Implicaciones del movimiento dental ortodóntico en dientes con tratamientos endodónticos. Abordaje odontológico multidisciplinar.

El tratamiento odontológico multidisciplinar tiene como objetivo proporcionar a los pacientes que acuden a consulta un servicio odontológico completo estableciendo una actuación conjunta entre las diferentes áreas de la odontología. En este sentido una minuciosa evaluación asegurará un correcto diagnóstico a través de la historia clínica, exploración y pruebas complementarias, que junto al conocimiento del profesional basado en la evidencia y en la práctica clínica, asegurarán el pronóstico y el éxito del tratamiento.El presente trabajo pretende realizar una evaluación íntegra de dos pacientes que acuden al Servicio de Prácticas Odontológicas de la Universidad de Zaragoza, con el propósito de llevar a cabo un diagnóstico y plantear las opciones de tratamiento mediante un enfoque interdisciplinar, analizando en profundidad las relaciones existentes entre la endodoncia y la ortodoncia en base a la literatura científica más actual.<br /

Changes in Alcohol Use during the COVID-19 Pandemic among Young Adults: The Prospective Effect of Anxiety and Depression

Versión editorHealth measures instantiated to reduce the spread of COVID-19 have imposed significant constraints for the population and impacted on drinking habits and mental health. This study longitudinally compared changes in alcohol consumption before and after the COVID-19 outbreak and the impact of sociodemographic and mental health variables on such changes among a community sample of young adults. Data were collected in the context of a larger, ongoing longitudinal study. The sample consisted of 305 young adults from Spain aged between 18 and 26 years (mean age = 21.27, (SD = 2.21), female = 53.4%; college students = 61.6%) who completed first (November-2019 and February-2020; i.e., before the outbreak of COVID-19) and second follow-up questionnaires (March 2021, a year after the COVID-19 outbreak). Alcohol use (quantity and drinking frequency), depression and anxiety symptoms were measured. Quantity and frequency of alcohol use decreased from the preto post-COVID-19 period. A decrease in drinking frequency was observed among college students, but not in noncollege peers. Although we found no effect of pre-COVID-19 anxiety on alcohol use changes, those with more depressive symptoms at the pre-COVID assessment were more resistant to decreasing their drinking quantity and frequency after the COVID-19 outbreak. This information will be of value when designing interventions aimed at reducing harmful alcohol use and highlights the role of mental health status when identifying high risk populations of young-adults during this, and future, public health crisesFunding for this study was provided by the Consejería de Salud (Junta de Andalucía, Andalucía, Spain) under Grant Number PI-0503-2018 (Principal Investigator: Fermín Fernández Calderón). BV was supported by Fundación Carolina and SEGIB, and Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET

BAMBI and CHGA in Prion Diseases: Neuropathological Assessment and Potential Role as Disease Biomarkers

Prion diseases affect both animals and humans. Research in the natural animal model of the disease could help in the understanding of neuropathological mechanisms and in the development of biomarkers for human pathologies. For this purpose, we studied the expression of 10 genes involved in prion propagation in vitro in the central nervous system of scrapie-infected sheep. Dysregulated genes (BAMBI and CHGA) were further analysed in a transgenic murine model (Tg338) of scrapie, and their protein distribution was determined using immunohistochemistry and Western blot. Their potential as biomarkers was finally assessed using enzyme-linked immunosorbent assay (ELISA) in cerebrospinal fluid (CSF) of scrapie sheep and Creutzfeldt-Jakob disease (CJD) patients. Protein BAMBI was upregulated in highly affected brain areas and CHGA was overexpressed along the brain in both models. Moreover, BAMBI and CHGA immunostaining scores strongly correlated with spongiosis and microgliosis in mice. Finally, levels of BAMBI were significantly higher in the CSF of clinical sheep and CJD patients. In addition to their potential as biomarkers, our work confirms the role of BAMBI and CHGA in prion neuropathology in vivo, but besides prion replication, they seem to be involved in the characteristic neuroinflammatory response associated to prion infection

Extended Floating Car Data System - Experimental Study-

IEEE Intelligent Vehicles Symposium (IV), , 06/06/2011-10/06/2011, Baden-Baden, AlemaniaThis paper presents the results of a set of extensive experiments carried out in daytime and nighttime conditions in real traffic using an enhanced or extended Floating Car Data system (xFCD) that includes a stereo vision sensor for detecting the local traffic ahead. The detection component implies the use of previously monocular approaches developed by our group in combination with new stereo vision algorithms that add robustness to the detection and increase the accuracy of the measurements corresponding to relative distance and speed. Besides the stereo pair of cameras, the vehicle is equipped with a low-cost GPS and an electronic device for CAN Bus interfacing. The xFCD system has been tested in a 198-minutes sequence recorded in real traffic scenarios with different weather and illumination conditions, which represents the main contribution of this paper. The results are promising and demonstrate that the system is ready for being used as a source of traffic state information

NWCSAF GEO v2016 : new products, changes and improvements

Póster presentado en: 2016 EUMETSAT Meteorological Satellite Conference, 26-30 September 2016, Darmstadt, GermanyThe objective of the Nowcasting Satellite Application Facility (NWC SAF) is the generation of satellite derived products for their direct application to Nowcasting for targeted users. To achieve this goal, the NWC SAF team develops, maintains and distributes software packages that allows the users to generate, at their premises and for the user defined area, satellite derived products with a direct application to Nowcasting. The NWC SAF distributes two different software packages for GEO and LEO satellites. Current operational software package for GEO satellites is MSG v2013, distributed in 2013 and applicable to MSG data. Products generated with MSG v2013 include Cloud Products (Cloud Mask, Cloud Top Temperature and Height, Cloud Type, Cloud phase), Precipitation Products (Probability of Precipitation and Convective Rainfall Rate and Probability of Precipitation and Convective Rainfall Rate from Cloud Microphysics), High Resolution Winds (HRW), Water content and Instability Indices, Automatic Satellite Image Interpretation and detection and tracking of Rapidly Developing Convective Cells. A new software package, GEO v2016, has been distributed in November 2016. Main changes and improvements of GEO v2016 respect to previous operational SW package MSG v2013 are highlighted in this paper

NWCSAF GEO v2016 : new products, changes and improvements

Ponencia presentada en: 2016 EUMETSAT Meteorological Satellite Conference, 26-30 September 2016, Darmstadt, GermanyThe objective of the Nowcasting Satellite Application Facility (NWC SAF) is the generation of satellite derived products for their direct application to Nowcasting for targeted users. To achieve this goal, the NWC SAF team develops, maintains and distributes software packages that allows the users to generate, at their premises and for the user defined area, satellite derived products with a direct application to Nowcasting. The NWC SAF distributes two different software packages for GEO and LEO satellites. Current operational software package for GEO satellites is MSG v2013, distributed in 2013 and applicable to MSG data. Products generated with MSG v2013 include Cloud Products (Cloud Mask, Cloud Top Temperature and Height, Cloud Type, Cloud phase), Precipitation Products (Probability of Precipitation and Convective Rainfall Rate and Probability of Precipitation and Convective Rainfall Rate from Cloud Microphysics), High Resolution Winds (HRW), Water content and Instability Indices, Automatic Satellite Image Interpretation and detection and tracking of Rapidly Developing Convective Cells. A new software package, GEO v2016, has been distributed in November 2016. Main changes and improvements of GEO v2016 respect to previous operational SW package MSG v2013 are highlighted in this paper

Liquid biopsy: a non-invasive approach for Hodgkin lymphoma genotyping

The Hodgkin lymphoma (HL) genomic landscape is hardly known due to the scarcity of tumour cells in the tissue. Liquid biopsy employing circulating tumour DNA (ctDNA) can emerge as an alternative tool for non-invasive genotyping. By using a custom next generation sequencing (NGS) panel in combination with unique molecule identifiers, we aimed to identify somatic variants in the ctDNA of 60 HL at diagnosis. A total of 277 variants were detected in 36 of the 49 samples (73·5%) with a good quality ctDNA sample. The median number of variants detected per patient was five (range 1–23) with a median variant allele frequency of 4·2% (0·84–28%). Genotyping revealed somatic variants in the following genes: SOCS1 (28%), IGLL5 (26%), TNFAIP3 (23%), GNA13 (23%), STAT6 (21%) and B2M (19%). Moreover, several poor prognosis features (high LDH, low serum albumin, B-symptoms, IPI ≥ 3 or at an advanced stage) were related to significantly higher amounts of ctDNA. Variant detection in ctDNA by NGS is a feasible approach to depict the genetic features of HL patients at diagnosis. Our data favour the implementation of liquid biopsy genotyping for the routine evaluation of HL patients.This work was partially supported by the Instituto de Salud Carlos III (ISCIII), Spanish Ministry of Economy and Competitiveness CIBERONC-CB16/12/00233, and “Una manera de hacer Europa” (Innocampus; CEI-2010-1-0010)”, the Health Council of the Junta de Castilla y León (GRS2037/A/19) (GRS1845/A/18) and private Gilead (GLD/18/00063). MGA is supported with a grant from the Accelerator consortia (Cancer Research UK; C355/A26819). CJ and AM are supported by the ISCII (CD19/00030 and FI19/00320). MES is supported by Contrato Miguel Servet tipo II (CPII18/00028). MA is financed by CIBER-CB16/12/00233. All Spanish funding is co-sponsored by the European Union FEDER program

Differences in breast cancer-risk factors between screen-detected and non-screen-detected cases (MCC-Spain study)

Purpose: The variation in breast cancer (BC)-risk factor associations between screen-detected (SD) and non-screen-detected (NSD) tumors has been poorly studied, despite the interest of this aspect in risk assessment and prevention. This study analyzes the differences in breast cancer-risk factor associations according to detection method and tumor phenotype in Spanish women aged between 50 and 69. Methods: We examined 900 BC cases and 896 controls aged between 50 and 69, recruited in the multicase-control MCC-Spain study. With regard to the cases, 460 were detected by screening mammography, whereas 144 were diagnosed by other means. By tumor phenotype, 591 were HR+, 153 were HER2+, and 58 were TN. Lifestyle, reproductive factors, family history of BC, and tumor characteristics were analyzed. Logistic regression models were used to compare cases vs. controls and SD vs. NSD cases. Multinomial regression models (controls used as a reference) were adjusted for case analysis according to phenotype and detection method. Results: TN was associated with a lower risk of SD BC (OR 0.30 IC 0.10-0.89), as were intermediate (OR 0.18 IC 0.07-0.44) and advanced stages at diagnosis (OR 0.11 IC 0.03-0.34). Nulliparity in postmenopausal women and age at menopause were related to an increased risk of SD BC (OR 1.60 IC 1.08-2.36; OR 1.48 IC 1.09-2.00, respectively). Nulliparity in postmenopausal women was associated with a higher risk of HR+ (OR 1.66 IC 1.15-2.40). Age at menopause was related to a greater risk of HR+ (OR 1.60 IC 1.22-2.11) and HER2+ (OR 1.59 IC 1.03-2.45) tumors. Conclusion: Reproductive risk factors are associated with SD BC, as are HR+ tumors. Differences in BC-risk factor associations according to detection method may be related to prevailing phenotypes among categories

Genetic complexity impacts the clinical outcome of follicular lymphoma patients

© The Author(s) 2021.Follicular lymphoma (FL) is the second most common non-Hodgkin lymphoma (NHL, 20–30%) after diffuse large B-cell lymphoma (DLBCL). Despite the introduction of rituximab and the high response rate to first-line treatment, approximately 20% of the FL patients relapse or progress within 2 years of receiving first-line therapy. Therefore, the major challenge is finding biomarkers that identify high-risk patients at diagnosis.This work was partially supported by the Instituto de Salud Carlos III (ISCIII), Spanish Ministry of Economy and Competitiveness PI15/01393, PI18/00410, CIBERONC-CB16/12/00233, and “Una manera de hacer Europa” (Innocampus; CEI-2010-1-0010)”, the Education Council or Health Council of the Junta de Castilla y León (CAS102P17, GRS 1180/A/15), Spanish Association Against Cancer (AECC; PROYE18020BEA), and Gilead Sciences (GLD17/00334). CJ, MES, and AMe are supported by the ISCII (CD19/00030, CPII18/00028, and FI19/00320). MGA, IPC, and CJ were supported by the Spanish Society of Hematology Foundation (FEHH). All Spanish funding is co-sponsored by the European Union FEDER program

The biota of the Upper Cretaceous site of Lo Hueco (Cuenca, Spain)

The Late Cretaceous (Campanian-Maastrichtian) fossil site of Lo Hueco was recently discovered close to the village of Fuentes (Cuenca, Spain) during the cutting of a little hill for installation of the railway of the Madrid-Levante high-speed train. To date, it has yielded a rich collection of well-preserved Cretaceous macrofossils, including plants, invertebrates, and vertebrates. The recovered fossil assemblage is mainly composed of plants, molluscs (bivalves and gastropods), actinopterygians and teleosteans fishes, amphibians, panpleurodiran (bothremydids) and pancryptodiran turtles, squamate lizards, eusuchian crocodyliforms, rhabdodontid ornithopods, theropods (mainly dromaeosaurids), and titanosaur sauropods. This assemblage was deposited in a near-coast continental muddy floodplain crossed by distributary sandy channels, exposed intermittently to brackish or marine and freshwater flooding as well as to partial or total desiccation events.The Konzentrat-Lagerstatt of Lo Hueco constitutes a singular accumulation of fossils representing individuals of some particular lineages of continental tetrapods, especially titanosaurs, eusuchians and bothremydid turtles. In the case of the titanosaurs, the site has yielded multiple partial skeletons in anatomical connection or with a low dispersion of their skeletal elements. A combination of new taxa, new records of taxa previously known in the Iberian Peninsula, and relatively common taxa in the European record compose the Lo Hueco biota. The particular conditions of the fossil site of Lo Hueco and the preliminary results indicate that the analysis of the geological context, the floral and faunal content, and the taphonomical features of the site provide elements that will be especially useful for reassess the evolutionary history of some lineages of European Late Cretaceous reptiles.Peer reviewe