4 research outputs found
Oral versus intramuscular administration of vitamin B12 for vitamin B12 deficiency in primary care : a pragmatic, randomised, non-inferiority clinical trial (OB12)
- Author
- Aguilar-Jiménez Monica
- Azcoaga-Lorenzo Amaya
- Baños-Morras Raquel
- Caballero-RamĂrez Nuria
- Cura-Gonzalez Isabel
- DĂaz-Laso ConcepciĂłn
- Escortell-Mayor Esperanza
- FernĂĄndez-GarcĂa Rosa
- GarcĂa de Blas-GonzĂĄlez Francisca
- Garrido-Elustondo SofĂa
- GonzĂĄlez-Escobar Paloma
- GonzĂĄlez-GarcĂa Inmaculada
- GĂłmez-GascĂłn TomĂĄs
- Herrero de-Dios Alicia
- Herrero-HernĂĄndez JesĂșs
- Mariño-Suårez Jose Enrique
- Martin-Fernandez Jesus
- Mateo-Ruiz Carmen
- Medina-Bustillo Beatriz
- Noguerol-Ălvarez Mar
- OB12 Group
- Pose-GarcĂa Belen
- Riesgo-Fuertes Rosario
- Sanz-Cuesta Teresa
- Sevillano-Palmero MarĂa Luisa
- Vargas-Machuca Cabañero Concepción
- Ălvarez-Villalba Mar
- Publication venue
- 'BMJ'
- Publication date
- 20/08/2020
- Field of study
The trial was financed by Ministerio de Sanidad y Consumo Español through their call for independent clinical research, Orden Ministerial SAS/2377, 2010 (EC10-115, EC10-116, EC10-117, EC10-119, EC10-122); CAIBERâSpanish Clinical Research Network, Instituto de Salud Carlos III (ISCIII) (CAI08/010044); and Gerencia Asistencial de AtenciĂłn Primaria de Madrid. This study is also supported by the Spanish Clinical Research Network (SCReN), funded by ISCIII-SubdirecciĂłn General de EvaluaciĂłn y Fomento de la InvestigaciĂłn, project number PT13/0002/0007, within the National Research Program I+D+I 2013-2016 and co-funded with European Union ERDF funds (European Regional Development Fund). This project received a grant for the translation and publication of this article from the Foundation for Biomedical Research and Innovation in Primary Care (FIIBAP) Call 2017 for grants to promote research programs.Objectives To compare the effectiveness of oral versus intramuscular (IM) vitamin B12 (VB12) in patients aged â„65 years with VB12 deficiency. Design Pragmatic, randomised, non-inferiority, multicentre trial in 22 primary healthcare centres in Madrid (Spain). Participants 283 patients â„65 years with VB12 deficiency were randomly assigned to oral (n=140) or IM (n=143) treatment arm. Interventions The IM arm received 1 mg VB12 on alternate days in weeks 1â2, 1 mg/week in weeks 3â8 and 1 mg/month in weeks 9â52. The oral arm received 1 mg/day in weeks 1â8 and 1 mg/week in weeks 9â52. Main outcomes Serum VB12 concentration normalisation (â„211 pg/mL) at 8, 26 and 52 weeks. Non-inferiority would be declared if the difference between arms is 10% or less. Secondary outcomes included symptoms, adverse events, adherence to treatment, quality of life, patient preferences and satisfaction. Results The follow-up period (52 weeks) was completed by 229 patients (80.9%). At week 8, the percentage of patients in each arm who achieved normal B12 levels was well above 90%; the differences in this percentage between the oral and IM arm were â0.7% (133 out of 135 vs 129 out of 130; 95% CI: â3.2 to 1.8; p>0.999) by per-protocol (PPT) analysis and 4.8% (133 out of 140 vs 129 out of 143; 95% CI: â1.3 to 10.9; p=0.124) by intention-to-treat (ITT) analysis. At week 52, the percentage of patients who achieved normal B12 levels was 73.6% in the oral arm and 80.4% in the IM arm; these differences were â6.3% (103 out of 112 vs 115 out of 117; 95% CI: â11.9 to â0.1; p=0.025) and â6.8% (103 out of 140 vs 115 out of 143; 95% CI: â16.6 to 2.9; p=0.171), respectively. Factors affecting the success rate at week 52 were age, OR=0.95 (95% CI: 0.91 to 0.99) and having reached VB12 levels â„281 pg/mL at week 8, OR=8.1 (95% CI: 2.4 to 27.3). Under a Bayesian framework, non-inferiority probabilities (Î>â10%) at week 52 were 0.036 (PPT) and 0.060 (ITT). Quality of life and adverse effects were comparable across groups. 83.4% of patients preferred the oral route. Conclusions Oral administration was no less effective than IM administration at 8 weeks. Although differences were found between administration routes at week 52, the probability that the differences were below the non-inferiority threshold was very low.Publisher PDFPeer reviewe
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- Abukhalaf  Sadi A.
- Abuleil  Amro
- Ackermann  Travis
- Acquah  Daniel Kwesi
- Adam  Mohammed Elmujtba Adam Essa
- Adamina  Michel
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- Arancibia  José Alfredo Calderón
- Arango  Maria Clara Mendoza
- Arbane  Gill
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- Arnalsteen  Laurent
- Arnaud  Alexis P.
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- Azevedo  José
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- Azzam  Ahmed Y.
- Bacalbasa  Nicolae
- Badareesh  L.
- Badenes  Rafael
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- Balanta-Melo  Juliån
- Balasubramanya  Supriya
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- Borowski  David W.
- Botero  Marcela Velez
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- Bouchenak  Kamel
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- Callcut  Rachael
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- Calvache  Jose Andres
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- Campana  Juan Pablo
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- Caruana  Edward
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- Chauhan  Govind Singh
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- Chew  Min Hoe
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- Chinyowa  Simbarashe
- Chiuyari  Jose Rios
- Choong  Peter
- Chowdappa  Raghunandan Gorantlu
- Chowdhury  Sharfuddin
- Christensen  Peter
- Chuan  Alwin
- Chwat  Carina
- Chwat  Carina
- Clancy  Cillian
- Coimbra  Felipe José Fernandez
- Coleman  Julia
- Colmenares  Yahaira Tatiana Carpio
- Colås-Ruiz  Enrique
- Connelly  Tara
- Connor  Clare O.
- Coonar  Aman
- Corbett  Harriet
- Corella  Fernando
- Corripio-Sanchez  Ramon
- Costa  Luciana Cidade
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- Cotta  EstefanĂa
- Cox  Daniel
- Cox  Daniel
- Creavin  Ben
- Croattini  Roberto Sebastiån
- Croghan  Stefanie M.
- Crétolle  Célia
- Cukier  Moises
- Cukier  Moises
- Cullinane  Carolyn
- Cunha  Miguel F.
- Cunha  Miguel F.
- Dajti  Irida
- Dajti  Irida
- Dajti  Irida
- Daoud  Hassan
- Das  Rishi
- Davies-Jones  Gareth
- Davis  Niall
- Dawson  Amanda Caroline
- Dawson  Amanda Caroline
- Dawson  Brett E.
- Dbeis  Rachel
- De Andrés-Asenjo  Beatriz
- De Cortazar  Unai Garcia
- de Dieu  Haragirimana Jean
- de LeĂłn  Laura RomĂĄn GarcĂa
- De Simone  Belinda
- Dean  Benjamin
- Degefa  Eyueal
- Del Pilar Paucar Urbina  Arazzelly
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- Delisau-Puig  Olga
- Dell  Angela
- Demetrashvili  Zaza
- Demetrashvili  Zaza
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- Derilo  Habtamu
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- Deus  Ana Clåudia
- Dharap  Satish
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- Dhufera  Hailu
- Di Martino  Marcello
- Di Saverio  Salomone
- Di Vincenzo  Marcela
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- Diehl  Thomas
- Dimofte  Mihail-Gabriel
- DiNome  Maggie
- Djahida  Bahraoui
- Doerner  Johannes
- Domenech  Julio
- Donlon  Noel
- Drake  Frederick
- Drake  Thomas
- Drasovean  Radu
- Duarte  Amalia Barrios
- Duarte  Carolina Lugo
- Dube  Surya Kumar
- Duchalais  Emilie
- Dudi-Venkata  Nagendra
- Duran  Irani
- Duric  Natalie
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- Dwaga  Sumayya Essayah
- Dziakova  Jana
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- Eberbach  Helge
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- Edwards  John
- Efetov  Sergey
- Efetov  Sergey
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- Eiras  Miguel Angel Freiria
- Ekenze  Sebastian
- El Helw  Amin
- El Kafsi  JihÚne
- El-Boghdadly  Kariem
- El-Boghdadly  Kariem
- El-Hussuna  Alaa
- Elhadi  Muhammed
- Elhadi  Muhammed
- Elhajdawe  Fras
- Elliott  Brodie
- Ellojli  Ibrahim
- Elwahab  Sami Abd
- Emerson  Hannah
- Emile  Sameh
- Emile  Sameh
- Enjuto  Diego
- Escartin  Jorge
- Escudero  DamiĂĄn GarcĂa
- Escudero  Mario I.
- Eskander  Antoine
- Espin-Basany  Eloy
- Espino  Pablo Calvo
- Espinosa-Bravo  Martin
- Esquivel  Carlos
- Estruch  Nuria Montferrer
- Etchill  Eric
- Evans  Jonathan
- Evelyn  Nissi
- Ezanno  Anne-Cecile
- Fahadullah  Muhammad
- Fahmy  Mohamed
- Fakhradiyev  Ildar
- Fakhradiyev  Ildar
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- Farik  Shebani
- Farooq  Umer
- Faulkner  Gemma
- Faustin  Ntirenganya
- Fernandez  Juan Delgado
- Fernandez  Laura Gomez
- Fernandez  Maria Sol
- Fernåndez  Fåtima Sånchez
- Fernåndez-López  Antonio-José
- Ferrer  Antonio Perez
- Ferry  Jenny
- Figari  Marcelo
- Figueroa  Rodrigo
- Figueroa-Casanova  Rafael
- Filipce  Venko
- Filipescu  Daniela
- Fiore  Marco
- Fisseha  Tigist
- Flamey  Nicolas
- Fleming  Christina
- Flexman  Alana
- Fluegen  Georg
- Flumignan  Ronald
- Ford  Samuel
- Forero-Torres  Alexander
- Forneris  Agustin Albani
- Fotopoulou  Christina
- Fowler  Alexander
- Fraidenraij  Uriel
- Fredon  Fabien
- Fuentes  Marta Alcaraz
- Fuentes  Tyare
- Fujimoto  Yuki
- Futaba  Kaori
- Gagnier  Joel
- Gahwagi  Milad
- Gallegos  Diego
- Gallino  Esteban Sebastian
- Gallo  Gaetano
- Ganly  Ian
- Garcia  Manuel
- Garcia-Adamez  Jorge
- GarcĂa  Lucia Diego
- GarcĂa  Pablo MartĂn
- GarcĂa-Mansilla  AgustĂn Maria
- GarcĂa-Montoya  Oscar-JuliĂĄn
- Gaujoux  Sebastien
- Gauna  Guillermo Hernandez
- Gempt  Jens
- Georgiades  Fanourios
- Gerchunoff  José Ignacio
- Ghani  Muhammad Owais Abdul
- Ghazal  Ahmad
- Ghazwani  Salman
- Ghodke  Rahul
- Ghosh  Dhruva
- Ghosh  Dhruva
- Ghosh  Indranil
- Ghozy  Sherief
- Ghunaim  Mohammed
- Gialamas  Eleftherios
- Gialamas  Eleftherios
- Gigena  Cecilia
- Gil-Sala  Daniel
- Ginghina  Octav
- Giorgakis  Emmanouil
- Girard  Edouard
- Girard  Noémie
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- Gjata  Arben
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- Glasbey  James C.
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- Glass  Nina
- Glowka  Tim R.
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- Golet  Marta Roldón
- Gomes  Gustavo Mendonça AtaĂde
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- Gomez-Rosado  Juan-Carlos
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- Gonzalez  Marcos
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- Gonzalez  Santiago Valderrabano
- Gonzålez  Javier Serrano
- Gonzålez-Gimeno  Maria Jose
- Gonzålez-Suårez  Susana
- Goransky  Jeremias
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- Gulla  Aiste
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- Gupta  Rahul
- Gurumeta  Alfredo Abad
- Gut  Anna Eleonora
- Gómez  Mercedes Estaire
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- Habumuremyi  Sosthene
- Hadzibegovic  Ana Danic
- Haidar  Hanan
- Haider  Fayza
- Haif  Assia
- Hailu  Samuel
- Hailu  Samuel
- Hakami  Ibrahim
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- Hammond  John
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- Hardie  John
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- Hodgson  Russell
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- Hollington  Paul
- Hollyman  Marianne
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- Hutchinson  Peter
- Hyman  Gabriella Yael
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- Imanishimwe  Alphonsine
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- Infante  Antonio Rodriguez
- Ingabire  Jc Allen
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- Isaac  Otolia
- Isik  Arda
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- Jain  Kavitha
- Jain  Ritu
- Jamal  Aiman
- Jamal  Mohammad
- James  Harelimana Grace
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- Jimenez  Virginia
- Jiménez  Pablo Mijahil Avilés
- Jiménez  Pablo Mijahil Avilés
- Jin-Young  Jang
- Jira  Moa
- Jisry  Ghassan
- Jlassi  Haithem
- Johnson  David
- Jones  Conor S.
- Jonker  Pascal
- Jouffret  Lionel
- JĂșnior  Samuel Aguiar
- Kaafarani  Haytham
- Kaafarani  Haytham
- Kaafarani  Haytham
- Kabir  Syed Mohammad Umar
- Kabweru  Wilberforce M.
- Kache  Stephen
- Kacimi  Salah Eddine Oussama
- Kaidarova  Dilyara
- Kaiser  Julia Christina
- Kakeeto  Andrew
- Kaman  Lileswar
- Kamarajah  Sivesh K.
- Kamarajah  Sivesh K.
- Kamphues  Carsten
- Kandevani  Naser Yousefzadeh
- Kannan  Ravi
- Karout  Lina
- Karthigeyan  Madhivanan
- Kassir  Radwan
- Kauppila  Joonas H.
- Kauppila  Joonas H.
- Kaups-Fresno  Krista
- Kavalakat  Alfie
- Keatley  James M.
- Kembuan  Gabriele
- Keppler  Alexander M.
- Keppler  Lena
- Kerawala  Asad Ali
- Kerawala  Cyrus
- Kerpaci  Jola
- Khadidja  Kouidri
- Khalifa  Houda
- Khalil  Kareem S.
- Khamees  Almu'atasim
- Khan  Tabassum
- Khatri  Chetan
- Kherani  Safeena
- Khokhar  Muhammad Imran
- Khosravi  Mohammad
- Khosravi  Mohammad Hossein
- Kieser  David
- King  Jasmin
- Kirov  Mikhail
- Kiweewa  Ronald
- Klat  Jaroslav
- Knight  Stephen Richard
- Kochetkov  Viktor
- Koh  Cherry
- Koh  Frederick
- Koh  Frederick
- Kolias  Angelos
- Komen  Niels
- Konate  Ibrahima
- Konrads  Christian
- Kopetskyi  Slava
- Kopjar  Tomislav
- Kornblith  Lucy
- Kowalski  Luiz Paulo
- Koƥir  Jurij Aleƥ
- Koƥir  Jurij Aleƥ
- Kpangon  Cyrille
- Kronberger  Irmgard
- Kronberger  Irmgard Elisabeth
- Kroon  Hidde M.
- Kruijff  Schelto
- Kudsk-Iversen  SÞren
- Kulimbet  Mukhtar
- Kulkarni  Amruta
- Kumar  Aruna
- Kumar  Ashwani
- Kundra  Rakesh
- Kuroda  Naoto
- Kwan  Tsun Yu
- Königsrainer  Alfred
- la Medina  Antonio Ramos-De
- Laban  Simon
- Lakkis  Zaher
- Lakpriya  Sathya
- Lalmi  Ismahene
- LalĂn  Agustina Florencia Castro
- Lami  Mariam
- Landaluce-Olavarria  Aitor
- Larrañaga  Juan
- Latif  Haider
- Lau  Lorena Fuentes Rivera
- Laudani  Veronica
- Laudani  Veronica
- Laura  Saura GarcĂa
- Lavanya Kannaiyan  R.
- Lawal  Taiwo Akeem
- Lawani  Ismaïl
- Lawani  Ismaïl
- Lawday  Samuel
- Le Bian  Alban Zarzavadjian
- Lederhuber  Hans
- Lekuya  Hervé Monka
- Lekuya  Hervé Monka
- Lekuya  Hervé Monka
- Leung  Elaine
- LeventoÄlu  Sezai
- LeventoÄlu  Sezai
- Lewis-Lloyd  Christopher
- Lewis-Lloyd  Christopher
- Li  Elizabeth
- Li  Elizabeth
- Lidder  Surjit
- Lincango-Naranjo  Eddy
- Lincango-Naranjo  Eddy
- Lindert  Judith
- Linz  Valerie Catherine
- Litvin  Andrey
- Litvin  Andrey
- Liveris  Anna
- Liyo  Juan
- Llano  Lionel
- Lo  Terence
- Loaloa  Mohamed Reda
- Lobos  Pablo
- Lohsiriwat  Varut
- Losada  Manuel
- Lott  Natalie
- Lou  Wenhui
- Lowey  Megan
- Lozada  Jorge Centeno
- LoÌffler  Markus W.
- Lucchini  Sergio Martin
- Lucchini  Sergio Martin
- Lueckel  Stephanie
- Lugones  Ignacio
- Lule  Herman
- Lule  Herman
- Lule  Herman
- Luna  Joaquin
- Luzzi  Emilia
- López  Anna Sånchez
- López  Cristina Barrena
- Mabood  Waleed
- Macchiavello  Roberto
- MacKenzie  Shawn
- Madabhavi  Irappa
- Madkhali  Tariq
- Madrid  Constanza
- Mahakalkar  Chandrashekhar
- Maher  Mark
- Maimbo  Mayaba
- Maji  Suvendu
- Majid  Haroon Javaid
- Major  Piotr
- Major  Piotr
- Makdissi  Fabiana
- Makkai-Popa  Silviu Tiberiu
- Maldonado-Marcos  Eloy
- Maleki  Esmaeil Rezghi
- Malik  Muhammad Usman
- Mallén  Victoria Duque
- Manceau  Gilles
- Mann  Harvinder
- Mann  Harvinder
- Mansour  Ahmed
- Maricic  Maximiliano
- Mariño  Lucia Porteiro
- Marquez  Lucila
- Marson  Ella J.
- Martin  Janet
- Martin  Janet
- Martinez  Antonio Alberto
- Martinez  Eneida Diaz
- Martinez  Laura
- Martins  Paulo
- MartĂn  Maria Teresa FernĂĄndez
- MartĂn-LĂĄez  RubĂ©n
- MartĂnez  Daniel FernĂĄndez
- MartĂnez  MarĂa JosĂ©
- MartĂnez  Mireia Riba
- Marçal  André
- Mashbari  Hassan
- Mashhour  Mohamed
- Mashhour  Mohamed
- Mashhour  Mohamed
- Massoud  John George
- Mastroianni  Gustavo
- Mata-Suarez  Santiago Miguel
- Matai  Anil
- Mateo-Sierra  Olga
- Matovu  Paul
- Mayer  Horacio F.
- Mayol  Julio
- Mazingi  Dennis
- Mc Loughlin  Santiago
- McDonnell  Brendan
- McGuinness  Matthew James
- McIntosh  Nick
- McKay  Siobhan
- Mclean  Kenneth A.
- Mclean  Kenneth A.
- McNestry  Catherine
- Meara  John G.
- Meelad  Ayman
- Mege  Diane
- Megersa  Abebe
- Mehraj  Asif
- MejĂa  Dolores
- Melendez  Robinson Mas
- Melero  Alba Vazquez
- Melo  Miguel Rocha
- Mendes  Filipa
- Mendiola  Gian
- Mendoza  Efrain
- Mendoza  Veronica Alonso
- Mengesha  Mengistu G.
- Mengesha  Mengistu G.
- Mengesha  Mengistu Gebreyohanes
- Mentz  Ricardo Esteban
- Meola  Antonio
- Mercado  Pedro
- Mersich  Tamås
- Metallidis  Symeon
- MeÌvo Romaric Tobome  S.
- Michael  Antony Louis Rex
- Migliorelli  Federico
- Mihanovic  Jakov
- Mihanovic  Jakov
- Milan  Peiman Brouki
- Mills  Emily
- Mimica  Ximena
- Mironescu  Aurel
- Mishra  Tushar
- Misra  Sanjeev
- Misrai  Vincent
- Mittal  Rohin
- Mitul  Ashrarur Rahman
- Mlambo  Busisiwe
- Modabber  Ali
- Modolo  Maria Marta
- Modolo  Maria Marta
- Modolo  Maria Marta
- Modolo  Maria Marta
- Mohamed  Awadelkarim
- Mohammed  Alsnosy Abdullah Khalefa
- Mohammed  Diary
- Mohan  Helen
- Mohsen  Mustafa Abo
- Mohyieldin  Omar
- Moir  John
- Molitvin  Yegor
- Mondino  Jose
- Montal  Silvina
- Montenegro  Emileth
- Morales-Puebla  José Manuel
- Morris  Brian
- Morsy  Amr
- Mosley  Frances
- Moss  Jana-Lee
- Mostafa  Badr
- Motas  Natalia
- Moug  Susan
- Moya-Angeler  Joaquin
- Moyano  Pablo
- Mozafari  Masoud
- Mozel  Michelle
- Mozo  Ana Sånchez
- Msherghi  Ahmed
- Mubezi  Isaac
- Muheilan  Muheilan
- Munyaneza  Emmanuel
- Munyika  Akutu
- Muralidharan  Vijayaragavan
- Muriel  MarĂa Emilia
- Mushiwokufa  Willard
- Muthu  Sathish
- Naem  Antoine
- Nagar  Manoj
- Nakagawa  Suely
- Nappi  Francesco
- Naseem  Muhammad Yasir
- Nashidengo  Pueya Rashid
- Nashidengo  Pueya Rashid
- Naunheim  Matthew
- Nayen  Alejandra
- Ncogoza  Isaie
- Ndayishyigikiye  Marcel Didier
- Ndong  Abdourahmane
- Ndong  Abdourahmane
- Negoi  Ionut
- Negoi  Ionut
- Negussie  Abraham
- Nepogodiev  Dmitri
- Nepogodiev  Dmitri
- Nepogodiev  Dmitri
- Nessim  Carolyn
- Neto  Joao Pedreira Duprat
- Newman  Samuel
- Ng-Kamstra  Joshua
- Ngu  James
- Ngulube  Allan
- Niazi  Sami Ullah
- Nicholson  Kristina
- Nidaw  Melkamu
- Nikolaieva  Karine
- Niquen-Jimenez  Milagros
- Nitschke  Christine
- Nkembi  Armande Subayi
- Nogueiro  Jorge
- Noll  Florencia
- Noltes  Milou
- Noltes  Milou
- Norman  Lisa
- Norman  Lisa
- Nouh  Thamer
- Novysedlåk  René
- Novysedlåk  René
- Nowak  Kai
- Ntirenganya  Faustin
- Nunez  Jade
- Nurgozhin  Talgat
- Nuñez  Jorge
- Nuñez  Jorge
- Nwegbu  Chukwuemeka
- NĂșñez  Bernardo
- Odejinmi  Funlayo
- Odetto  Diego
- Ofori  Bernard
- Ojeda  Ximena Paola Vasquez
- Okereke  Chukwuma
- Okonkwo  Ijeoma
- Okunlola  Abiodun
- Olaogun  Julius
- Olaywah  Noor
- Oliva  Agustina Rene
- Oliveira  João
- Olivos  Maricarmen
- Olivos  Maricarmen
- Olori  Samson
- Olson  Kristofor A.
- Omar  Omar M.
- Omari  Rand Y.
- Oosterlinck  Wouter
- Ortiz  Maria Rosa
- Oscco  Regina Amparo Ugarte
- Osinaike  Babatunde
- Ots  Riinu
- Outani  Oumaima
- Outani  Oumaima
- Outani  Oumaima
- Pablo  Carmignani
- Pachajoa  Diana Alejandra Pantoja
- Pacheco  Glenda Marina Falcon
- Pacilli  Maurizio
- Padmore  Greg
- Palacios  Nelson Morales
- Pallardel  Jenner Betalleluz
- Panyko  Arpåd
- Paranjape  Charu
- Parmar  Chetan
- Passadore  Martin
- Pata  Francesco
- Patel  Akshay
- Patel  Rakesh
- Pawar  Pranay
- Peiper  Christian
- Pejkova  Sofija
- Pejkova  Sofija
- Pellino  Gianluca
- Perdomo  Valentina Gutiérrez
- Pereira  Rita Gonçalves
- Perez Rivera  Carlos J.
- Perez Rivera  Carlos J.
- Perez-Chrzanowska  Hanna
- Perinotti  Roberto
- Pfister  Karin
- Phadnis  Ashish
- Picciochi  Maria
- Picciochi  Maria
- Pigeolet  Manon
- Pilar Tormos PeÌrez  M.
- Pius  Riinu
- Plarre  Philipp
- Pockney  Peter
- Pockney  Peter
- Pockney  Peter
- Pockney  Peter
- Poggi  Catalina
- Police  Andrea
- Ponugoti  Nikhil
- Portilla  Ana LucĂa
- Portilla  Fabian Rojas
- Porumb  Vlad
- Powell  Simon
- Prada  Jorge
- Pramesh  C. S.
- Prat-Ortells  Jordi
- Prats  Milagros Carrasco
- Premoli  Eduardo Jorge
- Prieto  Mikel
- Puiggrós  Laura Cårdenas
- Putnis  Soni
- Pykhteev  Vadim
- Pérez  Beatriz Gómez
- Pérez-Bertólez  Sonia
- Qasem  Abdulrahman
- Qassem  Faisal
- Qassem  Mohamed
- Quante  Markus
- Quintana-Villamandos  Begoña
- Qureshi  Ahmad Uzair
- Qureshi  Ahmad Uzair
- R Â Casadei
- Ra'ed  Hazim
- Radenkovic  Dejan
- Raevskaya  Marianna
- Rahbari  Nuh
- Rahy-MartĂn  Aida Cristina
- Rai  Lajpat
- Rajan  Shiv
- Rajanbabu  Anupama
- Ramallo-SolĂs  Irene
- Rammohan  Ashwin
- Ramos  MarĂa Lourdes
- Ramos-Luengo  Adolfo
- Ranganath  N.
- Rasoaherinomenjanahary  Fanjandrainy
- Rassweiler-Seyfried  Marie-Claire
- Rattan  Rishi
- Rattanasirivilai  Pornjittra
- Raut  Monish
- Recinos  Gustavo
- Recinos  Gustavo
- Regalo  Guillermo
- Reim  Daniel
- Reinhard  Tobias
- Reinke  Caroline
- Reisenauer  Janani
- Ren  Dong-Lin
- Rennie  Sarah
- Rennie  Sarah
- Rice  Henry E.
- Rice  Henry E.
- Rida  Ahmed Hossam Eldin Fouad
- Rio  Javier
- Ripollés-Melchor  Javier
- Rissmann  Anke
- Roberts  Keith
- Rodas  Alejandra
- Rodriguez  Juliana
- Rodriguez-Abreu  Julia
- Rodriquez  Jennifer
- RodrĂguez-Tesouro  Ana
- Rogers  Luke
- Rokohl  Alexander Christopher
- Roman  Igor Alberdi San
- Romera  Susana Bella
- Ronellenfitsch  Ulrich
- Rosas  Patricio
- Roslani  April Camilla
- Roslani  April Camilla
- Roslani  April Camilla
- Rossi  Gustavo
- Rossi  Luciano
- Rosso  Andres
- Roth  Andreas
- Rubio-Palau  Josep
- Ruiz  Alitza Gutiérrez
- Ruiz-MarĂn  Miguel
- Russell  Crispin
- RutegÄrd  Martin
- Ruzgar  Nensi Melissa
- Ryan  Ăanna
- Saad  Mahmoud M.
- Saadi  Jose
- Sacdalan  Marie Dione
- Sacdalan  Marie Dione
- Sacras  Maria LuĂs
- Saenz  Dinimo Bolivar
- Safieddine  Najib
- Sagar  Jayesh
- Saier  Tim
- Salazar  Esteban Gonzalez
- Salazar  Ivana Ines Pedraza
- Sale  Danjuma
- Saleh  Ismail Ali
- Salem  Marwa
- Saliev  Timur
- Saliev  Timur
- Sallam  Asser
- Samadov  Elgun
- Samaka  Rehab
- Samison  Luc Hervé
- Sampaio-Alves  Mafalda
- Sancho-Muriel  Jorge
- Sandoval  Danilo Alfonso Arévalo
- Sandoval  Danilo Alfonso Arévalo
- Santos  IrÚne
- Santos  IrÚne
- Santos-Costa  Paulo
- Sanz-Gonzalez  Rosa
- Sarjanoja  Elise
- Sarwar  Muhammad Zeeshan
- Satoi  Sohei
- Satoi  Sohei
- Sauvain  Marc-Olivier
- Sayyed  Raza
- Scalabre  Aurélien
- Schache  Andrew
- Scher  Pablo
- Scherñuk  Jordån
- Schlager  Daniel
- Schmedding  Andrea
- Schnitzbauer  Andreas
- Schoneveld  Martijn
- Seegert  Sara
- Seeliger  Barbara
- Seguin-Givelet  Agathe
- Sekar  Arunkumar
- Serralheiro  Pedro
- Seyi-Olajide  Justina
- Seyi-Olajide  Justina
- Shah  Rakesh
- Shaikh  Shafaque
- Shanthanna  Harsha
- Sharma  Abhishek
- Sharma  Rahul Deo
- Sharma  Shilpa
- Shaw  Catherine
- Shaw  Catherine
- Shaw  Richard
- Shehata  Sameh
- Shehta  Ahmed
- Sherif  Ahmed Elshawadfy
- Shih  Emily
- Shrestha  Ashish Lal
- Shumbash  Kibruyisfaw
- Siamuchembu  Maphios
- Siddique  Haleema
- Sieira-Gil  Ramon
- Sigamoney  Kohila
- Sikakulya  Franck K.
- Silva  Camilo Ortiz
- Silva  Nelson
- Silva-Igua  Liliana
- Simoes  Joana Ff
- Simoes  Joana Ff
- Simoes  Joana Ff
- Sin  MÂȘPilar Canals
- Singh  Harvinder
- Singisetti  Kiran
- Sinnerton  Robert
- Sisay  Silamlak
- Slavchev  Mihail
- Slavchev  Mihail
- Slim  Karem
- Slullitel  Pablo
- Smart  Neil
- Soares  Ana
- Sodhai  Vivek
- Sole  Oriol Martin
- SolĂ©  MisericĂČrdia JordĂ
- Soni  Rajesh
- Sonksen  Julian
- Sooriyabandara  Charitha
- Soria  Vanesa Garcia
- Soto-Darias  Ivån
- Soualili  Zineddine
- Spelsberg  Fritz
- Squiers  John
- Srishankar  Selvaratnam
- St-Germain  Pascal
- Stadler  Josef
- Stang  MarĂa Verona
- Stavridis  Sotir
- Stavrou  Gregor A.
- Steinkamp  Pieter
- Steinkamp  Pieter
- Stephens  Matthew
- Stevens  Sean
- Stewart  Grant D.
- Stewart  Grant D.
- Stijns  Jasper
- Stoleriu  Mircea Gabriel
- Suarez  Marcelo Moreno
- Subbian  Anbukkani
- Suliaman  Taha
- Sultan  Rizwan
- Sultana  Asma
- Sumadi  Adnan
- Sund  Malin
- Surendran  Arthika
- Suroy  Atul
- Szakmany  Tamas
- Sånchez  Alberto Cabañero
- Sånchez  Iran Irani Durån
- SĂĄnchez-CabĂșs  Santiago
- Tabiri  Stephen
- Taboada  MarĂa Victoria
- Tachella  Sofia
- Tadesse  Anteneh
- Talat  Nabila
- Talib  Ahmar Iftikhar
- Talwar  Rishi
- Tamoos  Khalil
- Tampaki  Ekaterini Christina
- Tan  Lorwai
- Tariq  Aiman
- Tariq  Muhammad
- Tarrado  Xavier
- Taylor  Elliott H.
- Teague  Rebecca
- Teasdale  Ella
- Tefera  Teshome
- Tejero-Pintor  Francisco J.
- Tendeng  Jacques
- Teo  Nan Zun
- Teresa GavaldaÌ PelliceÌ Â M.
- Testelin  Sylvie
- Thakar  Sumit
- Thereska  Dariel
- Thereska  Dariel
- Thies  Cristina Ojeda
- Thyavihally  Yuvaraja
- Tirapegui  Sebastian
- Todorovic  Lazar
- Tojal  André
- Tolani  Musliu Adetola
- Toma  Elena Adelina
- Tornini  Alejandra
- Toro  Carlos Andres Marulanda
- Torres  Martha Luz
- Toscano  Marta Jimenez
- Totty  Joshua
- Townend  Philip
- Traeger  Luke
- Traverso  Rogelio
- Tripathi  Manjul
- Trout  Isobel M.
- Trujillo  Lina MarĂa
- Tsegaye  Bereket
- Tsoulfas  Georgios
- Tudela  Kiara
- Turinawe  Gaston
- Turner  Paul
- Turrado-Rodriguez  Victor
- Uffelmann  Constanza
- Ugarte-Sierra  Bakarne
- Usang  Usang
- Vaccaro  Carlos
- Vagni  Roberto
- Vaishnav  Dhaivat
- Valcarcel  Cristina Rey
- Valdez  Pedro
- Valerio  Ana Clara
- Vallam  Karthik Chandra
- Vallve-Bernal  Marc
- van Ramshorst  Gabrielle
- van Ramshorst  Gabrielle
- Vargas  Lara
- Varghese  Chris
- Varghese  Chris
- Varghese  Chris
- Varghese  Chris
- Vartanian  Jose Guilherme
- Vaughan-Shaw  Peter
- Vayoth  Sudheer Othiyil
- Vaysburg  Dennis
- Vaysse  Charlotte
- Velasco  Jorge Caño
- Velasquez  Enrique Jose Ruiz
- Venkatappa  Sunil Kumar
- Venn  Mary L.
- Verhaeghe  Romain
- Verhaeghe  Romain
- Vidal  Rafael Perez
- Vidya  Raghavan
- Vijayakumar Vijayakumar  M.
- Villanueva  Julio
- Vimalakanthan  Thanusan
- Vita  Diana Crego
- Vivancos  Patricia Caja
- Viveiros  Octavio
- Vives  Inmaculada
- Vives  Josep Maria Muñoz
- Vo  Uyen Giao
- von Pusch  Silke
- Vrapi  Enxhi
- Våzquez  Irene Ortega
- Wafi  Omar
- Wagner  Arthur
- Waissbluth  Sofia
- Waqar  Shahzad Hussain
- Watson  David
- Watson  Eleanor
- Watters  David
- Weeraddana  Prabuth Dulanjan
- Wells  Cameron
- Welter  Stefan
- Wettstein  Dåniel
- Wickramasinghe  Dakshitha
- Wickramasinghe  Dakshitha
- Wiegering  Armin
- Wijeysundera  Duminda
- Williams  Emmanuel
- Williams  Omolara
- Williams  Omolara
- Wilson  Michael
- Wolf  Sebastian
- Wolfer  Susanne
- Wong  Enoch
- Wright  Deborah
- Wright  Deborah
- Wright  Naomi
- Wuraola  Funmilola
- Wuraola  Funmilola
- Xaviour  Okedi Francis
- Xu  William
- Yadev  I.
- Yagoub  Ghozlan
- Yaqoob  Eesha
- Yaqoob  Hassan Nawaz
- Yasin  Seid Mohammed
- Yazbek  Guilherme
- Yebes  Alvaro
- Yeung  Justin
- Yip  Sebastian Shu
- Youssef  Mina
- Zabaleta  Jon
- Zahid  Imdad Ahmad
- Zanoni  Gerardo
- Zapardiel  Ignacio
- Zapata  Carlos Shiraishi
- Zarnescu  Narcis Octavian
- Zarour  Ahmad
- Zarour  Ahmad
- Zarour  Ahmad
- Zarratea  Celeste Soledad
- Zegarra  Sergio
- Zequi  Stenio C.
- Zezular  Damaris Idara Anabel
- Zhou  Xuanyu
- Zhussupov  Baurzhan
- Zijaj  Lorena
- Zimmelman  Natalie
- Zmora  Oded
- Zmora  Oded
- Zohra  Belabbes Fatima
- Publication venue
- HAL CCSD
- Publication date
- 01/11/2021
- Field of study
We aimed to determine the impact of pre-operative isolation on postoperative pulmonary complications after elective surgery during the global SARS-CoV-2 pandemic. We performed an international prospective cohort study including patients undergoing elective surgery in October 2020. Isolation was defined as the period before surgery during which patients did not leave their house or receive visitors from outside their household. The primary outcome was postoperative pulmonary complications, adjusted in multivariable models for measured confounders. Pre-defined sub-group analyses were performed for the primary outcome. A total of 96,454 patients from 114 countries were included and overall, 26,948 (27.9%) patients isolated before surgery. Postoperative pulmonary complications were recorded in 1947 (2.0%) patients of which 227 (11.7%) were associated with SARS-CoV-2 infection. Patients who isolated pre-operatively were older, had more respiratory comorbidities and were more commonly from areas of high SARS-CoV-2 incidence and high-income countries. Although the overall rates of postoperative pulmonary complications were similar in those that isolated and those that did not (2.1% vs 2.0%, respectively), isolation was associated with higher rates of postoperative pulmonary complications after adjustment (adjusted OR 1.20, 95%CI 1.05â1.36, p = 0.005). Sensitivity analyses revealed no further differences when patients were categorised by: pre-operative testing; use of COVID-19-free pathways; or community SARS-CoV-2 prevalence. The rate of postoperative pulmonary complications increased with periods of isolation longer than 3 days, with an OR (95%CI) at 4â7 days or â„ 8 days of 1.25 (1.04â1.48), p = 0.015 and 1.31 (1.11â1.55), p = 0.001, respectively. Isolation before elective surgery might be associated with a small but clinically important increased risk of postoperative pulmonary complications. Longer periods of isolation showed no reduction in the risk of postoperative pulmonary complications. These findings have significant implications for global provision of elective surgical care. We aimed to determine the impact of pre-operative isolation on postoperative pulmonary complications after elective surgery during the global SARS-CoV-2 pandemic. We performed an international prospective cohort study including patients undergoing elective surgery in October 2020. Isolation was defined as the period before surgery during which patients did not leave their house or receive visitors from outside their household. The primary outcome was postoperative pulmonary complications, adjusted in multivariable models for measured confounders. Pre-defined sub-group analyses were performed for the primary outcome. A total of 96,454 patients from 114 countries were included and overall, 26,948 (27.9%) patients isolated before surgery. Postoperative pulmonary complications were recorded in 1947 (2.0%) patients of which 227 (11.7%) were associated with SARS-CoV-2 infection. Patients who isolated pre-operatively were older, had more respiratory comorbidities and were more commonly from areas of high SARS-CoV-2 incidence and high-income countries. Although the overall rates of postoperative pulmonary complications were similar in those that isolated and those that did not (2.1% vs 2.0%, respectively), isolation was associated with higher rates of postoperative pulmonary complications after adjustment (adjusted OR 1.20, 95%CI 1.05â1.36, p = 0.005). Sensitivity analyses revealed no further differences when patients were categorised by: pre-operative testing; use of COVID-19-free pathways; or community SARS-CoV-2 prevalence. The rate of postoperative pulmonary complications increased with periods of isolation longer than 3 days, with an OR (95%CI) at 4â7 days or â„ 8 days of 1.25 (1.04â1.48), p = 0.015 and 1.31 (1.11â1.55), p = 0.001, respectively. Isolation before elective surgery might be associated with a small but clinically important increased risk of postoperative pulmonary complications. Longer periods of isolation showed no reduction in the risk of postoperative pulmonary complications. These findings have significant implications for global provision of elective surgical care
Diminishing benefits of urban living for children and adolescentsâ growth and development
- Author
- Abarca-GĂłmez Leandra
- Abdeen Ziad A.
- Abdrakhmanova Shynar
- Abdul Rahim Hanan F.
- Abdurrahmonova Zulfiya
- Abril Guadalupe Longo
- Abu-Rmeileh Niveen M.
- Acosta-Cazares Benjamin
- Adam Ishag
- Adamczyk Marzena
- Adams Robert J.
- Adu-Afarwuah Seth
- Aekplakorn Wichai
- Afsana Kaosar
- Afzal Shoaib
- Agbor Valirie N.
- Agdeppa Imelda A.
- Aghazadeh-Attari Javad
- Aguenaou Hassan
- Aguilar-Salinas Carlos A.
- Agyemang Charles
- Ahmad Mohamad Hasnan
- Ahmad Noor Ani
- Ahmadi Ali
- Ahmadi Naser
- Ahmadi Nastaran
- Ahmed Imran
- Ahmed Soheir H.
- Ahrens Wolfgang
- Aitmurzaeva Gulmira
- Ajlouni Kamel
- Al Hourani Huda M.
- Al Qaoud Nawal M.
- Al-Hazzaa Hazzaa M.
- Al-Lahou Badreya
- Al-Raddadi Rajaa
- Alarouj Monira
- AlBuhairan Fadia
- AlDhukair Shahla
- Aldwairji Maryam A.
- Alexius Sylvia
- Ali Mohamed M.
- Alkandari Abdullah
- Alkerwi Alaâa
- Alkhatib Buthaina M.
- Allin Kristine
- Alvarez-Pedrerol Mar
- Aly Eman
- Amarapurkar Deepak N.
- Amoah John
- Amougou Norbert
- Amouyel Philippe
- Andersen Lars Bo
- Anderssen Sigmund A.
- Androutsos Odysseas
- Anjana Ranjit Mohan
- Ansari-Moghaddam Alireza
- Anufrieva Elena
- Aounallah-Skhiri Hajer
- AraĂșjo Joana
- Ariansen Inger
- Aris Tahir
- Arku Raphael E.
- Arlappa Nimmathota
- Aryal Krishna K.
- Aseffa Nega
- Aspelund Thor
- Assah Felix K.
- Assembekov Batyrbek
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- AvdiÄovĂĄ MĂĄria
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- Cilia Michelle
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- Cisneros Julio Zuñiga
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- Jarvelin Marjo-Riitta
- Jasienska Grazyna
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- Klimek Magdalena
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- Klumbiene Jurate
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- Korzycka Magdalena
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- Kouda Katsuyasu
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- Kovalskys Irina
- Kovtun Olga Petrovna
- KovĂĄcs Ăva
- Kowlessur Sudhir
- Koziel Slawomir
- Kratenova Jana
- Kratzer Wolfgang
- Kriaucioniene Vilma
- Kriemler Susi
- Kristensen Peter Lund
- Krizan Helena
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- Kurjata Pawel
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- Kutsenko Vladimir
- Kuulasmaa Kari
- Kyobutungi Catherine
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- La Quang Ngoc
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- Lachat Carl
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- Landais Edwige
- Lanska Vera
- Lappas Georg
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- Larissa Simo Pone
- Lassen Tina Harmer
- Latt Tint Swe
- Laurenzi Martino
- Lauria Laura
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- Lazo-Porras Maria
- Le Coroller Gwenaëlle
- Le Nguyen Bao Khanh
- Le Port AgnĂšs
- Le Tuyen D.
- Lee Jeannette
- Lee Jeonghee
- Lee Paul H.
- Lehmann Nils
- LehtimÀki Terho
- Lele Elysée Claude Bika
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- LeskoĆĄek Branimir
- Leszczak Justyna
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- Li Yanping
- Liivak Merike
- Lilly Christa L.
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- Lima-Costa M. Fernanda
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- Lin Xu
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- Linkohr Birgit
- Linneberg Allan
- Lissner Lauren
- Litwin Mieczyslaw
- Liu Jing
- Liu Lijuan
- Lo Wei-Cheng
- Loit Helle-Mai
- Long Khuong Quynh
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- Lukrafka Janice L.
- Luksiene Dalia
- Lundqvist Annamari
- Lunet Nuno
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- Marques Larissa Pruner
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- Mohammadi Mohammad Reza
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- Mostafa Aya
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- Movsesyan Yeva
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- Pandey Arvind
- Panza Francesco
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- Petrauskiene Ausra
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- Rahim Norsyamlina Che Abdul
- Rahimikazerooni Salar
- Rahman Mahfuzar
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- Raitakari Olli
- Raj Manu
- Rajabov Tamerlan
- Rakhmatulloev Sherali
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- RodrĂguez-Artalejo Fernando
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- Roggenbuck Ulla
- Rohloff Peter
- Rohner Fabian
- Rojas-Martinez Rosalba
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- Romeo Elisabetta L.
- Rosario Angelika Schaffrath
- Rosario Rafaela V.
- Rosengren Annika
- Rouse Ian
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- Sabbaghi Hamideh
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- Sachdev Harshpal S.
- Sadjadi Alireza
- Safarpour Ali Reza
- Safi Sare
- Safiri Saeid
- Saghi Mohammad Hossien
- Saidi Olfa
- Saki Nader
- Salanave Benoit
- Saleva Calogero
- SalmerĂłn Diego
- Salomaa Veikko
- Salonen Jukka T.
- Salvetti Massimo
- Samoutian Margarita
- Sandjaja [missing]
- Sans Susana
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- Santos Diana A.
- Santos Ina S.
- Santos LĂšlita C.
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- Sardinha Luis B.
- Sarrafzadegan Nizal
- Sathish Thirunavukkarasu
- Saum Kai-Uwe
- Savin Stefan
- Savva Savvas
- Savy Mathilde
- Sawada Norie
- Sbaraini Mariana
- Scazufca Marcia
- Schaan Beatriz D.
- Schargrodsky Herman
- Schienkiewitz Anja
- Schindler Karin
- Schipf Sabine
- Schmidt Carsten O.
- Schmidt Ida Maria
- Schneider Andrea
- Schnohr Peter
- Schramm Sara
- Schramm Stine
- Schröder Helmut
- Schultsz Constance
- Schulze Matthias B.
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- Schöttker Ben
- Sebert Sylvain
- Sedaghattalab Moslem
- Selamat Rusidah
- Sember Vedrana
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- Senbanjo Idowu O.
- Sepanlou Sadaf G.
- Sequera Guillermo
- Serra-Majem Luis
- Servais Jennifer
- Shalnova Svetlana
- Shamah-Levy Teresa
- Shamshirgaran Seyed Morteza
- Shanthirani Coimbatore Subramaniam
- Sharafkhah Maryam
- Sharma Sanjib K.
- Shaw Jonathan E.
- Shayanrad Amaneh
- Shayesteh Ali Akbar
- Sheffer Kate E.
- Shengelia Lela
- Shi Zumin
- Shibuya Kenji
- Shimizu-Furusawa Hana
- Shimony Tal
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- Sjöberg Agneta
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- Skoblina Natalia A.
- Skodje Gry
- Slazhnyova Tatyana
- Slowikowska-Hilczer Jolanta
- Slusarczyk PrzemysĆaw
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- So Hung-Kwan
- Soares Fernanda Cunha
- Sobek Grzegorz
- Sobngwi EugĂšne
- Sodemann Morten
- Soekatri Moesijanti Y. E.
- Soemantri Agustinus
- Sofat Reecha
- Solano Marta GarcĂa
- Solfrizzi Vincenzo
- Somi Mohammad Hossein
- Sonestedt Emily
- Song Yi
- Soofi Sajid
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- Soto-Rojas Victoria E.
- Soumaré Aïcha
- Sousa-Poza Alfonso
- Sovic Slavica
- Sparboe-Nilsen Bente
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- Spinelli Angela
- Spiroski Igor
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- Stokwiszewski Jakub
- Stoyanova Ekaterina
- Stratton Gareth
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- Suka Machi
- Sun Chien-An
- Sun Liang
- Sundström Johan
- Sung Yn-Tz
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- SuĂĄrez-Medina RamĂłn
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- Sy Rody G.
- Sylva René Charles
- Szklo Moyses
- Szponar Lucjan
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- Tai E. Shyong
- Tambalis Konstantinos D.
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- Tamosiunas Abdonas
- Tan Eng Joo
- Tang Xun
- Tanrygulyyeva Maya
- Tanser Frank
- Tao Yong
- Tarawneh Mohammed Rasoul
- Tarp Jakob
- Tarqui-Mamani Carolina B.
- Taylor Anne
- Taylor Julie
- Tchibindat Félicité
- Te Velde Saskia
- Tebar William R.
- Tell Grethe S.
- Tello Tania
- Tham Yih Chung
- Thankappan K. R.
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- Thomas Nihal
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- TichĂĄ Äœubica
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- TopĂłr-MÄ dry Roman
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- Tormo MarĂa JosĂ©
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- Torrent Maties
- Torres-Collado Laura
- Toselli Stefania
- Touloumi Giota
- Traissac Pierre
- Tran Thi Tuyet-Hanh
- Tremblay Mark S.
- Triantafyllou Areti
- Trichopoulos Dimitrios
- Trichopoulou Antonia
- Trinh Oanh T. H.
- Trivedi Atul
- Tsao Yu-Hsiang
- Tshepo Lechaba
- Tsigga Maria
- Tsintavis Panagiotis
- Tsugane Shoichiro
- Tuitele John
- Tuliakova Azaliia M.
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- Tuomainen Tomi-Pekka
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- Tynelius Per
- Tzala Evangelia
- Tzotzas Themistoklis
- Tzourio Christophe
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- Ukoli Flora A. M.
- Ulmer Hanno
- Unal Belgin
- Usupova Zhamyila
- Uusitalo Hannu M. T.
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- Wang Qian
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- Wang Ya Xing
- Wang Ying-Wei
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- Wareham Nicholas
- Weber Adelheid
- Webster-Kerr Karen
- Wedderkopp Niels
- Weghuber Daniel
- Wei Wenbin
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- WiÄcek Andrzej
- Wojciech Rusek
- Wojtyniak Bogdan
- Wolf Kathrin
- Wong Andrew
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- Wong Jyh Eiin
- Wong Norazizah Ibrahim
- Wong Tien Yin
- Wong-McClure Roy A.
- Woo Jean
- Woodward Mark
- Wu Frederick C.
- Wu Hon-Yen
- Wu Jianfeng
- Wu Li Juan
- Wu Shouling
- WyszyĆska Justyna
- Xu Haiquan
- Xu Liang
- Yaacob Nor Azwany
- Yamborisut Uruwan
- Yan Weili
- Yang Ling
- Yang Xiaoguang
- Yang Yang
- Yardim Nazan
- Yasuharu Tabara
- Yiallouros Panayiotis K.
- Yngve Agneta
- Yoosefi Moein
- Yoshihara Akihiro
- You Qi Sheng
- You San-Lin
- Younger-Coleman Novie O.
- Yu Yu-Ling
- Yu Yunjiang
- Yusof Safiah Md
- Yusoff Ahmad Faudzi
- Yusoff Muhammad Fadhli Mohd
- Zaccagni Luciana
- Zafiropulos Vassilis
- Zainuddin Ahmad A.
- Zakavi Seyed Rasoul
- Zamani Farhad
- Zambon Sabina
- Zampelas Antonis
- ZamrazilovĂĄ Hana
- Zapata Maria Elisa
- Zargar Abdul Hamid
- Zaw Ko Ko
- Zayed Ayman A.
- Zdrojewski Tomasz
- Zejglicova Kristyna
- Zeng Yi
- Zhang Luxia
- Zhang Zhen-Yu
- Zhao Dong
- Zhao Ming-Hui
- Zhao Wenhua
- Zhecheva Yanitsa V.
- Zhen Shiqi
- Zheng Wei
- Zheng Yingfeng
- Zholdin Bekbolat
- Zhou Bin
- Zhou Maigeng
- Zhu Dan
- Zins Marie
- Zitt Emanuel
- Zocalo Yanina
- Zoghlami Nada
- Zuziak Monika
- Ăngquist Lars
- ÄapkovĂĄ NadÄĆŸda
- Ćuszczki Edyta
- Ć alaj Sanja
- Ć evÄĂkovĂĄ Äœudmila
- Ć»egleĆ Magdalena
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2023
- Field of study
Optimal growth and development in childhood and adolescence is crucial for lifelong health and well-being1â6. Here we used data from 2,325 population-based studies, with measurements of height and weight from 71 million participants, to report the height and body-mass index (BMI) of children and adolescents aged 5â19 years on the basis of rural and urban place of residence in 200 countries and territories from 1990 to 2020. In 1990, children and adolescents residing in cities were taller than their rural counterparts in all but a few high-income countries. By 2020, the urban height advantage became smaller in most countries, and in many high-income western countries it reversed into a small urban-based disadvantage. The exception was for boys in most countries in sub-Saharan Africa and in some countries in Oceania, south Asia and the region of central Asia, Middle East and north Africa. In these countries, successive cohorts of boys from rural places either did not gain height or possibly became shorter, and hence fell further behind their urban peers. The difference between the age-standardized mean BMI of children in urban and rural areas was <1.1 kg mâ2 in the vast majority of countries. Within this small range, BMI increased slightly more in cities than in rural areas, except in south Asia, sub-Saharan Africa and some countries in central and eastern Europe. Our results show that in much of the world, the growth and developmental advantages of living in cities have diminished in the twenty-first century, whereas in much of sub-Saharan Africa they have amplified
Characteristics and predictors of death among 4035 consecutively hospitalized patients with COVID-19 in Spain
- Author
- AdoraciĂłn Valiente
- Adriana HernĂĄndez Belmonte
- Adriana SĂĄnchez Serrano
- AdriĂĄn SĂĄnchez MontalvĂĄ
- AgustĂn Rojas-Vieyra
- Aida GutiĂ©rrez GarcĂa
- Aina Gabarrell Pascuet
- Aina Gomila Grange
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