Efficiency of the Triage in the attention to the prison population in the hospital emergency service

Introducción: Para adaptarse al incremento de demanda asistencial los hospitales han implantado un sistema de Triage, considerado indicador de calidad. Objetivo: Conocer el cumplimiento de objetivos de calidad en tiempos medios de espera triage–asistencia médica. Metodología: Estudio descriptivo, observacional y retrospectivo. Población a estudio: pacientes penitenciarios, excluyendo menores de 18 años y embarazadas. Resultados: Los tiempos medios admisión–triage fueron: 5,58 minutos, triage: 1,17 minutos y triage–asistencia médica en prioridad II-Naranja 22,23 minutos, III-Amarillo 35,65 minutos y IV-Verde 36,08 minutos. Conclusiones: Se cumplen en la mayor parte los objetivos de calidad en tiempos medios admisión–triage–asistencia.Introduction: In order to adapt to the increase in healthcare demand, hospitals have implemented a Triage system, considered an indicator of quality. Objective: To know the fulfillment of quality objectives in average waiting times triage-medical assistance. Methodology: Descriptive, observational and retrospective study. Population under study: penitentiary patients, excluding children under 18 and pregnant. Results: The average admission-triage times were: 5.58 minutes, triage: 1.17 minutes and triage-medical assistance in priority II-Orange 22.23 minutes, III-Yellow 35.65 minutes and IV-Green 36.08 minutes Conclusions: The objectives of quality in average times admission-triage-assistance are fulfilled in most part

A putative Leishmania DNA polymerase theta protects the parasite against oxidative damage

Leishmania infantum is a protozoan parasite that is phagocytized by human macrophages. The host macrophages kill the parasite by generating oxidative compounds that induce DNA damage. We have identified, purified and biochemically characterized a DNA polymerase θ from L. infantum (LiPolθ), demonstrating that it is a DNA-dependent DNA polymerase involved in translesion synthesis of 8oxoG, abasic sites and thymine glycol lesions. Stably transfected L. infantum parasites expressing LiPolθ were significantly more resistant to oxidative and interstrand cross-linking agents, e.g. hydrogen peroxide, cisplatin and mitomycin C. Moreover, LiPolθ-overexpressing parasites showed an increased infectivity toward its natural macrophage host. Therefore, we propose that LiPolθ is a translesion synthesis polymerase involved in parasite DNA damage tolerance, to confer resistance against macrophage aggression.Spanish Ministry of Science and Innovation [AGL2010-21806-C02-01 to V.L., BFU2012-37969 to L.B.]; Comunidad deMadrid [S2010/BMD-2361 to L.B.]; Ramón Areces Foundation [050204100014 to V.L.]Peer Reviewe

Geriatric nursing on European Space for Higher Education

Producción CientíficaProblema: ¿Cómo se están estructurando las asignaturas relacionadas con la especialidad de Enfermería Geriátrica en la formación de Grado de Enfermería? Material y método: guías docentes de las universidades, escuelas/facultades de Enfermería, pertenecientes a la Conferencia Nacional de Directores de Centros Universitarios de Enfermería (CNDCUE). Análisis descriptivo de la asignatura que abordan los cuidados de enfermería durante la etapa de la vejez. Conclusiones: existe divergencia en el planteamiento de las asignaturas en las guías analizadas. Se ha modificado la denominación previa y común a todos los centros: Enfermería Geriátrica. El número de competencias propuestas es elevado, lo que puede complicar la evaluación formativa.Issue: how are subjects related to Geriatric Nursing being organized on Nursing degree education? Material and method: guidebooks about Shools/Faculties of Nursing wich belong to National Conference of Directors of University Centres of Nursing. A subject on nursing care descriptive analysis during old age. Conclusions: There are differences between the approach of the subjects on the guides we ve analized. The previous and common to all centres designation has been modified: Geriatric Nursing. The number of suggested competences is high, so formative evaluation will get complicated

COVID-19 patients with psoriasis and psoriatic arthritis on biologic immunosuppressant therapy versus apremilast in North Spain

Immunosuppressive and immunomodulatory treatments are critical for the management of inflammatory and autoimmune conditions such as psoriasis or psoriatic arthritis. Similar to those illnesses, the lung injury and acute respiratory distress shown in coronavirus disease 2019 (COVID‐19) patients are the result of a disruption in the balance of pro‐ and anti‐inflammatory cytokines. This hyperinflammatory response to severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), associated with the severity of the coronavirus disease, is called the cytokine storm. There is a growing concern regarding how patients on immunosuppressant biologic therapies might be at higher risk of being infected and whether they need to discontinue their treatment preemptively. Clinical data on COVID‐19‐infected patients with psoriasis or psoriatic arthritis are still scarce. Here, we presented seven cases of these type of patients. The patient infected with COVID‐19 on apremilast and the one on apremilast with infected spouse showed the best safety profile and mildest symptoms. One of the secukinumab patients also presented a relatively good outcome. Infliximab patients and the one with serious comorbidities showed the worst outcome. Even though more clinical data are yet needed to draw strong conclusions, apremilast could be a safer alternative for dermatology and rheumatology patients in case of clinically important active infection

Tecnología low-cost para motivar al alumno

RESUMEN: La docencia en Estructura y Organización de Computadores se imparte habitualmente utilizando una arquitectura como referencia, siendo MIPS una de las más usadas. Sin embargo, su baja penetración en el mercado actual tiene un efecto desmotivador en los alumnos. Esto, junto con la mayor relevancia de la arquitectura ARM, nos ha hecho plantearnos considerarla como referencia en nuestros planes de estudios. Con este objetivo, se ha desarrollado un proyecto de innovación docente para rediseñar las materias implicadas. Esta modificación ha implicado cambios en el laboratorio en el que se desarrollan las prácticas, para el que se ha seleccionado Raspberry Pi, una plataforma de bajo coste basada en ARM. Como principal diferencia respecto a otras soluciones, se ha elegido el sistema operativo RISC OS, que permite realizas prácticas de programación en ensamblador y Entrada/Salida en el mismo entorno. Además, se ha desarrollado un depurador en ARM llamado !UCDebug. En este artículo se describen las diferentes etapas del proyecto y los resultados obtenidos. Cabe destacar que, en los dos cursos que lleva implantado, la motivación y asistencia de los alumnos ha aumentado considerablemente y la tasa de éxito ha subido hasta un 13 %.ABSTRACT: Computer Organization and Design is usually instructed using a computer architecture as reference. The MIPS architecture has been traditionally widespread in that regard. However, its current low market share discourages the students. This, coupled with the greater relevance of the ARM architecture, has motivated our switch to the latter as the reference in our degree. With this aim, a redesign of the involved courses has been carried out through an educational innovation project. One of the effects has been a transition to the low-cost ARM Raspberry Pi platform for the computer lab where students perform their practical sessions. As a major difference to the approach followed by other universities, the RISC Operating System has been chosen, allowing to perform both assembly and Input/Output practices within the same environment. Moreover, an ARM debugger called !UCDebug has been developed to alleviate the lack of userfriendly debugging tools. This article describes the stages of the project and the results achieved. Notably, student motivation and attendance has remarkably risen, and the success rate has grown up to 13% since the implementation.el Ministerio de Economía, Industria y Competitividad bajo contrato TIN2016-76635-C2-2-R (AEI/FEDER, UE) y el Ministerio de Ciencia, Innovación y Universidades bajo beca Juan de la Cierva FJCI-2017-31643

Biología y Ciencias Ambientales frente al reto de la transición energética

En el contexto de la “transición ecológica justa” tanto a nivel español como europeo y mundial, se persigue frenar la crisis de abastecimiento de energía, y no comprometer la conservación del Patrimonio Natural, ya que esto empeoraría la actual crisis de biodiversidad que, sabemos, vertebra nuestra salubridad. Pero, ¿estamos preparados para asumir el cambio energético y la crisis de la biodiversidad de una manera coherente y coordinada? El objetivo de este artículo es realizar una pequeña revisión de la situación actual, desde la perspectiva de la conservación y evaluar las mejoras necesarias que debemos exigir como ciudadanos, analizando el papel del conocimiento científico y poniendo en valor nuestras capacidades que como biólogos y ambientólogos como ciudadanos y ciudadanas con conocimientos sobre temas, que afectan a los seres vivos y a su relación con la parte física del planeta

State-of-the-art in host-derived biomarkers of Chagas disease prognosis and early evaluation of anti-Trypanosoma cruzi treatment response

Chagas disease is caused by infection with the parasite Trypanosoma cruzi, which might lead to a chronic disease state and drive to irreversible damage to the heart and/or digestive tract tissues. Endemic in 21 countries in the Americas, it is the neglected disease with a highest burden in the region. Current estimates point at ~6 million people infected, of which ~30% will progress onto the symptomatic tissue disruptive stage. There is no vaccine but there are two anti-parasitic drugs available: benznidazole and nifurtimox. However, their efficacy is variable at the chronic symptomatic stage and both have frequent adverse effects. Since there are no prognosis markers, drugs should be administered to all T. cruzi-infected individuals in the indeterminate and early symptomatic stages. Nowadays, there are no tests-of-cure either, which greatly undermines patients' follow-up and the search of safer and more efficacious drugs. Therefore, the identification and validation of biomarkers of disease progression and/or treatment response on which to develop tests of prognosis and/or cure is a major research priority. Both parasite- and host-derived markers have been investigated. In the present manuscript we present an updated outlook of the latter

Assessing the Suitability of King Topologies for Interconnection Networks

In the late years many different interconnection networks have been used with two main tendencies. One is characterized by the use of high-degree routers with long wires while the other uses routers of much smaller degree. The latter rely on two-dimensional mesh and torus topologies with shorter local links. This paper focuses on doubling the degree of common 2D meshes and tori while still preserving an attractive layout for VLSI design. By adding a set of diagonal links in one direction, diagonal networks are obtained. By adding a second set of links, networks of degree eight are built, named king networks. This research presents a comprehensive study of these networks which includes a topological analysis, the proposal of appropriate routing procedures and an empirical evaluation. King networks exhibit a number of attractive characteristics which translate to reduced execution times of parallel applications. For example, the execution times NPB suite are reduced up to a 30 percent. In addition, this work reveals other properties of king networks such as perfect partitioning that deserves further attention for its convenient exploitation in forthcoming high-performance parallel systems

Asignatura de centro biosanitario: Implicaciones del género en la salud

Memoria ID12-0105. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2012-2013