La l?dica como estrategia para el fortalecimiento de la psicomotricidad de los ni?os y ni?as del nivel preescolar del Colegio ?ngelo Giuseppe Roncalli de la ciudad de Ibagu?.

92 p. Recurso Electr?nicoEl presente trabajo es llevado a cabo en el Colegio Angelo Giuseppe Roncalli con los ni?os del nivel preescolar, en los cuales se observ? que estos menores se caracterizan por ser din?micos, participativos y expresivos frente a lo que les gusta y les disgusta; gozan de una buena disposici?n en el momento de realizar tareas, dentro y fuera del aula. Sin embargo, en ciertas oportunidades algunos ni?os se les dificultan la realizaci?n de trabajos, debido a que poseen problemas relacionados con su psicomotricidad. Por lo mencionado anteriormente se construye un proyecto implementando la investigaci?n formativa, a trav?s de la metodolog?a cualitativa con un enfoque etnogr?fico; para este proceso se utiliz? t?cnicas e instrumentos que permitieron la recolecci?n de informaci?n como: fichas de observaci?n, entrevista informal, y diarios de campo. De igual manera se tienen en cuenta los diferentes estamentos legales nacionales, locales e institucionales. Adem?s, se crea e implementa un proyecto pedag?gico de aula El tren l?dico como instrumento facilitador en la estimulaci?n del proceso psicomotriz de los ni?os del nivel preescolar, de manera que se fortalezca su aprendizaje y desenvolvimiento en su contexto escolar; permiti?ndole a los docentes dise?ar actividades l?dico-pedag?gicas y cambiar la visi?n que tienen sobre la educaci?n f?sica como asignatura importante en el desarrollo integral de los ni?os. Por ?ltimo, el desarrollo de este proceso investigativo la comunidad educativa identifico la incidencia que tiene la psicomotricidad en el desarrollo integral de los ni?os. Palabras claves: psicomotricidad, desarrollo integral, estrategias, estimulaci?n, investigaci?n.The present work is carried out in the school Angelo Giuseppe Roncalli with the children of the preschool level, in which it was observed that these minors are characterized by being dynamic, participative and expressive in front of what they like and dislike them; Have a good disposition when performing tasks, inside and outside the classroom. However, in some cases, some children find it difficult to carry out work, because they have problems related to their psychomotor skills. For the aforementioned, a project is being implemented implementing the formative research, through the qualitative methodology with an ethnographic approach; For this process techniques and instruments were used that allowed the collection of information as: observation tokens, informal interview, and field diaries. Likewise, different national, local and institutional legal systems are taken into account. In addition, a pedagogical project of classroom "The ludic train" is created and implemented as a facilitating instrument in the stimulation of the psychomotor process of the children of the pre-school level, so as to strengthen their learning and development in their school context; Allowing teachers to design ludic-pedagogical activities and change the vision they have on physical education as an important subject in the integral development of children. Finally, the development of this research process, the educational community identifies the incidence of psychomotricity in the integral development of children. Keywords: psychomotricity, integral development, strategies, stimulation, research

Stability analysis for the background equations for inflation with dissipation and in a viscous radiation bath

The effects of bulk viscosity are examined for inflationary dynamics in which dissipation and thermalization are present. A complete stability analysis is done for the background inflaton evolution equations, which includes both inflaton dissipation and radiation bulk viscous effects. Three representative approaches of bulk viscous irreversible thermodynamics are analyzed: the Eckart noncausal theory, the linear and causal theory of Israel-Stewart and a more recent nonlinear and causal bulk viscous theory. It is found that the causal theories allow for larger bulk viscosities before encountering an instability in comparison to the noncausal Eckart theory. It is also shown that the causal theories tend to suppress the radiation production due to bulk viscous pressure, because of the presence of relaxation effects implicit in these theories. Bulk viscosity coefficients derived from quantum field theory are applied to warm inflation model building and an analysis is made of the effects to the duration of inflation. The treatment of bulk pressure would also be relevant to the reheating phase after inflation in cold inflation dynamics and during the radiation dominated regime, although very little work in both areas has been done, the methodology developed in this paper could be extended to apply to these other problems.Comment: 27 pages, 14 figures, Published version JCA

Clinical and Economic Evaluation after Adopting Contingent Cell-Free DNA Screening for Fetal Trisomies in South Spain.

Contingent cell-free (cf) DNA screening on the basis of the first-trimester combined test (FCT) results has emerged as a cost-effective strategy for screening of trisomy 21 (T21). Objectives: To assess performance, patients’ uptake, and cost of contingent cfDNA screening and to compare them with those of the established FCT. Methods: This is a prospective cohort study including all singleton pregnancies attending to their FCT for screening of T21 at 2 university hospitals in South Spain. When the FCT risk was ≥1:50, there were major fetal malformations, or the nuchal translucency was ≥3.5 mm, women were recommended invasive testing (IT); if the risk was between 1:50 and 1:270, women were recommended cfDNA testing; and for risks bellow 1:270, no further testing was recommended. Detection rate (DR), false-positive rate (FPR), patients’ uptake, and associated costs were evaluated. Results: We analyzed 10,541 women, including 46 T21 cases. DR of our contingent strategy was 89.1% (41/46) at 1.4% (146/10,541) FPR. Uptake of cfDNA testing was 91.2% (340/373), and overall IT rate was 2.0%. The total cost of our strategy was €1,462,895.7, similar to €1,446,525.7 had cfDNA testing not been available. Conclusions: Contingent cfDNA screening shows high DR, low IT rate, and high uptake at a similar cost than traditional screening.pre-print133 K

Reply: Benefit of genome-wide prenatal cfDNAtesting requires further investigation through acase–control study.

post-print50,1 K

Catalytically Active Imine-based Covalent Organic Frameworks for Detoxification of Nerve Agent Simulants in Aqueous Media

A series of imine-based covalent organic frameworks decorated in their cavities with di erent alkynyl, pyrrolidine, and N-methylpyrrolidine functional groups have been synthetized. These materials exhibit catalytic activity in aqueous media for the hydrolytic detoxification of nerve agents, as exemplified with nerve gas simulant diisopropylfluorophosphate (DIFP). These preliminary results suggest imine-based covalent organic frameworks (COFs) as promising materials for detoxification of highly toxic molecules.MINECO (MAT2016-77608-C3-1-P and 2-P, CTQ2017-84692-R) and EU FEDER fundin

Palatini versus metric formulation in higher curvature gravity

We compare the metric and the Palatini formalism to obtain the Einstein equations in the presence of higher-order curvature corrections that consist of contractions of the Riemann tensor, but not of its derivatives. We find that there is a class of theories for which the two formalisms are equivalent. This class contains the Palatini version of Lovelock theory, but also more Lagrangians that are not Lovelock, but respect certain symmetries. For the general case, we find that imposing the Levi-Civita connection as an Ansatz, the Palatini formalism is contained within the metric formalism, in the sense that any solution of the former also appears as a solution of the latter, but not necessarily the other way around. Finally we give the conditions the solutions of the metric equations should satisfy in order to solve the Palatini equations.Comment: 13 pages, latex. V2: reference added, major changes in section 3, conclusions partially correcte

A prospective study of the clinical outcomes and prognosis associated with comorbid COPD in the atrial fibrillation population

Background: Patients with COPD are at higher risk of presenting with atrial fibrillation (AF). Information about clinical outcomes and optimal medical treatment of AF in the setting of COPD remains missing. We aimed to describe the prevalence of COPD in a sizeable cohort of real-world AF patients belonging to the same healthcare area and to examine the relationship between comorbid COPD and AF prognosis. Methods: Prospective analysis performed in a specific healthcare area. Data were obtained from several sources within the "data warehouse of the Galician Healthcare Service" using multiple analytical tools. Statistical analyses were completed using SPSS 19 and STATA 14.0. Results: A total of 7,990 (2.08%) patients with AF were registered throughout 2013 in our healthcare area (n=348,985). Mean age was 76.83+/-10.51 years and 937 (11.7%) presented with COPD. COPD patients had a higher mean CHA2DS2-VASc (4.21 vs 3.46; P=0.02) and received less beta-blocker and more digoxin therapy than those without COPD. During a mean follow-up of 707+/-103 days, 1,361 patients (17%) died. All-cause mortality was close to two fold higher in the COPD group (28.3% vs 15.5%; P<0.001). Independent predictive factors for all-cause mortality were age, heart failure, diabetes, previous thromboembolic event, dementia, COPD, and oral anticoagulation (OA). There were nonsignificant differences in thromboembolic events (1.7% vs 1.5%; P=0.7), but the rate of hemorrhagic events was significantly higher in the COPD group (3.3% vs 1.9%; P=0.004). Age, valvular AF, OA, and COPD were independent predictive factors for hemorrhagic events. In COPD patients, age, heart failure, vasculopathy, lack of OA, and lack of beta-blocker use were independent predictive factors for all-cause mortality. Conclusion: AF patients with COPD have a higher incidence of adverse events with significantly increased rates of all-cause mortality and hemorrhagic events than AF patients without COPD. However, comorbid COPD was not associated with differences in cardiovascular death or stroke rate. OA and beta-blocker treatment presented a risk reduction in mortality while digoxin use exerted a neutral effect

Is nonperturbative inflatino production during preheating a real threat to cosmology?

We discuss toy models where supersymmetry is broken due to non-vanishing time-varying vacuum expectation value of the inflaton field during preheating. We discuss the production of inflatino the superpartner of inflaton due to vacuum fluctuations and then we argue that they do not survive until nucleosynthesis and decay along with the inflaton to produce a thermal bath after preheating. Thus the only relevant remnant is the helicity \pm 3/2 gravitinos which can genuinely cause problem to nucleosynthesis.Comment: 10 pages, Updates to match the accepted version in Phys. Rev.

Administration time effect of dietary proanthocyanidins on the metabolome of Fischer 344 rats is sex- and diet-dependent

Proanthocyanidins (PAs) are one of the most commonly ingested polyphenols in the human diet, with a wide range of beneficial health effects. Remarkably, PAs have been reported to influence core and peripheral clock genes expression, and their effects may change in a time-of-day dependent manner. Therefore, the aim of this study was to investigate whether the capacity of PAs to modulate the metabolome is conditioned by the time-of-day in which these compounds are consumed in a diet- and sexdependent manner. To do this, a grape seed proanthocyanidin extract (GSPE) was administered to female and male Fischer 344 rats at ZT0 (in the morning) and ZT12 (at night) and the GSPE administration time effect was evaluated on clock genes expression, melatonin hormone and serum metabolite levels in a healthy and obesogenic context. The results showed an administration time effect of GSPE on the metabolome in a sex and diet-dependent manner. Specifically, there was an effect on amino acid, lipid and cholate metabolite levels that correlated with the central clock genes expression. Therefore, this study shows a strong influence of sex and diet on the PAs effects on the metabolome, modulated in turn by the time-of-day