Biopax and Semantics

Biopax community is producing sets of data in RDF files, but most of them are not available through query interfaces. The publication of SPARQL endpoints is feasible with current sets of data, but the use of reasoning in these interfaces is unfeasible in many cases. The use of large scale reasoners is a need to take advantage of these data sets

Influence of refining processes on content of bioactive compounds, rheology, and texture of olive pomace oil for use in topical formulations

Retaining the bioactive ingredients of olive pomace oil is a crucial step in ensuring their functional or pharmaceutical value. To help select the best method for retaining bioactive compounds in olive pomace oil, three refining processes, namely, chemical, classical physical, or molecular distillation, were compared at different temperatures. For each method, the contents of triacylglycerols, fatty acids (oleic acid, linoleic, and linolenic acids), triterpenic acids (oleanolic and maslinic acids), and unsaponifiable matter (squalene, aliphatic, sterols, and terpenic) were studied. We observed that physical refining by molecular distillation provided oils with interesting amounts of bioactive compounds, especially triterpenic acids. Of these oils, the samples submitted to a temperature of 190°C exhibited a greater albeit low acidity compared with the other oils obtained by chemical and classical physical refining but exhibited higher amounts of all bioactive compounds. Conversely, the molecular distillation refining process had only a slight effect on the values of the consistency index. The firmness, cohesiveness, and adhesiveness parameters from texture profile analysis indicated that in general, all deodorized oils had high smoothness and spreadability but low adhesiveness. Molecular distillation was concluded to be the best refining process. Nevertheless, it is necessary to improve the working conditions of this process. Practical applications: Olive pomace oil has all functional compounds of extra virgin olive oil, but with a higher concentration of some minor components. It is, therefore, very interesting to use it in skin care formulations. However, for use in the pharmaceutical field must be refined. This study aimed to provide determine the influence of different refining processes (chemical refining, classical physical refining, or physical refining by molecular distillation at different temperatures) in determining the composition of bioactive compounds. The best refining process was selected based on the analytical determination of bioactive compounds by gas chromatography. Results indicated that molecular distillation is the best refining process. Nevertheless, it is necessary to improve the working conditions. Scheme of the extraction and refining processes to which olive pomace oil is subjected, to achieve the lowest losses of bioactive compounds for use in topical formulations

Impact of co-infection by hepatitis C virus on immunological and virological response to antiretroviral therapy in HIV-positive patients

We assessed the effect of co-infection by hepatitis C virus (HCV) on immunological and virological response at 48 weeks from initiation of antiretroviral therapy (ART).We included patients from the Cohort of Spanish HIV Research Network (CoRIS) starting ART between January 2004 and November 2014, had at least 1 CD4 T-cell count and viral load measurements both in the previous 6 months and at 48 (±12) weeks from ART initiation, and HCV serology before ART initiation. We used linear regression for mean differences in CD4 T-cell count increase from ART initiation and logistic regression to estimate odds ratios for virological response.Of 12,239 patients by November 30, 2015, 5070 met inclusion criteria: 4382 (86.4%) HIV mono-infected and 688 (13.6%) HIV/HCV co-infected. Co-infected patients were more likely to have acquired HIV through injecting drugs use (57.4% vs. 1.1%), to be women, older, and Spanish, have a lower educational level, and having started ART with lower CD4 counts and acquired immunodeficiency syndrome. CD4 T-cell count increase at 48 weeks was 229.7 cell/μL in HIV-monoinfected and 161.9 cell/μL in HIV/HCV-coinfected patients. The percentages of patients achieving a virological response at 48 weeks were 87.0% and 78.3% in mono and coinfected patients, respectively. Multivariable analyses showed that at 48 weeks, coinfected patients increased 44.5 (95% confidence interval [CI]: 24.8-64.3) cells/μL less than monoinfected and had lower probability of virological response (odds ratio: 0.62; 95% CI: 0.44-0.88).HIV/HCV-coinfected patients have lower immunological and virological responses at 48 weeks from ART initiation than monoinfected patients.This work has been supported by the Spanish Medical Fund Research (PI12/02134) and Spanish Research Network of Excellence on HIV (RD12/0017/0018, RD16CIII/0002/0006) and Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública (CIBERESP).S

Five-year results of accelerated partial breast irradiation: a single institution retrospective review of 289 cases

Purpose: the purpose of the study was to describe our institutional experience with accelerated partial breast irradiation (APBI) using multicatheter brachytherapy with high-dose-rate. We report 5-year survival outcomes, cosmesis, and treatment-related toxicity. Methods and materials: this included a retrospective review of patients who underwent breast-conserving surgery followed by APBI at our institution from 2004 to 2017. Results: a total of 289 patients were evaluated. Median followup was 72 months. Median age was 70 years. APBI was the only primary treatment in 86.2% of cases with early-stage breast cancer and a second conservative treatment in 13.8%. The implant was performed postoperatively in 213 patients (73.7%) and intraoperatively in 76 (26.3%). The most common radiation schemes were 10 fractions of 3.4 Gy and eight fractions of 4 Gy. Elderly or frail patients (10%) received a single 16 Gy dose. Of the 289 patients, 215 met Groupe Europ een de Curieth erapie-European Society for Radiotherapy and Oncology criteria for APBI; in this group, late side effects included Grade 2 (G2) fibrosis (14.8%), skin discoloration at the catheter points (8.8%), and telangiectasia (0.5%). The cosmetic result was considered excellent or good in 88.3% of cases. Five-year local control, disease-free, cancer-specific, and overall survival rates were 98.9%, 96.7%, 99.1%, and 95.6%, respectively. Conclusions: local control and survival outcomes at 5 years of followup in this group of well-selected patients were excellent, with low rates of treatment-related toxicity. These findings confirm the safety and effectiveness of APBI, even in elderly and frail patients. These results provide further support for the clinical use of APBI in suitable patients. 2021 Published by Elsevier Inc. on behalf of American Brachytherapy Society

La concesión de hábitos de caballeros de las Ordenes Militares: procedimiento y reflejo documental (s. XVI - XIX)

Sin resume

To the question of improving the outcomes of surgical treatment of genital prolapse in postmenopausal women

Currently, the frequency of genital prolapse in the structure of common gynecological diseases has no tendency to decrease and may take up to 15% of large gynecological operations. With the aim of improving outcomes of surgical treatment of this category of patients, at the stage of preoperative preparation and the postoperative period used vaginal capsules containing Lactobacillus + progesterone 2 mg + estriol 0.2 mg (Triozhinal). The study included 239 patients in postmenopausal women with genital prolapse and phenomena cystourethroscopy and vaginal atrophy. Of these, the main group consisted of 122 women who underwent the proposed scheme of preoperative preparation and postoperative period. Group comparisons were presented 117 patients admitted to the gynecological Department for surgical treatment of prolapse with traditional preoperative and postoperative management. The results of the study showed that in the group of patients receiving local therapy estriola in combination with progesterone and lactobacilli, was observed a significant improvement of the clinical picture of urinary disorders, quality of life, symptoms of urogenital atrophy during surgical correction of urinary incontinence or genital prolapse, and this tactic can be recommended as in the pre-and postoperative periods.В настоящее время частота пролапса гениталий в структуре гинекологических заболеваний не имеет тенденции к снижению и занимает до 15% гинекологических операций. С целью улучшения исходов хирургического лечения данной категории пациенток, на этапе предоперационной подготовки и в период послеоперационной реабилитации использованы вагинальные капсулы, содержащие лактобактерии + прогестерон 2мг + эстриол 0,2 мг (триожиналь). Под наблюдением находились 239 пациенток в постменопаузе с пролапсом гениталий и явлениями вагинальной и цистоуретральной атрофии. Из них основную группу составили 122 женщины, которым проводилась предложенная нами схема ведения предоперационной подготовки и послеоперационного периода. Группа сравнения была представлена 117 пациентками, поступившим в гинекологическое отделение с традиционной предоперационной подготовкой и послеоперационным ведением. Результаты исследования показали, что в группе пациенток, получающей локальную терапию эстриолом в сочетании с прогестероном и лактобактериями, наблюдалось значимое улучшение клинической картины расстройств мочеиспускания, показателей качества жизни, симптомов урогенитальной атрофии при хирургической коррекции недержания мочи или пролапса гениталий, и такая тактика может быть рекомендована как в пред-, так и в послеоперационном периодах

Confesar y mitificar

El artículo trata de la enseñanza como vía para formar a la gente en el modo de pensarThis article deals about teaching like way of people’s thinkin

Confesar y mitificar

El artículo trata de la enseñanza como vía para formar a la gente en el modo de pensarThis article deals about teaching like way of people’s thinkin

Los restos prehistóricos del Pomar (Jerez de los Caballeros) y su integración dentro del Calcolítico de la cuenca del Ardila

Materiales prehistóricos, encuadrables tipológicamente en el Calcolítico o Edad del Cobre, aparecieron en el curso de los trabajos de excavación llevados a cabo en la década de los años ochenta en la llamada casa romana del Pomar, situada en el barrio del mismo nombre en Jerez de los Caballeros. Más recientemente, con motivo de una serie de obras para la limpieza y consolidación de las ruinas romanas, nuevos elementos prehistóricos han sido encontrados, a la vez que se detectó la presencia de vestigios de un nivel de ocupación anterior al que sirvió de cimentación a las estructuras arquitectónicas romanas.Prehistoric materials, typologically framed in the Chalcolithic or Copper Age, appeared in the course of the excavation work carried out in the decade of the eighties in the so-called Roman house of Pomar, located in the neighborhood of the same name in Jerez de los Caballeros. More recently, on the occasion of a series of works for the cleaning and consolidation of the Roman ruins, new prehistoric elements have been found, at the same time as the presence of vestiges of a level of occupation previous to the one that served as a foundation to the Roman architectonic structures was detected.peerReviewe

Evolución del sistema político en la China posmaoísta

Tras la crisis y desaparición de los regímenes comunistas de Europa del Este, fueron muchos los que pronosticaron que el régimen comunista chino estaba abocado irreversiblemente a una profunda crisis, de la que había sido un primer acto la crisis de Tiananmen. No obstante, la evolución posterior de China se ha caracterizado por su estabilidad, y el régimen político aparecía sólidamente asentado sobre el pacto pos-Tiananmen entre lo que se ha dado en llamar grupos reformistas y conservadores en el poder.After the crisis and disappearance of the communist regimes of Eastern Europe, many predicted that the Chinese communist regime was irreversibly engaged in a deep crisis, of which the Tiananmen crisis had been a first act. However, the subsequent evolution of China has been characterized by its stability, and the political regime appeared solidly based on the post-Tiananmen pact between what has been called reformist and conservative groups in power.peerReviewe