Stability Oriented Routing in Mobile Ad-Hoc Networks Based on Simple Automatons

International audienceSince wireless ad-hoc networks with mobile nodes have not stable topology, the classical network functions as the routing are difficult to realize. The router nodes and the links between them are not stable and can appear and disappear randomly. So, classic routing algorithms can not be used successfully. New approaches should be used which deals with these dynamic changes. To avoid frequent route requests and volatile routes due to uncertain information, the objective of the routing can correspond to the route stability. The route computation can be based on random variables and becomes probabilistic routing. Our book chapter focuses on modeling the resilience of these information for ad hoc networks where topology information is uncertain. Our model is based on a dynamic graph where the existence of the nodes and the communication capability between them are modeled by simple two state automaton where the transitions are initiated by random events

Efficient Protection of Many-to-One Communications

International audienceThe dependability of a network is its ability to cope with failures , i.e., to maintain established connections even in case of failures. IP routing protocols (such as OSPF and RIP) do not fit the dependability objectives of today applications. Moreover, forwarding techniques based on destination address (like IP) induce many-to-one connections. If a dependable connection is needed, all primary paths and protections having the same destination must be established in a coordinated way. In this paper, we propose a fault recovery for many-to-one connections based on a cold (preplanned) protection. The main advantage of our approach is that the recovery in case of failures is achieved within a short delay. Additionally, with respect to other approaches, the dependability of the routing scheme is increased in the way that it statistically copes with many failures. The algorithm we propose computes an efficient backup for an arbitrary primary tree using an improved multi-tree algorithm

The Role of Slow Speech Amplitude Envelope for Speech Processing and Reading Development

Published: 31 August 2017This study examined the putative link between the entrainment to the slow rhythmic structure of speech, speech intelligibility and reading by means of a behavioral paradigm. Two groups of 20 children (Grades 2 and 5) were asked to recall a pseudoword embedded in sentences presented either in quiet or noisy listening conditions. Half of the sentences were primed with their syllabic and prosodic amplitude envelope to determine whether a boost in auditory entrainment to these speech features enhanced pseudoword intelligibility. Priming improved pseudoword recall performance only for the older children both in a quiet and a noisy listening environment, and such benefit from the prime correlated with reading skills and pseudoword recall. Our results support the role of syllabic and prosodic tracking of speech in reading development.This work was supported by the Severo Ochoa program grant [SEV-2015-049]; MaL was supported by the Spanish Ministry of Economy and Competitiveness [PSI2015-65338-P]

Model consent clauses for rare disease research

Background: Rare Disease research has seen tremendous advancements over the last decades, with the development of new technologies, various global collaborative efforts and improved data sharing. To maximize the impact of and to further build on these developments, there is a need for model consent clauses for rare diseases research, in order to improve data interoperability, to meet the informational needs of participants, and to ensure proper ethical and legal use of data sources and participants' overall protection. Methods: A global Task Force was set up to develop model consent clauses specific to rare diseases research, that are comprehensive, harmonized, readily accessible, and internationally applicable, facilitating the recruitment and consent of rare disease research participants around the world. Existing consent forms and notices of consent were analyzed and classified under different consent themes, which were used as background to develop the model consent clauses. Results: The IRDiRC-GA4GH MCC Task Force met in September 2018, to discuss and design model consent clauses. Based on analyzed consent forms, they listed generic core elements and designed the following rare disease research specific core elements; Rare Disease Research Introductory Clause, Familial Participation, Audio/Visual Imaging, Collecting, storing, sharing of rare disease data, Recontact for matching, Data Linkage, Return of Results to Family Members, Incapacity/Death, and Benefits. Conclusion: The model consent clauses presented in this article have been drafted to highlight consent elements that bear in mind the trends in rare disease research, while providing a tool to help foster harmonization and collaborative efforts

Genome-wide RNAi screen identifies novel players in human 60S subunit biogenesis including key enzymes of polyamine metabolism

Ribosome assembly is an essential process that is linked to human congenital diseases and tumorigenesis. While great progress has been made in deciphering mechanisms governing ribosome biogenesis in eukaryotes, an inventory of factors that support ribosome synthesis in human cells is still missing, in particular regarding the maturation of the large 60S subunit. Here, we performed a genome-wide RNAi screen using an imaging-based, single cell assay to unravel the cellular machinery promoting 60S subunit assembly in human cells. Our screen identified a group of 310 high confidence factors. These highlight the conservation of the process across eukaryotes and reveal the intricate connectivity of 60S subunit maturation with other key cellular processes, including splicing, translation, protein degradation, chromatin organization and transcription. Intriguingly, we also identified a cluster of hits comprising metabolic enzymes of the polyamine synthesis pathway. We demonstrate that polyamines, which have long been used as buffer additives to support ribosome assembly in vitro, are required for 60S maturation in living cells. Perturbation of polyamine metabolism results in early defects in 60S but not 40S subunit maturation. Collectively, our data reveal a novel function for polyamines in living cells and provide a rich source for future studies on ribosome synthesis.Peer reviewe

A randomized comparison of a sirolimus-eluting stent with a standard stent for coronary revascularization

BACKGROUND: The need for repeated treatment of restenosis of a treated vessel remains the main limitation of percutaneous coronary revascularization. Because sirolimus (rapamycin) inhibits the proliferation of lymphocytes and smooth-muscle cells, we compared a sirolimus-eluting stent with a standard uncoated stent in patients with angina pectoris. METHODS: We performed a randomized, double-blind trial to compare the two types of stents for revascularization of single, primary lesions in native coronary arteries. The trial included 238 patients at 19 medical centers. The primary end point was in-stent late luminal loss (the difference between the minimal luminal diameter immediately after the procedure and the diameter at six months). Secondary end points included the percentage of in-stent stenosis of the luminal diameter and the rate of restenosis (luminal narrowing of 50 percent or more). We also analyzed a composite clinical end point consisting of death, myocardial infarction, and percutaneous or surgical revascularization at 1, 6, and 12 months. RESULTS: At six months, the degree of neointimal proliferation, manifested as the mean (+/-SD) late luminal loss, was significantly lower in the sirolimus-stent group (-0.01+/-0.33 mm) than in the standard-stent group (0.80+/-0.53 mm, P<0.001). None of the patients in the sirolimus-stent group, as compared with 26.6 percent of those in the standard-stent group, had restenosis of 50 percent or more of the luminal diameter (P<0.001). There were no episodes of stent thrombosis. During a follow-up period of up to one year, the overall rate of major cardiac events was 5.8 percent in the sirolimus-stent group and 28.8 percent in the standard-stent group (P<0.001). The difference was due entirely to a higher rate of revascularization of the target vessel in the standard-stent group. CONCLUSIONS: As compared with a standard coronary stent, a sirolimus-eluting stent shows considerable promise for the prevention of neointimal proliferation, restenosis, and associated clinical events

Unveiling diversity in agricultural markets projections: from EU to Member States. A medium-term outlook with the AGMEMOD model

Every year the European Commission provides mid-term projections for agricultural markets. These projections are reported for the EU-28 aggregate and split into EU-15 and EU-N13 to reflect the diversity existing between the pre- and post-2004 Member States. However, the diversity of European agriculture goes beyond these two aggregates. This report presents the results of projections for agricultural markets in the EU Member States by 2026, generated using the AGMEMOD (Agriculture Member State Modelling) model. The projections are consistent with the European Commission's 2016 Mid-Term Outlook and represent production, consumption, yields, and trade for the main commodity groups (cereals, oilseeds, dairy and meats). In addition, the main characteristics of the model and the partnership that manages it are described. The report also provides examples of further analysis that can be performed with AGMEMOD in terms of country- or region-specific developments, focusing on agricultural markets in the EU-N13, and in terms of the relations between a single Member State and the rest of the EU, in this case focusing on the United Kingdom and the EU. Furthermore, an analysis of the implementation of coupled support in the EU Member States is presented. The report finishes with some testimonies of policy makers about the role AGMEMOD plays in their policy analysis, and sketching how AGMEMOD might develop in the mid-term.JRC.D.4-Economics of Agricultur

Outcomes of critically ill solid organ transplant patients with COVID‐19 in the United States

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/163464/2/ajt16280.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/163464/1/ajt16280_am.pd

Examination of the association of sex and race/ethnicity with appearance concerns: A Scleroderma Patient-centered Intervention Network (SPIN) cohort study

Objective: Appearance concerns are common in systemic sclerosis (SSc) and have been linked to younger age and more severe disease. No study has examined their association with sex or race/ethnicity. Methods: SSc patients were sampled from the Scleroderma Patient-centered Intervention Network Cohort. Presence of appearance concerns was assessed with a single item, and medical and sociodemographic information were collected. Results: Of 644 patients, appearance concerns were present in 72%, including 421 of 565 women (75%), 42 of 79 men (53%), 392 of 550 patients who identified as White (71%), 35 of 41 who identified as Black (85%), and 36 of 53 who identified as another race/ethnicity (68%). In multivariate analysis, women had significantly greater odds of reporting appearance concerns than men (odds ratio (OR)=2.97, 95% confidence interval (CI)=1.78-4.95,