Institutions and business customer experience: the role of interfunctional coordination and service co-design.

This paper contributes to a better understanding of the complex phenomenon of institutions and the moderation of the main antecedents of business customer experience. Following a combination of literature review and three fieldworks, the main antecedents of business customer experience have emerged: interfunctional coordination, customer engagement and participation in the co-design of services. The role of institutions (level of formalisation) has also been considered as a possible moderator. Consequently, a conceptual framework has been developed which includes seven research propositions. The first four research propositions are related to the main elements of the model and suggest new relationships among constructs. The other three research propositions are suggested and empirically examined using Fuzzy-Set Qualitative Comparative Analysis to find causal configurations and to identify pathways that lead to business customer experience. Necessity and sufficiency of conditions that lead to a positive business customer experience are discussed for both scenarios of high and low formalisation of institutions

Understanding the adipose tissue acetylome in obesity and insulin resistance

Obesity is a widely prevalent pathology with a high exponential growth worldwide. Altered lipid accumulation by adipose tissue is one of the main causes of obesity and exploring lipid homeostasis in this tissue may represent a source for the identifica-tion of possible therapeutic targets. The study of the proteome and the post -transla-tional modifications of proteins, specifically acetylation due to its involvement in energy metabolism, may be of great interest to understand the molecular mechanisms involved in adipose tissue dysfunction in obesity. The objective of this study was to characterize the subcutaneous and omental adipose tissue acetylome in conditions of obesity and insulin resistance and to describe the importance of acetylation of key molecules in adipose tissue to use them as therapeutic targets. The results describe for the first time the acetylome of subcutaneous and omental adipose tissue under physio-logical and physiopathological conditions such as obesity and insulin resistance. New evidence showed different acetylation patterns between two main depots and high-light the molecular complexity of adipose tissue. Results showed changes in FABP4 acetylation in subcutaneous fat in relation to insulin resistance, thus unveiling a poten-tial marker of depot-specific dysfunctional expansion in obesity-associated metabolic disease. Furthermore, it is shown that the acetylation of FABP4 affects its function, mod-ulating the capacity of differentiation in adipocytes. In conclusion, this study demon-strates a profound, depot-specific alteration of adipose tissue acetylome, wherein the acetylation of FABP4 may play a key role in adipocyte differentiation and lipid accu-mulation

Fox-Fordyce Disease

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Entrenamiento psicológico en tiro olímpico : estudio de un caso

Este artículo presenta una intervención psicológica con una tiradora olímpica de la modalidad pistola aire comprimido que presenta elevados niveles de estrés, ansiedad, síndrome de burnout y deseos de retirada deportiva. El objetivo fue reducir la sintomatología ansiosa y mejorar su rendimiento deportivo. La intervención tuvo una duración de doce meses y un seguimiento de seis meses. El entrenamiento psicológico estuvo compuesto por técnicas de planteamiento de objetivos, restructuración cognitiva, entrenamiento en parada de pensamiento, autoinstrucciones y técnicas de relajación y visualización. Tras la intervención psicológica desaparece el síndrome de burnout y mejoran los indicadores de estrés y ansiedad, aumentando el rendimiento deportivo de la tiradora y desapareciendo los pensamientos de abandono deportivo. Con esta investigación se pone de manifiesto la importancia del entrenamiento psicológico en los deportistas.This article sets out a psychological intervention on an Olympic shooter. She competes in the air gun class and shows high levels of stress, anxiety, burnout syndrome and desires to retire from the sport. The main objective was to cut down the symptoms of anxiety and to enhance her sporting performance. The intervention lasted twelve months and was followed up for six months. The psychological training was composed of target-setting techniques, cognitive restructuring, thought stopping training, self instruction and relaxation and visualisation techniques. After the psychological intervention, the burnout syndrome disappeared and stress and anxiety indicators improved which meant that the shooter's sporting performance increased and her desire to retire started to disappear. This research underscores the importance of psychological training in sport.Este artigo apresenta uma intervenção psicológica com uma atiradora olímpica da modalidade de pistola de ar comprimido que apresenta elevados níveis de stress, ansiedade, síndrome de burnout e desejos de retirada desportiva. O objectivo foi reduzir a sintomatologia ansiosa e potenciar o seu rendimento desportivo. A intervenção teve a duração de doze meses e um período de monitorização de seis meses. O treino psicológico foi composto por técnicas de formulação de objectivos, restruturação cognitiva, treino em paragem de pensamento, auto-instruções e técnicas de relaxamento e visualização. Após a intervenção psicológica o síndrome de burnout foi eliminado, bem como os pensamentos de abandono desportivo. Por seu turno, verificou-se uma melhoria nos indicadores de stress e ansiedade, tal como no rendimento desportivo da atiradora. Com esta investigação comprova-se a importância do treino psicológico nos desportistas

Un acercamiento a la comprensión de la psicología del deporte en espana. Análisis de la revista de psicología del deporte 1992-1999

En este trabajo abordamos la trayectoria científica de la Revista de Psicología del Deporte desde sus orígenes en el año 1992. Su análisis resulta de especial relevancia dado que en nuestro país esta disciplina aún mantiene un desarrollo creciente por su juventud y, sobre todo, porque tras unas pocas décadas de trabajo intenso, las perspectivas de futuro son las de una consolidación cada vez más clara de los tópicos científicos que aborda. Desde este planteamiento se ha realizado un análisis bibliométrico de diferentes aspectos, que nos ayudarán a comprender mejor el desarrollo mencionado. Para ello hemos descrito aspectos esenciales en cualquier análisis de este tipo, como son los autores más productivos, las instituciones donde se genera mayor producción científica, y las temáticas fundamentales de estudio, entre otros. Los resultados apoyan la primera afirmación de que efectivamente la consolidación de esta disciplina es un hecho.In the present work we approach the scientistic trayectory of the Revista de Psicología del Deporte (Journal of the Psychology of Sport) from its origins in the year of 1992. It research becomes to special outstanding because in our country this discipline still keeps its growing development due to its youth and, specially, because after a few decades of intense work, the future perspectives are a more consolidation of the scientistic topics approached. From this view it has been made an bibliometic analysis of different sides, that will help to a better understanding of the mentioned development. For this aim it has been described the essential aspects in every kind of analysis, as the most productive authors, the institutions where the major scientistic production is made, the fundamental subjects of study, among others. The results are supporting the first confirmation that, in fact, the consolidation of this discipline is real

Pomegranate Extract Improves Maximal Performance of Trained Cyclists after an Exhausting Endurance Trial: A Randomised Controlled Trial

The efficacy of pomegranate (Punica granatum) extract (PE) for improving performance and post-exercise recovery in an active population was equivocal in previous studies. In this study, a randomised, double-blinded, placebo-controlled, balanced, cross-over trial with two arms was conducted. Eligibility criteria for participants were as follows: male, amateur cyclist, with a training routine of 2 to 4 sessions per week (at least one hour per session). The cyclists (n = 26) were divided into treatment (PE) and placebo (PLA) groups for a period of 15 days. After physical tests, the groups were exchanged after a 14-day washout period. Exercise tests consisted of endurance bouts (square-wave endurance exercise test followed by an incremental exercise test to exhaustion) and an eccentric exercise drill. The objective was to assess the efficacy of PE in performance outcomes and post-exercise muscular recovery and force restoration after a prolonged submaximal effort. Twenty-six participants were included for statistical analysis. There was a statistically significant difference in total time to exhaustion (TTE)(17.66–170.94 s, p < 0.02) and the time to reach ventilatory threshold 2 (VT2)(26.98–82.55 s, p < 0.001), with greater values for the PE compared to the PLA group. No significant results were obtained for force restoration in the isokinetic unilateral low limb test. PE, after a prolonged submaximal effort, may be effective in improving performance outcomes at maximal effort and might help to restore force in the damaged muscles.Actividad Física y Deport

Academic climate and psychopathological symptomatology in Spanish medical students

©2023. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ This document is the Published, version of a Published Work that appeared in final form in BMC Medical Education. To access the final edited and published work see https://doi.org/10.1186/s12909-023-04811-2Introduction: Medical Education studies suggest that medical students experience depression, anxiety and psy‑chopathological symptomatology in a proportion higher than in the rest of the population. In the present study, we aimed to conduct a nationwide analysis to describe student’s perceptions of Educational Climate in Spanish medical schools, and its relationship with psychopathological symptomatology. Methods . The study was carried out in 2022 in all 44 medical schools in Spain, and analyses the academic climate, and psychopathological symptomatology among medical students (n=4374). To measure these variables, we used the Dundee Ready Education Environment Measure (DREEM) for academic climate, and the SA-45 (Symptom Assess‑ ment-45 Questionnaire was used to assess psychopathological symptomatology. Results: The mean DREEM global score was low, 95.8 (SD 22.6). Worse perception of the academic climate has been found in females (t -2.21, p 0.027), in students of the clinical academic years (t 16.9, p<0.001), and public medical schools ( t 15.6, p<0.001). The SA45 general index score was high (p90) in 25.6% of participants. In respect of gender, female students presented higher levels of SA45 general index score, depression, interpersonal sensitivity, somatization, anxiety, obsession-com‑ pulsion, and phobic anxiety symptoms. Higher DREEM global and subscale scores corresponded to a higher SA-45 global index score and higher SA-45 sub‑ scale scores. Conclusions: Our study suggests a correlation between a poor perception of academic climate, increased depres‑ sion, anxiety, and other psychopathological symptoms, with a pattern that varies between diferent faculties. The perception of academic climate varied between medical schools, as did the psychopathological symptoms scores. Our fnding suggests the prevalence of these variables in medical students is, at least in part, attributable to factors directly related to the learning atmosphere

Endoglin Protein Interactome Profiling Identifies TRIM21 and Galectin-3 as New Binding Partners

This article belongs to the Special Issue TGF-beta/BMP Signaling PathwayEndoglin is a 180-kDa glycoprotein receptor primarily expressed by the vascular endothelium and involved in cardiovascular disease and cancer. Heterozygous mutations in the endoglin gene (ENG) cause hereditary hemorrhagic telangiectasia type 1, a vascular disease that presents with nasal and gastrointestinal bleeding, skin and mucosa telangiectases, and arteriovenous malformations in internal organs. A circulating form of endoglin (alias soluble endoglin, sEng), proteolytically released from the membrane-bound protein, has been observed in several inflammation-related pathological conditions and appears to contribute to endothelial dysfunction and cancer development through unknown mechanisms. Membrane-bound endoglin is an auxiliary component of the TGF-ß receptor complex and the extracellular region of endoglin has been shown to interact with types I and II TGF-ß receptors, as well as with BMP9 and BMP10 ligands, both members of the TGF-ß family. To search for novel protein interactors, we screened a microarray containing over 9000 unique human proteins using recombinant sEng as bait. We find that sEng binds with high affinity, at least, to 22 new proteins. Among these, we validated the interaction of endoglin with galectin-3, a secreted member of the lectin family with capacity to bind membrane glycoproteins, and with tripartite motif-containing protein 21 (TRIM21), an E3 ubiquitin-protein ligase. Using human endothelial cells and Chinese hamster ovary cells, we showed that endoglin co-immunoprecipitates and co-localizes with galectin-3 or TRIM21. These results open new research avenues on endoglin function and regulation.This work was supported by grants from Ministerio de Ciencia, Innovación y Universidades of Spain (SAF2013-43421-R to CB and SAF2017-84183-R to MQ), Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER; ISCIII-CB06/07/0038 to CB and contract CNV-234-PRF-360 to LR-L) and Consejo Superior de Investigaciones Científicas (CSIC; 201920E022 to CB). JC-V was supported by a postdoctoral contract co-funded by Consejo Superior de Investigaciones Científicas, Ministerio de Ciencia, Innovación y Universidades and the European Social Fund (ESF). CIBERER and CIBERNED are initiatives of the Instituto de Salud Carlos III (ISCIII) of Spain supported by European Regional Development (FEDER) funds

The potential role of the adipokine HMGB1 in obesity and insulin resistance. Novel effects on adipose tissue biology

Discovery of the adipose tissue as a major source of signaling molecules almost three decades ago set a novel physiological paradigm that paved the way for the identification of metabolic organs as endocrine organs. Adipocytes, the main adipose tissue cell type, do not only represent the principal site of energy storage in form of triglycerides, but also produce a variety of molecules for short and long distance intercellular communication, named adipokines, which coordinate systemic responses. Although the best known adipokines identified and characterized hitherto are leptin and adiponectin, novel adipokines are continuously being described, what have significantly helped to elucidate the role of adipocyte biology in obesity and associated comorbidities. One of these novel adipokines is high-mobility group box 1 (HMGB1), a ubiquitous nuclear protein that has been recently reported to be dysregulated in obese dysfunctional adipocytes. Although the classical function of HMGB1 is related to inflammation and immunity, acting as an alarmin, novel advances evidence an active implication of HMGB1 in tissue remodeling and fibrosis. This review summarizes the current evidence on the mechanisms controlling HMGB1 release, as well as its role as a regulator of adipocyte function and extracellular matrix remodeling, with special emphasis on the potential of this novel adipokine as a target in the obesity treatment

Dinuclear CoIIYIII vs Tetranuclear Co2IIY2III complexes: The effect of increasing molecular size on magnetic anisotropy and relaxation dynamics

The authors acknowledge financial support from Ministerio de Economía y Competitividad (MINECO) for Project CTQ2014-56312-P. The authors also acknowledge a Maria de Maeztu grant (MDM-2017-0767) and thank Ministerio de Educación, Cultura y Deporte for projects PGC2018-093863-B-C21 and PGC2018-102052-B-C21, the Junta de Andalucía (FQM-195) and the Project of excellence P11-FQM-7756, the University of Granada and the Generalitat de Catalunya (SGR2017-1289). M. A. P. thanks MINECO for a Juan de la Cierva Incorporation contract (IJCI-2014-19485). E. R. thanks the Generalitat de Catalunya for an ICREA Academia fellowship and CSUC for computational resources. S. G.-C. thanks Generalitat de Catalunya for a Beatriu de Pinós Fellowship (2017 BP 00080). The HFEPR studies were supported by the NHMFL, which is funded by the National Science Foundation (Cooperative Agreement DMR 1157490) and the State of Florida. The authors thank Dr. A. Ozarowski (NHMFL) for his EPR software SPIN.A new CoII2YIII2 complex with the formula [{Co(u-L)Y(NO3)}2(u-CO3)2]·2CH3OH·2H2O (where H2L = N,N’,N”-trimethyl-N,N”-bis(2-hydroxy-3-methoxy-5-methylbenzyl) diethylenetriamine) has been prepared and its structure solved by single-crystal X-Ray diffraction. The tetranuclear structure is formed by the connection of two [Co(μ-L)Y(NO3)] dinuclear units through two carbonate bridging ligands, which exhibit a tetradentate coordination mode. The CoII ion exhibits a slightly distorted octahedral CoN3O3 coordination environment. From direct-current magnetic data a large and positive axial anisotropy parameter was extracted (D = +82.62 cm-1) and its sign unambiguously confirmed by HFEPR spectra and ab initio calculations. The extracted D value is rather larger than those previously reported for the analogous CoIIYIII dinuclear complexes, which agrees with the fact that the CoII ion in the CoII2YIII2 complex exhibits the lower distortion from the octahedral geometry in this family of CoIInYIIIn complexes. Dynamic ac magnetic measurements show that the reported compound presents field-induced slow relaxation for magnetization reversal, through a combination of direct and Raman processes. Magnetic measurements on the diluted magnetic counterpart (Zn/Co = 10/1) show the persistence of these processes, pointing out their single-ion origin. The Raman relaxation process for the Co2Y2 complex is faster that those observed for the CoY dinuclear counterparts. This fact and the existence of the persistent direct process at low temperature could be because the former molecule is larger and flexible than the latter ones.Maria de Maeztu grant MDM-2017-0767Ministerio de Educación, Cultura y Deporte PGC2018-093863-B-C21, PGC2018-102052-B-C21Junta de Andalucía FQM-195, P11-FQM-7756University of GranadaMinisterio de Economía y Competitividad CTQ2014-56312-P, IJCI-2014-19485Generalitat de Catalunya SGR2017-1289, 2017 BP 00080National Science Foundation DMR 115749