Fadel Mazen
- Accini Jose
- Acikel Sadik
- Adhyapak Srilakshmi
- Agaiby John
- Aggarwala Guarav
- Aguilera Roberto M
- Ahn Taehoon
- Aksentiev Sergei
- Akyea-Djamson Ayim
- Al-Amin Jessie
- Al-Faleh Hussam
- Al-Saif Shukri
- Al-Shehri Abdullah
- Al-Zoebi Ayham
- Aladellie Layth
- Albisu Juan
- Alfata Sarab
- Alshehri Halia
- Alvarado Odilon
- Alvarez Jose
- Alvarisqueta Andres
- Amerena John
- Amerena John
- Amin Amit
- Amoroso Giovanni
- Andersson Marielle
- Andersson Marielle
- Andersson Marielle
- Andrawis Nabil
- Andries Alin
- Andrássy Péter
- Angerås Oskar
- Angiolillo Dominick
- Angoulvant Denis
- Ansari Saadat
- Antalik Lubomir
- Aoyama Takahiko
- Appel Karl-Friedrich
- Arana Camilo
- Arat Alev
- Arbanil Hugo
- Arora Satish
- Arriagada German
- Arshad Tamjeed
- Arslan Sakir
- Arvind Moogali
- Arya Ktut
- Asenjo Roberto M
- Asfour Wail
- Askar Alfredo N
- Assanelli Emilio
- Atieh Mahmoud
- Auer Johann
- Avino David
- Babapulle Mohan
- Babilonia Noe
- Babilonia Noe A
- Bae Jang-Whan
- Baglikov Andrey
- Bailey Allan
- Bailey Gordon
- Bain Stephen
- Bakai Judit
- Bakhtari Ladan
- Ballyuzek Marina
- Bander Jeffrey
- Bandh Stellan
- Banerjee Subhash
- Banerjee Supratim
- Banerjee Suvro
- Barabashkina Anna
- Baracioli Luciano
- Barbarash Olga
- Barbas Benny
- Barettella Mark
- Bashkin Amir
- Basiak Marcin
- Baszak Jacek
- Bata Iqbal
- Bauer Michael
- Bayat Junaid
- Bazari Rasha
- Bednarova Jana
- Behnke Thomas
- Bell Alan
- Belle-Isle Jasmin
- Bellotti Sandro
- Belohlavek Jan
- Benczur Bela
- Bennett James
- Berg-Johansen Jan
- Berger Rudolf
- Berrospi Percy
- Bertolet Barry
- Bertrand Olivier
- Bertsch John
- Besada Diego
- Bessoudo Ricardo
- Beth Mary
- Bhargava Anuj
- Bhatt Deepak L
- Bhatt Deepak L
- Bhavsar Janak
- Bijata-Bronisz Renata
- Bittar George
- Bitters J'Cinda
- Black Robert
- Blagden Mark
- Blanco Antonio
- Blick David
- Bochenek Anna
- Boldueva Svetlana
- Bolshoun David
- Bonansea Teresa C
- Bongo Angelo S
- Bordonava Anselmo
- Borges Joao
- Borisov Borislav
- Bortnick Anna
- Bos Robert
- Botelho Roberto
- Botero Rodrigo
- Botero Rodrigo
- Bott Jochen
- Bouza Manuel
- Boyrazian Hagop
- Brabham David
- Braganza Denise
- Brath Helmut
- Brockmyre Andrew
- Broker Robert
- Brown Christopher
- Buchbinder Maurice
- Bueno Héctor
- Bugan Viliam
- Bula Larysa
- Burgess Lesley
- Busak Ladislav
- Busch Robert
- Busz-Papiez Benita
- Butman Samuel
- Buysschaert Ian
- Byanov Kolyo
- Cabrera Walter
- Calabrò Paolo
- Cantu Elias G
- Cantú Arnulfo G
- Carda Jiri
- Cardona Jose
- Carell Edgar
- Carnero Gabriela
- Carrasco Jose P
- Carrillo Luis V
- Cartwright Simon
- Castillo Armando G
- Cauthen Brett
- Cayla Guillaume
- Cercato Cintia
- Cermak Ondrej
- Cerqueira Maria J
- Ceyhan Ceyhun
- Cha James
- Cha Kwang S
- Chacon Carolina
- Chae In-Ho
- Chae Jei-Keon
- Chag Milan
- Chai Yingru
- Chamnarnphol Noppadol
- Chan Michael
- Chan Shih-Hung
- Chang Kiyuk
- Chang Kuan-Cheng
- Chatrathi Sridhar
- Chavez Carlos
- Chehayeb Raja
- Cheirif Jorge
- Chen Jersey
- Chen Jersey
- Chen Zhih-Cherng
- Chernyavsky Alexander
- Cheung Deanna
- Cheung Stephen
- Chhabra Anil
- Chiang Chern
- Chiang Chern-En
- Choi Si-Wan
- Choi Young J
- Chompalova Boryana
- Chorin Ehud
- Chouinard Guy
- Cinteza Mircea
- Clavijo Leonardo
- Clifford Piers
- Cobos Jorge
- Coching Raul M
- Coetzee Kathleen
- Colfer Harry
- Colquhoun David
- Coman Ioan
- Conejeros Carlos
- Constance Christian
- Corbalan Ramon
- Corbalán Ramón
- Corder Clinton
- Cordova Fernando
- Cornel Jan H
- Cornel Jan H
- Cortada Jorge B
- Cottin Yves
- Coussement Patrick
- Cox John
- Creteanu Mihai
- Crijns Hendrikus
- Curiac Dan
- Cygler Jerzy
- Cymerman Krzysztof
- Czigány Anna
- Czochra Wojciech
- Czyzycki Mariusz
- D'Agostino Ronald
- D'Urso Michael
- Dada Fredy T
- Dalby Anthony
- Dalby Anthony J
- Danchin Nicolas
- Danchin Nicolas
- Dantzig Jan-Melle
- Darius Harald
- Dart Anthony
- Das Asit
- Dawood Saleem
- de Cosmo Salvatore
- de la Torre Hernández José M
- de Labriolle Axel
- de los Ríos Ibarra Manuel
- de Luca Leonardo
- de Maeseneire Stefan
- de Melker Edwin
- de Nooijer Cornelis
- de Souza Weimar
- Debs-Perez Giselle
- Decoulx Eric
- Dedek Vratislav
- Deering Joseph
- DeGregorio Michele
- Dehghani Payam
- del Blanco Bruno G
- Delforge Marc
- Demchenko Elena
- Desai Pratik
- Deyoung Michael
- Di Pasquale Giuseppe
- Diaz Rafael
- Diaz Rafael
- Dickert Jim
- Didenko Yury
- Dimov Bojidar
- Dincheva Adriana
- Dion Danielle
- Distiller Lawrence
- Dixen Ulrik
- Do Huan
- Dobreanu Viorica
- Doi Tomofumi
- Dolzhenko Maryna
- Domínguez Antonio R
- Dong Xiaolin
- Dor Isaac
- Dorsch Micha
- dos Santos Fabio R
- Dotsenko Sergiy
- Doyle Timothy
- Drelich Grzegorz
- Drexel Heinz
- Drozd Marcin
- Dubreuil Olivier
- Dumas Richard
- Duronto Ernesto
- Dutra Oscar
- Dy Johnny
- Dzhaiani Nino
- Díaz Fernández José F
- Díaz Francisco F
- Eaves William
- Ebenbichler Christoph
- Eder Frank
- Edin Anton
- Egstrup Kenneth
- Eki Yutaka
- El Salah
- El-Amin Omer
- Elamin Omer
- Elbaz Meyer
- Elbl Lubomir
- Eliaschewitz Freddy
- Emerson Ronald
- Ereño Ainhoa R
- Erlinge David
- Ermoshkina Lyudmila
- Eshaghian Shervin
- Estrada José N
- Ezhov Andrey
- Faes Dirk
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- Farsky Stefan
- Fazekas Frantisek
- Feldman Robert
- Fernández Portales Francisco J
- Ferrario Emile
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- Ferrolino Arthur
- Figueiredo Estevao
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- Fil Wojciech
- Fillat Angel C
- Fischer Sabine
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- Fließer-Görzer Evelyn
- Fontaine Caroline
- Forgosh Leslie
- Forte Adriana
- Fortes Jose A
- Foster Malcolm
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- Fourie Nyda
- Fox Kim
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- Fulop Peter
- Furkalo Sergiy
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- Förster Andreas
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- Gadkari Milind
- Gallo Richard
- Galski Thomas
- Galyavich Albert
- Gamba Marco A
- Gandelman Glenn
- Ganim Ricky
- Gaona Raul
- Garas Samer
- García Lledó José A
- García Celso
- García Joel D
- Gardner Timothy
- Gaudet Daniel
- Gazmuri Raul
- Ge Junbo
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- Georgiev Svetoslav
- Georgieva Nikolina
- Gibbs Charlotte
- Gigliotti Osvaldo
- Glushko Liubomyr
- Gniot Jacek
- Godoy Armando
- Gogia Harinder
- Gogov Antoni
- Goldberg Cindy
- Goldberg Ronald
- Gomez-Cortes Jose
- Gonzalez Julian
- Gonzalez-Ortiz Elena
- González Juanatey José R
- González Alfonso S
- González Rosa S
- González Vicente B
- Goodfellow Ross
- Gordon Paul
- Gosparini Diego M
- Gossard Denis
- Gosselin Gilbert
- Goto Shinya
- Goto Shinya
- Goto Shinya
- Goube Pascal
- Gowdaiah Prakash
- Graham Bruce
- Graham John
- Gravdal Stein A
- Green Sandy
- Greenberg Gabriel
- Grena Paul
- Greschik István
- Gring Christian
- Grunfeldova Hana
- Guedes Antoine
- Guerra Yamirka D
- Guerrero Diego B
- Guillen Mario
- Guimaraes Fabio
- Guitton Javier
- Gullestad Lars
- Gupta Dinesh
- Guray Umit
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- Haddad Tariq
- Hage-Korban Elie
- Hagemeier Robert
- Hahn Joo-Yong
- Haisheva Larisa
- Hajek Petr
- Hall Jason
- Halperin Frank
- Hamilton Andrew
- Hammett Christopher
- Hammond Peter
- Handel Franklin
- Handelsman Yehuda
- Hansen Ole
- Hanson Lenita
- Hanusch Ursula
- Hargrove Joeseph
- Haro Jaime M
- Harrington Robert A
- Harrington Robert A
- Hart Randy
- Hart Terence
- Hartikainen Juha
- Hasegawa Toru
- HASH(0x55aa09b7f480)
- Hata Yoshiki
- Haught W H
- Hawa Zafir
- Hazan Lydie
- He Lanjie
- He Yong
- Hearne Steven
- Heath John
- Hedman Anders
- Hegde Vinayak
- Hei Pak
- Held Claes
- Hella Brent
- Henein Sam
- Hennig Dirk
- Henry Sheldon
- Heredia Javier
- Hernandes Mauro
- Higashiue Shinichi
- Hill Laurie
- Himmelmann Anders
- Himmelmann Anders
- Himmelmann Anders
- Hiotis Louis
- Hirohata Atsushi
- Hissa Miguel
- Hoffer Etienne
- Hoffman David
- Hofseth Ola D
- Hollanders Geert
- Holmvang Lene
- Hominal Miguel
- Hong Soon J
- Honkova Michaela
- Hoosen Farzana
- Horak Adrian
- Horibe Eishun
- Horoshko Olha
- Hotchkiss David
- Hou Charles
- Hsia Chien-Hsun
- Hsieh I-Chang
- Huang Wenjun
- Huber Kurt
- Huber Kurt
- Huling Randall
- Huth Mark
- Huynh Thao T
- Hwang Jin-Yong
- Idogaki Akira
- Iliev Nikolay
- Ilieva Katya
- Ing Douglas
- Iosipescu Laura C
- Isaza Daniel
- Ishiki Ryoji
- Istratoaie Octavian
- Iteld Bruce
- Izzo Mark
- Jaafar Feeroz
- Jaffrani Naseem
- Jagielo Ted
- Jain Ashit
- James Stefan K
- James Stefan K
- Jamil-Copley Shahnaz
- Jamriskova Livia
- Jankowski Maciej
- Janssens Luc
- Jaramillo Nicolás
- Jastrzebski Waldemar
- Javier Julian
- Jensen Jens
- Jensen Lisette O
- Jeong Myung H
- Jeong Myung H
- Jerabek Ondrej
- Jeserich Michael
- Jesionowski Pawel
- Jetty Preetham
- Jingo Ahmad
- Johnston Janice
- Johnston Nina
- Jones David
- Juhász Ferenc
- Junior Delcio S
- Jurowiecki Jaroslaw
- Kaczmarek Barbara
- Kadokami Toshiaki
- Kakinoki Shigeo
- Kakuta Tsunekazu
- Kamalov Gadel
- Kanadasi Mehmet
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- Kannarkat Vinod
- Kanorskiy Sergey
- Kantaros Louis
- Kapp Cornelia
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- Karakolev Venelin
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- Karim Amin
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- Karpov Yuri
- Kasper Joseph
- Kassam Saleem
- Kawamitsu Katsunori
- Kawasaki Satsuki
- Kaydashev Igor
- Kazakov Andrei
- Keeling Philip
- Kekki Sakari
- Kelberman Michael
- Kelly Allan
- Kemp Susan
- Kerr Saraiva José F
- Khaira Ajit
- Khan Ahtaram
- Khan Misal
- Khasanov Niyaz
- Khirmanov Vladimir
- Khlevchuk Tatiana
- Khomazyuk Tetyana
- Khovaeva Yaroslava
- Khrustalev Oleg
- Khurana Charanjit
- Khusrawi Alamdar
- Kichura George
- Kim Byung J
- Kim Doo-Il
- Kim Weon
- Kinasz Leszek
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- Kiss Robert G
- Kiss Róbert G
- Kiyosue Arihiro
- Kizhakekuttu Tinoy
- Kjærnli Thorbjørn
- Klausmann Gerhard
- Klutstein Marc
- Kobielusz-Gembala Iwona
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- Koleny Daniel
- Kolodziej Piotr
- Kolomanov Borislav
- Komatsu Sei
- Konczakowski Piotr
- Kondov Rumen
- Kong Xiangqing
- Konieczny Marek
- Konstantinov Vladimir
- Konteva Mariana
- Kontny Frederic
- Koo Bon K
- Kooy Jacobus
- Kopylov Philipp
- Korecki Janusz
- Kormann Adrian
- Korn David
- Korol Marek
- Korpas Denes
- Korzeniak Romuald
- Korányi László
- Kos Pavel
- Kosiborod Mikhail
- Kosiborod Mikhail N
- Kosiborod Mikhail N
- Kosmacheva Elena D
- Kosmicki Douglas
- Kostenko Victor
- Koszek Alina
- Kouz Simon
- Kovář František
- Koziolova Natalia
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- Kravchenko Anatoliy
- Krcova Eva
- Kristensen Dalby
- Kristensen Steen D
- Krolick Merrill
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- Kumar Priya
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- Kuusela Matti
- Kuznetsov Vadim
- Kyrychenko Igor
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- Labroo Ajay
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- Lappegård Knut T
- Larnefeldt Hans
- Laskowska-Derlaga Ewa
- Lawson William
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- Lee Tsung-Ming
- Lehman Ronald
- Leichter Steven
- Leiter Lawrence A
- Leiter Lawrence A
- Leiter Lawrence A
- Lendel Irina
- Leon Lucio
- Leonsson-Zachrisson Maria
- Lepor Norman
- Lev Eli
- Levchenko Olena
- Levinson Larry
- Lewis Basil
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- Li Hongwei
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- Liberman Alberto
- Libov Igor
- Lieber Ira
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- Lindholm Carl-Johan
- Linjawi Sultan
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- Liu Ming-En
- Liu Zhigang
- Liutkus Joanne F
- Lloret Ramon
- Lo Eric
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- Londono Juan
- Lopez Gabriel R
- Lorraine Richard
- Losa Beata
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- Luckow Anders
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- Luo Ming
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- López Víctor G
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- Mariankowski Rafal
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- Markov Dimitar
- Markov Valentin
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- Martinez Guillermo R
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- Mayordomo Petra S
- Mazur Stanislaw
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- McMurray John
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- Mediavilla García Juan D
- Medina Felix
- Medina Felix
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- Mehta Arvind
- Mehta Rajendra
- Mehta Shamir
- Mehta Shamir R
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- Mehta Vimal
- Merkely Béla
- Mesa Juan G
- Michalaros Yorghos
- Michalik Daniel
- Michisanti Massimo
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- Navarro Manuel J
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- Ortuño Francisco M
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- Panov Alexey
- Pansieri Michel
- Papp Andras
- Park Hun S
- Park Woo J
- Park Yong H
- Parkhomenko Alexander
- Parkhomenko Alexander N
- Parkhomenko Oleksandr
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- Paulweber Bernhard
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- Ragonese Mauro
- Rahman Aref
- Raisinghani Ajit
- Rajan Raj
- Ramamurthee Kannaiyan
- Ramanathan Krishnan
- Ramos López Gabriel A
- Randeva Harpal S.
- Range Gregoire
- Ranjith Naresh
- Rao Sunder
- Rasmussen Ole
- Rasputina Lesya
- Rassi Nelson
- Ray Kausik K
- Ray Kausik K
- Reddy Jeevren
- Reddy M
- Refsgaard Jens
- Regalado Susana
- Reis Gilmar
- Repin Alexey
- Reshotko Dmytro
- Reszka Zygfryd
- Reuter Hannes
- Revtyak George
- Rewerska Barbara
- Reznik Elena
- Rha Seung W
- Richwine Randall
- Ridderstråle Wilhelm
- Ridderstråle Wilhelm
- Rieker Werner
- Rihacek Ivan
- Risberg Knut
- Rishko Mykola
- Rista Lucas
- Rodriguez Aldo
- Rodriguez Lilia
- Rodriguez Manuel
- Rodriguez Mara
- Rodriguez Victor
- Roguin Ariel
- Rohr Kathryn
- Roman Oscar
- Roman-Miranda Amaury
- Romanowski Leszek
- Romo Andrés Í
- Ronner Eelko
- Rosas Enrique L
- Roseman Hal
- Rosen Robert
- Rossi Paulo
- Rozenman Yoseph
- Ruda Mikhail
- Rudenko Leonid
- Ruiz Nodar Juan M
- Ruiz Jose
- Rummel Reinhard
- Runev Nikolai
- Rupka Dennis
- Rusev Nikolay
- Rusicka Teresa
- Rusinov Veselin
- Russo Michael
- Ruíz José G
- Sabbah Eric
- Saini Satinder
- Sakuragi Satoru
- Salinas Carlos A
- Samaan Rodney
- Sanchez Carlos G
- Sandoval Jorge
- Sansanayudh Nakarin
- Santos Queulla
- Santos Vladimir
- Saporito Wladmir
- Saraiva José
- Sasaki Kenichiro
- Sathe Prachee
- Sato Tomohiko
- Sauter Joachim
- Sawhney Jitendra S
- Saxena Manish
- Schenkenberger Isabelle
- Schernthaner Gerit-Holger
- Schiavi Beatriz
- Schmedtje John
- Schmidt Ekkehard
- Schnack Christoph
- Schock Joel
- Schön Norbert
- Seki Kozaburo
- Senni Michele
- Sergienko Igor
- Sernia Virginia
- Severino Norma
- Shah Gopi
- Shah Mahesh
- Shaheen Wassim
- Shalaev Sergey
- Shammas Nicolas
- Shanes Jeffrey
- Sharma Susheel
- Sharman David
- Sharp Andrew
- Shealy Neal
- Sheu Huey-Herng
- Shibasaki Taro
- Shin Won-Yong
- Shukla Dinkar
- Shurmur Scott
- Shustov Sergey
- Shutemova Elena
- Shvarts Yuri
- Shyu Kou-Gi
- Sicer Maximiliano
- Siega Anthony D
- Silva Frederico
- Silver Marc
- Simon Tabassome
- Simon Tabassome
- Simonis Gregor
- Simpson Patrick
- Singal Dinesh
- Singal Robert
- Singh Deovrat
- Singh Narendra
- Singh Pradeep
- Singh Sanjay
- Sinnaeve Peter
- Sinnaeve Peter R
- Siu Shing C
- Sivak Vladimir
- Sizova J M
- Skalicka Hana
- Skierkowska Joanna
- Skjelvan Gunnar
- Skura Marek
- Skwarna Bartosz
- Slaby Josef
- Sliwinska Teresa
- Smilov Lachezar
- Smith Ray
- Smith Simon
- Smith Stephen
- Smolenskaya Olga
- Sokolova Liubov
- Solis Silvana
- Song Yang
- Song Zhifang
- Sonoda Masahiro
- Sookananchai Bancha
- Sopko Karen
- Sorbets Emmanuel
- Sorokina Inna
- Sorokivskyy Mykhaylo
- Sotolongo Rodolfo
- Souza Juliana
- Spinale Francis
- Spinar Jindrich
- Spiridon Marilena
- Srimahachota Suphot
- Srivastava Sunny
- St-Maurice Francois
- Stammen Francis
- Stanchev Georgi
- Stanciulescu Gabriela
- Stania Karol
- Staniloae Cezar
- Stanislavchuk Mykola
- Starczewski Pawel
- Stasinska Teresa
- Steg Philippe G
- Steg Philippe G
- Steg Philippe Gabriel
- Stolarczyk-Sowa Edyta
- Stone Jay
- Storey Robert
- Strand Jorma
- Strandberg Timo
- Strbova Jaroslava
- Striekwold Harry
- Strikwerda Sipke
- Strojek Krzysztof
- Stryuk Raisa
- Su Xi
- Such Slavomir
- Sudnik Wanda
- Sueyoshi Atsushi
- Sugino Hiroshi
- Sugiura Tatsushi
- Suh David
- Suneja Randeep
- Supryadkina Tatiana
- Suresh Damodhar
- Sussex Bruce
- Sutton Jennefer
- Suzuki Masahiro
- Svyshchenko Yevgeniya
- Swanson Neil
- Sychov Oleg
- Syed Faizullah
- Syed Mushtaq
- Sykulski Roman
- Szczasny Marcin
- Sztembis Rafal
- Szynal Slawomir
- Sánchez Raul V
- Sárszegi Zsolt
- Sørensen Torben
- Taggeselle Jens
- Taheri Hamid
- Tahk Seung-Jea
- Takagi Yuichiro
- Takase Shinichi
- Takenaka Takashi
- Takács János
- Tan Edgar
- Tan Michinao
- Tanajura Luiz
- Tao Liang
- Tarasov Nikolay
- Taurio Jyrki
- Teefy Patrick
- Teliatnikova Zinaida
- Tenev Doncho
- Terrelonge Antonio
- Thadani Udho
- The Salem
- The Salem
- The Salem
- Theron Rust
- Thomas Dustin
- Tihchev Tihomir
- Timmermans Patrick
- Tisheva Snezhanka
- Tokmakova Maria
- Tomala Tadeusz
- Tomobuchi Yoshiaki
- Tonnessen Glen
- Torres Gustavo
- Toursarkissian Nicole
- Treasure Charles
- Trenk Dietmar
- Treshkur Tatiana
- Tresukosol Damras
- Tresukosol Damras
- Trevisan Roberto
- Trokis Julien
- Truong Binh
- Tsang Chiu C
- Tse Hung F
- Tseluyko Vira
- Tseng Wei-Kung
- Tsujimoto Mitsuru
- Tsyba Larisa
- Turi Tibor
- Turner Traci
- Turturo Maurizio
- Ueda Osamu
- Uehara Hiroki
- Ueng Kwo-Chang
- Ueno Hideki
- Uguccioni Massimo
- Umpierrez Guillermo
- Urbach Dorothea
- Urban Miroslav
- Urbano Rafael H
- Urbinati Stefano
- Uretsky Barry
- Utsu Noriaki
- Uzunow Anna
- Vaca Carlos
- Vakaliuk Igor
- Valle Timo
- Vallejo Gregorio S
- van de Wal Ruud
- van den Heuvel Christian
- van der Zwaan Coen
- van Eck Martijn
- van Kesteren Henricus
- van Zyl Louis
- Varbella Ferdinando
- Varleta Paola
- Vasconcellos Eduardo
- Vasilyeva Larisa
- Vatova Ralitsa
- Vega Damaris
- Velichko Nataliia
- Vera Tomás R
- Vervoort Geert
- Verwerft Jan
- Viktorova Inna
- Vilamajo Oscar G
- Villablanca Alex
- Vinanska Daniela
- Vinereanu Dragos
- Vinereanu Dragos
- Vishneva Elena
- Vishnevsky Alexander
- Viswanathan Girish
- Vizel Saul
- Viñas Jaime A
- Vlastaris Anthony
- von Engelhardt Charlotte
- von Münchhausen Candy
- Vora Kishor
- Voyce Steven
- Vrolix Mathias
- Vykoukalova Tatiana
- Wang Hao
- Wang Ji-Hung
- Wang Yi-Chih
- Weiderman Ann-Charlotte
- Weigmann Ingo
- Weirick Troy
- Weiss Melvin
- Welch Michelle
- Welter Ryan
- Werner Henri
- Westendorp Iris
- Whelan Alan
- Widimský Petr
- Wierucki Lukasz
- Wilderman Igor
- Wilke Andreas
- Willems Frank
- Willis John
- Wilson Vance
- Wilson William
- Wiseman Alan
- Witek Robert
- Wojcik Ronald
- Wojnowski Lukasz
- Wolzt Michael
- Wong Brian
- Wong Michelle
- Wongvipaporn Chaiyasith
- Woolf Kevin
- Worthley Matthew
- Wozakowska-Kaplon Beata
- Wu Chih-Cheng
- Wu Yen-Wen
- Wujkowski Marek
- Yagensky Andriy
- Yakushin Sergey
- Yalcin Ahmet
- Yamamoto Fumi
- Yaneva Zdravka
- Yeh Hung-I
- Ying Man
- Yokoya Koichi
- Yoon Junghan
- Young Douglas
- Younis Liwa
- Yuan Zuyi
- Zadra Remo
- Zakharov Konstantin
- Zakhary Bosh
- Zaman Azfar
- Zamorano Gómez José L
- Zangroniz Pedro
- Zaniewski Michelle
- Zanini Alejandra
- Zarich Stuart
- Zateyschikova Anna
- Zateyshchikov Dmitry A
- Zebrack James
- Zelazowska Katarzyna
- Zhang Aidong
- Zhang Jian
- Zhang Ningru
- Zhang Wenwu
- Zhao Qiang
- Zhao Qiang
- Zhao Xue-Qiao
- Zharinova Viktoria
- Zidkova Eva
- Zilahi Zsolt
- Zinka Elzbieta
- Zonova Elena
- Zubeeva Galina
- Zucconi-Mazzini Roberto
- Zurakowski Aleksander
- Zólyomi Szilárd
- Édes István
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2019
- Field of study
Background:
Patients with stable coronary artery disease and diabetes with previous percutaneous coronary intervention (PCI), particularly those with previous stenting, are at high risk of ischaemic events. These patients are generally treated with aspirin. In this trial, we aimed to investigate if these patients would benefit from treatment with aspirin plus ticagrelor.
Methods:
The Effect of Ticagrelor on Health Outcomes in diabEtes Mellitus patients Intervention Study (THEMIS) was a phase 3 randomised, double-blinded, placebo-controlled trial, done in 1315 sites in 42 countries. Patients were eligible if 50 years or older, with type 2 diabetes, receiving anti-hyperglycaemic drugs for at least 6 months, with stable coronary artery disease, and one of three other mutually non-exclusive criteria: a history of previous PCI or of coronary artery bypass grafting, or documentation of angiographic stenosis of 50% or more in at least one coronary artery. Eligible patients were randomly assigned (1:1) to either ticagrelor or placebo, by use of an interactive voice-response or web-response system. The THEMIS-PCI trial comprised a prespecified subgroup of patients with previous PCI. The primary efficacy outcome was a composite of cardiovascular death, myocardial infarction, or stroke (measured in the intention-to-treat population).
Findings:
Between Feb 17, 2014, and May 24, 2016, 11 154 patients (58% of the overall THEMIS trial) with a history of previous PCI were enrolled in the THEMIS-PCI trial. Median follow-up was 3·3 years (IQR 2·8–3·8). In the previous PCI group, fewer patients receiving ticagrelor had a primary efficacy outcome event than in the placebo group (404 [7·3%] of 5558 vs 480 [8·6%] of 5596; HR 0·85 [95% CI 0·74–0·97], p=0·013). The same effect was not observed in patients without PCI (p=0·76, p interaction=0·16). The proportion of patients with cardiovascular death was similar in both treatment groups (174 [3·1%] with ticagrelor vs 183 (3·3%) with placebo; HR 0·96 [95% CI 0·78–1·18], p=0·68), as well as all-cause death (282 [5·1%] vs 323 [5·8%]; 0·88 [0·75–1·03], p=0·11). TIMI major bleeding occurred in 111 (2·0%) of 5536 patients receiving ticagrelor and 62 (1·1%) of 5564 patients receiving placebo (HR 2·03 [95% CI 1·48–2·76], p<0·0001), and fatal bleeding in 6 (0·1%) of 5536 patients with ticagrelor and 6 (0·1%) of 5564 with placebo (1·13 [0·36–3·50], p=0·83). Intracranial haemorrhage occurred in 33 (0·6%) and 31 (0·6%) patients (1·21 [0·74–1·97], p=0·45). Ticagrelor improved net clinical benefit: 519/5558 (9·3%) versus 617/5596 (11·0%), HR=0·85, 95% CI 0·75–0·95, p=0·005, in contrast to patients without PCI where it did not, p interaction=0·012. Benefit was present irrespective of time from most recent PCI.
Interpretation:
In patients with diabetes, stable coronary artery disease, and previous PCI, ticagrelor added to aspirin reduced cardiovascular death, myocardial infarction, and stroke, although with increased major bleeding. In that large, easily identified population, ticagrelor provided a favourable net clinical benefit (more than in patients without history of PCI). This effect shows that long-term therapy with ticagrelor in addition to aspirin should be considered in patients with diabetes and a history of PCI who have tolerated antiplatelet therapy, have high ischaemic risk, and low bleeding risk
[The effect of low-dose hydrocortisone on requirement of norepinephrine and lactate clearance in patients with refractory septic shock].
- Author
- Abbey Ianthe
- Abdel Rehim Marwa
- Abdel Rehim Marwa
- Abdul Rahman A
- Abduljawwad Emad
- Abduljawwad Emad
- Abe Emuri
- Abe Ryuzo
- Aboab Jerome
- Aboab Jerome
- Acevedo Juan
- Acharya Anand
- Acquarolo Annamaria
- Acquarolo Annamaria
- Adamzik Michael
- Adamzik Michael
- Adembri Chiara
- Adrie Christophe
- Adrie Christophe
- Afessa Bekele
- Ainoda Yusuke
- Aiyar S
- Al Dabbagh Tarek
- Al Dabbagh Tarek
- Al Knawy Bandar A
- Al Knawy Bandar A
- Al-Abdulkareem Abdulmajeed
- Al-Abdulkareem Abdulmajeed
- Al-Abdulkareem Abdulmajeed
- Al-Abdulkareem Abdulmajeed
- Al-Arabi Rida
- Al-Dorzi Hasan M
- Al-Dorzi Hasan M
- Al-Muhamadi Ali
- Al-Naeeb Yasseen
- Al-Naeeb Yasseen
- Al-Shaer Mohammad
- Al-Shaer Mohammad
- Al-Tamimi Waleed
- Al-Tamimi Waleed
- Alaniz Cesar
- Alevizaki Maria
- Alevizaki Maria
- Alinejad Faranak
- AlJumah Abdulrahman
- AlJumah Abdulrahman
- AlJumah Abdulrahman
- AlJumah Abdulrahman
- AlJumah Abdulrahman
- AlJumah Abdulrahman
- Allolio Bruno
- AlNajjar Taghreed
- AlNajjar Taghreed
- Altintas M A
- Alvarez Jean-Claude Claude
- Alvarez Jean-Claude Claude
- Alvarez Jean-Claude Claude
- Amano Kosaku
- Amano Kosaku
- Amathieu Roland
- Amathieu Roland
- Amathieu Roland
- Amathieu Roland
- Ambriz-Plascencia Ana Rosa
- Ameen Abdelbadee
- Ameen Abdelbadee
- Amini Amir
- Amini Amir
- Amini Amir
- Amos Taryn
- Amour Julien
- Anderegg Brent A
- Anderegg Brent A
- Andersson Liane
- Andersson Liane
- Andrade Bertha Coelho
- Androulakis Ioannis P
- Aneja Rajesh
- Angus Derek C
- Angus Derek C
- Anjum Aisha
- Anjum Aisha
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annetta M
- Antonelli M
- Antonopoulou Anastasia N
- Antonopoulou Anastasia N
- Antonucci E
- Apollonatou Sofia
- Apollonatou Sofia
- Apostolidou Efterpi N
- Apostolidou Efterpi N
- Apostolou K
- Apostolou K
- Arabi Yaseen M
- Arabi Yaseen M
- Arabi Yaseen M
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- Araujo Leonardo V
- Aravinthan Aloysious
- Aravinthan Aloysious
- Arbor Ann
- Arlt Wiebke
- Arlt Wiebke
- Armaganidis Apostolos
- Armaganidis Apostolos
- Armaganidis Apostolos
- Armaganidis Apostolos
- Aronowitz Paul
- Arriagada S Daniela
- Arroyo Vicente
- Arroyo Vicente
- Asahata Sayaka
- Asehnoune Karim
- Asehnoune Karim
- Asfar Pierre
- Asfar Pierre
- Ashby Deborah
- Ashby Deborah
- Ashby Deborah
- Ashby Deborah
- Ashby Deborah
- Ashby Deborah
- Atay Suleyman
- Atrash Jawad
- Atrash Jawad
- Aufort Sophie
- Aufort Sophie
- Augustatou Callirhoe
- Avidan Alexander
- Awasthi Shally
- Aya Hollmann D
- Aya Hollmann D
- Ayestaran Ignacio
- Ayestaran Ignacio
- Ayestaran Jose I
- Ayestaran Jose I
- Azoulay Elie
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- Belkouchi Abdelkader
- Bellissant Eric
- Bellissant Eric
- Bellissant Eric
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- Bellissant Eric
- Bellissant Eric
- Bellissant Eric
- Bellomo Rinaldo
- Bellomo Rinaldo
- Bellomo Rinaldo
- Bellomo Rinaldo
- Benbenishty Julie
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- Blum Claudine A
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- Castanon-Gonzalez Jorge Alberto
- Castel Muriel
- Catravas John
- Cavaliere F
- Cazalis Marie-Angelique
- Cecconi Maurizio
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- Cepkova Magda
- Cepkova Magda
- Cesari-Giordani Jean Francois
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- Cha Stephen S
- Chabre Olivier
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- Chagnon Frederic
- Chagnon Frederic
- Chagnon Jean-Luc
- Chagnon Jean-Luc
- Chaney Whitney
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- Chouinard Lucie
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- Craba A
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- Criado Antonio
- Cruces R Pablo
- Crucian B E
- Cuthbertson Brian H
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- Cuthbertson Brian H
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- Czepielewski Mauro Antonio
- Czepielewski Mauro Antonio
- Czepielewski Mauro Antonio
- Czepielewski Mauro Antonio
- Czeslick Elke
- D'honneur Gilles
- D'honneur Gilles
- D'Silva Celma
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- da Silva Fabiano Pinheiro
- Da Jiping
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- Danner Robert L
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- Davidson Fraser
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- De Gaudio A Raffaele
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- Dellamonica Jean
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- Deshmukh C T
- Deutschman Clifford S
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- Devaux Christian
- Deymann Andreas
- Dhar Rajat
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- Dias Eduardo Pimentel
- Diaz R Franco
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- Diener K R
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- Dijstelbloem Hilde M
- Dimopoulou Ioanna
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- Dimopoulou Ioanna
- Dimopoulou Ioanna
- Dimopoulou Ioanna
- Dimopoulou Ioanna
- Dimopoulou Ioanna
- Dimopoulou Ioanna
- Dizier Stephanie
- Dmello Dayton
- Dobb Geoffrey
- Dobb Geoffrey
- Doctor Allan
- Donal Erwan
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- Donal Erwan
- Donati Yannis
- Dondorp Arjen
- Dong Guijuan
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- Donoso F Alejandro
- Dorin Richard I
- Dorin Richard I
- Dorin Richard I
- dos Santos Jose Wellington A
- Douglas Ivor S
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- Douka Evangelia
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- Du Bin
- Ducrocq Nicolas
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- Duff John
- Dugas Marc-Andre
- Dumaine Robert
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- Duncan Alan
- Dunser Martin W
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- Dupuis Clement
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- Dutta Pinaki
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- El Malki Hadj Omar
- Elatar Sayed L
- Elder Peter A
- Elhadd Tarik A
- Elsenbruch Sigrid
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- Elsouri Naser
- Emonts Marieke
- Engel Christoph
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- Engeland William C
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- Estrada-Y-Martin Rosa M
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- Evans Barry
- Faivre V
- Fang Ji-Tseng
- Fartoukh Muriel
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- Fatemi Mohammad Javad
- Faure Patrice
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- Fede Giuseppe
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- Feldman Jonathan
- Felipe Vanessa
- Felmet Kathryn
- Ferguson D C
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- Fernandez-Balsells Mercedes
- Fernandez-de-Castillo Ana G
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- Ferreira Jason A
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- Festic Emir
- Festti Josiane
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- Festti Luciana
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- Fiaccadori E
- Fick Wilhelmina F
- Fiedler Fritz
- Finfer Simon
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- Finkielman Javier D
- Fiorese Bertilla
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- Fisher Gene
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- Flores-Barrientos Oscar Israel
- Forceville Xavier
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- Forst Helmuth
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- Freivogel Klaus
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- Frey Ulrich H
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- Friedman Gilberto
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- Fries Michael
- Fritz H
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- Frostell Claes
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- Fujita Motoki
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- Gaillard Jean-Luis
- Gallix Benoit
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- Gallo-Payet Nicole
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- Gan Quan
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- Garcia Audwin J
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- Garfield Mark
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- Gaspari R
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- Gellert M
- Gentilhomme Anne
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- Genty Celine
- Gerlach Herwig
- Gerlach Herwig
- Gerlach Herwig
- Gerlach Herwig
- Gerlach Herwig
- Gerlach Herwig
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- Gessner Sophia
- Geurts-Moespot Anneke
- Ghosh Sujoy Shubhra
- Ghosh Sujoy Shubhra
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- Giamarellos-Bourboulis Evangelos J
- Giamarellos-Bourboulis Evangelos J
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- Giannoni Eric
- Gibbs Toby
- Gibson Mary
- Giguere Steeve
- Gilfoyle Elaine
- Gines Pere
- Girbes Armand Roelof Johan
- Girbes Armand Roelof Johan
- Girbes Armand Roelof Johan
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- Giroux Leprieur E
- Gizewski Elke R
- Glass Parisa
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- Gluud C
- Gogos C H
- Goldberg P
- Golden Emmel
- Goldmann Anton
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- Goodman Sergey V
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- Gopal Katherason S
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- Goulart Alessandra Carvalho
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- Graham Petra L
- Grander Wilhelm
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- Gray Nicole D
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- Grechi Serenella
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- Gregg Sara R
- Griesdale Donald E G
- Grigoleit Jan-Sebastian
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- Grion Cintia Magalhaes Carvalho
- Grion Cintia Magalhaes Carvalho
- Groeneveld Arie Bastiaan Johan
- Groeneveld Arie Bastiaan Johan
- Groeneveld Arie Bastiaan Johan
- Groeneveld Arie Bastiaan Johan
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- Groger Andreas
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- Guo Lei
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- Gurlich R
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- Gutierrez Juan
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- Hallett David
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- Hallman Mikko
- Hallstrom Lars
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- Hamitouche Noureddine
- Hammer Fabian
- Han Seo Goo
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- Handschin A E
- Haniffa Rashan
- Hanson James
- Hart Kelsey A
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- Harward Meg
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- Hazelzet Jan A
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- Hou Kuan-Ting
- Hovilehto Seppo
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- Hovilehto Seppo
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- Hraiech Sami
- Hsiao Fone-Ching
- Hsieh Chang-Hsun
- Hsieh Susan
- Hsu Hui-Chi
- Hu Bo
- Hu Bo
- Hua Chung-Ching
- Hua Chung-Ching
- Huang Chun-Jui
- Huang Karen E
- Huang Ruolan
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- Huber-Lang Markus
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- Hyvernat Herve
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- Hyzy Robert
- Ibanez Jordi
- Ibanez Jordi
- Ibanez Jordi
- Ibanez Jordi
- Ibrahim Fidaa
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- Ikka Leon
- Ilias Ioannis
- Ilias Ioannis
- Ilias Ioannis
- Imamoglu Mustafa
- Imeson Lee
- Indyk Justin A
- Ioakeimidou Aikaterini
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- Ismail A
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- Iwaki Noriko
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- Jelastopoulou Eleni
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- Jochberger Stefan
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- Johan Groeneveld A B
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- Jokuszies A
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- Juneja Deven
- Jung Boris
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- Jutla Sukhdeep
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- Kache Saraswati
- Kado-Fong Helen
- Kaidomar Michel
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- Kalafateli Maria
- Kalenka Armin
- Kalpakou Georgia Th
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- Kamarul Iman Musa K
- Kamisoglu Kubra
- Kaneko Tadashi
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- Kang Eun-Hae Eunhae
- Kang Eun-Hae Eunhae
- Kappel Dean
- Karaguzel Gungor Gulay
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- Kasaoka Shunji
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- Kashiwabara Moto
- Katagami Hideki
- Katagiri Satosi
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- Katsenos Chrysostomos S
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- Kawamata Takakazu
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- Khangoora Vikramjit
- Khashana Abdelmoneim
- Kiff Jane
- Kikuchi Ken
- Kilger E
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- Kim Chol
- Kim Dong Soon
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- Kluge Stefan
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- Knawy Bandar Al
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- Knippschild Uwe
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- Kocak Mehmet
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- Konstandelou Evangellia
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- Kotanidou Anastasia
- Kotanidou Anastasia
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- Kotsaki Antigone
- Kox Matthijs
- Kraemer Dale F
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- Kreth Simone
- Kruger Peter
- Kubo Osami
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- Kubo Toshio
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- Kuchel Timothy R
- Kufera Joseph A
- Kuhn Sven-Olaf
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- Kuittinen Taru
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- Kullmann Jennifer S
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- Kuo Chin-Sung
- Kupfer Yizhak
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- Kwizera Arthur
- Kwon O Jung
- Kwon O Jung
- Kwon O Jung
- Kwon O Jung
- Kwon Yong Soo
- Kwon Yong Soo
- Kwon Yong Soo
- Kwon Yong Soo
- Kyriazopoulou Venetsana
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- Laborde Kathleen
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- Lagu Tara
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- Laine Fabrice
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- Larsson Anders
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- Lavenu A
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- Lawson Margaret
- Le Maguet Pascale
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- Lebrec Didier
- Lecuyer L
- Ledderose Carola
- Lee Chih-Hsin
- Lee Ming-Chia
- Lee Rita S F
- Lee Sang D O
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- Leemingsawat Chantanij
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- Lehmann Blandine
- Lehmke Josefa
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- Leishman Amy G
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- Lejeune Julie
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- Lekkou Alexandra A
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- Lemeshow Stanley
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- Leskinen Markku
- Lesur Olivier
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- Levy Bruno
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- Levy Mitchell M
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- Li Chun-Sheng Chen
- Li Chun-Sheng Chen
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- Li Enyou
- Li Enyou
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- Li Jinyue Jian-guo
- Li Lu
- Li Lu
- Li Yi
- Liang Hui
- Liang Hui
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- Liaudet L
- Lichte Philipp
- Lien Jau-Min
- Lim Chae-Man
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- Lim So Yeon
- Lima-Valassi Helena Pantelion
- Lima-Valassi Helena Pantelion
- Limbeck Elisabeth
- Limor Rona
- Lin John
- Lindenauer Peter K
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- Liotier Jerome
- Lipcsey Miklos
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- Lipiner-Friedman Diane
- Listernick Robert
- Little Anjuli
- Little Anjuli
- Liu Chang
- Liu Chang
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- Liu Yu-Chih
- Liu Yu-Chih
- Livaditi Olga
- Livaditi Olga
- Livaditi Olga
- Livaditi Olga
- Llompart-Pou Juan Antonio
- Llompart-Pou Juan Antonio
- Llompart-Pou Juan Antonio
- Llompart-Pou Juan Antonio
- Lo Yuan-Hao
- Loeffler Markus
- Loeffler Markus
- Lofaso Frederic
- Loisa Pekka
- Loisa Pekka
- Loisa Pekka
- Loisa Pekka
- Loisa Pekka
- London Vanessa
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- Loriaux D Lynn
- Lorts Angie
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- Luo Yun
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- Madero Rosario
- Madgundi Venugopal V
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- Magri Silvia
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- Makino Hiroshi
- Malik Iqbal A
- Mallat Jihad
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- Maralihalli M B
- Margeli T
- Marik Paul E
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- Mariscalco Michelle
- Marklin Gary
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- Massart Catherine
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- Mathonet Armelle
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- Matsushita Kazuyuki
- Matsutani Takeshi
- Maviglia R
- Mavrommatis Antonis
- Mavrommatis Antonis
- Maxime Virginie
- Maxime Virginie
- Maxime Virginie
- Maxime Virginie
- Maxime Virginie
- Maxime Virginie
- Mayaux Julien
- Mayaux Julien
- Mayr Viktoria
- Mazzuco Tania Longo
- Mazzuco Tania Longo
- McArthur Colin
- McArthur Colin
- McCracken Courtney
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- McGree James
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- McLean Anthony S
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- Meersseman Philippe
- Megarbane Bruno
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- Meggison Hilary
- Mehta Renuka
- Mehta Sangeeta K
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- Meier-Hellmann Andreas
- Meier-Hellmann Andreas
- Mello Gustavo W
- Mello Romulo Carvalho Vaz de
- Menaker Jay
- Meng Xinke
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- Menon Kusum
- Mentzelopoulos Spyros
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- Mercier Gregoire
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- Meziani F
- Michaeli Burkhard
- Michalaki Marina
- Michalaki Marina
- Michel Gustavo T
- Miki Nobuhiro
- Miki Nobuhiro
- Millul Valerie
- Minami Daisuke
- Minami Daisuke
- Miranda-Ruiz Rogelio
- Misset Benoit
- Misset Benoit
- Misset Benoit
- Mittelman Steven D
- Miura Hitomi
- Miyashita Masao
- Miyauchi Takashi
- Miyauchi Takashi
- Mohammad Zulfiqar
- Mohnle Patrick
- Mohnle Patrick
- Mohnle Patrick
- Mohnle Patrick
- Mohsine Raouf
- Molenaar Nienke
- Molenaar Nienke
- Molenaar Nienke
- Molinari Nicolas
- Molinari Nicolas
- Momeni Mahnoush
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- Moran John L
- Moreau Richard
- Morel Jerome
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- Morichika Daisuke
- Morichika Daisuke
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- Mount Joshua C
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- Mueller Christian Cornelia
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- Myburgh John
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- Nanas S
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- Natanson Charles
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- Nathanson Brian H
- Navasa Miguel
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- Nazer Lama
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- Nenke M A
- Nenke M A
- Nesseler Nicolas
- Netea Mihai G
- Neves Suzane Pretti Figueiredo
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- Nieman Lynnette K
- Nieman Lynnette K
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- Nierhaus Axel
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- Nisbet Janelle
- Nishikawa Toshio
- Nishikawa Toshio
- Nishimura N
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- Noble David W
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- Nougaret Stephanie
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- Nougaret Stephanie
- Nousiainen Tapio
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- Nunnally Mark E
- O'Beirne James
- O'Beirne James
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- O'Connor S
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- Okada Yoshikazu
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- Ono H
- Ono Masami
- Ono Masami
- Opal Steven M
- Opal Steven M
- Oppert Michael
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- Orfanos Stylianos E
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- Orfanos Stylianos E
- Orfanos Stylianos E
- Orlander Philip R
- Orlander Philip R
- Orlikowski David
- Orlikowski David
- Osborn Tiffany M
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- Osborn Tiffany M
- Osborn Tiffany M
- Ospina-Tascon Gustavo Adolfo
- Oudemans-van Straaten Heleen M
- Oudemans-van Straaten Heleen M
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- Pai Hemanth K
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- Perez-Barcena Jon
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- Pettila Ville
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- Pettila Ville
- Peynet Jacqueline
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- Pfister David
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- Phillips Gary S
- Pickkers Peter
- Pickkers Peter
- Pierson D L
- Piriou V
- Piriou V
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- Pistiki Aikaterini C
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- Pogson David G
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- Ramsay Graham
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- Rankin W
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- Raurich Joan Maria
- Raurich Joan Maria
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- Reinhart Konrad
- Reinhart Konrad
- Reinhart Konrad
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- Richardson Paul
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- Rintala Esa
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- Rishu Asgar H
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- Roth-Kleiner Matthias
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- Rushing G D
- Russel J A
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- Saarela Timo
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- Sadahiro Tomohito
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- Salgado D R
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- Saltz Henrique
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- Sarret Philippe
- Satapathy Rashmi R
- Sato-Hisamoto Akiko
- Sato-Hisamoto Akiko
- Satoh Mamoru
- Sattarzade Mahboobeh
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- Savva Athina A
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- Schadler Dirk
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- Schafer Simon T
- Schedlowski Manfred
- Schedlowski Manfred
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- Schmittinger Christian A
- Schmittinger Christian A
- Schmittinger Christian A
- Schnitzler Eduardo
- Schoonhoven Lisette
- Schrader Ronald M
- Schrader Ronald M
- Schroder Daniel C H
- Schroder Daniel C H
- Schuerholz Tobias
- Schuerholz Tobias
- Schuetz Philipp
- Schuetz Philipp
- Schultz Marcus J
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- Seki Toshiro
- Seki Toshiro
- Selbst Steven M
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- Sevransky Jonathan E
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- Shaaban Yasser Hassan
- Shafarin M S
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- Shibata Audrey R Ogawa
- Shigeta Osamu
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- Shih Kuang-Chung
- Shim Tae Sun
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- Shmuelevitz Lev
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- Siami Shidasp
- Siami Shidasp
- Siami Shidasp
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- Singer Mervyn
- Singh Anita
- Singh Georgene
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- Singhi Sunit
- Sirola Joonas
- Sirola Joonas
- Sjolin Jan
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- Slovis N M
- Slovis N M
- Smeekens Sanne P
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- Smielewski Peter
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- Smith Melissa Lassig
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- Smitz Johan
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- Soderberg Ewa
- Sogawa Kazuyuki
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- Sollevi Alf
- Solomkin Joseph S
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- Solomon Steven B
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- Souweine Bertrand
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- Spadaro Luisa
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- Spijkstra Jan-Jaap
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- Sprung Charles L
- Sprung Charles L
- Sprung Charles L
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- Spuler Simone
- Srivijitkamol Apiradee
- Srivijitkamol Apiradee
- Stanciu Carol
- Stein Deborah M Dan J
- Stein Deborah M Dan J
- Steinau H-U
- Steiner Luzius A
- Steingrub Jay S
- Steingrub Jay S
- Steinmann Jorg
- Steinmann Jorg
- Steinstrasser L
- Stellini Roberto
- Stellini Roberto
- Sterk Ethan
- Sterk Ethan
- Stern Naftali
- Stevens N E
- Stevens N E
- Stewart Paul M
- Stiefelhagen Peter
- Stockwell Jana A
- Stockwell Jana A
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- Stojadinovic Bonnie
- Stolz Daiana
- Stolz Daiana
- Stone Angela
- Storms Michelle M
- Stotz Martin
- Stotz Martin
- Stowe R P
- Strack van Schijndel Rob J M
- Strauss Julian
- Strebel Stephan P
- Stromeyer Hans G
- Sturgess David J
- Sturgess David J
- Su Deng-Huang
- Suh Gee Young
- Suh Gee Young
- Suh Gee Young
- Suh Gee Young
- Sun Jiaxiao Junfeng
- Sun Jiaxiao Junfeng
- Sun Jiaxiao Junfeng
- Sun Jiaxiao Junfeng
- Suter Fredy
- Suter Fredy
- Sweeney Daniel A
- Sweeney Daniel A
- Sweeney Lori B
- Sweep Fred C G J
- Tabah Alexis
- Tabah Alexis
- Taccone F S
- Tajiri Takashi
- Takahashi O
- Takano Kazue
- Takano Kazue
- Takata Katsuyoshi
- Takata Katsuyoshi
- Takeda Shinhiro
- Tamim Hani M
- Tamim Hani M
- Tamim Hani M
- Tamim Hani M
- Tamim Hani M
- Tamim Hani M
- Tamimi Waleed
- Tamimi Waleed
- Tamimi Waleed
- Tamimi Waleed
- Tamm Michael
- Tamm Michael
- Tan Terrence
- Tan Terrence
- Tan Terrence
- Tang Benjamin M
- Tang Yee-Loong
- Tanimoto Mitsune
- Tanimoto Mitsune
- Tappy Luc
- Tassin C
- Tassin C
- Taylor Edwin
- Teng Lihua
- Tenhunen Jyrki
- Terblanche Marius
- Terblanche Marius
- Tesniere Antoine
- Tesniere Antoine
- Textoris Julien
- Thalassinos N C
- Theodorakopoulou Maria
- Theodorakopoulou Maria
- Theodorakopoulou Maria
- Thiel Manfred
- Thierry S
- Thirunavukkarasu Neeraja
- Thirunavukkarasu Neeraja
- Thomas Michael
- Thomas Michael
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- Thomas Zachariah
- Thomasy Sara M
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- Timsit Jean-Francois Francois
- Timsit Jean-Francois Francois
- Timsit Jean-Francois Francois
- Tissot Sylvie
- Tol Maneesha M
- Tol Maneesha M
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- Torpy David J
- Torpy David J
- Torpy David J
- Torpy David J
- Torpy David J
- Torpy David J
- Torpy David J
- Torpy David J
- Torres Adalberto
- Townsend Sean R
- Townsend Sean R
- Triantos Christos K
- Trifan Anca
- Trips Evelyn
- Trips Evelyn
- Troster Eduardo J
- Trouve-Buisson Thibaut
- Trummler Michael
- Tsagarakis Stylianos
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- Tsagarakis Stylianos
- Tsai Ming-Hung
- Tsai Wen-Hui
- Tsekouras A
- Tseng Jo-Chi
- Tseng Jo-Chi
- Tsirantonaki M
- Tsochatzis Emmanuel
- Tsochatzis Emmanuel
- Tsochatzis Emmanuel
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- Tsuruta Ryoske
- Tucci Marisa
- Tuckermann Jan
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- Tung Kelly
- Tung Kelly
- Tung Kelly
- Tung Kelly
- Tung Kelly
- Twisk Jos W R
- Tzanela Marinella
- Tzanela Marinella
- Tzanela Marinella
- Tzanela Marinella
- Tzanela Marinella
- Tzanela Marinella
- Uchida Koji
- Uchida Koji
- Uchiyama N
- Udompanturak Suthipol
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- Umberger Reba
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- Ungerer Jacobus P J
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- Uusaro Ari
- Uusaro Ari
- Uusaro Ari
- Vagenakis A G
- Vallet Benoit
- Vallet Benoit
- Valleur Patrice
- Valoor Harsha T
- van Alfen Nens
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- Van den Berghe Greet
- Van den Berghe Greet
- van den Boogaard Mark
- van der Hoeven Johannes G
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- van der Sluijs Veer Gertjan
- van der Voort Peter H J
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- van der Werf Sieberen P
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- van Stijn Ilse
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- van Zanten Mark
- van Zanten Mark
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- Vanska Matti
- Vardas K
- Vardas K
- Varpula Marjut
- Vassiliadi Dimitra Argyro
- Vassiliadi Dimitra Argyro
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- Vassiliadi Dimitra Argyro
- Vassiliadi Dimitra Argyro
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- Vassiliagkou Spyridoula D
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- Venkatesh Balasubramanian
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- Venkatesh Balasubramanian
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- Venkatesh Balasubramanian
- Venkatesh Balasubramanian
- Venkatesh Balasubramanian
- Venkatesh Balasubramanian
- Verbeek Marcel M
- Verdeal Juan C
- Verdier M-C
- Vermes Istvan
- Viana Marina Vercoza
- Viana Marina Vercoza
- Vicaut Eric
- Villa F
- Villagran Maria J
- Vincent Jean Louis J-L Jean-Louis L
- Vincent Jean Louis J-L Jean-Louis L
- Vincent Jean Louis J-L Jean-Louis L
- Vincent Jean Louis J-L Jean-Louis L
- Vincent Jean Louis J-L Jean-Louis L
- Vincent Jean Louis J-L Jean-Louis L
- Vincent Jean Louis J-L Jean-Louis L
- Vincent Jean Louis J-L Jean-Louis L
- Vincent Jean Louis J-L Jean-Louis L
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- Vincent Jean Louis J-L Jean-Louis L
- Vincent Jean Louis J-L Jean-Louis L
- Vincent Jean Louis J-L Jean-Louis L
- Vinclair Marc
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- Vogeser Michael
- Vogeser Michael
- Vogeser Michael
- Vogt P M
- Volbeda M
- Voll K
- Vollmar Brigitte
- von Dessauer Bettina
- Wagner Nana-Maria
- Walker Mark L
- Walley Keith R
- Wang Chun-Hua Changsong
- Wang Chun-Hua Changsong
- Wang Chun-Hua Changsong
- Wang Ling
- Wang Ling
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- Wang Miaomiao
- Wang Ti-Hao
- Ward Gregory
- Ward Gregory
- Watson Dale
- Webb Ian
- Webb Steven A R
- Webb Steven A R
- Webb Steven A R
- Webb Steven A R
- Webb Steven A R
- Weber-Carstens Steffen
- Wegner Alexander
- Wegner Alexander
- Wegner Alexander
- Weiler Norbert
- Weiler Norbert
- Weingarten Jacki
- Weireter L J
- Weis Florian
- Weis Florian
- Weiss Manfred
- Weiss Yoram G
- Weiss Yoram G
- Weiss Yoram G
- Weiss Yoram G
- Weiss Yoram G
- Weiss Yoram G
- Weiss Yoram G
- Weiss Yoram G
- Wensley David
- Wenzel Volker
- Werdan K
- Wernecke Klaus D
- Westendorf Astrid M
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- Wester Jos P J
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- Westermeyer Hans D
- Westphal Martin
- Wetterslev J
- Weyland Andreas
- Weyland Andreas
- Whitley Elizabeth M
- Whitley Elizabeth M
- Wiaterek Gregory K
- Williams Mark D
- Williams Mark D
- Winkler Margaret
- Wirtz Stefan P
- Wirtz Stefan P
- Witchel Selma F
- Wolf Anna M
- Wolf Irene M
- Wolf Michel
- Wolf Michel
- Wolf Oliver T
- Wolter Timm
- Won Justin Ging-Shing
- Wong Chieh-Lee
- Wong Hector R
- Wong Hector R
- Wong Hector R
- Wood John C
- Wouters Pieter J
- Woyciechowsky Tiago G
- Wright Robert
- Wu Cheng-Shyong
- Wu Huang-Pin
- Wu Huang-Pin
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- Wynn James L
- Xirouchakis Elias
- Xu Jun
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- Xu Mujuan
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- Yamamoto Masakazu
- Yamashita Kiyohiko
- Yang Chunli
- Yang Chunli
- Yee Kristen S
- Yee Kristen S
- Yeh Timothy
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- Yu Chung-Chieh
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- Zakynthinos Spyros
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- Zaman Muhammad
- Zampieri Fernando Godinho
- Zamri-Saad M
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- Zandstra Durk F
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- Zhang Fengmin
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- Zhao Xin
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- Zhou Qing
- Zhou Qing
- Zhu Huadong
- Ziegenfuss Marc
- Ziegenfuss Marc
- Zijlstra J G
- Zimmerman Jerry J
- Zimmerman Jerry J
- Zuckerberg Aaron
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/10/2007
- Field of study
Mapping the human genetic architecture of COVID-19
- Author
- Abdelrazik M
- Abdullah T
- Abe R
- Abe S
- Abecasis GR
- Abel L
- Abernathy C
- Abraheem A
- Abul-Husn NS
- Acosta-Herrera M
- Acquilini D
- Acquilini D
- Adachi T
- Adachi Y
- Adams C
- Adams K
- Adanini O
- Adeleye O
- Adeniji K
- Adra D
- Afifi N
- Afilalo J
- Afilalo M
- Afolabi D
- Afrasiabi Z
- Afset JE
- Agasou A
- Aghemo A
- Agranoff D
- Agrawal S
- Aguirre LA
- Agwuh K
- Ahmad HF
- Ahmad N
- Ahmed A
- Ahmed C
- Ahmed KA
- Ai M
- Ail D
- Akeroyd L
- Akhtar MN
- Akhtar S
- Akinkugbe O
- Aksentijevich A
- Al Thani A
- Al-Muftah W
- Al-Sarraj Y
- Alarcon C
- Alarcon-Riquelme ME
- Alasdair F
- Alaverdian D
- Alavere H
- Albertos R
- Albillos A
- Albrecht W
- Albrich W
- Albrich WC
- Aldera EL
- Aldridge J
- Alegria A
- Alex B
- Alexander P
- Alfonso J
- Algera AG
- Ali A
- Ali IMA
- Ali S
- Aliberti S
- Allan A
- Allan E
- Allan J
- Alldis Z
- Allen L
- Allen S
- Allibone S
- Allison KS
- Allos R
- Ally SM
- Almaden-Boyle C
- Altabaibeh A
- Altmueller J
- Alvaro A
- Amar D
- Amin V
- Amitrano S
- Amiya S
- Ampuero J
- Anan R
- Anania S
- Anastasescu E
- Anderson F
- Anderson J
- Anderson M
- Anderson P
- Anderson S
- Anderson S
- Anderson T
- Ando A
- Andolfo I
- Andrade V
- Andretta F
- Andreucci E
- Andreucci E
- Andrew A
- Andrew B
- Andrew G
- Andrews E
- Andrews SJ
- Andrews SJ
- Andrews SJ
- Andrews SJ
- Andrikopoulos P
- Anedda F
- Aneli S
- Anemoli V
- Angelini C
- Angus B
- Annis A
- Antcliffe D
- Antinori A
- Antoni MD
- Anumakonda V
- Anwar M
- Anzai T
- Apetri E
- Arai D
- Arana E
- Arbane G
- Archer K
- Arciero E
- Arden T
- Arias SS
- Arif S
- Arimura K
- Armstrong J
- Armstrong JA
- Armstrong L
- Armstrong R
- Arning N
- Arnold S
- Arora J
- Artuso R
- Arumugam P
- Asakura T
- Asano K
- Aschard H
- Ascolillo S
- Ashish A
- Ashley E
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- Ashworth M
- Asiimwe IG
- Aslibekyan S
- Asselta R
- Atanasovska B
- Atkinson D
- Atkinson EG
- Attwood B
- Aucella F
- Augustin M
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- Auld F
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- Awano N
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- Aziz F
- Azuma M
- Azuure C
- Azzolini E
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- Badalamenti S
- Badia JR
- Badji RM
- Bahmer T
- Baikady RR
- Baillie JK
- Baillie JK
- Baillie JK
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- Bakthavatsalam D
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- Baldassarri M
- Baldini M
- Ball CA
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- Baltzell AH
- Bamford A
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- Banales JM
- Bancroft H
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- Bandla N
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- Baptista D
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- Blakemore H
- Blanco-Grau A
- Blasi F
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- Blow S
- Blunt M
- Boada M
- Board S
- Bocciardi R
- Bocciolone M
- Bochud M
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- Bochud PY
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- Bociek A
- Boer C
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- Bogaard HJ
- Bogaert D
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- Borra C
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- Bosari S
- Bosio G
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- Bothma P
- Botta G
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- Boujemla B
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- Bradshaw Z
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- Branney D
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- Braun A
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- Brealey D
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- Brenner T
- Bretherick AD
- Brett M
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- Bridgett V
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- Brinkworth E
- Briton K
- Brittain-Long R
- Britvan B
- Bromley M
- Brooke H
- Brooks S
- Brouwer MC
- Brown A
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- Brown CW
- Brown E
- Brown J
- Bruce M
- Brunak S
- Bruno R
- Brunton M
- Brusco A
- Bruttini M
- Bryant J
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- Buckley C
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- Bugiani M
- Bujanda L
- Bulik CM
- Bulle E
- Bullock K
- Bulteel N
- Bunni L
- Burda D
- Burden T
- Burn I
- Burnett C
- Burns K
- Burt K
- Burtenshaw A
- Burtenshaw A
- Burton M
- Busani S
- Busson A
- Bussotti M
- Bustamante C
- Butcher D
- Buti M
- Butler A
- Butler S
- Butler-Laporte G
- Butler-Laporte G
- Butler-Laporte G
- Butler-Laporte G
- Butte MJ
- Butterworth AS
- Butterworth-Cowin N
- Button H
- Buxbaum JD
- Buxbaum JD
- Buxbaum JD
- Byun J
- Caba Llero-Garralda A
- Cabrelli L
- Caceres M
- Cadilla CL
- Cagova L
- Caldarelli GP
- Calderon EJ
- Callaghan M
- Callier S
- Camby S
- Cameli P
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- Campbell R
- Campos S
- Camsooksai J
- Canaccini A
- Canakoglu A
- Cantarini L
- Cantor MN
- Capasso M
- Capitani K
- Cappadona C
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- Carbral-Ortega L
- Cardamone G
- Carella M
- Carey DJ
- Carli D
- Carlucci N
- Carmody M
- Carmody S
- Carnahan M
- Carnero-Montoro E
- Carrabba M
- Carracedo AD
- Carreras Nolla A
- Carreras A
- Carriero ML
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- Carter S
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- Caruth V
- Casey M
- Cass E
- Castano-Vinyals G
- Castelli F
- Castle K
- Castoldi M
- Castori M
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- Caulfield MJ
- Cavazza A
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- Cawthron K
- Cazzaniga M
- Cea C
- Cecconi M
- Ceri S
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- Cerny A
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- Chadbourn I
- Chadwick D
- Chadwick D
- Chambler D
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- Chandler B
- Chang D
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- Chang X
- Chang Y
- Chapman S
- Charles B
- Charlesworth R
- Charney AW
- Charnock R
- Chasse M
- Chassot J
- Chaudhary K
- Chavan S
- Chechi K
- Chee N
- Cheema Y
- Chen H-H
- Cheng N
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- Chernitsov A
- Cherubini A
- Chetam L
- Cheyne C
- Chiba S
- Chihara Y
- Child J
- Childs D
- Chittoor G
- Chiu A
- Cho JH
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- Choudhury Y
- Chowdhury M
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- Chukkambotla S
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- Cirulli ET
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- Clapham M
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- Clark V
- Clarke D
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- Clarkson M
- Clayton S
- Clement I
- Clements S
- Clerc O
- Cloherty A
- Clohisey S
- Clohisey S
- Clohisey S
- Clohisey S
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- Cockrell M
- Coetzee S
- Coghlan P
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- Cole J
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- Costantino G
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- de Cid R
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- de Gordoa LO-R
- de Gordoa LO-R
- De Grandi A
- de Jong H
- de Jong MD
- De la Horra C
- De Neef M
- de Pablo R
- de Rojas I
- de Salazar A
- de Silva T
- De Vivo O
- De Vivo O
- de Vries H
- Deacon B
- Deacon B
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- Death Y
- Deboever C
- Debreceni G
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- Deery J
- Degenhardt F
- Dei S
- Dela Rosa A
- Delaneau O
- Delgado CC
- Delgado J
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- Dellot P
- Deloukas P
- Demetriou C
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- Depante M
- Dervisevic S
- Desanctis E
- Desgranges F
- deSouza F
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- di Bartolomeo C
- Di Biagio A
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- Doonan R
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- Farzad Z
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- Paik N-J
- Pairo-Castineira E
- Pais M
- Palmarini M
- Palmer DS
- Palmieri C
- Palmieri M
- Palmieri O
- Palom A
- Palotie A
- Palotie A
- Panchatsharam S
- Pancrazi A
- Panese S
- Pantet O
- Papakonstantinou D
- Papineni P
- Pappa E
- Paraboschi EM
- Paraiso H
- Paramsothy R
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- Parisi SG
- Park D
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- Park L
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- Park WB
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- Parkin J
- Parkinson N
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- Parkinson P
- Parmar C
- Parravicini P
- Parris V
- Parris V
- Parsons P
- Partha R
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- Parzibut G
- Pasaniuc B
- Pasaniuc B
- Pascual-Iglesias A
- Pasko D
- Pasko D
- Pasko D
- Passmore H
- Patel A
- Patel B
- Patel B
- Patel BV
- Patel K
- Patel M
- Patel S
- Patel T
- Paterson T
- Pathak GA
- Pathak GA
- Pathak GA
- Pathan N
- Pattaro C
- Pattaro C
- Pattison N
- Pattison N
- Paul P
- Paulus F
- Pavlovic M
- Paxton WA
- Pazos MDLM
- Pearson H
- Pearson NM
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- Peloso G
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- Pesenti A
- Pessina G
- Pestana D
- Pesukova J
- Peter W
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- Petrocelli P
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- Peyvandi F
- Pezzoli G
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- Pogreban T
- Pogson D
- Polgar O
- Polgarova P
- Polikowsky HG
- Polimanti R
- Pollakis G
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- Ponting CP
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- Poole A
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- Popescu M
- Popov I
- Porteous DJ
- Portopena L
- Poscente M
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- Post F
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- Pothecary C
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- Potla D
- Potoczna D
- Potts K
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- Povysil G
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- Prijatelj V
- Prime Z
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- Prokic I
- Protti A
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- Regina J
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- Rojo R
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- Russell CD
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- Saha S
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- Saito F
- Saito F
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- Sakagami S
- Salberg A
- Salciute E
- Saleem M
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- Sales D
- Salib I
- Salmi S
- Salmon K
- Salpietro V
- Saluja T
- Salutous D
- Saluzzio RP
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- Sander LE
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- Seed C
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- Seilmaier MJ
- Sekikawa Y
- Sell C
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- Selvanayagam S
- Semple G
- Semple MG
- Semple MG
- Senaratne D
- Sengupta S
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- Shah A
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- Shankar-Hari M
- Shankar-Hari M
- Shankar-Hari M
- Shanmuga P
- Shanmugasundaram P
- Sharma A
- Shastri AJ
- Shaw CA
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- Shawcross A
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- Shelton JF
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- Shen X
- Shepardson S
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- Shi H
- Shibata Y
- Shibusawa T
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- Shih B
- Shimada H
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- Shoko T
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- Shuey MM
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- Sigfrid L
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- Sivanadhan I
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- Skurk C
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- Slawson N
- Slevin K
- Sloan B
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- Sloofman L
- Sloofman LG
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- Smedley C
- Smit M
- Smith AV
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- Smith GD
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- Smoller JW
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- Spinner CD
- Spittle N
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- Springle P
- Squeo GM
- Sri-Chandana C
- Srikaran S
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- Stacey A
- Staderoli A
- Staines N
- Staines N
- Stambach T
- Stammers K
- Starkopf J
- Stead R
- Stefansson K
- Stella A
- Stenhouse A
- Stephens D
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- Stijnis CS
- Stilma W
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- Stone S
- Stones E
- Stowe B
- Strachan D
- Striano P
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- Striano P
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- Stuckey A
- Suardi C
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- Subramaniam KS
- Subramanian D
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- Sugiura H
- Suh N
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- Sun YV
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- Sutherland I
- Sutherland S-B
- Suttels V
- Sutton S
- Suwalski P
- Suzuki K
- Suzuki S
- Suzuki Y
- Sveinbjornsson G
- Swain A
- Swann OV
- Sweeney L
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- Tacconi D
- Tada MT
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- Tagaya E
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- Tahmasebi F
- Takada M
- Takagi H
- Takahashi K
- Takahashi K
- Takahashi K
- Takahashi M
- Takahashi M
- Takahashi T
- Takaku Y
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- Takats Z
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- Takeda Y
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- Tamm A
- Tanaka A
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- Tanck A
- Taneski F
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- Tanigawa Y
- Tanigawa Y
- Tanino Y
- Taniyama D
- Tanudjaja F
- Tariq A
- Task HGC
- Tateishi T
- Tateno H
- Tatham K
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- Tavares S
- Tavecchia L
- Taylor A
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- Team AC
- Team GHR
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- Tedder RS
- Teles A
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- Templeton M
- Tench H
- Tenesa A
- Tentorio P
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- Terranova L
- Terron Arcos V
- Tetla D
- Teumer A
- Teunissen C
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- Thanasi M
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- Thibeault C
- Thirlwall Y
- Thirumaran M
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- Thomas E
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- Thomas M
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- Thomis L
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- Thompson AAR
- Thompson C
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- Thompson RC
- Thomson EC
- Thomson N
- Thonon R
- Thoral P
- Thornton D
- Thornton L
- Thorpe C
- Thorsteinsdottir U
- Thrasyvoulou L
- Thrush J
- Thwaites RS
- Thwaites V
- Thwaites V
- Thys M
- Tibke C
- Tierney C
- Tilbey S
- Tilney E
- Timens W
- Timlick E
- Ting L
- Tiseo G
- Tiseo G
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- Tita R
- Tivenan H
- Toapanta D
- Todd A
- Togashi Y
- Tohda S
- Tokunaga K
- Tolson M
- Tomas AL
- Tommasi A
- Tomono K
- Tonby K
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- Torrents D
- Tran F
- Trankiem A
- Trankiem A
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- Trembath RC
- Trembath RC
- Tridente A
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- Trivedi B
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- Trochu E
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- Tsao P
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- Tselios C
- Tsinaslanidis G
- Tsonas A
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- Tucci A
- Tuck M
- Tuckey V
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- Turki S
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- Turner-Bone I
- Turney S
- Turtle LCW
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- Tutton R
- Twagira M
- Twiss S
- Tyl D
- Tyler A
- Uchimura Y
- Uddin MJ
- Uddin MM
- Ueda S
- Ueda T
- Uellendahl-Werth F
- Uffelmann E
- Umeda A
- Underwood SJ
- Urrechaga E
- Ustianowski A
- Ustinova M
- Utrilla A
- Utsugi M
- Uwamino Y
- Vadgama N
- Vadla MS
- Vaghi M
- Valente S
- Valenti L
- Valentin Quiroga J
- Valentine J
- Valentino F
- Valino K
- Vallerga C
- Vallotton N
- Valsecchi MG
- van Agtmael M
- van Baarle F
- van Blokland I
- van de Beek D
- van den Berge M
- van der Poll T
- van der Valk M
- van Heel D
- van Heel DA
- van Heel DA
- van Koutrik L
- van Mourik N
- Van Singer M
- van Tonder L
- van Uffelen KWJ
- van Vugt M
- Vandernoot I
- Varghese M
- Vari MS
- Varnai R
- Vecchia M
- Vedage D
- Veelo D
- Veerapen K
- Veerapen K
- Veerapen K
- Vehreschild MJGT
- Velho M
- Venkatesh H
- Venturelli S
- Verdugo RA
- Vergori A
- Verlander M
- Verma A
- Verma SS
- Vertue M
- Vertue M
- Verula J
- Verzuri A
- Viala B
- Vigurs C
- Vincent R
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- Vincenti A
- Viollet RM
- Visuvanathan S
- Vitart V
- Vizcaychipi MP
- Vlaar APJ
- Vochin A
- Voide C
- Voide C
- Volland S
- Vollenweider P
- Vollenweider P
- Von Frenckell C
- von Hohenstaufen K
- von Mering C
- Vonk JM
- Voza A
- Vulesevic B
- Vuylsteke A
- Vuylsteke A
- Wacker EM
- Wackett T
- Wadams B
- Waddington N
- Waddy S
- Wagstaff V
- Waite AAC
- Wakabayashi A
- Wakahara K
- Wake R
- Wakefield P
- Wakinshaw F
- Walden A
- Waldron J
- Walker D
- Walker R
- Walker S
- Walker S
- Walker S
- Wall A
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- Walter J
- Walters RK
- Walton O
- Wang B
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- Wang H
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- Wang Q
- Wang X
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- Ward G
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- Warmerdam R
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- Washington NL
- Wassall H
- Wasson C
- Watanabe H
- Watanabe K
- Watson E
- Watson G
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- Watson N
- Watters M
- Waugh V
- Weaver J
- Webster A
- Webster D
- Webster K
- Wei S
- Weiss ST
- Weldon CH
- Wells C
- Welters I
- Welters ID
- Wendorff M
- Wendt FR
- Wery M
- Wesse T
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- Weston H
- Wham M
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- White D
- White I
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- White S
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- Whiteley S
- Whiteside J
- Whittaker P
- Whittington A
- Whittle H
- Whitton C
- Whyte C
- Wicks SJ
- Wienbrandt L
- Wiersinga WJ
- Wijesinghe M
- Wilby E
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- Willer CJ
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- Williams G
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- Williams M
- Williams M
- Williams P
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- Williams T
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- Wilson JF
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- Wiselka M
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- Woodford C
- Woodruff M
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- Woodyatt W
- Woolley AE
- Wooton DG
- Working UCLAHATLASDM
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- Wrobel N
- Wu Y
- Wulandari R
- Wyllie DH
- Wynter I
- Xavier K
- Xue X
- Yadav A
- Yagi K
- Yamada M
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- Yamagata K
- Yamasaki M
- Yang G
- Yang J
- Yang Z
- Yaspan B
- Yasui Y
- Yates B
- Yates B
- Yatomi M
- Ye C
- Yengo L
- Yermakovich D
- Yi X
- Yonekawa A
- Yoon H
- Yoon KJ
- Yoshida K
- Yoshida S
- Yoshida S
- Yoshida T
- Yoshihara T
- Yoshiya K
- Yoshiyama T
- Youlton N
- Younes SE
- Young P
- Yun N
- Zak A
- Zaki A
- Zambon M
- Zamikula J
- Zanella A
- Zanella I
- Zanelli G
- Zara F
- Zara F
- Zarate R
- Zarate R
- Zborowski AC
- Zeberg H
- Zechner M
- Zechner M
- Zguro K
- Zhai R
- Zhang JE
- Zhang M
- Zhao JH
- Zhen J
- Zheng C
- Zheng T
- Zhou W
- Zhou W
- Zhu W
- Zitter L
- Zlatopolsky M
- Zoller H
- Zollner S
- Zongo O
- zu Bentrup FM
- Zucchi P
- Zwinderman AHK
- Zyndorf M
- Publication venue
- Publication date
- 01/01/2021
- Field of study
The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-191,2, host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across 19 countries. We report 13 genome-wide significant loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of these loci correspond to previously documented associations to lung or autoimmune and inflammatory diseases3,4,5,6,7. They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated with COVID-19 was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks. This working model of international collaboration underscores what is possible for future genetic discoveries in emerging pandemics, or indeed for any complex human disease