587 research outputs found
Valproic acid for the treatment of low-risk myelodisplastic syndromes: a case report and a review of literature
- Publication venue
- 'Elsevier BV'
- Publication date
- 11/06/2013
- Field of study
none4openAntonella poloni; Benedetta Costantini; Marianna Mariani; Pietro LeoniPoloni, Antonella; Benedetta, Costantini; Marianna, Mariani; Leoni, Pietr
HER2-based recombinant immunogen to target DCs through FcÎłRs for cancer immunotherapy
- Author
- AO Hovden
- Aurelia Rughetti
- B Pulendran
- C Mastini
- C Napoletano
- C Napoletano
- C Napoletano
- Chiara Napoletano
- CJ Melief
- DB Lowe
- DH Schuurhuis
- DH Schuurhuis
- E Gilboa
- E Quaglino
- EA Mittendorf
- Elena Quaglino
- EM Hiltbold
- F Nimmerjahn
- Federica Riccardo
- Federica Taurino
- Filippo Bellati
- Filippo Veglia
- Francesca Belleudi
- G Mariani
- GE Peoples
- Hassan Rahimi
- HG Rammensee
- Ilaria Grazia Zizzari
- J Eyles
- JO Richards
- K Palucka
- Luigi Frati
- M Wang
- Maria Rosaria Torrisi
- Marianna Nuti
- MD Vesely
- Morena Antonilli
- MZ Ladjemi
- N Hollander
- Pierluigi Benedetti-Panici
- PJ Tacken
- PS Kim
- S Vertuani
- W Sun
- Y Ma
- YJ Bang
- Z You
- Publication venue
- Springer-Verlag
- Publication date
- 01/01/2011
- Field of study
Dendritic cell (DC)-based immunotherapy is an attractive approach to induce long lasting antitumor effector cells aiming to control cancer progression. DC targeting is a critical step in the design of DC vaccines in order to optimize delivery and processing of the antigen, and several receptors have been characterized for this purpose. In this study, we employed the FcÎłRs to target DCs both in vitro and in vivo. We designed a recombinant molecule (HER2-Fc) composed of the immunogenic sequence of the human tumor-associated antigen HER2 (aa 364â391) and the Fc domain of a human IgG1. In a mouse model, HER2-Fc cDNA vaccination activated significant T cell-mediated immune responses towards HER2 peptide epitopes as detected by IFN-Îł ELIspot and induced longer tumor latency as compared to Ctrl-Fc-vaccinated control mice. Human in vitro studies indicated that the recombinant HER2-Fc immunogen efficiently targeted human DCs through the FcÎłRs resulting in protein cross-processing and in the activation of autologous HER2-specific CD8+ T cells from breast cancer patients
Ceftolozane/Tazobactam for Treatment of Severe ESBL-Producing Enterobacterales Infections: A Multicenter Nationwide Clinical Experience (CEFTABUSE II Study)
- Author
- Alberto Enrico Maraolo
- Alessandra Oliva
- Alessandro Capone
- Alessandro Russo
- Alessandro âą CEFTABUSE Study Group: Matteo Bassetti
- Alessia Carnellutti
- Angarano Gioacchino
- Angela Raffaella Losito
- Annamaria Cattelan
- Antonio Cascio
- Antonio Mastroianni
- Antonio Vena
- Barbara Cadeo
- Bassetti Matteo
- Camilla Ajassa
- Carannante Novella
- Carbonara Sergio
- Carlo Tascini
- Claudia Gioe
- Claudio Maria Mastroianni
- Claudio Viscoli
- Cristina Mussini
- Cristina Rovelli
- Daniele Roberto Giacobbe
- Davide Coletto
- Davide Pecori
- Digaetano Margherita
- Elena Graziano
- Emanuele Malfatto
- Falcone Marco
- Filippo Givone
- Filippo Urso
- Francesca Raffaelli
- Francesca Trave
- Francesco Menichetti
- Giacobbe Daniele Roberto
- Giannella Maddalena
- Gioacchino Angarano
- Giorgia Caruana
- Giulia Bontempo
- Giuliana Guadagnino
- Giuliano Rizzardini
- Giustino Parruti
- Giusy Tiseo
- Grossi Paolo
- Guglielmo Borgia
- Ivan Gentile
- Losito Angela Raffaella
- Ludovica Cipriani
- Maddalena Giannella
- Maddalena Peghin
- Marco Anselmo
- Marco Falcone
- Margherita Digaetano
- Maria Merelli
- Maria Rosa Ciardi
- Mariani Michele Fabiano
- Mario Tumbarello
- Massimo Coen
- Massimo Crapis
- Massimo Girardis
- Mastroianni Antonio
- Mastroianni Claudio Maria
- Matteo Passerini
- Menichetti Francesco
- Meschiari Marianna
- Michele Fabiano Mariani
- Mussini Cristina
- Nadia Castaldo
- Nicola Petrosillo
- Novella Carannante
- Oliva Alessandra
- Paolo Grossi
- Pascale Renato
- Pierlugi Viale
- Renato Pascale
- Roberto Luzzati
- Rovelli Cristina
- Russo
- Russo Gianluca
- Sergio Carbonara
- Sergio Venturini
- Silvia Fabiani
- Stefania Artioli
- Stefano Verdenelli
- Tascini Carlo
- Tiseo Giusy
- Tiziana Tieghi
- Tumbarello Mario
- Vena Antonio
- Viale Pierluigi
- Viscoli Claudio
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2020
- Field of study
Background. Few data are reported in the literature about the outcome of patients with severe extended-spectrum beta-lactamase-producing Enterobacterales (ESBL-E) infections treated with ceftolozane/tazobactam (C/T), in empiric or definitive therapy.Methods. A multicenter retrospective study was performed in Italy (June 2016-June 2019). Successful clinical outcome was defined as complete resolution of clinical signs/symptoms related to ESBL-E infection and lack of microbiological evidence of infection. The primary end point was to identify predictors of clinical failure of C/T therapy.Results. C/T treatment was documented in 153 patients: pneumonia was the most common diagnosis (n = 46, 30%), followed by 34 cases of complicated urinary tract infections (22.2%). Septic shock was observed in 42 (27.5%) patients. C/T was used as empiric therapy in 46 (30%) patients and as monotherapy in 127 (83%) patients. Favorable clinical outcome was observed in 128 (83.7%) patients; 25 patients were considered to have failed C/T therapy. Overall, 30-day mortality was reported for 15 (9.8%) patients. At multivariate analysis, Charlson comorbidity index >4 (odds ratio [OR], 2.3; 95% confidence interval [CI], 1.9-3.5; P = .02), septic shock (OR, 6.2; 95% CI, 3.8-7.9; P < .001), and continuous renal replacement therapy (OR, 3.1; 95% CI, 1.9-5.3; P = .001) were independently associated with clinical failure, whereas empiric therapy displaying in vitro activity (OR, 0.12; 95% CI, 0.01-0.34; P < .001) and adequate source control of infection (OR, 0.42; 95% CI, 0.14-0.55; P < .001) were associated with clinical success.Conclusions. Data show that C/T could be a valid option in empiric and/or targeted therapy in patients with severe infections caused by ESBL-producing Enterobacterales. Clinicians should be aware of the risk of clinical failure with standard-dose C/T therapy in septic patients receiving CRRT
A machine-learning based bio-psycho-social model for the prediction of non-obstructive and obstructive coronary artery disease
- Author
- Adriana Servello
- Agostino Rossoni
- Alessandra Di Vincenzo
- Alessandra Tanzilli
- Alessandra Violi
- Alessandro Bella
- Alessandro Coppola
- Alfredo De Giorgi
- Alice Lipari
- Amanpreet Kaur
- Andrea Cutini
- Andrea DâAmuri
- Andrea Isidori
- Andrea Moretti
- Andrea Zito
- Angelina Passaro
- Anna Rita Vestri
- Annarita Vernile
- Anne Falcou
- Antonello Rosa
- Antonio Fraioli
- Antonio Segatori
- Basili Stefania
- Biagio Scotti
- Brombo Gloria
- Camilla Scala
- Cangemi Roberto
- Carlo Gaudio
- Carlotta Sapia
- Cinzia Marchese
- Clara Crescioli
- Claudia Tucci
- Claudio Cantelmi
- Claudio Tiberti
- Corica Bernadette
- Cristina Antinozzi
- Cristina Nocella. Carlo Catalano
- Danilo Toni
- Daria Amoroso
- Di Teodoro Giulia
- Edoardo Dalla Nora
- Eleni Anastasiadou
- Eleonora Capatti
- Eleonora Indolfi
- Eleonora Ruscio
- Elisa Giannetta
- Emilio Centaro
- Enrico Mangieri
- Evaristo Ettorre
- Fabio Miraldi
- Fabrizio Consorti
- Fabrizio Neri
- Fabrizio Recchia
- Federica Panimolle
- Filippo Toriello
- Flego Davide
- Floriana Santomenna
- Floriana Testa
- Francesca Di Vece
- Francesca Megiorni
- Francesca Serena Pignataro
- Francesco BarillĂ
- Francesco Morricone
- Gaetano Pero
- Gaetano Tanzilli
- Gennaro Petriello
- Gerarda Scaglione
- Giacomo Costanzo
- Giacomo Visioli
- Gianluca Costabile
- Gioacchino Galardo
- Giovanni Talerico
- Giovanni Zuliani
- Giulia Ricci
- Giulia Tosti
- Giulio Illuminati
- Giuseppe Santangelo
- Gloria Rozzi
- Guglielmo Tellan
- Hassan Behlouli
- Iacopo Carbone
- Ilaria Vellucci
- Laura GioffrĂš
- Laura Napoleone
- Laurent Tellini
- Loredana Iannetta
- Lucas RumbolĂ
- Ludovica Maria Antonini
- Marco Borgi
- Marco Vano
- Maria Alessandroni
- Mariangela Palladino
- Marianna Suppa
- Marianna Vincenti
- Mariateresa Santoliquido
- Mario Fontana
- Marrapodi Ramona
- Marta Novo
- Marta Tomassi
- Martina Di Iorio
- Mary Anna Venneri
- Michele Polastri
- Nicola Galea
- Nicola Viceconte
- NicolĂČ Rubini
- NicolĂČ Sperduti
- Nino Cocco
- Palagi Laura
- Paola Mariani
- Paolo Salis
- Pasquale Pignatelli
- Patrizia Ferroni
- Piergiovanni Mazzonna
- Pilote Louise
- Proietti Marco
- Raparelli Valeria
- Riccardo Iorio
- Riccardo Spaggiari
- Roberto Carnevale
- Roberto Manfredini
- Roberto Scacciavillani
- Romiti Giulio Francesco
- Salvatore Giarrizzo
- Salvatore Greco
- Salvatore Minisola
- Sara Giannuzzi
- Seccia Ruggiero
- Sergio Morelli
- Silvia Nocchi
- Silvia Pietropaolo
- Silvia Quattrino
- Silvia Robuffo
- Simona Bartimoccia
- Simona Ceccarelli
- Sonia Cristina Sergi
- Stefanini Lucia
- Suleyman Al Kindy
- Tanzilli Gaetano
- Tiziana Bellini
- Tommaso Romagnoli
- Tommaso Todisco
- Valeria Fortunato
- Valeria Spugnardi
- Verdiana Santori
- Viceconte Nicola
- Vincenzo Paravati
- Publication venue
- Publication date
- 01/01/2023
- Field of study
Background: Mechanisms of myocardial ischemia in obstructive and non-obstructive coronary artery disease (CAD), and the interplay between clinical, functional, biological and psycho-social features, are still far to be fully elucidated. Objectives: To develop a machine-learning (ML) model for the supervised prediction of obstructive versus non-obstructive CAD. Methods: From the EVA study, we analysed adults hospitalized for IHD undergoing conventional coronary angiography (CCA). Non-obstructive CAD was defined by a stenosisâ<â50% in one or more vessels. Baseline clinical and psycho-socio-cultural characteristics were used for computing a Rockwood and Mitnitski frailty index, and a gender score according to GENESIS-PRAXY methodology. Serum concentration of inflammatory cytokines was measured with a multiplex flow cytometry assay. Through an XGBoost classifier combined with an explainable artificial intelligence tool (SHAP), we identified the most influential features in discriminating obstructive versus non-obstructive CAD. Results: Among the overall EVA cohort (nâ=â509), 311 individuals (mean age 67â±â11 years, 38% females; 67% obstructive CAD) with complete data were analysed. The ML-based model (83% accuracy and 87% precision) showed that while obstructive CAD was associated with higher frailty index, older age and a cytokine signature characterized by IL-1ÎČ, IL-12p70 and IL-33, non-obstructive CAD was associated with a higher gender score (i.e., social characteristics traditionally ascribed to women) and with a cytokine signature characterized by IL-18, IL-8, IL-23. Conclusions: Integrating clinical, biological, and psycho-social features, we have optimized a sex- and gender-unbiased model that discriminates obstructive and non-obstructive CAD. Further mechanistic studies will shed light on the biological plausibility of these associations. Clinical trial registration: NCT02737982
Colorectal Cancer Stage at Diagnosis Before vs During the COVID-19 Pandemic in Italy
- Author
- Abate Emmanuele
- Abdallah Hussein
- Adinolfi Elvira
- Agnesi Stefano
- Aguzzi Daniele
- Aisoni Filippo
- Albertini Nicola
- Allaix Marco E
- Altieri Caterina
- Amato Antonio
- Ammirati Carlo A
- Anastasi Alessandro
- Andreuccetti Jacopo
- Andriola Valeria
- Aniello Santoro Giulio
- Annunziata Domenico
- Aprea Giovanni
- Aquilino Krizia
- Arganini Marco
- Armentano Serena
- Ascanelli Simona
- Assisi Alberto
- Asta Vito F
- Avanzolini Andrea
- Aversano Alessia
- Baccalini Edoardo
- Badessi Giorgio
- Bagaglini Giulia
- Baldari Ludovica
- Baldi Caterina
- Balestri Riccardo
- Balla Andrea
- Ballauri Edoardo
- Balzarotti Laura
- Banchini Filippo
- Barbosa Augusto
- Barina Andrea
- Barlettai Marco
- Bartolini Ilenia
- Basile Raffaele
- Batistotti Paola
- Bellora Paolo
- Beltrami Elsa
- Belvedere Angela
- Bernante Paolo
- Bianchi Paolo M
- Bianchini Federica
- Bianchini Matteo
- Bindi Marco
- Biondo Santino Antonio
- Birindelli Arianna
- Bizzoca Cinzia
- Bogoni Selene
- Bonaldi Marta
- Bonari Federica
- Bonati Elena
- Bondurri Andrea
- Bonfili Deborah
- Boni Giulia
- Boni Luigi
- Bonomi Alessandro
- Bottalico Bernardino
- Botti Marta
- Botto Massimiliano
- Bracchetti Greta
- Brachini Gioia
- Bressan Alice
- Brizzolari Marco
- Buccianti Piero
- Cabula Roberta
- CalabrĂČ Marcello
- Calafiore Eleonora
- Calandra Sergio
- Calef Riccardo
- Calini Giacomo
- Callegari Francesco
- Cammarata Francesco
- Campanelli Michela
- CampennĂŹ Paola
- Canavese Anna
- Canfora Ilaria
- Canitano Nicola
- Cannata Gaspare
- Cannavera Alessandro
- Canonico Giuseppe
- Cantafio Stefano
- Capelli Patrizio
- Capolupo Gabriella T
- Capomagi Perla
- Capuano Marianna
- Carannante Filippo
- Carbone Fabio
- Cardelli Stefano
- Cardile Mathieu
- Carganico Giacomo
- Caricato Marco
- Carissimi Francesca
- Carlini Massimo
- Carvello Michele
- Casati Massimiliano
- Casiraghi Silvia
- Casole Giovanni
- Cassiani Giovanna
- Cassinotti Elisa
- Catalioto Caterina
- Catarsini Nivia
- Catena Fausto
- Cattaneo Antonio
- Cavaliere Davide
- Celentano Valerio
- Cervellera Maurizio
- Cervone Carmela
- Cesana Giovanni C
- Cherchi Vittorio
- Cherubini Valeria
- Chiarella Leonardo L
- Chimisso Laura
- Chini Alessia
- Cianci Pasquale
- Cigagna Luca
- Cigognini Maria
- Cillara Nicola
- Cipressi Chiara
- Cirillo Bruno
- Ciulla Salvatore L
- Clementi Ilaria
- Clocchiatti Lucrezia
- Codignola Claudio
- Cojutti Alessandro
- Coletta Diego
- Colombo Francesco
- Conti Luigi
- Convertini Girolamo
- Corbellini Carlo
- Cortinovis Sara
- Cossu Andrea
- Cossu Maria L
- Cotsoglou Christian
- Cozzani Federico
- Crestale Sara
- CricrĂŹ Michele
- Crocco Veronica
- Crocetti Daniele
- Cucinotta Eugenio
- Cuicchi Dajana
- Curzi Federica
- Cuzzola Bruno
- D'Abrosca Vera
- D'Acapito Fabrizio
- D'Alessio Rossella
- d'Ischia Roberto
- Da Lio Corrado
- Dajti Gerti
- Dameno Vitale R
- Damigella Andrea
- Danelli Piergiorgio
- Danese Francesco
- De Capua Michele
- De Carlo Antonio
- De Carlo Giulia
- De Franciscis Silvia
- De Leo Eugenio
- De Lucia Francesca
- de Manzini NicolĂČ
- De Palma Giovanni D
- De Simone Giuseppe
- De Simone Veronica
- De Simoni Ottavia
- Deiana Selene
- Deidda Simona
- Del Rio Paolo
- Delogu Daniele
- Delrio Paolo
- Deserra Antonello
- Dester Sara E
- Dettori Manuela
- Di Martino Carmela
- Di Marzo Massimiliano
- Di Pietrantonio Daniela
- Dibra Rigers
- Dominioni Tommaso
- Doni Marco
- Elmore Ugo
- Ercolani Giorgio
- Esposito Giuseppe
- Fabbri NicolĂČ
- Faccio Luca
- Fancellu Alessandro
- Favi Francesco
- Fazzin Marta
- Federico Pipitone Nicoletta S
- Feo Carlo V
- Feo Claudio F
- Ferrero Alessandro
- Filippone Eleonora
- Fioravanti Emanuela
- Fiori Enrico
- Flacco Maria Elena
- Fleres Francesco
- Folliero Cristina
- Fracon Stefano
- Franceschi Angelo
- Franceschilli Marzia
- Franzato Boris
- Frascaroli Giacomo
- Frasson Alvise
- Fratarcangeli Riccardo
- Frongia Federica
- Frontali Alice
- Fuschillo Giacomo
- Galleano Raffaele
- Gambino Elena
- Garosio Ilenia
- Gattesco Davide
- Gattulli Domenico
- Gennari Silvia
- Gentilli Sergio
- Germani Paola
- Ghignone Federico
- Ghio Giacomo
- Ginesu Giorgio C
- Giordano Alessio
- Giovenzana Marco
- Giuffrida Maria C
- Giuffrida Mario
- Giuliani Beatrice
- Giunta Carlotta
- Glavas Dajana
- Gobbi Pietro
- Goletti Orlando
- Gonella Federica
- Gori Alice
- Gozzini Lorenzo
- Gramignano Giulia
- Grande Michele
- Grande Simona
- Granieri Stefano
- Graziano Michele
- Greco Paola A
- Grifoni Lucrezia
- Grossi Ugo
- Guerrini Luca
- Guida Andrea M
- Guida Anna
- Herranz van Nood Elena
- Incani Silvia
- Ippolito Luca
- Jovine Elio
- Laface Letizia
- Lamperti Giulia
- Lanci Lanci Antonio
- Langone Antonio
- Lantone Giuliano
- Lapolla Pierfrancesco
- Larotonda Cristina
- Lauricella Sara
- Lepiane Pasquale
- Lezoche Giovanni
- Lirusso Chiara
- Lisi Giorgio
- Litta Francesco
- Livi Serena
- Loderer Tommaso
- Lombardi Erica
- Lombardi Raffaele
- Lorusso Leonardo
- Lozito Concetta
- Luberto Antonio
- Luglio Gaetano
- Macchi Lorenzo
- Maffioli Anna
- Magarini Riccardo
- Maione Francesco
- Mammano Enzo
- Manigrasso Michele
- Manzo Carlo A
- Marchegiani Francesco
- Marchetti Francesco
- Marchetti Marcello E
- Marello Alessandra
- Margiani Carla
- Mariani NicolĂČ M
- Marinelli Laura
- Marra Angelo A
- Marra Bruno
- Marrelli Martina
- Marrosu Antonio
- Martellucci Cecilia
- Martines Gennaro
- Martinuzzo Lisa
- MascianĂ Gianluca
- Masetti Michele
- Massani Marco
- Mastrangeli Maria R
- Matani Davide
- Mattara Genny
- Maurino Ludovica
- Mazzeo Carmelo
- Mazzucchelli Carlo
- Menegon Tasselli Francesco
- Messina Valentina
- Miacci Valentina
- Milanesi Maria
- Milardi Francesco
- Milone Marco
- Mina Elisa
- Minafra Marina
- Mineccia Michela
- Mingoli Andrea
- Molfino Sarah
- Molteni Mattia
- Mondi Isabella
- Mongelli Claudia
- Monni Manuela
- Montroni Isacco
- Morelli Giulia
- Moretti Luisa
- Morezzi Daniele
- Morino Mario
- Mozzon Marta
- Muratore Andrea
- Murzi Valentina
- Muschitiello Davide
- Muttillo Irnerio A
- Nardo Bruno
- Nascimbeni Riccardo
- Nelli Tommaso
- Nespoli Luca
- Nikaj Herald
- Novello Simone
- Oddis Lidia
- Offi Maria F
- Oldani Massimo
- Olmi Stefano
- Opocher Enrico
- Orlandoni Elena S
- Ortenzi Monica
- Osenda Edoardo
- Osso Mariasara
- Ottaviani Luca
- Pace Ugo
- Pagano Gianluca
- Paglione Daniele
- Palisi Marco
- Palmeri Matteo
- Palmieri Gerardo
- Palmieri Miriam
- Palomba Giuseppe
- Pansini Mauro
- Parello Angelo
- Parlanti Daniele
- Passuello Nicola
- Pata Francesco
- Patriti Alberto
- Pellegrini Sara
- Pellino Gianluca
- Peluso Claudia
- Pepe Francesco
- Peri Andrea
- Perotti Bruno
- Perotti Serena
- Perra Teresa
- Perri Roberto
- Pertile Davide
- Pesce Antonio
- Petrelli Filippo
- Pezzati Daniele
- Pezzoli Isabella
- Pezzuto Paola
- Picardi Biagio
- Picarelli Matteo
- Picciariello Arcangelo
- Piccolo Roberta
- Piceni Chiara
- Pietrabissa Andrea
- Pignata Giusto
- Pilati Pierluigi
- Pilia Tiziana
- Pisani Ceretti Andrea
- Pisanu Adolfo
- Pisconti Salvatore
- Podda Mauro
- Poggioli Gilberto
- Porcu Alberto
- Portolani Nazario
- Preve Gabriele
- Puccetti Francesco
- Pucciarelli Salvatore
- Puccini Marco
- Pugliese Luigi
- Puglisi Silvana B
- Quartierini Giorgio
- Ratto Carlo
- Rausa Emanuele
- Rega Daniela
- Restini Enrico
- Restivo Angelo
- Riboni Cristiana
- Rigosa Diego
- Rinaldi Marcella
- Ringressi Maria N
- Risaliti Matteo
- Rizzi Nicholas
- Romano Angela
- Romanzi Andrea
- Romboli Andrea
- Ronconi Diana
- Ronconi Maurizio
- Rosati Riccardo
- Rossi Del Monte Simone
- Rossi Fabrizio
- Rossi Stefano
- Rossin Eleonora
- Rossini Matteo
- Rottoli Matteo
- Russo Iris S
- Sacchi Matteo
- Salvetti Francesco
- Sampietro Gianluca M
- Santolamazza Giuliano
- Sapienza Paolo
- Saraceno Federica
- Sargenti Benedetta
- Sartarelli Lodovico
- Sarzo Giacomo
- Sasia Diego
- Scabini Stefano
- Scanu Antonio M
- Scaramuzzo Rosa
- Scarpa Edoardo
- Sciaudone Guido
- Scognamillo Fabrizio
- Scolaro Roberta
- Sederino Maria G
- Selvaggi Francesco
- Selvaggi Lucio
- Sensi Bruno
- Serventi Alberto
- Severi Silvia
- Shahu Juliana
- Sica Giuseppe S
- Siragusa Leandro
- Sironi Martina
- Solaini Leonardo
- Soriero Domenico
- Sorrentino Mario
- Spadoni Claudia
- Sperotto Beatrice
- Spina Eduardo
- Spinelli Antonino
- Spoletini Domenico
- Spolverato Gaya
- Taddei Antonio
- Taddei Giacomo
- Taffurelli Giovanni
- Taglietti Lucio
- Tamini NicolĂČ
- Tanzanu Marta
- Terrosu Giovanni
- Tiberio Guido A M
- Tirloni Luca
- Tomasicchio Giovanni
- Tomassi Monica
- Tonello Marco
- Tonini Valeria
- Tonti Carlo
- Torchiaro Marco
- Trigiante Giuseppe
- Tropeano Francesca P
- Tumolo Rocco
- Tutino Roberta
- Uccelli Matteo
- Ugolini Giampaolo
- Vago Gabriele
- Vaiana Roberto
- Vallicelli Carlo
- Vannelli Alberto
- Vecchiato Massimo
- Vercellone Barbara
- Verdi Daunia
- Vertaldi Sara
- Vignali Andrea
- Vignati Barbara
- Vincenti Leonardo
- Vinci Danilo
- Violante Tommaso
- Viscosi Francesca
- Vitali Francesca
- Vittadello Fabrizio
- Zagolin Gaya
- Zanini Nicola
- Zanus Giacomo
- Zanzi Federico
- Zattoni Davide
- Ziccarelli Antonio
- Zorcolo Luigi
- Publication venue
- Publication date
- 01/01/2022
- Field of study
IMPORTANCE Delays in screening programs and the reluctance of patients to seek medical
attention because of the outbreak of SARS-CoV-2 could be associated with the risk of more advanced
colorectal cancers at diagnosis.
OBJECTIVE To evaluate whether the SARS-CoV-2 pandemic was associated with more advanced
oncologic stage and change in clinical presentation for patients with colorectal cancer.
DESIGN, SETTING, AND PARTICIPANTS This retrospective, multicenter cohort study included all
17 938 adult patients who underwent surgery for colorectal cancer from March 1, 2020, to December
31, 2021 (pandemic period), and from January 1, 2018, to February 29, 2020 (prepandemic period),
in 81 participating centers in Italy, including tertiary centers and community hospitals. Follow-up was
30 days from surgery.
EXPOSURES Any type of surgical procedure for colorectal cancer, including explorative surgery,
palliative procedures, and atypical or segmental resections.
MAIN OUTCOMES AND MEASURES The primary outcome was advanced stage of colorectal cancer
at diagnosis. Secondary outcomes were distant metastasis, T4 stage, aggressive biology (defined as
cancer with at least 1 of the following characteristics: signet ring cells, mucinous tumor, budding,
lymphovascular invasion, perineural invasion, and lymphangitis), stenotic lesion, emergency surgery,
and palliative surgery. The independent association between the pandemic period and the outcomes
was assessed using multivariate random-effects logistic regression, with hospital as the cluster
variable.
RESULTS A total of 17 938 patients (10 007 men [55.8%]; mean [SD] age, 70.6 [12.2] years)
underwent surgery for colorectal cancer: 7796 (43.5%) during the pandemic period and 10 142
(56.5%) during the prepandemic period. Logistic regression indicated that the pandemic period was
significantly associated with an increased rate of advanced-stage colorectal cancer (odds ratio [OR],
1.07; 95%CI, 1.01-1.13; P = .03), aggressive biology (OR, 1.32; 95%CI, 1.15-1.53; P < .001), and stenotic
lesions (OR, 1.15; 95%CI, 1.01-1.31; P = .03).
CONCLUSIONS AND RELEVANCE This cohort study suggests a significant association between the
SARS-CoV-2 pandemic and the risk of a more advanced oncologic stage at diagnosis among patients
undergoing surgery for colorectal cancer and might indicate a potential reduction of survival for
these patients
Why Are Outcomes Different for Registry Patients Enrolled Prospectively and Retrospectively? Insights from the Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF).
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- Yoshida T. (Tomoki)
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- Yousef G.
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- Yuksekdag V
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- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2018
- Field of study
Background: Retrospective and prospective observational studies are designed to reflect real-world evidence on clinical practice, but can yield conflicting results. The GARFIELD-AF Registry includes both methods of enrolment and allows analysis of differences in patient characteristics and outcomes that may result. Methods and Results: Patients with atrial fibrillation (AF) and â„1 risk factor for stroke at diagnosis of AF were recruited either retrospectively (nâ=â5069) or prospectively (nâ=â5501) from 19 countries and then followed prospectively. The retrospectively enrolled cohort comprised patients with established AF (for a least 6, and up to 24 months before enrolment), who were identified retrospectively (and baseline and partial follow-up data were collected from the emedical records) and then followed prospectively between 0-18 months (such that the total time of follow-up was 24 months; data collection Dec-2009 and Oct-2010). In the prospectively enrolled cohort, patients with newly diagnosed AF (â€6 weeks after diagnosis) were recruited between Mar-2010 and Oct-2011 and were followed for 24 months after enrolment. Differences between the cohorts were observed in clinical characteristics, including type of AF, stroke prevention strategies, and event rates. More patients in the retrospectively identified cohort received vitamin K antagonists (62.1% vs. 53.2%) and fewer received non-vitamin K oral anticoagulants (1.8% vs . 4.2%). All-cause mortality rates per 100 person-years during the prospective follow-up (starting the first study visit up to 1 year) were significantly lower in the retrospective than prospectively identified cohort (3.04 [95% CI 2.51 to 3.67] vs . 4.05 [95% CI 3.53 to 4.63]; pâ=â0.016). Conclusions: Interpretations of data from registries that aim to evaluate the characteristics and outcomes of patients with AF must take account of differences in registry design and the impact of recall bias and survivorship bias that is incurred with retrospective enrolment. Clinical Trial Registration: - URL: http://www.clinicaltrials.gov . Unique identifier for GARFIELD-AF (NCT01090362)
Multidifferential study of identified charged hadron distributions in Z-tagged jets in proton-proton collisions at sâ=13 TeV
- Author
- Aaij Roel
- Abdelmotteleb Ahmed Sameh Wagih
- Abellan Beteta Carlos
- Abudinén Fernando Jesus
- Ackernley Thomas
- Adeva Bernardo
- Adinolfi Marco
- Afsharnia Hossein
- Agapopoulou Christina
- Aidala Christine Angela
- Aiola Salvatore
- Ajaltouni Ziad
- Akar Simon
- Akiba Kazuyoshi
- Albrecht Johannes
- Alessio Federico
- Alexander Michael
- Alfonso Albero Alejandro
- Aliouche Zakariya
- Alvarez Cartelle Paula
- Amalric Renaud
- Amato Sandra
- Amey Jake Lewis
- Amhis Yasmine
- An Liupan
- Anderlini Lucio
- Andersson Martin
- Andreianov Aleksei
- Andreotti Mirco
- Andreou Dimitra
- Ao Dong
- Archilli Flavio
- Artamonov Alexander
- Artuso Marina
- Aslanides Elie
- Atzeni Michele
- Audurier Benjamin
- Bachmann Sebastian
- Bachmayer Marie
- Back John
- Bailly-Reyre Aurelien
- Baladron Rodriguez Pablo
- Balagura Vladislav
- Baldini Wander
- Baptista de Souza Leite Juan
- Barbetti Matteo
- Barlow Roger
- Barsuk Sergey
- Barter William
- Bartolini Matteo
- Baryshnikov Fedor
- Basels Jan-Marc
- Bassi Giovanni
- Batsukh Baasansuren
- Battig Alexander
- Bay Aurelio
- Beck Anja
- Becker Maik
- Bedeschi Franco
- Bediaga Ignacio
- Beiter Andrew
- Belavin Vladislav
- Belin Samuel
- Bellee Violaine
- Belous Konstantin
- Belov Ilia
- Belyaev Ivan
- Ben-Haim Eli
- Benane Gaya
- Bencivenni Giovanni
- Berezhnoy Alexander
- Bernet Roland
- Berninghoff Daniel
- Bernstein Harris Conan
- Bertella Claudia
- Bertolin Alessandro
- Betancourt Christopher
- Betti Federico
- Bezshyiko Iaroslava
- Bhasin Srishti
- Bhom Jihyun
- Bian Lingzhu
- Bieker Martin Stefan
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- Wang Jike
- Wang Mengzhen
- Wang Rui
- Wang Xiaolin
- Wang Yilong
- Wang Zhenzi
- Wang Zirui
- Wang Ziyi
- Ward Jake Alexander
- Watson Nigel
- Websdale David
- Wei Yajing
- Weisser Constantin
- Westhenry Benedict Donald C
- White Dylan Jaide
- Whitehead Mark
- Wiederhold Aidan Richard
- Wiedner Dirk
- Wilkinson Guy
- Wilkinson Michael K
- Williams Ifan
- Williams Mark Richard James
- Williams Mike
- Williams Richard Morgan
- Wilson Fergus
- Wislicki Wojciech
- Witek Mariusz
- Witola Lukas
- Wong Cheuk Ping
- Wormser Guy
- Wotton Stephen
- Wu Hangyi
- Wyllie Kenneth
- Xiang Zhiyu
- Xiao Dong
- Xie Yuehong
- Xu Ao
- Xu Jingyi
- Xu Li
- Xu Liangjun
- Xu Menglin
- Xu Qingnian
- Xu Zehua
- Xu Zhihao
- Yang Di
- Yang Shuangli
- Yang Youhua
- Yang Zhenwei
- Yang Zishuo
- Yeomans Lauren Emma
- Yin Hang
- Yu Jiesheng
- Yuan Xuhao
- Zaffaroni Ettore
- Zavertyaev Mikhail
- Zdybal Milosz
- Zenaiev Oleksandr
- Zeng Ming
- Zhang Chenjia
- Zhang Dongliang
- Zhang Liming
- Zhang Shulei
- Zhang Shunan
- Zhang Yanxi
- Zhang Yu
- Zharkova Alina
- Zhelezov Alexey
- Zheng Yangheng
- Zhou Tianwen
- Zhou Xiaokang
- Zhou Yixiong
- Zhovkovska Valeriia
- Zhu Xianglei
- Zhu Xiaoyu
- Zhu Zhanwen
- Zhukov Valery
- Zou Quan
- Zucchelli Stefano
- Zuliani Davide
- Zunica Gianluca
- Publication venue
- Publication date
- 24/08/2022
- Field of study
Jet fragmentation functions are measured for the first time in proton-proton
collisions for charged pions, kaons, and protons within jets recoiling against
a Z boson. The charged-hadron distributions are studied longitudinally and
transversely to the jet direction for jets with transverse momentum 20 <pTâ<100 GeV and in the pseudorapidity range 2.5<η<4. The
data sample was collected with the LHCb experiment at a center-of-mass energy
of 13 TeV, corresponding to an integrated luminosity of 1.64 fbâ1. Triple
differential distributions as a function of the hadron longitudinal momentum
fraction, hadron transverse momentum, and jet transverse momentum are also
measured for the first time. This helps constrain transverse-momentum-dependent
fragmentation functions. Differences in the shapes and magnitudes of the
measured distributions for the different hadron species provide insights into
the hadronization process for jets predominantly initiated by light quarks.Comment: All figures and tables, along with machine-readable versions and any
supplementary material and additional information, are available at
https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-013.html (LHCb
public pages
Study of the BââÎc+âÎËcââKâ decay
- Author
- Aaij Roel
- Abdelmotteleb Ahmed Sameh Wagih
- Abellan Beteta Carlos
- Abudinén Fernando Jesus
- Ackernley Thomas
- Adeva Bernardo
- Adinolfi Marco
- Adlarson Patrik Harri
- Afsharnia Hossein
- Agapopoulou Christina
- Aidala Christine Angela
- Aiola Salvatore
- Ajaltouni Ziad
- Akar Simon
- Akiba Kazuyoshi
- Albrecht Johannes
- Alessio Federico
- Alexander Michael
- Alfonso Albero Alejandro
- Aliouche Zakariya
- Alvarez Cartelle Paula
- Amalric Renaud
- Amato Sandra
- Amey Jake Lewis
- Amhis Yasmine
- An Liupan
- Anderlini Lucio
- Andersson Martin
- Andreianov Aleksei
- Andreotti Mirco
- Andreou Dimitra
- Ao Dong
- Archilli Flavio
- Artamonov Alexander
- Artuso Marina
- Aslanides Elie
- Atzeni Michele
- Audurier Benjamin
- Bachmann Sebastian
- Bachmayer Marie
- Back John
- Bailly-Reyre Aurelien
- Baladron Rodriguez Pablo
- Balagura Vladislav
- Baldini Wander
- Baptista de Souza Leite Juan
- Barbetti Matteo
- Barlow Roger
- Barsuk Sergey
- Barter William
- Bartolini Matteo
- Baryshnikov Fedor
- Basels Jan-Marc
- Bassi Giovanni
- Batsukh Baasansuren
- Battig Alexander
- Bay Aurelio
- Beck Anja
- Becker Maik
- Bedeschi Franco
- Bediaga Ignacio
- Beiter Andrew
- Belavin Vladislav
- Belin Samuel
- Bellee Violaine
- Belous Konstantin
- Belov Ilia
- Belyaev Ivan
- Ben-Haim Eli
- Benane Gaya
- Bencivenni Giovanni
- Berezhnoy Alexander
- Bernet Andres Sergi
- Bernet Roland
- Berninghoff Daniel
- Bernstein Harris Conan
- Bertella Claudia
- Bertolin Alessandro
- Betancourt Christopher
- Betti Federico
- Bezshyiko Iaroslava
- Bhasin Srishti
- Bhom Jihyun
- Bian Lingzhu
- Bieker Martin Stefan
- Biesuz Nicolo Vladi
- Bifani Simone
- Billoir Pierre
- Biolchini Alice
- Birch Matthew
- Bishop Fionn Caitlin Ros
- Bitadze Alexander
- Bizzeti Andrea
- Blago Michele Piero
- Blake Thomas
- Blanc Frederic
- Blank Jonah Evan
- Blusk Steven
- Bobulska Dana
- Boelhauve Julian Alexander
- Boente Garcia Oscar
- Boettcher Thomas
- Boldyrev Alexey
- Bolognani Carolina
- Bolzonella Riccardo
- Bondar Nikolay
- Borgato Federica
- Borghi Silvia
- Borsato Martino
- Borsuk Jozef Tomasz
- Bouchiba Sonia Amina
- Bowcock Themistocles
- Boyer Alexandre
- Bozzi Concezio
- Bradley Matthew John
- Braun Svende
- Brea Rodriguez Alexandre
- Brodzicka Jolanta
- Brossa Gonzalo Arnau
- Brown James David
- Brundu Davide
- Buonaura Annarita
- Buonincontri Laura
- Burke Aodhan Tomas
- Burr Christopher
- Bursche Albert
- Butkevich Anatoly
- Butter Jordy Sebastiaan
- Buytaert Jan
- Byczynski Wiktor
- Cadeddu Sandro
- Cai Hao
- Calabrese Roberto
- Calefice Lukas
- Cali Stefano
- Calladine Ryan
- Calvi Marta
- Calvo Gomez Miriam
- Campana Pierluigi
- Campora Perez Daniel Hugo
- Campoverde Quezada Angel Fernando
- Capelli Simone
- Capriotti Lorenzo
- Carbone Angelo
- Carboni Giovanni
- Cardinale Roberta
- Cardini Alessandro
- Carniti Paolo
- Carus Leon David
- Casais Vidal Adrian
- Caspary Rowina
- Casse Gianluigi
- Cattaneo Marco
- Cavallero Giovanni
- Cavallini Viola
- Celani Sara
- Cerasoli Jacopo
- Cervenkov Daniel
- Chadwick Abbie Jane
- Chapman Matthew George
- Charles Matthew
- Charpentier Philippe
- Chavez Barajas Carlos Alberto
- Chefdeville Maximilien
- Chen Chen
- Chen Shanzhen
- Chernov Aleksei
- Chernyshenko Serhii
- Chobanova Veronika
- Cholak Serhii
- Chrzaszcz Marcin
- Chubykin Aleksei
- Chulikov Vladimir
- Ciambrone Paolo
- Cicala Maria Flavia
- Cid Vidal Xabier
- Ciezarek Gregory
- Clarke Peter
- Clemencic Marco
- Cliff Harry
- Closier Joel
- Cobbledick John Leslie
- Coco Victor
- Coelho Joao A.B
- Cogan Julien
- Cogneras Eric
- Cojocariu Lucian
- Collins Paula
- Colombo Tommaso
- Congedo Liliana
- Contu Andrea
- Cooke Naomi
- Corredoira Imanol
- Corti Gloria
- Couturier Benjamin
- Craik Daniel Charles
- Cruz Torres Melissa Maria
- Currie Robert
- d'Ambrosio Carmelo
- d'Argent Philippe
- da Silva Cesar Luiz
- Dadabaev Shakhzod
- Dai Lingyun
- Dai Xinchen
- Dall'Occo Elena
- Dalseno Jeremy
- Daniel Jessy
- Danilina Anna
- Davies Jonathan Edward
- Davis Adam
- de Aguiar Francisco Oscar
- de Boer Jan
- de Bruyn Kristof
- de Capua Stefano
- de Cian Michel
- de Freitas Carneiro da Graca Ulisses
- de Lucia Erika
- de Miranda Jussara
- de Paula Leandro
- de Serio Marilisa
- de Simone Dario
- de Simone Patrizia
- de Vellis Fabio
- de Vries Jacco
- Dean Cameron Thomas
- Debernardis Francesco
- Decamp Daniel
- Dedu Vlad-George
- del Buono Luigi
- Delaney Blaise
- Dembinski Hans Peter
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- Dettori Francesco
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- Ding Shuchong
- Dobishuk Vasyl
- Dolmatov Aleksandr
- Dong Chenzhi
- Donohoe Amanda May
- Dordei Francesca
- dos Reis Alberto
- Douglas Lauren
- Downes Anthony Gavin
- Duda Piotr Jakub
- Dudek Maciej Wojciech
- Dufour Laurent
- Duk Viacheslav
- Durante Paolo
- Duras Maciej
- Durham John Matthew
- Dutta Deepanwita
- Dziurda Agnieszka
- Dzyuba Alexey
- Easo Sajan
- Egede Ulrik
- Egorychev Victor
- Eidelman Semen
- Eirea Orro Caetano
- Eisenhardt Stephan
- Ejopu Enoch
- Ek-In Surapat
- Eklund Lars
- Ely Scott
- Ene Alexandru
- Epple Eliane
- Escher Stephan
- Eschle Jonas Nathanael
- Esen Sevda
- Evans Timothy
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- Ferro-Luzzi Massimiliano
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- Fiorini Massimiliano
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- Frei Christoph
- Friday David Anthony
- Fu Jinlin
- Fuehring Quentin
- Fulghesu Tommaso
- Gabriel Emmy
- Galati Giuliana
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- Gan Yuyue
- Gandelman Miriam
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- Gligorov Vladimir
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- Gomez Fernandez Sergio
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- Grabowski Jascha Peter
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- Henderson Riley Dylan Leslie
- Hennequin Arthur Marius
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- Hill Donal
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- Horswill Joshua Ethan
- Hou Ruiwen
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- Huang Xiaotao
- Hulsbergen Wouter
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- Hushchyn Mikhail
- Hutchcroft David
- Ibis Philipp
- Idzik Marek
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- Jage Hendrik
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- Jakobsen Sune
- Jans Eddy
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- Jawahery Abolhassan
- Jevtic Vukan
- Jiang Emily Kaiyin
- Jiang Xiaojie
- Jiang Yi
- John Malcolm
- Johnson Daniel
- Jones Christopher
- Jones Thomas Peter
- Jost Beat
- Jurik Nathan
- Juszczak Izabela
- Kandybei Sergii
- Kang Youen
- Karacson Matthias
- Karpenkov Dmitrii
- Karpov Maksim
- Kautz Jacob William
- Keizer Floris
- Keller Dustin Michael
- Kenzie Matthew
- Ketel Tjeerd
- Khanji Basem
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- Swallow Paul Nathaniel
- Swientek Krzysztof
- Szabelski Adam
- Szumlak Tomasz
- Szymanski Maciej Pawel
- t'Jampens Stephane
- Tan Yinghua
- Taneja Shantam
- Tanner Alastair Roger
- Tat Martin Duy
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- Torres Machado Diego
- Tou da Yu
- Trilov Stoyan Miroslavov
- Trippl Carina
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- Ukleja Artur
- Unverzagt Daniel Joachim
- Usachov Andrii
- Ustyuzhanin Andrey
- Uwer Ulrich
- Vagner Alexander
- Vagnoni Vincenzo
- Valassi Andrea
- Valenti Giovanni
- Valls Canudas Nuria
- van Beuzekom Martinus
- van Dijk Maarten
- van Hecke Hubert
- van Herwijnen Eric
- van Hulse Charlotte Barbara
- van Veghel Maarten
- Vazquez Gomez Ricardo
- Vazquez Regueiro Pablo
- Vecchi Stefania
- Velthuis Jaap
- Veltri Michele
- Venkateswaran Aravindhan
- Veronesi Michele
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- Vincent Pascal
- Volle Felicia Carolin
- Vom Bruch Dorothea
- Vorobyev Alexey
- Vorobyev Vitaly
- Voropaev Nikolai
- Vos Kimberley
- Vrahas Constantinos
- VĂĄzquez Sierra Carlos
- Waldi Roland
- Walsh John
- Wan Guanyue
- Wang Chishuai
- Wang Ganrong
- Wang Jialu
- Wang Jianchun
- Wang Jianqiao
- Wang Jike
- Wang Mengzhen
- Wang Rui
- Wang Xiaolin
- Wang Yilong
- Wang Zhenzi
- Wang Zirui
- Wang Ziyi
- Ward Jake Alexander
- Watson Nigel
- Websdale David
- Wei Yajing
- Weisser Constantin
- Westhenry Benedict Donald C
- White Dylan Jaide
- Whitehead Mark
- Wiederhold Aidan Richard
- Wiedner Dirk
- Wilkinson Guy
- Wilkinson Michael K
- Williams Ifan
- Williams Mark Richard James
- Williams Mike
- Williams Richard Morgan
- Wilson Fergus
- Wislicki Wojciech
- Witek Mariusz
- Witola Lukas
- Wong Cheuk Ping
- Wormser Guy
- Wotton Stephen
- Wu Hangyi
- Wu Jie
- Wyllie Kenneth
- Xiang Zhiyu
- Xiao Dong
- Xie Yuehong
- Xu Ao
- Xu Jingyi
- Xu Li
- Xu Liangjun
- Xu Menglin
- Xu Qingnian
- Xu Zehua
- Xu Zhihao
- Yang Di
- Yang Shuangli
- Yang Xueting
- Yang Youhua
- Yang Zhenwei
- Yang Zishuo
- Yeomans Lauren Emma
- Yeroshenko Vsevolod
- Yeung Ho Yin Dereck
- Yin Hang
- Yu Jiesheng
- Yuan Xuhao
- Zaffaroni Ettore
- Zavertyaev Mikhail
- Zdybal Milosz
- Zenaiev Oleksandr
- Zeng Ming
- Zhang Chenjia
- Zhang Dongliang
- Zhang Liming
- Zhang Shulei
- Zhang Shunan
- Zhang Yanxi
- Zhang Yu
- Zharkova Alina
- Zhelezov Alexey
- Zheng Yangheng
- Zhou Tianwen
- Zhou Xiaokang
- Zhou Yixiong
- Zhovkovska Valeriia
- Zhu Xianglei
- Zhu Xiaoyu
- Zhu Zhanwen
- Zhukov Valery
- Zou Quan
- Zucchelli Stefano
- Zuliani Davide
- Zunica Gianluca
- Publication venue
- Publication date
- 02/11/2022
- Field of study
The decay BââÎc+âÎËcââKâ is studied
in proton-proton collisions at a center-of-mass energy of sâ=13 TeV
using data corresponding to an integrated luminosity of 5 fbâ1
collected by the LHCb experiment. In the Îc+âKâ system, the
Îcâ(2930)0 state observed at the BaBar and Belle experiments is
resolved into two narrower states, Îcâ(2923)0 and Îcâ(2939)0,
whose masses and widths are measured to be m(Îcâ(2923)0)=2924.5±0.4±1.1MeV,m(Îcâ(2939)0)=2938.5±0.9±2.3MeV,Î(Îcâ(2923)0)=0004.8±0.9±1.5MeV,Î(Îcâ(2939)0)=0011.0±1.9±7.5MeV, where the first uncertainties are statistical and the second
systematic. The results are consistent with a previous LHCb measurement using a
prompt Îc+âKâ sample. Evidence of a new Îcâ(2880)0
state is found with a local significance of 3.8Ï, whose mass and width
are measured to be 2881.8±3.1±8.5MeV and 12.4±5.3±5.8MeV, respectively. In addition, evidence of a new decay mode
Îcâ(2790)0âÎc+âKâ is found with a significance of
3.7Ï. The relative branching fraction of BââÎc+âÎËcââKâ with respect to the BââD+DâKâ
decay is measured to be 2.36±0.11±0.22±0.25, where the first
uncertainty is statistical, the second systematic and the third originates from
the branching fractions of charm hadron decays.Comment: All figures and tables, along with any supplementary material and
additional information, are available at
https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-028.html (LHCb
public pages
Measurement of the ratios of branching fractions R(Dâ) and R(D0)
- Author
- Aaij Roel
- Abdelmotteleb Ahmed Sameh Wagih
- Abellan Beteta Carlos
- Abudinén Fernando Jesus
- Ackernley Thomas
- Adeva Bernardo
- Adinolfi Marco
- Adlarson Patrik Harri
- Afsharnia Hossein
- Agapopoulou Christina
- Aidala Christine Angela
- Ajaltouni Ziad
- Akar Simon
- Akiba Kazuyoshi
- Albicocco Pietro
- Albrecht Johannes
- Alessio Federico
- Alexander Michael
- Alfonso Albero Alejandro
- Aliouche Zakariya
- Alvarez Cartelle Paula
- Amalric Renaud
- Amato Sandra
- Amey Jake Lewis
- Amhis Yasmine
- An Liupan
- Anderlini Lucio
- Andersson Martin
- Andreianov Aleksei
- Andreotti Mirco
- Andreou Dimitra
- Ao Dong
- Archilli Flavio
- Artamonov Alexander
- Artuso Marina
- Aslanides Elie
- Atzeni Michele
- Audurier Benjamin
- Bachiller Perea Irene
- Bachmann Sebastian
- Bachmayer Marie
- Back John
- Bailly-Reyre Aurelien
- Baladron Rodriguez Pablo
- Balagura Vladislav
- Baldini Wander
- Baptista de Souza Leite Juan
- Barbetti Matteo
- Barlow Roger
- Barsuk Sergey
- Barter William
- Bartolini Matteo
- Baryshnikov Fedor
- Basels Jan-Marc
- Bassi Giovanni
- Batsukh Baasansuren
- Battig Alexander
- Bay Aurelio
- Beck Anja
- Becker Maik
- Bedeschi Franco
- Bediaga Ignacio
- Beiter Andrew
- Belin Samuel
- Bellee Violaine
- Belous Konstantin
- Belov Ilia
- Belyaev Ivan
- Ben-Haim Eli
- Benane Gaya
- Bencivenni Giovanni
- Berezhnoy Alexander
- Bernet Andres Sergi
- Bernet Roland
- Berninghoff Daniel
- Bernstein Harris Conan
- Bertella Claudia
- Bertolin Alessandro
- Betancourt Christopher
- Betti Federico
- Bezshyiko Iaroslava
- Bhasin Srishti
- Bhom Jihyun
- Bian Lingzhu
- Bieker Martin Stefan
- Biesuz Nicolo Vladi
- Billoir Pierre
- Biolchini Alice
- Birch Matthew
- Bishop Fionn Caitlin Ros
- Bitadze Alexander
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- Xu Menglin
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- Xu Zhihao
- Yang Di
- Yang Shuangli
- Yang Xueting
- Yang Youhua
- Yang Zhenwei
- Yang Zishuo
- Yeomans Lauren Emma
- Yeroshenko Vsevolod
- Yeung Ho Yin Dereck
- Yin Hang
- Yu Jiesheng
- Yuan Xuhao
- Zaffaroni Ettore
- Zavertyaev Mikhail
- Zdybal Milosz
- Zeng Ming
- Zhang Chenjia
- Zhang Dongliang
- Zhang Liming
- Zhang Shulei
- Zhang Shunan
- Zhang Yanxi
- Zhang Yu
- Zhao Ya
- Zharkova Alina
- Zhelezov Alexey
- Zheng Yangheng
- Zhou Tianwen
- Zhou Xiaokang
- Zhou Yixiong
- Zhovkovska Valeriia
- Zhu Xianglei
- Zhu Xiaoyu
- Zhu Zhanwen
- Zhukov Valery
- Zou Quan
- Zucchelli Stefano
- Zuliani Davide
- Zunica Gianluca
- Publication venue
- Publication date
- 01/01/2023
- Field of study
The ratios of branching fractions
R(Dâ)âĄB(BËâDâÏâÎœËÏâ)/B(BËâDâÎŒâÎœËÎŒâ) and R(D0)âĄB(BââD0ÏâÎœËÏâ)/B(BââD0ÎŒâÎœËÎŒâ) are measured, assuming isospin symmetry, using a
sample of proton-proton collision data corresponding to 3.0 fbâ1 of
integrated luminosity recorded by the LHCb experiment during 2011 and 2012. The
tau lepton is identified in the decay mode
ÏââÎŒâÎœÏâÎœËÎŒâ. The measured values are
R(Dâ)=0.281±0.018±0.024 and
R(D0)=0.441±0.060±0.066, where the first uncertainty is
statistical and the second is systematic. The correlation between these
measurements is Ï=â0.43. Results are consistent with the current average
of these quantities and are at a combined 1.9 standard deviations from the
predictions based on lepton flavor universality in the Standard Model.Comment: All figures and tables, along with any supplementary material and
additional information, are available at
https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-039.html (LHCb
public pages
Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.
- Author
- A. Abd El-Aziz
- A. Abdul
- A. Agakhanyan
- A. Aggarwala
- A. Agrawal
- A. Al Mulla
- A. Al Naeemi
- A. Alfieri
- A. Ali
- A. Altun
- A. Alvarez D'Amelio
- A. Andersson
- A. Argena
- A. Austria
- A. Aydinlar
- A. Babyesiza
- A. Barai
- A. Barreau
- A. Barszcz
- A. Bartes
- A. Bazzoni Ruiz
- A. Beattie
- A. Bianchi
- A. Biernacka
- A. Black
- A. Blenkhorn
- A. Branjovich Tijuan
- A. Bremmelgaard
- A. Brown
- A. Browne
- A. Capucci
- A. Caspar
- A. Catanchin
- A. Chmielowski
- A. Choi
- A. Cieszynska
- A. Conde Y Bolado
- A. Connelly
- A. Cortada Cabrera
- A. Davids
- A. De Blasio
- A. De Wolf
- A. Dickerson
- A. Domenech Borras
- A. Dumikyan
- A. Edin
- A. Egilsson
- A. El-Etreby
- A. Elbahry
- A. Elorriaga Madariaga
- A. Espallargas
- A. Ewert
- A. Fearon
- A. Fedorowsky
- A. Ferreira-Jardim
- A. Ferrer
- A. Filippi
- A. Fleck
- A. Flynn
- A. Forero
- A. Frankiewicz
- A. Fujisawa
- A. Gallagher
- A. Ganatra
- A. Gegenhuber
- A. Gieroba
- A. Gilliland
- A. Giombolini
- A. Gonzales Segovia
- A. Grande Ruiz
- A. Grau
- A. Grytzmann
- A. Gubanov
- A. Guerrero Molina
- A. Guinand
- A. Haideri
- A. Hajimirsadeghi
- A. HallarÄker
- A. Halpin
- A. Hay
- A. Heer
- A. Heyse
- A. Horak
- A. Hot-Bjelac
- A. Howitt
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- T. Myhill
- T. Nagatomo
- T. Nagoshi
- T. Nakayama
- T. Nanke
- T. Novikova
- T. Ogawa
- T. Ono
- T. Ovdiienko
- T. Parrott
- T. Patching
- T. Phan
- T. Pillay
- T. Purcell
- T. Railton
- T. Richardson
- T. Ripoll Vera
- T. Ruaro Reichert
- T. Rusicka-Piekarz
- T. Saito
- T. Sanghera
- T. Sasaki
- T. Sayin
- T. Scarponi
- T. Schatzberger
- T. Schwarz
- T. SchÀfer
- T. Seker
- T. Seo
- T. Seto
- T. Shindo
- T. Shinozuka
- T. Shirai
- T. Shiraiwa
- T. Stephenson
- T. Suetsugu
- T. Suga
- T. Suttana
- T. Tabuchi
- T. Taguchi
- T. Takagi
- T. Tana
- T. Taniguchi
- T. Tau
- T. Toennishoff
- T. Traczyk
- T. Trahey
- T. Tripti
- T. Tsuji
- T. Ueda
- T. Ueda
- T. Unoki
- T. van der Kley
- T. Vargas
- T. Vasankari
- T. Viana
- T. Vydt
- T. Wakiyama
- T. Washizuka
- T. Weyn
- T. Wisaratapong
- T. Wolf
- T. Wong
- T. Yamada
- T. Yamagishi
- T. Yamamoto
- T. Yu
- T. Ăien
- T.-J. Cha
- T.A.A. Alfaro
- T.G. Wu
- T.J. Hong
- T.M. Caimi
- T.T. Liu
- T.W. Lim
- T.Y. Ma
- Tadashi Nakamura
- Tetsuro Yoshida
- Tomoki Yoshida
- Toon Wei Lim
- Tsugihiro Nakamura
- U. Börjesson
- U. Dichristin
- U. Gerbaulet
- U. Hintze
- U. Horstmeier
- U. Kitmapawanont
- U. Weiser
- U.M. Nagamalesh
- V. Araujo
- V. Becerra Munoz
- V. Biagioli
- V. Bisne
- V. Campisi
- V. Dedek
- V. Dhyani
- V. Durdil
- V. Eissing
- V. Eltishcheva
- V. Fernandez Caputi
- V. Garcia Millan
- V. Hansen
- V. Hubacova
- V. Jain
- V. Klein
- V. Korley
- V. Kostenko
- V. Lawlor
- V. LilienweiĂ
- V. Machova
- V. Mitrovic
- V. Mochonyi
- V. Nagalingam
- V. Navarre
- V. Nemtsova
- V. Nilsen
- V. Novas
- V. O'May
- V. Olguin
- V. Oriana
- V. Palumbo
- V. Pannacci
- V. Paul
- V. Pengo
- V. Piamonte
- V. Quintern
- V. Rasanen
- V. Rios
- V. Roa Castro
- V. St Joseph
- V. Thyssen
- V. Tseluyko
- V. Ueckermann
- V. Vanajakshamma
- V. Varenov
- V. Wilson
- V. Worthy
- V. Yuksekdag
- V.A. Kothiwale
- V.A. Sinisi
- V.L. Pereira
- V.M. Ortega
- V.M. Vijan
- Veerappa A. Kothiwale
- Velam Vanajakshamma
- Vikas Bisne
- W. Abhayaratna
- W. Ahmed
- W. Al Mahmeed
- W. Anné
- W. Boonyapisit
- W. Brzozowski
- W. Coulson
- W. Dorsch
- W. Eder
- W. Erdle
- W. Faron
- W. Furumoto
- W. Gadzinski
- W. Gulliver
- W. Haverkamp
- W. Hermans
- W. Jetten
- W. Kunz Sebba Barroso de Souza
- W. Kurdzielewicz
- W. Lang
- W. Lumb
- W. Murdoch
- W. Myszka
- W. Oosthuysen
- W. Rogowski
- W. Smolders
- W. Suebjaksing
- W. Supinski
- W. Szkrobka
- W. Terpstra
- W. Tiyanon
- W. Van Gaal
- W. Wieczorek
- W. Wildenauer
- W. Willcock
- W. Wongcharoen
- W. Wongtheptien
- W.H. Li
- W.J. Chi
- W.L. Liu
- W.M. Kutayli
- W.N. Guo
- W.S. Son
- W.T. Lim
- W.Y. Lee
- W.Y. Zheng
- Wael Al Mahmeed
- Werner Hacke
- X. Chen
- X. Giry
- X. Li
- X. Robiro Robiro
- X. Sheng
- X. Vandamme
- X. Viñolas
- X.A. He
- X.F. Huang
- X.J. Gao
- X.J. Shi
- X.L. Luo
- X.S. Cheng
- X.S. Hu
- X.W. Yan
- X.Y. Zhu
- Xavier Viñolas
- Y. Abe
- Y. Atsuchi
- Y. Balthazar
- Y. Belenkova
- Y. Campisto
- Y. Emura
- Y. Fujii
- Y. Fujisawa
- Y. Go
- Y. Gomez Perez
- Y. Gottwalles
- Y. Guo
- Y. Haraguchi
- Y. Hata
- Y. Hatori
- Y. Hayashi
- Y. Ivanova
- Y. Jiao
- Y. Kamogawa
- Y. Kato
- Y. Katsube
- Y. Katsuda
- Y. Kawada
- Y. Kelfkens
- Y. Kitami
- Y. Koretsune
- Y. Koshibu
- Y. Kumai
- Y. Maruyama
- Y. Matsuura
- Y. Mizuno
- Y. Moiseeva
- Y. Mostovoy
- Y. Niijima
- Y. Nishida
- Y. Nishihata
- Y. Oba
- Y. Onuki Pearce
- Y. Orlov
- Y. Osmolovskaya
- Y. Park
- Y. Saito
- Y. Sakamoto
- Y. Samejima
- Y. Santanakorn
- Y. Sasagawa
- Y. Sekine
- Y. Seta
- Y. Shapovalova
- Y. Shiina
- Y. Shimoyama
- Y. Shozawa
- Y. Stipp
- Y. Suzuki
- Y. Svyshchenko
- Y. Takagi
- Y. Tsuchiya
- Y. Ueyama
- Y. Vandekerckhove
- Y. Vorasettakarnkij
- Y. Wakasa
- Y. Ye
- Y. Yokoyama
- Y. Zhang
- Y.-I. Kim
- Y.H. Li
- Y.H. Sun
- Y.H. Yin
- Y.J. Yang
- Y.J. Yang
- Y.K. On
- Y.M. Chen
- Y.M. Lee
- Y.M. Sohn
- Y.R. Jeon
- Y.S. Oh
- Y.S. Son
- Y.S. Zhao
- Y.Y. Liu
- Ying Wang
- Yoichi Nakamura
- Yong Wang
- Yoshihisa Fujiura
- Yoshitake Fujiura
- Yuhei Shiga
- Yuichiro Nakamura
- Yukihiro Koretsune
- Yukio Shiga
- Z. Babjakova
- Z. Boda
- Z. Djaidani
- Z. Lajkowski
- Z. Laszlo
- Z. May
- Z. Monhart
- Z. Ongen
- Z. Radics
- Z.C. Lu
- Z.H. Zhou
- Z.M. Yang
- Publication venue
- Indian Heart J
- Publication date
- 01/01/2018
- Field of study
BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362
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