Ácidos grasos esenciales en el perro (II) : aplicaciones clínicas

Este artículo de revisión hace referencia a las posibles aplicaciones clínicas de los ácidos grasos esenciales (AGE) en la medicina veterinaria. Se revisan tanto sus usos terapéuticos como profilácticos en diversas patologías y se pretenden explicar los mecanismos mediante los cuales realizan sus efectos beneficiosos.This review article refers to the applications of the essential fatty acids in veterinary medicine. The thera- peutic and prophylactic effects of essential fatty acids in several pathologies are reviewed and the mechanisms by which they provide their beneficial effects are explained

Ácidos grasos esenciales en el perro (I) : generalidades y mecanismo de acción

En este artículo de revisión se hace referencia a las generalidades de los ácidos grasos esenciales, sus diferentes familias, su síntesis y metabolismo. Así mismo, se revisan los diferentes procesos en los cuales se ven implicados, con objeto de entender cuáles podrían ser sus posibles aplicaciones a nivel clínico.This review article refers to the general traits of essential fatty acids, their different famílies, synthesis and metabolismo Even so, the different processes in which they are involved are reviewed, with the object of understanding which could be their clinical applications

Principios básicos de nutrición canina

Del tipo de alimentación que el perro recibe dependen, en gran medida, su estado de salud y su bienestar, por lo que es imprescindible conocer los requerimientos nutricionales en cada etapa de la vida y en cada estado fisiológico. Así, se podrá seleccionar el tipo de dicta que mejor satisfaga estas necesidades. Han de tenerse en cuenta, además, las características organolépticas - sabor, olor y textura- de ésta, para favorecer su ingestión

La nutrición del perro en todas sus fases de desarrollo

El manejo nutrícionol y la elección del tipo de alimento son de gran importancia para la correcta alimentación del perro. El número de comidas al día, la cantidad en coda toma, la hora a la cual se ingieren y los coracíeríslicas organolépticas más adecuadas pueden variar dependiendo de la raza, situación fisiológica y estado de salud de! animal

The Histone Marks Signature in Exonic and Intronic Regions Is Relevant in Early Response of Tomato Genes to Botrytis cinerea and in miRNA Regulation

Research into the relationship between epigenetic regulation and resistance to biotic stresses provides alternatives for plant protection and crop improvement. To unravel the mechanisms underlying tomato responses to Botrytis cinerea, we performed a chromatin immunoprecipitation (ChIP) analysis showing the increase in H3K9ac mark along the early induced genes SlyDES, SlyDOX1, and SlyLoxD encoding oxylipin-pathway enzymes, and SlyWRKY75 coding for a transcriptional regulator of hormonal signaling. This histone mark showed a more distinct distribution than the previously studied H3K4me3. The RNAPol-ChIP analysis reflected the actual gene transcription associated with increased histone modifications. A different pattern of marks in the oxylipin-related genes against P. syringae supported a pathogen-specific profile, while no significant differences occurred in SlyWRKY75. The epigenetic regulation of SlyWRKY75 by the intron-binding miR1127-3p was supported by the presence of SlyWRKY75 pre-mRNA in control plants. Interestingly, mRNA was found to be accumulated in response to B. cinerea and P. syringae, while reduction in miRNA only occurred against B. cinerea. The intronic region presented a similar pattern of marks than the rest of the gene in both pathosystems, except for H3K4me3 in the miRNA binding site upon B. cinerea. We located the gene encoding Sly-miR1127-3p, which presented reduced H3K4me3 on its promoter against B. cinerea

Expression and potential role of apolipoprotein D on the death–survival balance of human colorectal cancer cells under oxidative stress conditions

Producción CientíficaPurpose Inverse correlations of apolipoprotein D (ApoD) expression with tumor growth have been shown, therefore proposing ApoD as a good prognostic marker for diverse cancer types, including colorectal cancer (CRC). Besides, ApoD expression is boosted upon oxidative stress (OS) in many pathological situations. This study aims at understanding the role of ApoD in the progression of human CRC. Methods Samples of CRC and distant normal tissue (n051) were assayed for levels of lipid peroxidation, expression profile of OS-dependent genes, and protein expression. Three single-nucleotide polymorphisms in the ApoD gene were analyzed (n0139), with no significant associations found. Finally, we assayed the effect of ApoD in proliferation and apoptosis in the CRC HT-29 cell line

Estudios históricos 8 : arquitectura y diseño

1 archivo PDF (157 páginas)Trabajo que se divide en tres apartados: arquitectura y ciudad; diseño gráfico e industrial; teoría; Al final se suma un apartado denominado "conferencias" que fueron impartidas por invitados de otros grupo académicos en el Seminario Anual de Historia del Diseño

Erratum to “Palaeoecological context for the extinction of the Neanderthals: A small mammal study of Stratigraphic Unit V of the El Salt site, Alcoi, eastern Spain” [Palaeogeography, Palaeoclimatology, Palaeoecology 530 (2019) 163–175]

El Salt is an important reference site for understanding the extinction of Neanderthal populations in the eastern Iberian Peninsula during MIS 3. In this paper, we describe the small mammal assemblage from Stratigraphic Unit V, the youngest unit with evidence of human presence, based on nearly 1300 specimens. A total of seven rodents (Microtus arvalis, Microtus duodecimcostatus, Microtus cabrerae, Sciurus vulgaris, Arvicola sapidus, Eliomys quercinus and Apodemus sylvaticus), three insectivores (Talpa occidentalis, Crocidura sp., Sorex sp.) and one lagomorph (Oryctolagus cf. cuniculus) were identified. Palaeocological analyses point to drier conditions in this part of the stratigraphic sequence, supporting the hypothesis that an aridification scenario may have played a role in the extinction of the Neanderthal groups inhabiting this region of the Iberian Peninsula.Fil: Fagoaga, Ana. Universidad de Valencia; EspañaFil: Laplana, César. Museo Arqueológico Regional de la Comunidad de Madrid; EspañaFil: Marquina Blasco, Rafael. Universidad de Valencia; EspañaFil: Machado, Jorge. Universidad de La Laguna; EspañaFil: Marin Monfort, María Dolores. Universidad de Valencia; España. Consejo Superior de Investigaciones Científicas. Museo Nacional de Ciencias Naturales; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto Geológico del Sur. Universidad Nacional del Sur. Departamento de Geología. Instituto Geológico del Sur; ArgentinaFil: Crespo Roures, Vicente Daniel. Universidad de Valencia; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Museo Paleontológico de Alpuente; EspañaFil: Hernández, Cristo M.. Universidad de La Laguna; EspañaFil: Mallol, Carolina. Universidad de La Laguna; EspañaFil: Galván, Bertila. Universidad de La Laguna; EspañaFil: Ruiz Sánchez, Francisco Javier. Universidad de Valencia; España. Universidad Estatal Península de Santa Elena; Ecuado

Prognostic stratification of adult primary glioblastoma multiforme patients based on their tumor gene amplification profiles

[EN]everal classification systems have been proposed to address genomic heterogeneity of glioblastoma multiforme, but they either showed limited prognostic value and/or are difficult to implement in routine diagnostics. Here we propose a prognostic stratification model for these primary tumors based on tumor gene amplification profiles, that might be easily implemented in routine diagnostics, and potentially improve the patients management. Gene amplification profiles were prospectively evaluated in 80 primary glioblastoma multiforme tumors using singlenucleotide polymorphism arrays and the results obtained validated in publicly available data from 267/347 cases. Gene amplification was detected in 45% of patients, and chromosome 7p11.2 including the EGFR gene, was the most frequently amplified chromosomal region - either alone (18%) or in combination with amplification of DNA sequences in other chromosomal regions (10% of cases). Other frequently amplified DNA sequences included regions in chromosomes 12q(10%), 4q12(7%) and 1q32.1(4%). Based on their gene amplification profiles, glioblastomas were subdivided into: i) tumors with no gene amplification (55%); ii) tumors with chromosome 7p/EGFR gene amplification (with or without amplification of other chromosomal regions) (38%); and iii) glioblastoma multiforme with a single (11%) or multiple (6%) amplified DNA sequences in chromosomal regions other than chromosome 7p

Análisis de la demanda en el equipo de salud mental de Andújar: Evolución y estudio comparativo a los 20 años de apertura.

Se presentan los resultados de un análisis de la evolución de la demanda asistencial en un ESMD para la población general desde su creación en 1981 hasta 2001, analizando variables sociodemográficas, clínicas y psicoterapéuticas de 200 historias clínica