Semi-synthetic zigzag optical lattice for ultracold bosons

We consider a one-dimensional "zigzag" lattice, pictured as a two-site wide single strip taken from a triangular lattice, affected by a tunable homogeneous magnetic flux piercing its triangular plaquettes. We focus on a semi-synthetic lattice produced by combining a one-dimensional spin-dependent lattice in the long direction with laser-induced transitions between atomic internal states that define the short synthetic dimension. In contrast to previous studies on semi-synthetic lattices, the atom-atom interactions are nonlocal in both lattice directions. We investigate the ground-state properties of the system for the case of strongly interacting bosons, and find that the interplay between the frustration induced by the magnetic field and the interactions gives rise to an exotic gapped phase at fractional filling factors corresponding to one particle per magnetic unit cell.Comment: 9 pages, 6 figures; v3: final version to appear in PR

Un San Antonio de Padua con el Niño inédito de Sebastián Martínez Domedel en el museo del Monasterio de Poblet.

La creación de nuevos espacios expositivos de las ins-tituciones museísticas o la mejora de sus instalaciones suponen una gran oportunidad para la realización de nuevos estudios de los inventarios y los catálogos de sus fondos artísticos. Así, las actividades de revisión y actualización de su información suelen arrojar nueva luz e interesantes novedades como la asignación de nuevas atribuciones sobre obras que hasta la fecha estaban catalogadas como anónimas. Gracias a la rea-lización de estos trabajos, se ha ampliado el conoci-miento en torno al lienzo de San Antonio de Padua con el Niño del museo del Real Monasterio de Poblet (Tarragona) al relacionar su autoría con el pintor Sebastián Martínez Domedel. Se trata por tanto de la presentación de una obra inédita que se incorpora al catálogo de este artista del siglo XVII.The creation of new exhibition spaces and the improvement of museum facilities represents a great opportunity for the realization of new studies regarding their art inventories and catalogs. In this way, the review and updating of existing information sheds new light on the works, including interesting developments such as the designation of works which until now were cataloged as anonymous. Thanks to the completion of these projects, knowledge surrounding the canvas Saint Anthony of Padua with the Childin the Real Monastery of Poblet Museum (Tarragona) has been extended, attributing its authorship to the painter Sebastián Martínez Domedel. Presented here is an unpublished work that is included in this XVII century artist¿s catalog.Universidad Pablo de Olavid

Production and Use of Ceramics in the First Millennium BC: Jebel Moya, Sudan

The site of Jebel Moya, situated in the center of the southern Gezira Plain in southcentral Sudan, has an occupational sequence spanning at least five millennia until around 2000 years ago. Renewed excavation is shedding new light on its occupational chronology and socioeconomic history, including activities such as burial, savanna herding, and domesticated sorghum cultivation practices dating to at least the mid-third millennium BC. In the present study, predominantly final phase pottery sherds from the first millennium BC to the start of the first millennium AD (Assemblage 3) have been analyzed via a combination of thin section petrography and instrumental geochemistry to determine their raw materials and place of manufacture and reconstruct their manufacturing technology. Organic residue analysis was also conducted to identify the products processed within vessels found at the site. The results suggest the existence of a well-developed local ceramic craft tradition that persisted for over one thousand years. Pots from Assemblage 3 were used to process, store, and consume animal and plant products, thus reinforcing emerging evidence for early agro-pastoral activities

Demonstration of low power and highly uniform 6-bit operation in SiO2-based memristors embedded with Pt nanoparticles

In this work, an optimized method was implemented for attaining stable multibit operation with low energy consumption in a two-terminal memory element made from the following layers: Ag/Pt nanoparticles (NPs)/SiO2/TiN in a 1-Transistor-1-Memristor configuration. Compared to the reference sample where no NPs were embedded, an enlarged memory window was recorded in conjunction with reduced variability for both switching states. A comprehensive numerical model was also applied to shed light on this enhanced performance, which was attributed to the spatial confinement effect induced by the presence of the Pt NPs and its impact on the properties of the percolating conducting filaments (CFs). Although 5-bit precision was demonstrated with the application of the incremental-step-pulse-programming (ISPP) algorithm, the reset process was unreliable and the output current increased abnormally when exceeded the value of 150 uA. As a result, the multibit operation was limited. To address this issue, a modified scheme was developed to accurately control the distance between the various resistance levels and achieve highly reliable 6-bit precision. Our work provides valuable insights for the development of energy-efficient memories for applications where a high density of conductance levels is required

Evaluation of positive mental health and sense of coherence in mental health professionals

Background: the Sense of Coherence (SOC) of Antonowsky (1996) which is based on salutogenic theory and the multifactor Positive Mental Health (PMH) model of Lluch (1999) provide two constructs for comprehending, evaluating, and intervening in the promotion and maintenance of a good state of mental health. Aim: were assessed self-rated mental health of health professionals working in mental health services and relations between both constructs and sociodemographic, work, and health variables. Methods: the sample was made up of n=102 attending professionals at the mental health units of the Parc Hospitalari Martí i Julià, in Salt, Girona. The variables studied were sociodemographic work-related, health-related, and self-perception of mental health, evaluated by means of the Sense of Coherence questionnaire and the Positive Mental Health questionnaire. The questionnaires were self-administered. Results: overall, the sample studied scored high in the Sense of Coherence and the Positive Mental Health questionnaires. In terms of the relation between the overall scores of the SOC questionnaire and the PMH, analysis revealed a positive relation between the two. Conclusions: this positive relation between the two questionnaires may be of particular interest in future studies of the multifactor model of Positive Mental Health and the salutogenic model that underlies the Sense of Coherence, by generating a global conceptual framework for the study of mental health from a positive perspective

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

Background: Experimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. Methods: We conducted a randomized, double-blind trial of canakinumab, a therapeutic monoclonal antibody targeting interleukin-1β, involving 10,061 patients with previous myocardial infarction and a high-sensitivity C-reactive protein level of 2 mg or more per liter. The trial compared three doses of canakinumab (50 mg, 150 mg, and 300 mg, administered subcutaneously every 3 months) with placebo. The primary efficacy end point was nonfatal myocardial infarction, nonfatal stroke, or cardiovascular death. RESULTS: At 48 months, the median reduction from baseline in the high-sensitivity C-reactive protein level was 26 percentage points greater in the group that received the 50-mg dose of canakinumab, 37 percentage points greater in the 150-mg group, and 41 percentage points greater in the 300-mg group than in the placebo group. Canakinumab did not reduce lipid levels from baseline. At a median follow-up of 3.7 years, the incidence rate for the primary end point was 4.50 events per 100 person-years in the placebo group, 4.11 events per 100 person-years in the 50-mg group, 3.86 events per 100 person-years in the 150-mg group, and 3.90 events per 100 person-years in the 300-mg group. The hazard ratios as compared with placebo were as follows: in the 50-mg group, 0.93 (95% confidence interval [CI], 0.80 to 1.07; P = 0.30); in the 150-mg group, 0.85 (95% CI, 0.74 to 0.98; P = 0.021); and in the 300-mg group, 0.86 (95% CI, 0.75 to 0.99; P = 0.031). The 150-mg dose, but not the other doses, met the prespecified multiplicity-adjusted threshold for statistical significance for the primary end point and the secondary end point that additionally included hospitalization for unstable angina that led to urgent revascularization (hazard ratio vs. placebo, 0.83; 95% CI, 0.73 to 0.95; P = 0.005). Canakinumab was associated with a higher incidence of fatal infection than was placebo. There was no significant difference in all-cause mortality (hazard ratio for all canakinumab doses vs. placebo, 0.94; 95% CI, 0.83 to 1.06; P = 0.31). Conclusions: Antiinflammatory therapy targeting the interleukin-1β innate immunity pathway with canakinumab at a dose of 150 mg every 3 months led to a significantly lower rate of recurrent cardiovascular events than placebo, independent of lipid-level lowering. (Funded by Novartis; CANTOS ClinicalTrials.gov number, NCT01327846.

Skeletal muscle hypertrophy rewires glucose metabolism: an experimental investigation and systematic review

BACKGROUND: Proliferating cancer cells shift their metabolism towards glycolysis, even in the presence of oxygen, to especially generate glycolytic intermediates as substrates for anabolic reactions. We hypothesize that a similar metabolic remodelling occurs during skeletal muscle hypertrophy. METHODS: We used mass spectrometry in hypertrophying C2C12 myotubes in vitro and plantaris mouse muscle in vivo and assessed metabolomic changes and the incorporation of the [U-13C6]glucose tracer. We performed enzyme inhibition of the key serine synthesis pathway enzyme phosphoglycerate dehydrogenase (Phgdh) for further mechanistic analysis and conducted a systematic review to align any changes in metabolomics during muscle growth with published findings. Finally, the UK Biobank was used to link the findings to population level. RESULTS: The metabolomics analysis in myotubes revealed insulin-like growth factor-1 (IGF-1)-induced altered metabolite concentrations in anabolic pathways such as pentose phosphate (ribose-5-phosphate/ribulose-5-phosphate: +40%; P = 0.01) and serine synthesis pathway (serine: -36.8%; P = 0.009). Like the hypertrophy stimulation with IGF-1 in myotubes in vitro, the concentration of the dipeptide l-carnosine was decreased by 26.6% (P = 0.001) during skeletal muscle growth in vivo. However, phosphorylated sugar (glucose-6-phosphate, fructose-6-phosphate or glucose-1-phosphate) decreased by 32.2% (P = 0.004) in the overloaded muscle in vivo while increasing in the IGF-1-stimulated myotubes in vitro. The systematic review revealed that 10 metabolites linked to muscle hypertrophy were directly associated with glycolysis and its interconnected anabolic pathways. We demonstrated that labelled carbon from [U-13C6]glucose is increasingly incorporated by ~13% (P = 0.001) into the non-essential amino acids in hypertrophying myotubes, which is accompanied by an increased depletion of media serine (P = 0.006). The inhibition of Phgdh suppressed muscle protein synthesis in growing myotubes by 58.1% (P < 0.001), highlighting the importance of the serine synthesis pathway for maintaining muscle size. Utilizing data from the UK Biobank (n = 450 243), we then discerned genetic variations linked to the serine synthesis pathway (PHGDH and PSPH) and to its downstream enzyme (SHMT1), revealing their association with appendicular lean mass in humans (P < 5.0e-8). CONCLUSIONS: Understanding the mechanisms that regulate skeletal muscle mass will help in developing effective treatments for muscle weakness. Our results provide evidence for the metabolic rewiring of glycolytic intermediates into anabolic pathways during muscle growth, such as in serine synthesis

Security threats in network coding-enabled mobile small cells

The recent explosive growth of mobile data traffic, the continuously growing demand for higher data rates, and the steadily increasing pressure for higher mobility have led to the fifth-generation mobile networks. To this end, network-coding (NC)-enabled mobile small cells are considered as a promising 5G technology to cover the urban landscape by being set up on-demand at any place, and at any time on any device. In particular, this emerging paradigm has the potential to provide significant benefits to mobile networks as it can decrease packet transmission in wireless multicast, provide network capacity improvement, and achieve robustness to packet losses with low energy consumption. However, despite these significant advantages, NC-enabled mobile small cells are vulnerable to various types of attacks due to the inherent vulnerabilities of NC. Therefore, in this paper, we provide a categorization of potential security attacks in NC-enabled mobile small cells. Particularly, our focus is on the identification and categorization of the main potential security attacks on a scenario architecture of the ongoing EU funded H2020-MSCA project “SECRET” being focused on secure network coding-enabled mobile small cells

Marcadores da paisagem e intervenção cadastral no território próximo da cidade de <i>Bracara Augusta (Hispania Citerior Tarraconensis)</i>

This paper focuses the organization of the rural landscape around the Roman town of <i>Bracara Augusta</i> and the identification of a Roman cadastre, perfectly adapted to the relief and to the main hydrographical network of the region. This cadastre is organized in modules of 20 by 20 <i>actus</i> with a predominant orientation of 16º NNW, what may be inferred by the clear intersection of some important axes. We have also detected two <i>cippi</i> with a cross engraved on their upper face, separated by 20 <i>actus</i>, probably connected with limits or <i>termini</i>.<br><br>Este trabajo tiene como objetivo presentar algunos de los resultados del estudio sobre el poblamiento y la organizacion del paisaje rural en torno a la ciudad romana de <i>Bracara Augusta</i>. La existencia de un cadastro romano con una orientación dominante de 16º NNO y una modulación de 20x20 <i>actus</i>, se confirma gracias a la documentación de algunos elementos de delimitación, de los que podemos destacar dos cipos con una distancia entre sí de 20 <i>actus</i>. [pt] Este artigo propõe-se apresentar os resultados do estudo do povoamento e da organização da paisagem em torno da cidade romana de <i>Bracara Augusta</i>. Este objectivo orienta-se, mais especificamente, para os dados relativos à identificação de um cadastro romano perfeitamente adaptado às formas estruturantes do relevo e da rede hidrográfica. Este cadastro possui uma orientação de cerca de 16º NNO com uma modulação de 20x20 <i>actus</i>, e encontra-se confirmado por alguns elementos demarcatórios, nomeadamente dois cipos que possuem entre si 20 <i>actus</i> de distância