Mean sea-level variability along the northeast American Atlantic coast and the roles of the wind and the overturning circulation

The variability in mean sea level (MSL) during 1950–2009 along the northeast American Atlantic coast north of Cape Hatteras has been studied, using data from tide gauges and satellite altimetry and information from the Liverpool/Hadley Centre (LHC) ocean model, thereby providing new insights into the spatial and temporal scales of the variability. Although a relationship between sea level and the overturning circulation can be identified (an increase of approximately 1.5 cm in MSL for a decrease of 1 Sv in overturning transport), it is the effect of the nearshore wind forcing on the shelf that is found to dominate the interannual sea-level variability. In particular, winds are found to be capable of producing low-frequency changes in MSL (“accelerations”) in a narrow coastal band, comparable to those observed by the tide gauges. Evidence is presented supporting the idea of a “'common mode” of spatially coherent low-frequency MSL variability, both to the north and south of Cape Hatteras and throughout the northwest Atlantic, which is associated with large spatial-scale density changes from year to year

Structure of the vacuum states in the presence of isovector and isoscalar pairing correlations

The long standing problem of proton-neutron pairing and, in particular, the limitations imposed on the solutions by the available symmetries, is revisited. We look for solutions with non-vanishing expectation values of the proton, the neutron and the isoscalar gaps. For an equal number of protons and neutrons we find two solutions where the absolute values of proton and neutrons gaps are equal but have the same or opposite sign. The behavior and structure of these solutions differ for spin saturated (single l-shell) and spin unsaturared systems (single j-shell). In the former case the BCS results are checked against an exact calculation.Comment: 19 pages, 5 postscript figure

Improved procedural workflow for catheter ablation of paroxysmal AF with high-density mapping system and advanced technology: Rationale and study design of a multicenter international study

The antral region of pulmonary veins (PV)s seems to play a key role in a strategy aimed at preventing atrial fibrillation (AF) recurrence. Particularly, low-voltage activity in tissue such as the PV antra and residual potential within the antral scar likely represent vulnerabilities in antral lesion sets, and ablation of these targets seems to improve freedom from AF. The aim of this study is to validate a structured application of an approach that includes the complete abolition of any antral potential achieving electrical quiescence in antral regions.The improveD procEdural workfLow for cathETEr ablation of paroxysmal AF with high density mapping system and advanced technology (DELETE AF) study is a prospective, single-arm, international post-market cohort study designed to demonstrate a low rate of clinical atrial arrhythmias recurrence with an improved procedural workflow for catheter ablation of paroxysmal AF, using the most advanced point-by-point RF ablation technology in a multicenter setting. About 300 consecutive patients with standard indications for AF ablation will be enrolled in this study. Post-ablation, all patients will be monitored with ambulatory event monitoring, starting within 30 days post-ablation to proactively detect and manage any recurrences within the 90-day blanking period, as well as Holter monitoring at 3, 6, 9, and 12 months post-ablation. Healthcare resource utilization, clinical data, complications, patients' medical complaints related to the ablation procedure and patient's reported outcome measures will be prospectively traced and evaluated.The DELETE AF trial will provide additional knowledge on long-term outcome following a structured ablation workflow, with high density mapping, advanced algorithms and local impedance technology, in an international multicentric fashion. DELETE AF is registered at ClinicalTrials.gov (NCT05005143).© 2022 The Authors. Clinical Cardiology published by Wiley Periodicals LLC

Electrical properties of bismuth ferrites:Bi2Fe4O9 and Bi25FeO39

Bi2Fe4O9 was prepared by solid-state reaction and the electrical properties measured by impedance spectroscopy. After annealing in O2 at 900 °C, Bi2Fe4O9 is an electrically-homogeneous insulator. Its high frequency permittivity is constant (∼14.1) over the temperature range 300–400 °C and shows no evidence of incipient ferroelectricity at lower temperatures. On annealing in N2 at 900 °C, the pellets gradually decompose. Bi25FeO39 was prepared by both solid-state reaction and mechanosynthesis. It showed a modest amount of mixed conduction of both oxide ions and holes. Impedance analysis showed a complex response that best fitted an equivalent circuit consisting of a parallel combination of long-range conduction and short range dielectric relaxation elements. The electrical conductivity of both Bi2Fe4O9 and Bi25FeO39 is less than that of BiFeO3 prepared by solid-state reaction, which indicates that any leakage conductivity of BiFeO3 is not due to the possible presence of small amounts of these secondary phases

Data Science for Justice: The Short-Term Effects of a Randomized Judicial Reform in Kenya

Can data science be used to improve the functioning of courts, and unlock the positive effects of institutions on economic development? In a nationwide randomized experiment in Kenya, we use algorithms to identify the greatest sources of court delay for each court and recommend actions. We randomly assign courts to receive no information, information, or an information and accountability intervention. Information and accountability reduces case duration by 22%. We find an effect on contracting behaviour, with more written labor contracts being signed by firms, and an effect on wage, since jobs with written labor contracts pay more. These results demonstrate a causal relationship between judicial institutions and development outcomes

CyBase: a database of cyclic protein sequences and structures, with applications in protein discovery and engineering

CyBase was originally developed as a database for backbone-cyclized proteins, providing search and display capabilities for sequence, structure and function data. Cyclic proteins are interesting because, compared to conventional proteins, they have increased stability and enhanced binding affinity and therefore can potentially be developed as protein drugs. The new CyBase release features a redesigned interface and internal architecture to improve user-interactivity, collates double the amount of data compared to the initial release, and hosts a novel suite of tools that are useful for the visualization, characterization and engineering of cyclic proteins. These tools comprise sequence/structure 2D representations, a summary of grafting and mutation studies of synthetic analogues, a study of N- to C-terminal distances in known protein structures and a structural modelling tool to predict the best linker length to cyclize a protein. These updates are useful because they have the potential to help accelerate the discovery of naturally occurring cyclic proteins and the engineering of cyclic protein drugs. The new release of CyBase is available at http://research1t.imb.uq.edu.au/cybas

The physical oceanography of the transport of floating marine debris

Marine plastic debris floating on the ocean surface is a major environmental problem. However, its distribution in the ocean is poorly mapped, and most of the plastic waste estimated to have entered the ocean from land is unaccounted for. Better understanding of how plastic debris is transported from coastal and marine sources is crucial to quantify and close the global inventory of marine plastics, which in turn represents critical information for mitigation or policy strategies. At the same time, plastic is a unique tracer that provides an opportunity to learn more about the physics and dynamics of our ocean across multiple scales, from the Ekman convergence in basin-scale gyres to individual waves in the surfzone. In this review, we comprehensively discuss what is known about the different processes that govern the transport of floating marine plastic debris in both the open ocean and the coastal zones, based on the published literature and referring to insights from neighbouring fields such as oil spill dispersion, marine safety recovery, plankton connectivity, and others. We discuss how measurements of marine plastics (both in situ and in the laboratory), remote sensing, and numerical simulations can elucidate these processes and their interactions across spatio-temporal scales